Y Shukla

..CONCLUSION: The results of the present study suggest that DAS is effective in exerting antioxidant effects by inhibiting testosterone-induced oxidative stress and might be helpful in preventing prostate cancer...

..26% prevention, at 96 h time interval, against DMBA induced DNA strand breakage. The results suggest preventive effects of lupeol on DMBA induced DNA alkylation damage in Swiss albino mice...

..49% protection, at an intermittent period of 48 h, against DMBA-induced DNA strand breakage. These findings suggest that DAS can effectively check the mutations induced by environmental toxicants...

..Thus, the results of this study demonstrate that lupeol/MPE is effective in combating testosterone-induced changes in mouse prostate as well as causing apoptosis by modulating cell-growth regulators...

....

..In the present review we attempted to describe the present scenario and project the future of herbal medicine...

..Altogether, we have highlighted the possibilities of the use of senescence targeting drugs, mitotic kinases and anti-mitotic agents in fabricating novel strategies in cancer control...

..These results indicate the possible tumourigenic risk associated with mustard oil consumption...

..Thus, [6]-gingerol shows its protective effects in both in vivo and in vitro prostate cancer models by modulation of proteins involved in apoptosis pathway...

..This article reviews the different popular alternative cancer therapies practiced in India and neighboring south east Asian countries to project the current international scenario on complementary and alternative cancer therapies...

..The antimutagenic potential of 13C towards CP was also evident as the status of mitotic index (MI) was found to show an increment. This study revealed the antigenotoxic potential of I3C against CP-induced chromosomal mutations...

..We postulate that the true mutagenic potential of Mancozeb may be masked by its toxic effect to the tester strain used...

..This review highlights the effects of physical activity on various malignancies in the context of redox status modulated during exercise...

..These results thus suggest the chemopreventive effect of I3C in rat hepatocarcinogenesis by suppressing DEN- and AAF-induced AHF development...

..A number of mechanisms that may be involved in the chemopreventive effects of ginger and its components have been reported from the laboratory studies in a wide range of experimental models...

..This review discusses mechanistic basis of cancer chemopreventive effects of garlic-derived products, their implication in cancer management and ways and means to take these agents from bench to real life situations...

..Here, we focus on some of the myriad pathways that resveratrol targets to exert its chemopreventive role and advocate that resveratrol holds tremendous potential as an efficient anticancer drug of the future...

..Our results showed that CYP has mutagenic activity, inducing dominant lethal mutations in male germ cells of mice and caution is recommended in the use of this insecticide...

..CYM when tested for complete carcinogenic activity induced tumour formation in both male and female animals at all the three tested dose levels...

..Thus results of the present investigations revealed that GE has chemopreventive potential against CP induced chromosomal mutations in Swiss albino mice...

..Hence the study suggests that tea has a protective effect against BaP-induced genetic damage to germ cells in Swiss albino mice...

..The number of animals showing pulmonary adenocarcinomas induced by DEN was found to be inhibited significantly by 4% ATE. In addition, splenomegaly was found to be protected by ATE administration...

..Localization of the glutathione dependent Nitroblue tetrazolium (NBT) reductase in fresh frozen sections of mouse skin and possible dependence of NBT reductase on tissue thiol levels has been investigated...

..These results show that curcumin can effectively suppress the DEN-induced development of AHF in rat liver...

..The anticytotoxic potential of curcumin towards CP was also evident as the status of mitotic index was found to show increment. The study revealed the antigenotoxic potential of curcumin against CP induced chromosomal mutations...

..To study the effects of diallyl sulfide (DAS), an organosulfur compound present in garlic (Allium sativum), on the life span of ehrlich ascites (EA) tumor bearing Swiss albino mice, cytotoxicity and angiogenesis...

..In this review, we summarize the results of those studies that report combinatorial cancer chemopreventive action of various nutraceuticals and their combinations with anticancer drugs...

....

..These findings suggest the protective role of DAS in rat hepatocarcinogenesis, by suppressing DEN- and 2-AAF-induced AHF development...

..Deltamethrin exposure failed to show any tumour promoting and complete tumorigenic potential at all the three tested dose levels...

..However, 1% sulphur administration failed to induce AHF up to significant levels. The results thus revealed the possible tumorigenic risk associated with the high sulphur-containing diet...

..A significant decrease in the relative and absolute hepatic weight of RCO-supplemented rats was recorded (P<0·05). In conclusion, dietary consumption of RCO can cause a genotoxic and preneoplastic change in the liver...

....

....

..wt.), in the two-stage mouse skin model of carcinogenesis. Quinalphos exposure failed to produce neoplasia when tested for complete carcinogenic activity at all three tested dose levels or tumour promoting activity...

..A slight increase in dominant lethal mutation rate was observed by increasing doses of deltamethrin in early weeks but decreased in later weeks, so an apparent dose response was not observed...

..Hence the study revealed that black tea has a protective efficacy in suppressing BaP and CP induced mutagenicity in a microbial test system...

..Hence, the study reveals that constituents present in black tea impart protection against androgen induced oxidative injury that may result in development of prostate cancer...

..Although there is no significant recovery at 12 weeks assessment but still significant impairment persist on biochemical and behavioural parameters...

..sanctum provides protection against chemical carcinogenesis in one or more of the following mechanisms: (i) by acting as an antioxidant; (ii) by modulating phase I and II enzymes; (iii) by exhibiting antiproliferative activity...

..In the present study, we studied the chemopreventive effects of green tea polyphenols (GTP) and black tea polyphenols (BTP) against diethylnitrosoamine (DEN) induced lung tumors in Swiss albino mice...

..Thus, results of the present investigation revealed that lupeol and MPE have protective effects against B[a]P-induced clastogenic changes in Swiss albino mice...

..Our results revealed that BTE provides protection against oxidative damage induced by xenobiotics...

..Thus, we can conclude that the polyphenolic constituents present in black tea and green tea induce mitochondrial pathway of apoptosis and hence can be used as a potential chemopreventive agents against skin cancer...

..Thus, one mechanism of the growth inhibitory properties of DAS is through the suppression of development of tumors that harbor ras mutations by inhibiting the membrane association of oncogenic p21/ras protein...

..Thus the study reveals the antimutagenic potential of these dietary compounds towards BaP- and CP-induced genotoxicity in microbial and mammalian test systems...

..These observations suggest that induction of apoptosis may be the major contributing factor for antitumorigenic properties of DAS...

..Thus, augmented NO availability subsequent to iNOS induction seems to play an important role in the initial phase of neurodegeneration...

....

..Thus, our data suggests that tea polyphenols exhibit anti-cancer potential against cervical cancer by inhibition of cell growth and induction of apoptosis...

..These alterations were restored by lupeol/MPE, indicating inhibition of apoptosis. Thus, lupeol/MPE was found to be effective in combating oxidative stress induced cellular injury of mouse liver by modulating cell-growth regulators...

..To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice...

..Thus, it can be concluded that TF acts as an effective anti-proliferative agent by modulating cell growth regulators in prostate cancer cells...

..The above features thus indicate that I3C could be used as a novel modulator of P-gp-mediated multidrug resistance in vitro and may be effective as a dietary adjuvant in the treatment of MDR cancers...

..The present investigation suggests that I3C can significantly inhibit the P-gp over-expression and may have utility as a dietary adjuvant in the treatment of cancer for the reversal of multiple drug resistance...

..The above features thus indicate that DAS can serve as a novel, non-toxic modulator of MDR and can be used as a dietary adjuvant...

..These firmly suggest that [6]-gingerol can be effectively used for the treatment of skin cancer...

..Thus, our results indicate that lupeol has novel anti-proliferative and apoptotic potential that may be helpful in designing strategies to fight skin cancer...

..Thus, DAS can be a potential chemopreventive agent against skin tumor development...

....

..To investigate the chemopreventive potential of resveratrol, a phytoalexin found in seeds and skin of grapes, berries and peanuts in 7,12 dimethyl benz(a)anthracene (DMBA) induced mouse skin tumorigenesis...

....

....

..v. injection showed maximum expression of the reporter gene in the spleen. These results demonstrate the potential of these particles as efficient transfection reagents...

..Therefore, it is a concept of an HPV screening with reflex cytology in combination with DNA flow cytometry to detect progressive lesions with the greatest possible sensitivity and specificity...

....

..Altogether, these results suggested that glyphosate has tumor promoting potential in skin carcinogenesis and its mechanism seems to be similar to TPA...

....

..This review covers the current knowledge about the DRs, summarizes main signaling in DRs and also summarizes the preclinical approaches of these DRs in cancer therapy...

....

..Thus, modulation of inappropriate cell signaling cascades driven by bromelain is a coherent approach in achieving chemoprevention...

..Thus, our study suggests that lupeol possess novel antiproliferative and apoptotic potential against PCa...

..Thus, effect of TF on PCA cell lines seems to be irrespective of their androgen status...

..Conclusively, plk1 gene silencing can enhance the sensitivity of A431 cells to low doses of CDDP by upregulating p73α expression and thus can be a revolutionary approach in cancer chemotherapy...

..In conclusion, our study demonstrates that the combination of resveratrol and UVB act synergistically against skin cancer cells. Thus, resveratrol is a potential chemotherapeutic agent against skin carcinogenesis...

..These results suggest that lupeol could be an effective anti-cancer agent and merits further investigation...

..The promising chemo-preventive nature of liposomal DAS may form the basis for establishing effective means of controlling various forms of cancer, including skin papilloma...

..This study examines the role of cell survival/apoptosis related proteins involved in NFkappaB signaling pathways and its associated events in GTP-induced chemoprevention of prostate cancer in TRAMP mice...

..The present studies reveal the antitumor and protective potential of TA against polycyclic aromatic hydrocarbon induced skin carcinogenesis...