Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancerFarbod Shojaei
Pfizer Global Research and Development, Department of Oncology, La Jolla, CA, USA
J Exp Clin Cancer Res 31:26. 2012
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Role of the microenvironment in tumor growth and in refractoriness/resistance to anti-angiogenic therapiesFarbod Shojaei
Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Drug Resist Updat 11:219-30. 2008
..The current review focuses on the role of stromal cells in tumor growth and in refractoriness to anti-VEGF treatment...
- Molecular profiling of candidate human hematopoietic stem cells derived from human embryonic stem cells
Farbod Shojaei
Robarts Research Institute, London, ON, Canada
Exp Hematol 36:1436-48. 2008
..Whether these differences are cell-autonomous or driven by their microenvironment remains to be elucidated...
- Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
Lisheng Wang
Robarts Research Institute, Krembil Center for Stem Cell Biology and Regenerative Medicine, Ontario, Canada
J Exp Med 201:1603-14. 2005
..Our study demonstrates that HSCs can be derived from hESCs and provides an in vivo system and molecular foundation to evaluate strategies for the generation of clinically transplantable HSC from hESC lines...
- G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
Farbod Shojaei
Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 106:6742-7. 2009
..We conclude that, at least in the models examined, G-CSF expression by tumor or stromal cells is a determinant of refractoriness to anti-VEGF-A treatment...
- Refractoriness to antivascular endothelial growth factor treatment: role of myeloid cells
Farbod Shojaei
Genentech, Inc, South San Francisco, California 94080, USA
Cancer Res 68:5501-4. 2008
..Thus, G-CSF may promote tumor angiogenesis through a Bv8-dependent pathway that bypasses VEGF and renders tumors refractory to anti-VEGF therapy...
Hierarchical and ontogenic positions serve to define the molecular basis of human hematopoietic stem cell behaviorFarbod Shojaei
Stem Cell Biology and Regenerative Medicine, Robarts Research Institute, London, Ontario, Canada
Dev Cell 8:651-63. 2005
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- Bv8 regulates myeloid-cell-dependent tumour angiogenesis
Farbod Shojaei
Genentech Inc, 1 DNA Way, South San Francisco, California 94080, USA
Nature 450:825-31. 2007
..Thus, Bv8 modulates mobilization of CD11b+Gr1+ cells from the bone marrow during tumour development and also promotes angiogenesis locally...
- Role of Bv8 in neutrophil-dependent angiogenesis in a transgenic model of cancer progression
Farbod Shojaei
Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Proc Natl Acad Sci U S A 105:2640-5. 2008
..In summary, our studies verify a role for Bv8 in the mobilization and recruitment of myeloid cells and in the induction of tumor angiogenesis in the early stages of neoplastic progression...
- Role of myeloid cells in tumor angiogenesis and growth
Farbod Shojaei
Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Trends Cell Biol 18:372-8. 2008
..This function of myeloid cells occurs through a proangiogenic pathway that is, at least in part, driven by the secreted protein Bv8. This review summarizes recent findings on the complex role of bone marrow-derived cells in tumor growth...
- Antiangiogenesis to treat cancer and intraocular neovascular disorders
Farbod Shojaei
Genentech Inc, South San Francisco, CA 94080, USA
Lab Invest 87:227-30. 2007
..This brief review focuses on the progress in targeting one of the major regulators of angiogenesis, VEGF-A, and also discusses potential cellular and molecular mechanisms underlying resistance to antiangiogenic treatments...
- Antiangiogenic therapy for cancer: an update
Farbod Shojaei
Genentech, Inc, South San Francisco, CA 94080, USA
Cancer J 13:345-8. 2007
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- Combination of a MEK inhibitor at sub-MTD with a PI3K/mTOR inhibitor significantly suppresses growth of lung adenocarcinoma tumors in Kras(G12D-LSL) mice
Brett H Simmons
Oncology Research Unit, Pfizer Global R and D, San Diego, CA 92121, USA
Cancer Chemother Pharmacol 70:213-20. 2012
..In conclusion, our data suggest that PD-0325901 at doses below MTD is still a potent compound capable of tumor growth inhibition where Kras and/or PI3K are drivers of tumor growth and progression...
- HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors
Farbod Shojaei
Oncology Research Unit, Pfizer, La Jolla, California, USA
Cancer Res 70:10090-100. 2010
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- Tumor refractoriness to anti-VEGF treatment is mediated by CD11b+Gr1+ myeloid cells
Farbod Shojaei
Genentech, Inc, 1 DNA Way, S San Francisco, California 94080, USA
Nat Biotechnol 25:911-20. 2007
..These findings indicate that, in our models, refractoriness to anti-VEGF treatment is determined by the ability of tumors to prime and recruit CD11b+Gr1+ cells...
- Endothelium-microenvironment interactions in the developing embryo and in the adult
Kristy Red Horse
Genentech, Inc, 1 DNA Way, South San Francisco, CA 94080, USA
Dev Cell 12:181-94. 2007
..Such interactions appear to be important also in the adult, in normal and pathological conditions...
- Smad7 alters cell fate decisions of human hematopoietic repopulating cells
Kristin Chadwick
Krembil Centre for Stem Cell Biology, Robarts Research Institute, 100 Perth Dr, London, ON N6A 5K8, Canada
Blood 105:1905-15. 2005
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- Endothelial and hematopoietic cell fate of human embryonic stem cells originates from primitive endothelium with hemangioblastic properties
Lisheng Wang
Robarts Research Institute, Krembil Centre for Stem Cell Biology and Regenerative Medicine, 100 Perth Drive, London, Ontario N6A 5K8, Canada
Immunity 21:31-41. 2004
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