Soichiro Shimizu

Summary

Publications

  1. pmc Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia
    Soichiro Shimizu
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Brain Imaging Behav 4:46-54. 2010
  2. ncbi request reprint SPECT follow-up study of cerebral blood flow changes during Donepezil therapy in patients with Alzheimer's disease
    Soichiro Shimizu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Neuroimaging 16:16-23. 2006
  3. ncbi request reprint The role of 123I-metaiodobenzylguanidine myocardial scintigraphy in the diagnosis of Lewy body disease in patients with dementia in a memory clinic
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 22:379-84. 2006
  4. doi request reprint Prediction of response to donepezil in Alzheimer's disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusion
    Hidekazu Kanetaka
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Nucl Med Commun 29:568-73. 2008
  5. ncbi request reprint Differentiation of dementia with Lewy bodies from Alzheimer's disease using Mini-Mental State Examination and brain perfusion SPECT
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Neurol Sci 250:97-102. 2006
  6. doi request reprint Vascular risk factors are associated with faster decline of Alzheimer disease: a longitudinal SPECT study
    Kazumasa Kume
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    J Neurol 258:1295-303. 2011
  7. doi request reprint Subgroups of Alzheimer's disease associated with diabetes mellitus based on brain imaging
    Raita Fukazawa
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    Dement Geriatr Cogn Disord 35:280-90. 2013
  8. ncbi request reprint Differences in magnetization transfer ratios of the hippocampus between dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Neurosci Lett 380:166-9. 2005
  9. doi request reprint Value of analyzing deep gray matter and occipital lobe perfusion to differentiate dementia with Lewy bodies from Alzheimer's disease
    Soichiro Shimizu
    Department of Radiology, Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Ann Nucl Med 22:911-6. 2008
  10. ncbi request reprint Differences in regional cerebral blood flow patterns in male versus female patients with Alzheimer disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    AJNR Am J Neuroradiol 25:1199-204. 2004

Collaborators

Detail Information

Publications27

  1. pmc Concordance and discordance between brain perfusion and atrophy in frontotemporal dementia
    Soichiro Shimizu
    Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Brain Imaging Behav 4:46-54. 2010
    ..Detection of discordance between brain perfusion and structure in FTD might aid diagnosis and staging of the disease...
  2. ncbi request reprint SPECT follow-up study of cerebral blood flow changes during Donepezil therapy in patients with Alzheimer's disease
    Soichiro Shimizu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Neuroimaging 16:16-23. 2006
    ..We attempted to evaluate the possible correlation between regional cerebral blood flow (rCBF) differences in patients with AD and response to donepezil hydrochloride (Donepezil) therapy...
  3. ncbi request reprint The role of 123I-metaiodobenzylguanidine myocardial scintigraphy in the diagnosis of Lewy body disease in patients with dementia in a memory clinic
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 22:379-84. 2006
    ..The scintigraphy may provide a valuable and adjunctive method in the diagnosis of Lewy body disease and a differential diagnostic tool for patients with dementias...
  4. doi request reprint Prediction of response to donepezil in Alzheimer's disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusion
    Hidekazu Kanetaka
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Nucl Med Commun 29:568-73. 2008
    ....
  5. ncbi request reprint Differentiation of dementia with Lewy bodies from Alzheimer's disease using Mini-Mental State Examination and brain perfusion SPECT
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    J Neurol Sci 250:97-102. 2006
    ..Our findings will need to be substantiated in an independent and prospective study sample...
  6. doi request reprint Vascular risk factors are associated with faster decline of Alzheimer disease: a longitudinal SPECT study
    Kazumasa Kume
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    J Neurol 258:1295-303. 2011
    ..Multiple vascular risk factors are associated with a greater rate of decline in cognition, function, and rCBF in patients with AD. Our results highlight the contribution of vascular risk factors on the progression of AD...
  7. doi request reprint Subgroups of Alzheimer's disease associated with diabetes mellitus based on brain imaging
    Raita Fukazawa
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    Dement Geriatr Cogn Disord 35:280-90. 2013
    ..We attempted to define possible subgroups of Alzheimer's disease (AD) associated with diabetes mellitus (DM) based on brain imaging...
  8. ncbi request reprint Differences in magnetization transfer ratios of the hippocampus between dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Neurosci Lett 380:166-9. 2005
    ..These results may reflect underlying histopathological differences with less severe neuronal degeneration in the hippocampus of DLB. MTR measurement of the hippocampus may contribute to the clinical differentiation between DLB and AD...
  9. doi request reprint Value of analyzing deep gray matter and occipital lobe perfusion to differentiate dementia with Lewy bodies from Alzheimer's disease
    Soichiro Shimizu
    Department of Radiology, Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
    Ann Nucl Med 22:911-6. 2008
    ..However, not all patients with DLB have this feature. We explored characteristics of rCBF pattern changes to improve the identification of DLB, in addition to occipital hypoperfusion...
  10. ncbi request reprint Differences in regional cerebral blood flow patterns in male versus female patients with Alzheimer disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    AJNR Am J Neuroradiol 25:1199-204. 2004
    ..There may be some differences in the pathophysiology between men and women with Alzheimer disease (AD). This study was undertaken to explore the possible influence of sex on regional cerebral blood flow (rCBF) patterns in patients with AD...
  11. ncbi request reprint Phenylephrine and pilocarpine eye drop test for dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
    Neurosci Lett 414:174-7. 2007
    ..The pupil assay using combined phenylephrine and pilocarpine eye drop test may be useful in the detection of patients with DLB and AD and in distinguishing between them...
  12. ncbi request reprint MR features of the substantia innominata and therapeutic implications in dementias
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Nishishinjuku Shinjuku ku, Tokyo, Japan
    Neurobiol Aging 28:548-54. 2007
    ..Clinical response to cholinergic therapy may be partly attributable to damaged cholinergic neurons in AD and DLB, but not in VaD, suggesting differences in the therapeutic implication of cholinergic system degeneration...
  13. ncbi request reprint Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
    Eur J Nucl Med Mol Imaging 33:248-53. 2006
    ..The aim of this study was to compare the diagnostic value of these two methods for differentiation of DLB from Alzheimer's disease (AD)...
  14. ncbi request reprint [Regional cerebral blood flow patterns in extremely elderly patients with Alzheimer's disease]
    Kentaro Hirao
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Ronen Igakkai Zasshi 45:408-13. 2008
    ....
  15. doi request reprint Neuroanatomical correlates of unawareness of memory deficits in early Alzheimer's disease
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 25:347-53. 2008
    ..To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD)...
  16. ncbi request reprint [Prediction of the development of Alzheimer disease in patients with mild cognitive impairment]
    Kazumasa Kume
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Ronen Igakkai Zasshi 47:147-52. 2010
    ....
  17. doi request reprint Vascular risk factors and progression in Alzheimer's disease
    Hirofumi Sakurai
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Geriatr Gerontol Int 11:211-4. 2011
    ..To determine whether vascular risk factors such as hypertension, diabetes and hypercholesterolemia affect the progression of Alzheimer's disease (AD)...
  18. ncbi request reprint [Characteristics of MRI features in Alzheimer's disease patients predicting response to donepezil treatment]
    Yuriko Tanaka
    Department of Geriatric Medicine, Tokyo Medical University
    Nihon Ronen Igakkai Zasshi 40:261-6. 2003
    ..These results suggest that AD patients who show more severe cholinergic dysfunction and less severe structural damage of the hippocampus and parahippocampus as shown on MRI are likely to respond to donepezil treatment...
  19. doi request reprint The effect of education on rCBF changes in Alzheimer's disease: a longitudinal SPECT study
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Eur J Nucl Med Mol Imaging 35:2182-90. 2008
    ..To determine the relationship of differing levels of education on regional cerebral blood flow (rCBF) in patients with Alzheimer's disease (AD)...
  20. doi request reprint Association between ApoE phenotypes and telomere erosion in Alzheimer's disease
    Yusuke Takata
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    J Gerontol A Biol Sci Med Sci 67:330-5. 2012
    ..001) and noncarriers (p < .001). These findings suggest that shortened telomere length may be associated with the ApoE4 homozygote in AD patients...
  21. pmc A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer's Disease with or without Diabetes
    Kentaro Hirao
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord Extra 1:62-74. 2011
    ..To determine the effect of diabetes mellitus (DM) on regional cerebral blood flow (rCBF) patterns in patients with Alzheimer's disease (AD)...
  22. ncbi request reprint Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Japan
    Nucl Med Commun 28:281-7. 2007
    ..We compared the effects of nilvadipine and amlodipine on the cognitive function and regional cerebral blood flow (rCBF) in patients with mild cognitive impairment (MCI) and hypertension...
  23. ncbi request reprint Differentiation of dementia with Lewy bodies from Alzheimer's disease using brain SPECT
    Soichiro Shimizu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
    Dement Geriatr Cogn Disord 20:25-30. 2005
    ..Objective and quantitative CBF measurement in the medial occipital lobe may be useful in the clinical differentiation of DLB and AD...
  24. ncbi request reprint Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study
    Haruo Hanyu
    Department of Geriatric Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
    Neurosci Lett 340:213-6. 2003
    ..Patients with BD exhibited a high frequency and number of MBs, indicating advanced bleeding-prone microangiopathy within the brain, which should be taken into account in treatment and management...
  25. ncbi request reprint Unawareness of memory deficits depending on cerebral perfusion pattern in mild cognitive impairment
    Haruo Hanyu
    J Am Geriatr Soc 55:470-1. 2007
  26. ncbi request reprint Differences in MR features of the substantia innominata between dementia with Lewy bodies and Alzheimer's disease
    Haruo Hanyu
    J Neurol 252:482-4. 2005
  27. ncbi request reprint Cerebral microbleeds in Alzheimer's disease
    Haruo Hanyu
    J Neurol 250:1496-7. 2003