Farbod Shojaei

Summary

Publications

  1. pmc Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer
    Farbod Shojaei
    Pfizer Global Research and Development, Department of Oncology, La Jolla, CA, USA
    J Exp Clin Cancer Res 31:26. 2012
  2. doi request reprint Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies
    Farbod Shojaei
    Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Drug Resist Updat 11:219-30. 2008
  3. doi request reprint Molecular profiling of candidate human hematopoietic stem cells derived from human embryonic stem cells
    Farbod Shojaei
    Robarts Research Institute, London, ON, Canada
    Exp Hematol 36:1436-48. 2008
  4. pmc Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
    Lisheng Wang
    Robarts Research Institute, Krembil Center for Stem Cell Biology and Regenerative Medicine, Ontario, Canada
    J Exp Med 201:1603-14. 2005
  5. pmc G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 106:6742-7. 2009
  6. doi request reprint Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells
    Farbod Shojaei
    Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 68:5501-4. 2008
  7. ncbi request reprint Hierarchical and ontogenic positions serve to define the molecular basis of human hematopoietic stem cell behavior
    Farbod Shojaei
    Stem Cell Biology and Regenerative Medicine, Robarts Research Institute, London, Ontario, Canada
    Dev Cell 8:651-63. 2005
  8. ncbi request reprint Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    Farbod Shojaei
    Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 450:825-31. 2007
  9. pmc Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 105:2640-5. 2008
  10. doi request reprint Role of myeloid cells in tumor angiogenesis and growth
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Trends Cell Biol 18:372-8. 2008

Collaborators

Detail Information

Publications18

  1. pmc Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer
    Farbod Shojaei
    Pfizer Global Research and Development, Department of Oncology, La Jolla, CA, USA
    J Exp Clin Cancer Res 31:26. 2012
    ....
  2. doi request reprint Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapies
    Farbod Shojaei
    Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Drug Resist Updat 11:219-30. 2008
    ..The current review focuses on the role of stromal cells in tumor growth and in refractoriness to anti-VEGF treatment...
  3. doi request reprint Molecular profiling of candidate human hematopoietic stem cells derived from human embryonic stem cells
    Farbod Shojaei
    Robarts Research Institute, London, ON, Canada
    Exp Hematol 36:1436-48. 2008
    ..Whether these differences are cell-autonomous or driven by their microenvironment remains to be elucidated...
  4. pmc Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
    Lisheng Wang
    Robarts Research Institute, Krembil Center for Stem Cell Biology and Regenerative Medicine, Ontario, Canada
    J Exp Med 201:1603-14. 2005
    ..Our study demonstrates that HSCs can be derived from hESCs and provides an in vivo system and molecular foundation to evaluate strategies for the generation of clinically transplantable HSC from hESC lines...
  5. pmc G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 106:6742-7. 2009
    ..We conclude that, at least in the models examined, G-CSF expression by tumor or stromal cells is a determinant of refractoriness to anti-VEGF-A treatment...
  6. doi request reprint Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells
    Farbod Shojaei
    Genentech, Inc, South San Francisco, California 94080, USA
    Cancer Res 68:5501-4. 2008
    ..Thus, G-CSF may promote tumor angiogenesis through a Bv8-dependent pathway that bypasses VEGF and renders tumors refractory to anti-VEGF therapy...
  7. ncbi request reprint Hierarchical and ontogenic positions serve to define the molecular basis of human hematopoietic stem cell behavior
    Farbod Shojaei
    Stem Cell Biology and Regenerative Medicine, Robarts Research Institute, London, Ontario, Canada
    Dev Cell 8:651-63. 2005
    ....
  8. ncbi request reprint Bv8 regulates myeloid-cell-dependent tumour angiogenesis
    Farbod Shojaei
    Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
    Nature 450:825-31. 2007
    ..Thus, Bv8 modulates mobilization of CD11b+Gr1+ cells from the bone marrow during tumour development and also promotes angiogenesis locally...
  9. pmc Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 105:2640-5. 2008
    ..In summary, our studies verify a role for Bv8 in the mobilization and recruitment of myeloid cells and in the induction of tumor angiogenesis in the early stages of neoplastic progression...
  10. doi request reprint Role of myeloid cells in tumor angiogenesis and growth
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Trends Cell Biol 18:372-8. 2008
    ..This function of myeloid cells occurs through a proangiogenic pathway that is, at least in part, driven by the secreted protein Bv8. This review summarizes recent findings on the complex role of bone marrow-derived cells in tumor growth...
  11. ncbi request reprint Antiangiogenesis to treat cancer and intraocular neovascular disorders
    Farbod Shojaei
    Genentech Inc, South San Francisco, CA 94080, USA
    Lab Invest 87:227-30. 2007
    ..This brief review focuses on the progress in targeting one of the major regulators of angiogenesis, VEGF-A, and also discusses potential cellular and molecular mechanisms underlying resistance to antiangiogenic treatments...
  12. ncbi request reprint Antiangiogenic therapy for cancer: an update
    Farbod Shojaei
    Genentech, Inc, South San Francisco, CA 94080, USA
    Cancer J 13:345-8. 2007
    ....
  13. doi request reprint Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice
    Brett H Simmons
    Oncology Research Unit, Pfizer Global R and D, San Diego, CA 92121, USA
    Cancer Chemother Pharmacol 70:213-20. 2012
    ..In conclusion, our data suggest that PD-0325901 at doses below MTD is still a potent compound capable of tumor growth inhibition where Kras and/or PI3K are drivers of tumor growth and progression...
  14. doi request reprint HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors
    Farbod Shojaei
    Oncology Research Unit, Pfizer, La Jolla, California, USA
    Cancer Res 70:10090-100. 2010
    ....
  15. ncbi request reprint Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
    Farbod Shojaei
    Genentech, Inc, 1 DNA Way, S San Francisco, California 94080, USA
    Nat Biotechnol 25:911-20. 2007
    ..These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by the ability of tumors to prime and recruit CD11b+Gr1+ cells...
  16. ncbi request reprint Endothelium-microenvironment interactions in the developing embryo and in the adult
    Kristy Red-Horse
    Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
    Dev Cell 12:181-94. 2007
    ..Such interactions appear to be important also in the adult, in normal and pathological conditions...
  17. ncbi request reprint Smad7 alters cell fate decisions of human hematopoietic repopulating cells
    Kristin Chadwick
    Krembil Centre for Stem Cell Biology, Robarts Research Institute, 100 Perth Dr, London, ON N6A 5K8, Canada
    Blood 105:1905-15. 2005
    ....
  18. ncbi request reprint Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties
    Lisheng Wang
    Robarts Research Institute, Krembil Centre for Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada
    Immunity 21:31-41. 2004
    ....