Bidirectional association of anogenital and oral cavity/pharyngeal carcinomas in menAndrew G Sikora
Department of Otolaryngology, Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY 10029, USA
Arch Otolaryngol Head Neck Surg 135:402-5. 2009
..To test the hypothesis of a bidirectional association of anogenital and oral cavity/pharyngeal human papillomavirus (HPV)-associated cancers in men...
Anatomic sites at elevated risk of second primary cancer after an index head and neck cancerLuc G T Morris
Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Cancer Causes Control 22:671-9. 2011
..Our objectives were to quantify the excess risk of SPM across all anatomic sites in which SPM risk is meaningfully elevated, including non-HNLE sites, in a large cohort of US patients...
Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapyCharles C L Tong
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, USA
Oncol Rep 27:1580-6. 2012
..The most common grade 3-4 toxicities were mucositis (46%), leukopenia (18%), anemia (18%) and dermatitis (17%). Concurrent 5-FU, HU, cetuximab and SIB-IMRT is a highly active regimen, particularly in patients with p16-positive disease...
Predictors of survival in mucosal melanoma of the head and neckDaniel Jethanamest
Department of Otolaryngology Head and Neck Surgery, New York University School of Medicine, New York, NY, USA
Ann Surg Oncol 18:2748-56. 2011
..In order to identify factors predictive of survival, we analyzed MMHN outcomes in a large US cohort...
Second primary cancers after an index head and neck cancer: subsite-specific trends in the era of human papillomavirus-associated oropharyngeal cancerLuc G T Morris
Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY 10021, USA
J Clin Oncol 29:739-46. 2011
..Our objectives were to identify HNSCC subsite-specific differences in SPM risk and distribution and to describe trends in risk over 3 decades, before and during the era of human papillomavirus (HPV) -associated oropharyngeal SCC...
Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor releasePadmini Jayaraman
Department of Otolaryngology, Mount Sinai School of Medicine, New York, NY 10028, USA
J Immunol 188:5365-76. 2012
..These data suggest a critical role for tumor-expressed iNOS in the recruitment and induction of functional MDSC by modulation of tumor VEGF secretion and upregulation of STAT3 and ROS in MDSC...
Conference scene: immune effector mechanisms in tumor immunityAndrew G Sikora
Departments of Otolaryngology, Immunology, Oncological Sciences and Dermatology, Mount Sinai School of Medicine, New York, NY 10029, USA
Immunotherapy 4:141-3. 2012
..The conference built on these early successes and aimed to push further into the uncharted territories of successful cancer immunotherapy...
Targeting immune suppressing myeloid-derived suppressor cells in oncologyJohnny Kao
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY 10029, United States
Crit Rev Oncol Hematol 77:12-9. 2011
..Since c-kit can be readily inhibited by several small molecule inhibitors including imatinib, sunitinib and dasatinib, targeting immune suppressing cells can be readily accomplished in the clinic...
Tall-cell variant of papillary thyroid carcinoma: a matched-pair analysis of survivalLuc G T Morris
Head and Neck Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Thyroid 20:153-8. 2010
..Our objective was to utilize a large cancer registry to obtain sufficient power to differentiate between outcomes in cases of TCV and PTC...
Tamoxifen therapy for aggressive fibromatosis of the posterior triangle of the neckLuc G Morris
Division of Head and Neck Surgery and Oncology, Department of Otolaryngology, New York University School of Medicine, New York, NY 1016, USA
Otolaryngol Head Neck Surg 136:674-6. 2007
The basis of racial differences in the incidence of thyroid cancerLuc G T Morris
Head and Neck Service, Department of Otolaryngology, New York University Cancer Institute, New York University School of Medicine, New York, NY, USA
Ann Surg Oncol 15:1169-76. 2008
..The incidence of thyroid cancer in black Americans is half that in white Americans. It is unknown whether this gap represents a population difference in disease or is attributable to inferior cancer screening in the black population...
Esthesioneuroblastoma: a population-based analysis of survival and prognostic factorsDaniel Jethanamest
Department of Otolaryngology, New York University School of Medicine, New York, NY, USA
Arch Otolaryngol Head Neck Surg 133:276-80. 2007
..To investigate the characteristics associated with survival in esthesioneuroblastoma and to determine whether the modified Kadish staging system can predict outcome...
Discrimination of benign and neoplastic mucosa with a high-resolution microendoscope (HRME) in head and neck cancerPeter M Vila
Department of Otolaryngology Head and Neck Surgery, Mount Sinai School of Medicine, New York, NY, USA
Ann Surg Oncol 19:3534-9. 2012
..Our goal was to determine the accuracy and inter-rater reliability of head and neck cancer specialists using high-resolution microendoscopic (HRME) images to discriminate between cancerous and benign mucosa...
Recognizing and reversing the immunosuppressive tumor microenvironment of head and neck cancerCharles C L Tong
Department of Otolaryngology, Head and Neck Surgery, The Mount Sinai School of Medicine, One Gustave L Levy Place, Box 1189, New York, NY, USA
Immunol Res 54:266-74. 2012
..This article outlines significant immune-suppressive mechanisms in the HNSCC tumor microenvironment and potential approaches to enhancing the antitumor immune response...
HPV-induced oropharyngeal cancer, immune response and response to therapyHa Linh Vu
Department of Radiation Oncology, Mount Sinai School of Medicine, New York, NY, United States
Cancer Lett 288:149-55. 2010
..This article outlines several mechanisms whereby the observed improved response of HPV-positive tumors to radiotherapy may be related to enhancement of the immune response following radiotherapy...
Transoral robotic resection and reconstruction for head and neck cancerEric M Genden
Mount Sinai School of Medicine, Department of Otolaryngology Head and Neck Surgery, New York, New York 10029, USA
Laryngoscope 121:1668-74. 2011
..To evaluate the patterns of failure, survival, and functional outcomes for patients treated with transoral robotic surgery (TORS) and compare these results with those from a cohort of patients treated with concurrent chemoradiation (CRT)...
Emergency parotidectomy for penetrating zone III neck traumaLuc G Morris
Division of Acute Care Surgery, New York Presbyterian Hospital, Columbia College of Physicians and Surgeons, 161 Fort Washington Ave, Herbert Irving Pavilion, HIP 8 808, New York, NY 10032, USA
Arch Surg 142:1206-8. 2007
..The management of penetrating trauma to the parotid region,and relevant anatomy, are discussed...
Oropharyngeal kaposi sarcoma in related persons negative for human immunodeficiency virusAndrew G Sikora
Department of Otolaryngology Head and Neck Surgery, New York University School of Medicine, New York, New York, USA
Ann Otol Rhinol Laryngol 117:172-6. 2008
..We describe an unusual presentation of KS in 2 related individuals and describe our attempts to determine whether oropharyngeal KS is associated with human herpesvirus 8 (HHV-8)...
The changing demographics of head and neck squamous cell carcinoma in the United StatesAndrew G Sikora
Department of Otolaryngology, New York University School of Medicine, New York, New York, USA
Laryngoscope 114:1915-23. 2004
..During this time, substantial immigration from other countries has occurred, and the average lifespan has increased. We tested the hypothesis that these trends have altered the HNSCCA patient population...