Concordance and discordance between brain perfusion and atrophy in frontotemporal dementiaSoichiro Shimizu
Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, Department of Radiology and Biomedical Imaging, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
Brain Imaging Behav 4:46-54. 2010
..Detection of discordance between brain perfusion and structure in FTD might aid diagnosis and staging of the disease...
SPECT follow-up study of cerebral blood flow changes during Donepezil therapy in patients with Alzheimer's diseaseSoichiro Shimizu
Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
J Neuroimaging 16:16-23. 2006
..We attempted to evaluate the possible correlation between regional cerebral blood flow (rCBF) differences in patients with AD and response to donepezil hydrochloride (Donepezil) therapy...
- The role of 123I-metaiodobenzylguanidine myocardial scintigraphy in the diagnosis of Lewy body disease in patients with dementia in a memory clinic
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
Dement Geriatr Cogn Disord 22:379-84. 2006
..The scintigraphy may provide a valuable and adjunctive method in the diagnosis of Lewy body disease and a differential diagnostic tool for patients with dementias...
Prediction of response to donepezil in Alzheimer's disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusionHidekazu Kanetaka
Department of Geriatric Medicine, Tokyo Medical University, Japan
Nucl Med Commun 29:568-73. 2008
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- Vascular risk factors are associated with faster decline of Alzheimer disease: a longitudinal SPECT study
Kazumasa Kume
Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
J Neurol 258:1295-303. 2011
..Multiple vascular risk factors are associated with a greater rate of decline in cognition, function, and rCBF in patients with AD. Our results highlight the contribution of vascular risk factors on the progression of AD...
- Differentiation of dementia with Lewy bodies from Alzheimer's disease using Mini-Mental State Examination and brain perfusion SPECT
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
J Neurol Sci 250:97-102. 2006
..Our findings will need to be substantiated in an independent and prospective study sample...
- Phenylephrine and pilocarpine eye drop test for dementia with Lewy bodies and Alzheimer's disease
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku, Shinjuku ku, Tokyo 160 0023, Japan
Neurosci Lett 414:174-7. 2007
..The pupil assay using combined phenylephrine and pilocarpine eye drop test may be useful in the detection of patients with DLB and AD and in distinguishing between them...
- Value of analyzing deep gray matter and occipital lobe perfusion to differentiate dementia with Lewy bodies from Alzheimer's disease
Soichiro Shimizu
Department of Radiology, Center for Imaging of Neurodegenerative Diseases, Veterans Affairs Medical Center, University of California, San Francisco, 4150 Clement Street, 114M, San Francisco, CA 94121, USA
Ann Nucl Med 22:911-6. 2008
..However, not all patients with DLB have this feature. We explored characteristics of rCBF pattern changes to improve the identification of DLB, in addition to occipital hypoperfusion...
- Differences in magnetization transfer ratios of the hippocampus between dementia with Lewy bodies and Alzheimer's disease
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
Neurosci Lett 380:166-9. 2005
..These results may reflect underlying histopathological differences with less severe neuronal degeneration in the hippocampus of DLB. MTR measurement of the hippocampus may contribute to the clinical differentiation between DLB and AD...
- Differences in regional cerebral blood flow patterns in male versus female patients with Alzheimer disease
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
AJNR Am J Neuroradiol 25:1199-204. 2004
..CONCLUSION: These data provide evidence that patterns of rCBF deficits differ between the sexes, a finding that supports the concept of heterogeneity of the underlying pathophysiology of AD...
- MR features of the substantia innominata and therapeutic implications in dementias
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, Nishishinjuku Shinjuku ku, Tokyo, Japan
Neurobiol Aging 28:548-54. 2007
..Clinical response to cholinergic therapy may be partly attributable to damaged cholinergic neurons in AD and DLB, but not in VaD, suggesting differences in the therapeutic implication of cholinergic system degeneration...
- Comparative value of brain perfusion SPECT and [(123)I]MIBG myocardial scintigraphy in distinguishing between dementia with Lewy bodies and Alzheimer's disease
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, 6 7 1 Nishishinjuku Shinjuku ku, Tokyo 160 0023, Japan
Eur J Nucl Med Mol Imaging 33:248-53. 2006
..The aim of this study was to compare the diagnostic value of these two methods for differentiation of DLB from Alzheimer's disease (AD)...
- [Regional cerebral blood flow patterns in extremely elderly patients with Alzheimer's disease]
Kentaro Hirao
Department of Geriatric Medicine, Tokyo Medical University
Nihon Ronen Igakkai Zasshi 45:408-13. 2008
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- Neuroanatomical correlates of unawareness of memory deficits in early Alzheimer's disease
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
Dement Geriatr Cogn Disord 25:347-53. 2008
..To investigate neuroanatomical substrates of unawareness of memory deficits in patients with early Alzheimer's disease (AD)...
- [Prediction of the development of Alzheimer disease in patients with mild cognitive impairment]
Kazumasa Kume
Department of Geriatric Medicine, Tokyo Medical University
Nihon Ronen Igakkai Zasshi 47:147-52. 2010
....
- Vascular risk factors and progression in Alzheimer's disease
Hirofumi Sakurai
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
Geriatr Gerontol Int 11:211-4. 2011
..To determine whether vascular risk factors such as hypertension, diabetes and hypercholesterolemia affect the progression of Alzheimer's disease (AD)...
- [Characteristics of MRI features in Alzheimer's disease patients predicting response to donepezil treatment]
Yuriko Tanaka
Department of Geriatric Medicine, Tokyo Medical University
Nippon Ronen Igakkai Zasshi 40:261-6. 2003
..These results suggest that AD patients who show more severe cholinergic dysfunction and less severe structural damage of the hippocampus and parahippocampus as shown on MRI are likely to respond to donepezil treatment...
- The effect of education on rCBF changes in Alzheimer's disease: a longitudinal SPECT study
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
Eur J Nucl Med Mol Imaging 35:2182-90. 2008
..To determine the relationship of differing levels of education on regional cerebral blood flow (rCBF) in patients with Alzheimer's disease (AD)...
- Association between ApoE phenotypes and telomere erosion in Alzheimer's disease
Yusuke Takata
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
J Gerontol A Biol Sci Med Sci 67:330-5. 2012
..001) and noncarriers (p < .001). These findings suggest that shortened telomere length may be associated with the ApoE4 homozygote in AD patients...
- A Longitudinal SPECT Study of Different Patterns of Regional Cerebral Blood Flow in Alzheimer's Disease with or without Diabetes
Kentaro Hirao
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
Dement Geriatr Cogn Disord Extra 1:62-74. 2011
..To determine the effect of diabetes mellitus (DM) on regional cerebral blood flow (rCBF) patterns in patients with Alzheimer's disease (AD)...
- Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, Japan
Nucl Med Commun 28:281-7. 2007
..We compared the effects of nilvadipine and amlodipine on the cognitive function and regional cerebral blood flow (rCBF) in patients with mild cognitive impairment (MCI) and hypertension...
- Differentiation of dementia with Lewy bodies from Alzheimer's disease using brain SPECT
Soichiro Shimizu
Department of Geriatric Medicine, Tokyo Medical University, Tokyo, Japan
Dement Geriatr Cogn Disord 20:25-30. 2005
..Objective and quantitative CBF measurement in the medial occipital lobe may be useful in the clinical differentiation of DLB and AD...
- Cerebral microbleeds in Binswanger's disease: a gradient-echo T2*-weighted magnetic resonance imaging study
Haruo Hanyu
Department of Geriatric Medicine, Tokyo Medical University, Tokyo 160 0023, Japan
Neurosci Lett 340:213-6. 2003
..Patients with BD exhibited a high frequency and number of MBs, indicating advanced bleeding-prone microangiopathy within the brain, which should be taken into account in treatment and management...
- Unawareness of memory deficits depending on cerebral perfusion pattern in mild cognitive impairment
Haruo Hanyu
J Am Geriatr Soc 55:470-1. 2007
- Differences in MR features of the substantia innominata between dementia with Lewy bodies and Alzheimer's disease
Haruo Hanyu
J Neurol 252:482-4. 2005
- Cerebral microbleeds in Alzheimer's disease
Haruo Hanyu
J Neurol 250:1496-7. 2003
