Hans B Sieburg

Summary

Publications

  1. pmc Lifespan differences in hematopoietic stem cells are due to imperfect repair and unstable mean-reversion
    Hans B Sieburg
    Stem Cell and Regenerative Medicine Program, The Sanford Burnham Medical Research Institute, La Jolla, California, USA
    PLoS Comput Biol 9:e1003006. 2013
  2. pmc Predicting clonal self-renewal and extinction of hematopoietic stem cells
    Hans B Sieburg
    Stem Cells and Regenerative Biology Program, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:4370-5. 2011
  3. pmc Stem cell heterogeneity: implications for aging and regenerative medicine
    Christa E Muller-Sieburg
    Sanford Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 119:3900-7. 2012
  4. ncbi request reprint Classification of short kinetics by shape
    Hans B Sieburg
    Department of Mathematics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    In Silico Biol 4:209-17. 2004

Detail Information

Publications4

  1. pmc Lifespan differences in hematopoietic stem cells are due to imperfect repair and unstable mean-reversion
    Hans B Sieburg
    Stem Cell and Regenerative Medicine Program, The Sanford Burnham Medical Research Institute, La Jolla, California, USA
    PLoS Comput Biol 9:e1003006. 2013
    ..A likely interpretation of these findings is that the lifespan of HSCs is determined by preprogrammed differences in repair capacity...
  2. pmc Predicting clonal self-renewal and extinction of hematopoietic stem cells
    Hans B Sieburg
    Stem Cells and Regenerative Biology Program, Sanford Burnham Medical Research Institute, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 108:4370-5. 2011
    ..Other decay functions lead to either graft failure or leukemic proliferation. We propose that dynamical fate probabilities are a crucial condition that leads to self-limiting clonal proliferation...
  3. pmc Stem cell heterogeneity: implications for aging and regenerative medicine
    Christa E Muller-Sieburg
    Sanford Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA 92037, USA
    Blood 119:3900-7. 2012
    ..This finding has implications for other aspects of HSC biology and applications in re-generative medicine. The possibility that other adult tissue stem cells show similar heterogeneity and mechanisms of aging is discussed...
  4. ncbi request reprint Classification of short kinetics by shape
    Hans B Sieburg
    Department of Mathematics, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    In Silico Biol 4:209-17. 2004
    ..Examples from stem cell research are presented to illustrate different aspects of the method. The approach is likely to have applications in many fields...