Y Shukla

Summary

Publications

  1. ncbi request reprint Modulatory effects of diallyl sulfide against testosterone- induced oxidative stress in Swiss albino mice
    Sahdeo Prasad
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, PO Box 80 M G Marg, Lucknow 226001, India
    Asian J Androl 8:719-23. 2006
  2. ncbi request reprint Preventive effects of lupeol on DMBA induced DNA alkylation damage in mouse skin
    Nidhi Nigam
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Food Chem Toxicol 45:2331-5. 2007
  3. ncbi request reprint Preventive effects of diallyl sulfide on 7,12-dimethylbenz[a]anthracene induced DNA alkylation damage in mouse skin
    Nidhi Nigam
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    Mol Nutr Food Res 51:1324-8. 2007
  4. doi request reprint Induction of apoptosis by lupeol and mango extract in mouse prostate and LNCaP cells
    Sahdeo Prasad
    Proteomics Laboratory, Industrial Toxicology Research Centre, Lucknow, India
    Nutr Cancer 60:120-30. 2008
  5. pmc Clastogenic effects of glyphosate in bone marrow cells of swiss albino mice
    Sahdeo Prasad
    Proteomics Laboratory, Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow 226001, India
    J Toxicol 2009:308985. 2009
  6. pmc New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals: In Vitro and In Vivo Studies and the Underlying Mechanisms
    Madhulika Singh
    Proteomics Laboratory, Council of Scientific and Industrial Research, Indian Institute of Toxicology Research, P O Box 80, M G Marg, Lucknow 226001, India
    Biomed Res Int 2014:243452. 2014
  7. pmc Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53
    Jasmine George
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, Uttar Pradesh, India
    PLoS ONE 6:e23395. 2011
  8. ncbi request reprint Expression of P-glycoprotein is positively correlated with p53 in human papilloma virus induced squamous intraepithelial lesions of uterine cervix: poor prognosis association
    Madhulika Singh
    Proteomics Laboratory, Indian Institute of Toxicology Research Council of Scientific and Industrial Research, Lucknow, India
    Asian Pac J Cancer Prev 13:6039-45. 2012
  9. ncbi request reprint Antimutagenic effect of black tea extract using 'rodent dominant lethal mutation assay'
    Y Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, India
    Toxicology 168:269-74. 2001
  10. pmc Role of senescence and mitotic catastrophe in cancer therapy
    Richa Singh
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, PO Box 80, MG Marg, Lucknow 226001, India
    Cell Div 5:4. 2010

Collaborators

Detail Information

Publications84

  1. ncbi request reprint Modulatory effects of diallyl sulfide against testosterone- induced oxidative stress in Swiss albino mice
    Sahdeo Prasad
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, PO Box 80 M G Marg, Lucknow 226001, India
    Asian J Androl 8:719-23. 2006
    ..To investigate the protective effect of diallyl sulfide (DAS), a constituent of garlic, against testosterone-induced oxidative stress in male Swiss albino mice...
  2. ncbi request reprint Preventive effects of lupeol on DMBA induced DNA alkylation damage in mouse skin
    Nidhi Nigam
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Food Chem Toxicol 45:2331-5. 2007
    ..26% prevention, at 96 h time interval, against DMBA induced DNA strand breakage. The results suggest preventive effects of lupeol on DMBA induced DNA alkylation damage in Swiss albino mice...
  3. ncbi request reprint Preventive effects of diallyl sulfide on 7,12-dimethylbenz[a]anthracene induced DNA alkylation damage in mouse skin
    Nidhi Nigam
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    Mol Nutr Food Res 51:1324-8. 2007
    ..49% protection, at an intermittent period of 48 h, against DMBA-induced DNA strand breakage. These findings suggest that DAS can effectively check the mutations induced by environmental toxicants...
  4. doi request reprint Induction of apoptosis by lupeol and mango extract in mouse prostate and LNCaP cells
    Sahdeo Prasad
    Proteomics Laboratory, Industrial Toxicology Research Centre, Lucknow, India
    Nutr Cancer 60:120-30. 2008
    ..Thus, the results of this study demonstrate that lupeol/MPE is effective in combating testosterone-induced changes in mouse prostate as well as causing apoptosis by modulating cell-growth regulators...
  5. pmc Clastogenic effects of glyphosate in bone marrow cells of swiss albino mice
    Sahdeo Prasad
    Proteomics Laboratory, Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow 226001, India
    J Toxicol 2009:308985. 2009
    ..05). The cytotoxic effects of glyphosate were also evident, as observed by significant decrease in mitotic index (MI). The present results indicate that glyphosate is clastogenic and cytotoxic to mouse bone marrow...
  6. pmc New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals: In Vitro and In Vivo Studies and the Underlying Mechanisms
    Madhulika Singh
    Proteomics Laboratory, Council of Scientific and Industrial Research, Indian Institute of Toxicology Research, P O Box 80, M G Marg, Lucknow 226001, India
    Biomed Res Int 2014:243452. 2014
    ..This revision presents a comprehensive knowledge and the main molecular mechanisms of actions of various phytochemicals in the chemoprevention of skin cancer. ..
  7. pmc Resveratrol and black tea polyphenol combination synergistically suppress mouse skin tumors growth by inhibition of activated MAPKs and p53
    Jasmine George
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, Uttar Pradesh, India
    PLoS ONE 6:e23395. 2011
    ..This promising combination should be examined in therapeutic trials of skin and possibly other cancers...
  8. ncbi request reprint Expression of P-glycoprotein is positively correlated with p53 in human papilloma virus induced squamous intraepithelial lesions of uterine cervix: poor prognosis association
    Madhulika Singh
    Proteomics Laboratory, Indian Institute of Toxicology Research Council of Scientific and Industrial Research, Lucknow, India
    Asian Pac J Cancer Prev 13:6039-45. 2012
    ....
  9. ncbi request reprint Antimutagenic effect of black tea extract using 'rodent dominant lethal mutation assay'
    Y Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, India
    Toxicology 168:269-74. 2001
    ..Hence the study suggests that tea has a protective effect against BaP-induced genetic damage to germ cells in Swiss albino mice...
  10. pmc Role of senescence and mitotic catastrophe in cancer therapy
    Richa Singh
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, PO Box 80, MG Marg, Lucknow 226001, India
    Cell Div 5:4. 2010
    ..Altogether, we have highlighted the possibilities of the use of senescence targeting drugs, mitotic kinases and anti-mitotic agents in fabricating novel strategies in cancer control...
  11. ncbi request reprint In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]-gingerol
    Yogeshwer Shukla
    Proteomics Laboratory, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India
    Mol Nutr Food Res 51:1492-502. 2007
    ..Thus, [6]-gingerol shows its protective effects in both in vivo and in vitro prostate cancer models by modulation of proteins involved in apoptosis pathway...
  12. ncbi request reprint Complementary and alternative cancer therapies: past, present and the future scenario
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow 226 001, India
    Asian Pac J Cancer Prev 5:3-14. 2004
    ..This article reviews the different popular alternative cancer therapies practiced in India and neighboring south east Asian countries to project the current international scenario on complementary and alternative cancer therapies...
  13. ncbi request reprint Cancer chemoprevention with garlic and its constituents
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Cancer Lett 247:167-81. 2007
    ..This review discusses mechanistic basis of cancer chemopreventive effects of garlic-derived products, their implication in cancer management and ways and means to take these agents from bench to real life situations...
  14. ncbi request reprint Protective effects of indole-3-carbinol on cyclophosphamide-induced clastogenecity in mouse bone marrow cells
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg PO Box No 80, Lucknow 226 001, India
    Hum Exp Toxicol 23:245-50. 2004
    ..The antimutagenic potential of 13C towards CP was also evident as the status of mitotic index (MI) was found to show an increment. This study revealed the antigenotoxic potential of I3C against CP-induced chromosomal mutations...
  15. doi request reprint Effects of physical activity on cancer prevention
    Hye Kyung Na
    Department of Food and Nutrition, College of Human Ecology, Sungshin Women s University, Seoul, South Korea
    Ann N Y Acad Sci 1229:176-83. 2011
    ..This review highlights the effects of physical activity on various malignancies in the context of redox status modulated during exercise...
  16. ncbi request reprint Mutagenic potential of Mancozeb in Salmonella typhimurium
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    J Environ Pathol Toxicol Oncol 23:297-302. 2004
    ..We postulate that the true mutagenic potential of Mancozeb may be masked by its toxic effect to the tester strain used...
  17. doi request reprint Combinatorial strategies employing nutraceuticals for cancer development
    Yogeshwer Shukla
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, Lucknow, Uttar Pradesh, India
    Ann N Y Acad Sci 1229:162-75. 2011
    ..In this review, we summarize the results of those studies that report combinatorial cancer chemopreventive action of various nutraceuticals and their combinations with anticancer drugs...
  18. ncbi request reprint Chemopreventive effect of indole-3-carbinol on induction of preneoplastic altered hepatic foci
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    Nutr Cancer 50:214-20. 2004
    ..These results thus suggest the chemopreventive effect of I3C in rat hepatocarcinogenesis by suppressing DEN- and AAF-induced AHF development...
  19. ncbi request reprint Cancer preventive properties of ginger: a brief review
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226 001, Uttar Pradesh, India
    Food Chem Toxicol 45:683-90. 2007
    ..A number of mechanisms that may be involved in the chemopreventive effects of ginger and its components have been reported from the laboratory studies in a wide range of experimental models...
  20. ncbi request reprint Suppression of altered hepatic foci development by curcumin in wistar rats
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow 226 001, India
    Nutr Cancer 45:53-9. 2003
    ..These results show that curcumin can effectively suppress the DEN-induced development of AHF in rat liver...
  21. ncbi request reprint Enhancing effects of mustard oil on preneoplastic hepatic foci development in Wistar rats
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, MG Marg, PO Box No 80, Lucknow 226 001, India
    Hum Exp Toxicol 22:51-5. 2003
    ..These results indicate the possible tumourigenic risk associated with mustard oil consumption...
  22. doi request reprint Resveratrol and cellular mechanisms of cancer prevention
    Yogeshwer Shukla
    Indian Institute of Toxicology Research, Lucknow, India
    Ann N Y Acad Sci 1215:1-8. 2011
    ..Here, we focus on some of the myriad pathways that resveratrol targets to exert its chemopreventive role and advocate that resveratrol holds tremendous potential as an efficient anticancer drug of the future...
  23. ncbi request reprint Histochemical localization of glutathione dependent NBT-reductase in mouse skin
    Y Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Post Box 80, M G Marg, Lucknow 226 001, India
    Biomed Environ Sci 14:237-40. 2001
    ..Localization of the glutathione dependent Nitroblue tetrazolium (NBT) reductase in fresh frozen sections of mouse skin and possible dependence of NBT reductase on tissue thiol levels has been investigated...
  24. ncbi request reprint Antimutagenic effects of garlic extract on chromosomal aberrations
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, MG Marg, Lucknow 226 001, India
    Cancer Lett 176:31-6. 2002
    ..Thus results of the present investigations revealed that GE has chemopreventive potential against CP induced chromosomal mutations in Swiss albino mice...
  25. ncbi request reprint Anticarcinogenic effect of black tea on pulmonary tumors in Swiss albino mice
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box No 80, M G Marg, Lucknow 226 001, India
    Cancer Lett 176:137-41. 2002
    ..The number of animals showing pulmonary adenocarcinomas induced by DEN was found to be inhibited significantly by 4% ATE. In addition, splenomegaly was found to be protected by ATE administration...
  26. ncbi request reprint Antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, UP 226001, Lucknow, India
    Mutat Res 515:197-202. 2002
    ..The anticytotoxic potential of curcumin towards CP was also evident as the status of mitotic index was found to show increment. The study revealed the antigenotoxic potential of curcumin against CP induced chromosomal mutations...
  27. ncbi request reprint Antitumorigenic potential of diallyl sulfide in Ehrlich ascites tumor bearing mice
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg, P O Box 80, Lucknow 226001, India
    Biomed Environ Sci 15:41-7. 2002
    ..To study the effects of diallyl sulfide (DAS), an organosulfur compound present in garlic (Allium sativum), on the life span of ehrlich ascites (EA) tumor bearing Swiss albino mice, cytotoxicity and angiogenesis...
  28. ncbi request reprint Carcinogenic and cocarcinogenic potential of cypermethrin on mouse skin
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box No 80, M G Marg, Lucknow 226 001, India
    Cancer Lett 182:33-41. 2002
    ..CYM when tested for complete carcinogenic activity induced tumour formation in both male and female animals at all the three tested dose levels...
  29. ncbi request reprint Mutagenic potential of cypermethrin in mouse dominant lethal assay
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    J Environ Pathol Toxicol Oncol 21:259-65. 2002
    ..Our results showed that CYP has mutagenic activity, inducing dominant lethal mutations in male germ cells of mice and caution is recommended in the use of this insecticide...
  30. ncbi request reprint Herbal medicine: current status and the future
    Sanjoy Kumar Pal
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box No 80, M G Marg, Lucknow 226 001, India
    Asian Pac J Cancer Prev 4:281-8. 2003
    ..In the present review we attempted to describe the present scenario and project the future of herbal medicine...
  31. ncbi request reprint Tea and cancer chemoprevention: a comprehensive review
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India
    Asian Pac J Cancer Prev 8:155-66. 2007
    ....
  32. ncbi request reprint Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease
    R K Chaturvedi
    Developmental Toxicology Division, Industrial Toxicology Research Centre, Post Box 80, M G Marg Lucknow 226001, India
    Neurobiol Dis 22:421-34. 2006
    ....
  33. ncbi request reprint Modulation of altered hepatic foci induction by diallyl sulphide in Wistar rats
    A Singh
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, PO Box No 80, M G Marg, Lucknow 226 001, India
    Eur J Cancer Prev 13:263-9. 2004
    ..These findings suggest the protective role of DAS in rat hepatocarcinogenesis, by suppressing DEN- and 2-AAF-induced AHF development...
  34. ncbi request reprint Transplacental carcinogenic potential of the carbamate fungicide mancozeb
    Y Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    J Environ Pathol Toxicol Oncol 20:127-31. 2001
    ....
  35. ncbi request reprint Tumourigenic studies on deltamethrin in Swiss albino mice
    Y Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg, P O Box 80, 226001, Lucknow, India
    Toxicology 163:1-9. 2001
    ..Deltamethrin exposure failed to show any tumour promoting and complete tumorigenic potential at all the three tested dose levels...
  36. doi request reprint Genotoxic and carcinogenic risks associated with the dietary consumption of repeatedly heated coconut oil
    Smita Srivastava
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, Mahatma Gandhi Marg, Lucknow 226 001, UP, India
    Br J Nutr 104:1343-52. 2010
    ..A significant decrease in the relative and absolute hepatic weight of RCO-supplemented rats was recorded (P<0·05). In conclusion, dietary consumption of RCO can cause a genotoxic and preneoplastic change in the liver...
  37. ncbi request reprint Induction of preneoplastic altered hepatic foci following dietary sulphur supplementation
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg PO Box No 80, Lucknow 226 001, India
    Hum Exp Toxicol 23:229-34. 2004
    ..However, 1% sulphur administration failed to induce AHF up to significant levels. The results thus revealed the possible tumorigenic risk associated with the high sulphur-containing diet...
  38. ncbi request reprint Evaluation of carcinogenic and co-carcinogenic potential Quinalphos in mouse skin
    Y Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    Cancer Lett 148:1-7. 2000
    ..wt.), in the two-stage mouse skin model of carcinogenesis. Quinalphos exposure failed to produce neoplasia when tested for complete carcinogenic activity at all three tested dose levels or tumour promoting activity...
  39. doi request reprint Regulation of oxidative stress-mediated apoptosis by diallyl sulfide in DMBA-exposed Swiss mice
    S Prasad
    Proteomics Laboratory, Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow, India
    Hum Exp Toxicol 27:55-63. 2008
    ....
  40. ncbi request reprint Mutagenic evaluation of deltamethrin using rodent dominant lethal assay
    Y Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, 226 001, Lucknow, India
    Mutat Res 467:119-27. 2000
    ..A slight increase in dominant lethal mutation rate was observed by increasing doses of deltamethrin in early weeks but decreased in later weeks, so an apparent dose response was not observed...
  41. ncbi request reprint Antimutagenic effects of black tea in the Salmonella typhimurium reverse mutation assay
    Pankaj Taneja
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box No 80, M G Marg, Lucknow 226 001 India
    Asian Pac J Cancer Prev 4:193-8. 2003
    ..Hence the study revealed that black tea has a protective efficacy in suppressing BaP and CP induced mutagenicity in a microbial test system...
  42. ncbi request reprint Protective effects of black tea extract on testosterone induced oxidative damage in prostate
    Imtiaz A Siddiqui
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg, P O Box 80, Lucknow 226 001, India
    Cancer Lett 227:125-32. 2005
    ..Hence, the study reveals that constituents present in black tea impart protection against androgen induced oxidative injury that may result in development of prostate cancer...
  43. ncbi request reprint Neurodevelopmental consequences of gestational exposure (GD14-GD20) to low dose deltamethrin in rats
    M H Aziz
    Developmental Toxicology Division, Industrial Toxicology Research Center, Mahatma Gandhi Marg, Post Box No. 80, Lucknow, India
    Neurosci Lett 300:161-5. 2001
    ..Although there is no significant recovery at 12 weeks assessment but still significant impairment persist on biochemical and behavioural parameters...
  44. doi request reprint Tea polyphenols inhibit cyclooxygenase-2 expression and block activation of nuclear factor-kappa B and Akt in diethylnitrosoamine induced lung tumors in Swiss mice
    Preeti Roy
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, P O Box 80, M G Marg, Lucknow, 226001, India
    Invest New Drugs 28:466-71. 2010
    ..In the present study, we studied the chemopreventive effects of green tea polyphenols (GTP) and black tea polyphenols (BTP) against diethylnitrosoamine (DEN) induced lung tumors in Swiss albino mice...
  45. ncbi request reprint Protective effect of Ocimum sanctum on 3-methylcholanthrene, 7,12-dimethylbenz(a)anthracene and aflatoxin B1 induced skin tumorigenesis in mice
    Shipra Rastogi
    Industrial Toxicology Research Centre, Mahatma Gandhi Marg, P O Box 80, Lucknow 226001, India
    Toxicol Appl Pharmacol 224:228-40. 2007
    ..sanctum provides protection against chemical carcinogenesis in one or more of the following mechanisms: (i) by acting as an antioxidant; (ii) by modulating phase I and II enzymes; (iii) by exhibiting antiproliferative activity...
  46. ncbi request reprint Antioxidant potential of black tea against 7,12-dimethylbenz(a)anthracene- induced oxidative stress in Swiss albino mice
    Neetu Kalra
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow 226001, India
    J Environ Pathol Toxicol Oncol 24:105-14. 2005
    ..Our results revealed that BTE provides protection against oxidative damage induced by xenobiotics...
  47. doi request reprint Protective effects of lupeol against benzo[a]pyrene induced clastogenicity in mouse bone marrow cells
    Sahdeo Prasad
    Proteomics Laboratory, Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow, India
    Mol Nutr Food Res 52:1117-20. 2008
    ..Thus, results of the present investigation revealed that lupeol and MPE have protective effects against B[a]P-induced clastogenic changes in Swiss albino mice...
  48. ncbi request reprint Regulation of p21/ras protein expression by diallyl sulfide in DMBA induced neoplastic changes in mouse skin
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Cancer Lett 242:28-36. 2006
    ..Thus, one mechanism of the growth inhibitory properties of DAS is through the suppression of development of tumors that harbor ras mutations by inhibiting the membrane association of oncogenic p21/ras protein...
  49. ncbi request reprint Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow 226 001, India
    Nutr Cancer 44:89-94. 2002
    ..These observations suggest that induction of apoptosis may be the major contributing factor for antitumorigenic properties of DAS...
  50. ncbi request reprint Induction of apoptosis by tea polyphenols mediated through mitochondrial cell death pathway in mouse skin tumors
    Preeti Roy
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, Lucknow 226001, India
    Cancer Biol Ther 8:1281-7. 2009
    ..Thus, we can conclude that the polyphenolic constituents present in black tea and green tea induce mitochondrial pathway of apoptosis and hence can be used as a potential chemopreventive agents against skin cancer...
  51. ncbi request reprint Antigenotoxic potential of certain dietary constituents
    Yogeshwer Shukla
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow, India
    Teratog Carcinog Mutagen . 2003
    ..Thus the study reveals the antimutagenic potential of these dietary compounds towards BaP- and CP-induced genotoxicity in microbial and mammalian test systems...
  52. ncbi request reprint Involvement of nitric oxide in neurodegeneration: a study on the experimental models of Parkinson's disease
    Sarika Singh
    Division of Pharmacology, Central Drug Research Institute, Lucknow, India
    Redox Rep 10:103-9. 2005
    ..Thus, augmented NO availability subsequent to iNOS induction seems to play an important role in the initial phase of neurodegeneration...
  53. ncbi request reprint Theaflavins induce G2/M arrest by modulating expression of p21waf1/cip1, cdc25C and cyclin B in human prostate carcinoma PC-3 cells
    Sahdeo Prasad
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow 226001, India
    Life Sci 81:1323-31. 2007
    ..Thus, it can be concluded that TF acts as an effective anti-proliferative agent by modulating cell growth regulators in prostate cancer cells...
  54. ncbi request reprint Modulation of P-glycoprotein-mediated multidrug resistance in K562 leukemic cells by indole-3-carbinol
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg, Lucknow 226001, India
    Toxicol Appl Pharmacol 202:237-43. 2005
    ..The above features thus indicate that I3C could be used as a novel modulator of P-gp-mediated multidrug resistance in vitro and may be effective as a dietary adjuvant in the treatment of MDR cancers...
  55. ncbi request reprint Involvement of multiple signaling pathways in diallyl sulfide mediated apoptosis in mouse skin tumors
    Neetu Kalra
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, Lucknow 226001, India
    Asian Pac J Cancer Prev 7:556-62. 2006
    ....
  56. ncbi request reprint Hepatoprotective effects of lupeol and mango pulp extract of carcinogen induced alteration in Swiss albino mice
    Sahdeo Prasad
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg, Lucknow 226001, India
    Mol Nutr Food Res 51:352-9. 2007
    ..These alterations were restored by lupeol/MPE, indicating inhibition of apoptosis. Thus, lupeol/MPE was found to be effective in combating oxidative stress induced cellular injury of mouse liver by modulating cell-growth regulators...
  57. ncbi request reprint Protective effects of lupeol and mango extract against androgen induced oxidative stress in Swiss albino mice
    Sahdeo Prasad
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg, Lucknow, India
    Asian J Androl 10:313-8. 2008
    ..To investigate antioxidant potential of lupeol/mango pulp extract (MPE) in testosterone induced oxidative stress in prostate of male Swiss albino mice...
  58. doi request reprint Regulation of cell growth through cell cycle arrest and apoptosis in HPV 16 positive human cervical cancer cells by tea polyphenols
    Madhulika Singh
    Proteomics Laboratory, Indian Institute of Toxicology Research Council of Scientific and Industrial Research, PO Box 80, MG Marg, Lucknow 226001, India
    Invest New Drugs 28:216-24. 2010
    ..Thus, our data suggests that tea polyphenols exhibit anti-cancer potential against cervical cancer by inhibition of cell growth and induction of apoptosis...
  59. ncbi request reprint [6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells
    Nidhi Nigam
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, M G Marg, Lucknow, India
    Chem Biol Interact 181:77-84. 2009
    ..These firmly suggest that [6]-gingerol can be effectively used for the treatment of skin cancer...
  60. doi request reprint Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis
    Nidhi Nigam
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, M G Marg, P O Box 80, Lucknow 226001, India
    Cancer Chemother Pharmacol 65:687-96. 2010
    ....
  61. doi request reprint Lupeol induces p53 and cyclin-B-mediated G2/M arrest and targets apoptosis through activation of caspase in mouse skin
    Nidhi Nigam
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, P O Box 80, M G Marg, Lucknow 226001, UP, India
    Biochem Biophys Res Commun 381:253-8. 2009
    ..Thus, our results indicate that lupeol has novel anti-proliferative and apoptotic potential that may be helpful in designing strategies to fight skin cancer...
  62. doi request reprint Chemopreventive potential of resveratrol in mouse skin tumors through regulation of mitochondrial and PI3K/AKT signaling pathways
    Preeti Roy
    Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, India, P O Box 80, M G Marg, Lucknow, 226001, India
    Pharm Res 26:211-7. 2009
    ..To investigate the chemopreventive potential of resveratrol, a phytoalexin found in seeds and skin of grapes, berries and peanuts in 7,12 dimethyl benz(a)anthracene (DMBA) induced mouse skin tumorigenesis...
  63. ncbi request reprint Correlation of DNA damage in epidemic dropsy patients to carcinogenic potential of argemone oil and isolated sanguinarine alkaloid in mice
    Mukul Das
    Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India
    Int J Cancer 117:709-17. 2005
    ....
  64. doi request reprint Resveratrol induces apoptosis involving mitochondrial pathways in mouse skin tumorigenesis
    Neetu Kalra
    Proteomics Laboratory, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Life Sci 82:348-58. 2008
    ....
  65. ncbi request reprint Modulation of p53 in 7,12-dimethylbenz[a]anthracene-induced skin tumors by diallyl sulfide in Swiss albino mice
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Center, PO Box 80, MG Marg, Lucknow 226001, India
    Mol Cancer Ther 3:1459-66. 2004
    ..Thus, DAS can be a potential chemopreventive agent against skin tumor development...
  66. ncbi request reprint Reversal of P-glycoprotein-mediated multidrug resistance by diallyl sulfide in K562 leukemic cells and in mouse liver
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, PO Box 80, M G Marg, Lucknow 226001, India
    Carcinogenesis 25:941-9. 2004
    ..The above features thus indicate that DAS can serve as a novel, non-toxic modulator of MDR and can be used as a dietary adjuvant...
  67. ncbi request reprint Modulation of vinca-alkaloid induced P-glycoprotein expression by indole-3-carbinol
    Annu Arora
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, M G Marg, P O Box 80, Lucknow 226001, India
    Cancer Lett 189:167-73. 2003
    ..The present investigation suggests that I3C can significantly inhibit the P-gp over-expression and may have utility as a dietary adjuvant in the treatment of cancer for the reversal of multiple drug resistance...
  68. ncbi request reprint Co-transplantation of carotid body and ventral mesencephalic cells as an alternative approach towards functional restoration in 6-hydroxydopamine-lesioned rats: implications for Parkinson's disease
    S Shukla
    Developmental Toxicology Division, Industrial Toxicology Research Centre, Lucknow, India
    J Neurochem 91:274-84. 2004
    ....
  69. pmc Correlation of DNA ploidy with progression of cervical cancer
    M Singh
    Industrial Toxicology Research Center, P O Box 80, M G Marg, Lucknow 226001, India
    J Cancer Epidemiol 2008:298495. 2008
    ..Therefore, it is a concept of an HPV screening with reflex cytology in combination with DNA flow cytometry to detect progressive lesions with the greatest possible sensitivity and specificity...
  70. ncbi request reprint In vitro and in vivo evaluation of linear polyethylenimine nanoparticles
    Ritu Goyal
    Institute of Genomics and Integrative Biology Council of Scientific and Industrial Research, India, Mall Road, Delhi University Campus, Delhi 110007, India
    J Biomed Nanotechnol 7:52-3. 2011
    ..v. injection showed maximum expression of the reporter gene in the spleen. These results demonstrate the potential of these particles as efficient transfection reagents...
  71. doi request reprint Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
    Kulpreet Bhui
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, P O Box 80, M G Marg, Lucknow 226 001, India
    Cancer Lett 282:167-76. 2009
    ..Thus, modulation of inappropriate cell signaling cascades driven by bromelain is a coherent approach in achieving chemoprevention...
  72. doi request reprint Studies on glyphosate-induced carcinogenicity in mouse skin: a proteomic approach
    Jasmine George
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, Mahatma Gandhi Marg, Lucknow 226001 UP, India
    J Proteomics 73:951-64. 2010
    ..Altogether, these results suggested that glyphosate has tumor promoting potential in skin carcinogenesis and its mechanism seems to be similar to TPA...
  73. doi request reprint Death receptors: targets for cancer therapy
    Zafar Mahmood
    Proteomics Laboratory, Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow 226001, India
    Exp Cell Res 316:887-99. 2010
    ..This review covers the current knowledge about the DRs, summarizes main signaling in DRs and also summarizes the preclinical approaches of these DRs in cancer therapy...
  74. doi request reprint Lupeol: connotations for chemoprevention
    Pranav K Chaturvedi
    Proteomics Laboratory, Industrial Toxicology Research Centre, Environmental Carcinogenesis Division, P O Box 80, M G Marg, Lucknow 226001, India
    Cancer Lett 263:1-13. 2008
    ....
  75. ncbi request reprint Regulation of p53, nuclear factor kappaB and cyclooxygenase-2 expression by bromelain through targeting mitogen-activated protein kinase pathway in mouse skin
    Neetu Kalra
    Proteomics Laboratory, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Toxicol Appl Pharmacol 226:30-7. 2008
    ....
  76. doi request reprint Polo-like kinase1 (Plk1) knockdown enhances cisplatin chemosensitivity via up-regulation of p73α in p53 mutant human epidermoid squamous carcinoma cells
    Shilpa Tyagi
    Indian Institute of Toxicology Research, Council of Scientific and Industrial Research, Mahatma Gandhi Marg, Lucknow, U P, India
    Biochem Pharmacol 80:1326-34. 2010
    ..Conclusively, plk1 gene silencing can enhance the sensitivity of A431 cells to low doses of CDDP by upregulating p73α expression and thus can be a revolutionary approach in cancer chemotherapy...
  77. doi request reprint Resveratrol enhances ultraviolet B-induced cell death through nuclear factor-kappaB pathway in human epidermoid carcinoma A431 cells
    Preeti Roy
    Proteomics Laboratory, Indian Institute of Toxicology Research CSIR, P O Box 80, M G Marg, Lucknow 226001, India
    Biochem Biophys Res Commun 384:215-20. 2009
    ..In conclusion, our study demonstrates that the combination of resveratrol and UVB act synergistically against skin cancer cells. Thus, resveratrol is a potential chemotherapeutic agent against skin carcinogenesis...
  78. ncbi request reprint Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NFkappaB signaling pathways
    Sahdeo Prasad
    Proteomics Laboratory, Indian Institute of Toxicology Research, Mahatma Gandhi Marg, Lucknow, India
    Cancer Biol Ther 8:1632-9. 2009
    ..These results suggest that lupeol could be an effective anti-cancer agent and merits further investigation...
  79. ncbi request reprint Theaflavins induced apoptosis of LNCaP cells is mediated through induction of p53, down-regulation of NF-kappa B and mitogen-activated protein kinases pathways
    Neetu Kalra
    Environmental Carcinogenesis Division, Industrial Toxicology Research Centre, P O Box 80, M G Marg, Lucknow 226001, India
    Life Sci 80:2137-46. 2007
    ..Thus, effect of TF on PCA cell lines seems to be irrespective of their androgen status...
  80. doi request reprint Regulation of signaling pathways involved in lupeol induced inhibition of proliferation and induction of apoptosis in human prostate cancer cells
    Sahdeo Prasad
    Proteomics Laboratory, Indian Institute of Toxicology Research, Lucknow, India
    Mol Carcinog 47:916-24. 2008
    ..Thus, our study suggests that lupeol possess novel antiproliferative and apoptotic potential against PCa...
  81. pmc Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model
    Imtiaz A Siddiqui
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA
    Pharm Res 25:2135-42. 2008
    ..This study examines the role of cell survival/apoptosis related proteins involved in NFkappaB signaling pathways and its associated events in GTP-induced chemoprevention of prostate cancer in TRAMP mice...
  82. ncbi request reprint Protective effect of tenuazonic acid against dimethyl benz(a)antracene-induced skin carcinogenesis in mice
    Mary Antony
    National Environmental Engineering Research Institute, Kochi, India
    Teratog Carcinog Mutagen 22:309-14. 2002
    ..The present studies reveal the antitumor and protective potential of TA against polycyclic aromatic hydrocarbon induced skin carcinogenesis...
  83. pmc Potential of diallyl sulfide bearing pH-sensitive liposomes in chemoprevention against DMBA-induced skin papilloma
    Arif Khan
    Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India
    Mol Med 13:443-51. 2007
    ..The promising chemo-preventive nature of liposomal DAS may form the basis for establishing effective means of controlling various forms of cancer, including skin papilloma...