Igor Shuryak

Summary

Publications

  1. pmc A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 48:275-86. 2009
  2. pmc A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 48:263-74. 2009
  3. doi request reprint Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radiodurans
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 49:693-703. 2010
  4. pmc Cancer risks after radiation exposure in middle age
    Igor Shuryak
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA
    J Natl Cancer Inst 102:1628-36. 2010
  5. doi request reprint Predicting the risk of secondary lung malignancies associated with whole-breast radiation therapy
    John Ng
    Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 83:1101-6. 2012
  6. ncbi request reprint Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    J Natl Cancer Inst 98:1794-806. 2006
  7. pmc The balance between initiation and promotion in radiation-induced murine carcinogenesis
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 174:357-66. 2010
  8. pmc Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 178:17-24. 2012
  9. pmc A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    J Theor Biol 261:305-17. 2009
  10. doi request reprint Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging
    David J Brenner
    Center for Radiological Research and Department of Medicine and Radiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Radiology 261:193-8. 2011

Collaborators

Detail Information

Publications14

  1. pmc A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 48:275-86. 2009
    ..Potentially, the model can be incorporated into radiotherapy treatment planning algorithms, adding second cancer risk as an optimization criterion...
  2. pmc A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: approach
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 48:263-74. 2009
    ....
  3. doi request reprint Effects of radiation quality on interactions between oxidative stress, protein and DNA damage in Deinococcus radiodurans
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, NY 10032, USA
    Radiat Environ Biophys 49:693-703. 2010
    ..These results suggest that synergism between oxidative stress and DNA damage may play an important role not only during γ-ray exposure, but during high-LET radiation exposure as well...
  4. pmc Cancer risks after radiation exposure in middle age
    Igor Shuryak
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA
    J Natl Cancer Inst 102:1628-36. 2010
    ..These observations are inconsistent with most standard models of radiation-induced cancer, which predict that relative risks decrease monotonically with increasing age at exposure, at all ages...
  5. doi request reprint Predicting the risk of secondary lung malignancies associated with whole-breast radiation therapy
    John Ng
    Department of Radiation Oncology, Columbia University Medical Center, New York, NY 10032, USA
    Int J Radiat Oncol Biol Phys 83:1101-6. 2012
    ..In this study, a biologically based secondary malignancy model was used to quantify the risk of secondary lung malignancies (SLMs) associated with several common methods of delivering whole-breast radiation therapy (RT)...
  6. ncbi request reprint Radiation-induced leukemia at doses relevant to radiation therapy: modeling mechanisms and estimating risks
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    J Natl Cancer Inst 98:1794-806. 2006
    ..This earlier model predicted the risks of solid tumors induced by radiation therapy but overestimated the corresponding leukemia risks...
  7. pmc The balance between initiation and promotion in radiation-induced murine carcinogenesis
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 174:357-66. 2010
    ..Also similar to findings in humans, initiation dominates the ERR at young ages in mice, when there are few background pre-malignant cells, and promotion becomes important at older ages...
  8. pmc Mechanistic analysis of the contributions of DNA and protein damage to radiation-induced cell death
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 178:17-24. 2012
    ..Enhanced understanding of these causes can stimulate research on novel radioprotection strategies...
  9. pmc A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, 630 West 168th St, New York, NY 10032, USA
    J Theor Biol 261:305-17. 2009
    ..Our model of radiogenic oxidative stress is consistent with these data and can potentially be generalized to other organisms and lower radiation doses...
  10. doi request reprint Impact of reduced patient life expectancy on potential cancer risks from radiologic imaging
    David J Brenner
    Center for Radiological Research and Department of Medicine and Radiology, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10032, USA
    Radiology 261:193-8. 2011
    ....
  11. ncbi request reprint Reducing second breast cancers: a potential role for prophylactic mammary irradiation
    David J Brenner
    Center for Radiological Research, Department of Radiation Oncology, Columbia University Medical Center, New York, NY, USA
    J Clin Oncol 25:4868-72. 2007
  12. pmc Radiation-induced carcinogenesis: mechanistically based differences between gamma-rays and neutrons, and interactions with DMBA
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York, United States of America
    PLoS ONE 6:e28559. 2011
    ..The model provides a mechanistic and quantitative explanation which is consistent with the data and may provide useful insight into human carcinogenesis...
  13. pmc Adapting the γ-H2AX assay for automated processing in human lymphocytes. 1. Technological aspects
    Helen C Turner
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 175:282-90. 2011
    ..This study demonstrates for the first time the optimization and use of our robotically based biodosimetry workstation to successfully quantify γ-H2AX total fluorescence in irradiated peripheral lymphocytes...
  14. ncbi request reprint Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues
    Igor Shuryak
    Center for Radiological Research, Columbia University Medical Center, New York, New York 10032, USA
    Radiat Res 168:741-9. 2007
    ..These assumptions are implemented by a mathematical formalism and computational algorithms. The model adequately describes data on bystander responses in the 3D system using a small number of adjustable parameters...