Tracheal responsiveness to methacholine and ovalbumin; and lung inflammation in guinea pigs exposed to inhaled lead after sensitizationMohammad Hossein Boskabady
Department of Physiology, School of Medicine and Pharmaceutical Research Centre, Mashhad University of Medical Sciences, Mashhad, Islamic Republic of Iran Electronic address
Ecotoxicol Environ Saf 86:233-8. 2012
..Therefore, environmental exposure to lead may aggravate the severity of asthma...
- The effect of the extract of Crocus sativus and its constituent safranal, on lung pathology and lung inflammation of ovalbumin sensitized guinea-pigs
M H Boskabady
Department of Physiology, School of Medicine and Pharmaceutical Research Centre, Mashhad University of Medical Sciences, Mashhad 177948564, Iran
Phytomedicine 19:904-11. 2012
..sativus and its constituent safranal on lung inflammation of sensitized guinea pigs. The results also showed that the effect of the plant is perhaps due to its constituent safranal...
Improvement in symptoms and pulmonary function of asthmatic patients due to their treatment according to the Global Strategy for Asthma Management (GINA)Mohammad H Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
BMC Pulm Med 8:26. 2008
..Global Initiative Strategy for Asthma Management (GINA) is poorly applied in undeveloped and developing countries. The current study examined the effects of applying GINA guidelines on treatment efficacy in asthmatic patients in Iran...
- The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs
Mohammad Hossein Boskabady
Department of Physiology and Pharmaceutical Research Centre, School of Medicine, Mashhad University of Medical Sciences, Postal Code 9177948564, Mashhad, Iran
J Ethnopharmacol 137:1028-34. 2011
..ETHNOMEDICAL RELEVANCE: The anti-inflammatory activity of both systemic and local administrations of essential oil from Nigella sativa L. has been shown...
- [Effect of inhaled fluticasone on lung inflammation administered during and after guinea pig sensitization]
Mohammad Hossein Boskabady
Department of Physiology and Pharmacological Research Centre of Medical Plants, Mashhad, Iran
Arch Bronconeumol 46:215-22. 2010
..The effect of an inhaled corticosteroid, fluticasone propionate (FP) lung inflammation of sensitized guinea pig was examined...
Prevalence of asthma symptoms among the adult population in the city of Mashhad (north-east of Iran)Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Respirology 7:267-72. 2002
..Although there is evidence of worldwide variation in the prevalence of asthma, the prevalence of asthma in adult populations in Iran is not known...
- The possible prophylactic effect of Nigella sativa seed extract in asthmatic patients
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad 91735, Iran
Fundam Clin Pharmacol 21:559-66. 2007
..The results of phase I study generally suggest a prophylactic effect of N. sativa on asthma disease and warrant further research regarding this effect...
- Influence of epithelium on beta-adrenoceptor desensitization of guinea pig tracheal smooth muscle
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Post Code 91735, Iran
Respir Physiol Neurobiol 156:69-78. 2007
..05). These results indicate decrease in both tracheal response to beta-agonist (tolerance) and CR-1 (due to incubation of tissues with isoprenaline), which were greater in denuded epithelium groups...
- Influence of epithelium and isoprenaline incubation on responsiveness of guinea-pig trachea to methacholine
M H Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Pharmacology 76:1-7. 2006
..The results of this study indicate reduction of tracheal response to methacholine due to incubation of tissues with isoprenaline, which was relatively more pronounced in epithelium denuded trachea...
- Airway responsiveness to beta-adrenergic agonist (salbutamol) in asthma
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
J Asthma 40:917-25. 2003
..The increased sensitivity of asthmatics to inhaled salbutamol suggests that they also may be more sensitive to their endogenous adrenaline, which may thus dilate and stabilize their airways...
Possible mechanism(s) for relaxant effect of aqueous and macerated extracts from Nigella sativa on tracheal chains of guinea pigMohammad H Boskabady
Dept of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
BMC Pharmacol 4:3. 2004
..To elucidate the other mechanisms responsible for the relaxant effect of this plant, its inhibitory effect on the calcium channel was examined in this study...
- The influence of epithelium on the responsiveness of guinea-pig trachea to -adrenergic agonist and antagonist
Mohammad H Boskabady
Dept of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Med Sci Monit 9:BR336-42. 2003
..Therefore, the present study focused on the effect of epithelial denudation of guinea pig tracheal chains in response to isoprenaline and b-adrenergic receptor blockade...
- Inhibitory effect of Bunium persicum on histamine (H1) receptors of guinea pig tracheal chains
M H Boskabady
Department of Physiology, Ghlaem Medical Centre, Mashhad University of Medical Sciences, Mashhad 91735, Iran
Phytomedicine 11:411-5. 2004
..These results indicated a competitive antagonistic effect of Bunium persicum at histamine H1 receptors...
- Effect of ascorbic acid on airway responsiveness in ovalbumin sensitized guinea pigs
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Respirology 8:473-8. 2003
..The aim of this study was to evaluate the effects of both acute exposure and a 30-day administration of ascorbic acid (AA), which has an antioxidant effect, on airway responsiveness in sensitized guinea pigs...
- Prediction equations for pulmonary function values in healthy young Iranians aged 8-18 years
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Respirology 9:535-42. 2004
..In addition, there is evidence of PFT variation in different ethnic groups. Prediction equations for PFT from a healthy, non-smoking, urban young population in the city of Mashhad (north-east Iran) have been derived...
- Relaxant effects of carvacrol on guinea pig tracheal chains and its possible mechanisms
M H Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Pharmazie 58:661-3. 2003
..05 to p < 0.001). These results indicated that carvacrol has a potent relaxant effect on tracheal chains of guinea pigs which is not due to beta2-adrenergic stimulatory, histamine H1, and muscarinic blocking effect...
- The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs
Mohammad Hossein Boskabady
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
Inhal Toxicol 23:157-65. 2011
..01) and SME + D (P < 0.05) groups. The results showed a preventive effect of vitamin E, dexamethasone and their combination on TR and lung inflammation in SME guinea pigs...
- The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and white blood cell count in lung lavage of sensitized guinea pigs
Rana Keyhanmanesh
Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran
Planta Med 76:218-22. 2010
..sativa, on tracheal responsiveness and inflammatory cells of lung lavage of sensitized guinea pigs which was comparable or even greater than that of the inhaled steroid...
- Potential immunomodulation effect of the extract of Nigella sativa on ovalbumin sensitized guinea pigs
Mohammad Hossein Boskabady
Pharmaceutical Research Centre, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
J Zhejiang Univ Sci B 12:201-9. 2011
..001), except for the oedema in the sensitized group treated with low concentration of the extract, but an increased IFN-γ. These results confirm a preventive effect of N. sativa extract on lung inflammation of sensitized guinea pigs...
- Effect of aqueous extract from Nigella sativa L. on guinea pig isolated heart
Mohammad Naser Shafei
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, 91735, Iran
Indian J Exp Biol 43:635-9. 2005
..sativa on calcium channel of guinea pig heart was found comparable and even greater than that of diltazem. The results may also indicate an opening effect for the plant on potassium channel of isolated heart...
- Effect of Zataria multiflora Bois L. on histamine (H1) receptor of guinea pig tracheal chains
Mohammad Hossein Boskabady
Department of Physiology and Pharmaceutical Research Centre, School of Medicine, Mashhad University of Medical Sciences, Mashhad, 9177948564, Iran Mehrdad Iranshahi
Indian J Exp Biol 49:679-83. 2011
..There were parallel right ward shift in concentration response curves obtained in presence of all concentrations of the extract in both the groups. These results indicated an inhibitory effect of Z. multiflora at histamine H1 receptors...
- Tracheal responsiveness to both isoprenaline and beta2-adrenoreceptor blockade by propranolol in cigarette smoke exposed and sensitized guinea pigs
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad 91735, Iran
Respirology 11:572-8. 2006
..In this study, tracheal responsiveness to isoprenaline and beta-adrenergic receptor blockade was investigated in animals exposed to cigarette smoke (AECS) with or without sensitization by ovalbumin (OA)...
- The effect of safranal on histamine (H(1)) receptors of guinea pig tracheal chains
Mohammad Hossein Boskabady
Department of Physiology and Pharmaceutical Research Centre, Medical School Mashhad University of Medical Sciences, Mashhad, Iran
Fitoterapia 82:162-7. 2011
..05 to p < 0.001). The EC(50) obtained in the presence of all concentrations of safranal and maximum response of its two higher concentrations (1.25 and 2.5 μg/mL) in group 2 were greater than in group 1 (p < 0.05 to p < 0.001)...
- Bronchodilatory effect of Carum copticum in airways of asthmatic patients
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Therapie 62:23-9. 2007
..In the present study, the bronchodilatory effect of boiled extract from Carum copticum in the airways of asthmatic patients was examined...
- Occupational exposures and obstructive lung disease: a case-control study in hairdressers
Nastran Hashemi
Department of Physiology, Mashhad University of Medical Sciences, Mashhad, Iran, 177948564
Respir Care 55:895-900. 2010
..Hairdressers are exposed to various irritating chemicals during work...
- The prevalence of smoking among the population in the city of Mashhad (north east of Iran) and pulmonary function tests among smokers
Mohammad Hossein Boskabady
Department of Physiology and Pharmaceutical Research Centre, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Pneumonol Alergol Pol 79:21-5. 2011
..Smoking is known as a major cause of chronic obstructive pulmonary disease (COPD). In this study the prevalence of smoking in the population of Mashhad city was evaluated as well as pulmonary function tests (PFTs) of smokers...
- Relation of airway responsiveness to salbutamol and to methacholine in smokers
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Med Sci Monit 11:CR344-50. 2005
..After our previous studies had shown AHR to b-agonists in asthmatic patients, we examined airway responsiveness to salbutamol and its relationship to responsiveness to methachline in smokers...
- The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs
Mohammad Hossein Boskabady
Dept of Physiology and Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Clinics (Sao Paulo) 66:879-87. 2011
..To examine the preventive effect of a hydro-ethanolic extract of Nigella sativa on the tracheal responsiveness and white blood cell count in the lung lavage fluid of sensitized guinea pigs...
- The effect of inhaled salmeterol, alone and in combination with fluticasone propionate, on management of COPD patients
Fariba Mansori
Department of Medicine, Medical School, Kermanshah University of Medical Sciences, Mashhad, Iran
Clin Respir J 4:241-7. 2010
..We examined the effect of inhaled salmeterol, alone and in combination with fluticasone propionate, on the management of patients with COPD...
- Association of the expression of IL-4 and IL-13 genes, IL-4 and IgE serum levels with allergic asthma
Jalil Tavakkol Afshari
Department of Immunogenetics, Immunology Research Centre, Bu Ali Research Institute, Mashhad, Iran
Iran J Allergy Asthma Immunol 6:67-72. 2007
..The results showed that there was a correlation between the expression of IL-4 gene and the level of serum IL-4. Levels of serum IgE and IL-4 were considerably higher in asthmatics than non-asthmatic controls...
- Respiratory symptoms and pulmonary function changes among carpet weavers in Iran
Mohammad Hossein Boskabady
Department of Physiology, Ghaem Hospital, Mashad University of Medical Sciences MUMS, Mashad, Iran
Int J Occup Environ Health 13:369-75. 2007
..01 - p<0.001). Pulmonary function test results of the carpet weavers showed significant impairment compared with controls (p<0.05 - p<0.001)...
- The possible prophylactic effect of Nigella sativa seed aqueous extract on respiratory symptoms and pulmonary function tests on chemical war victims: a randomized, double-blind, placebo-controlled trial
Mohammad H Boskabady
Department of Physiology, Medical School, and Pharmacological Research Centre of Medical Plants, Mashhad University of Medical Sciences, Mashhad, Iran
J Altern Complement Med 14:1137-44. 2008
..In the present study, the prophylactic effect of a boiled aqueous extract of nigella seed on chemical war victims was examined...
- The effect of natural adjuvants on tracheal responsiveness and cell count in lung lavage of sensitized guinea pigs
Ali Neamati
Department of Biology, Islamic Azad University, Mashhad Branch, Mashhad University of Medical Sciences, Mashad, Iran
Respirology 14:877-84. 2009
..Airway inflammation is a well-characterized pathological feature of asthma. The effects of two natural adjuvants on lungs of sensitized guinea pigs were examined...
- Airway responses to salbutamol after exposure to chemical warfare
Mohammad H Boskabady
Department of Physiology, Ghaem Medical Centre, Mashhad University of Medical Sciences, Mashhad, Iran
Respirology 13:288-93. 2008
..There is little understanding of airway hyperresponsiveness to beta-agonist drugs in chemical war victims and this study examined airway responsiveness to salbutamol in victims of chemical warfare...
- Work-related respiratory symptoms and pulmonary function tests in Iranian printers
Mohammad H Boskabady
Department of Physiology and Pharmacological Research Centre of Medical Plants, Medical School, Mashhad University of Medical Sciences, Mashhad, Iran
Saudi Med J 30:1170-5. 2009
..To assess lung function tests and self-reported frequency of work related respiratory and allergic symptoms among subjects working as printers...
