Yongyong Shi

Summary

Publications

  1. pmc Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population
    Ti Wang
    Bio X Center and affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 5:e13662. 2010
  2. doi request reprint A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12
    Yongyong Shi
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Nat Genet 45:918-22. 2013
  3. pmc Association between paraoxonase gene and stroke in the Han Chinese population
    Guojun Zhang
    Laboratory Diagnosis Center, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
    BMC Med Genet 14:16. 2013
  4. pmc Common variants on 8p12 and 1q24.2 confer risk of schizophrenia
    Yongyong Shi
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, China
    Nat Genet 43:1224-7. 2011
  5. doi request reprint A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
    Yongyong Shi
    Bio X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, China
    Nat Genet 43:1215-8. 2011
  6. pmc No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis
    Ronglin Che
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    BMC Med Genet 10:31. 2009
  7. ncbi request reprint An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population
    Gang Ma
    Bio X Center, PO Box 501, Hao Ran Building, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030, China
    Neurosci Lett 425:146-50. 2007
  8. doi request reprint The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis
    Zhao Zhang
    Bio X Center, Shanghai Jiao Tong University, PO Box 501, Haoran Building, 1954 Huashan Road, 200030, Shanghai, People s Republic of China
    J Neural Transm 116:1193-200. 2009
  9. doi request reprint Association study between RGS4 and bipolar disorder in the Chinese Han population
    You Li
    Bio X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong University, Jiulong, Matang District, Wuhu, China
    Psychiatr Genet 20:130-2. 2010
  10. doi request reprint CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population
    Jie Liu
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Brain Behav Immun 25:429-33. 2011

Collaborators

Detail Information

Publications56

  1. pmc Common SNPs in myelin transcription factor 1-like (MYT1L): association with major depressive disorder in the Chinese Han population
    Ti Wang
    Bio X Center and affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    PLoS ONE 5:e13662. 2010
    ..On the basis of a recent copy number variation (CNV) study showing that this gene is disrupted in mental disorder patients, we investigated whether MYT1L also plays a role in MDD...
  2. doi request reprint A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12
    Yongyong Shi
    Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
    Nat Genet 45:918-22. 2013
    ..32 and cervical cancer (rs4282438, Pcombined, stringently matched=4.52×10(-27), per-allele ORstringently matched=0.75). Our findings provide new insights into the genetic etiology of cervical cancer...
  3. pmc Association between paraoxonase gene and stroke in the Han Chinese population
    Guojun Zhang
    Laboratory Diagnosis Center, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China
    BMC Med Genet 14:16. 2013
    ..This study evaluated the association between the genetic variants of all three PON genes and the risks of total stroke, ischemic stroke and hemorrhagic stroke in the Han Chinese population...
  4. pmc Common variants on 8p12 and 1q24.2 confer risk of schizophrenia
    Yongyong Shi
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, China
    Nat Genet 43:1224-7. 2011
    ..27 × 10(-10)) and 1q24.2 (rs10489202, P = 9.50 × 10(-9)). Our findings provide new insights into the pathogenesis of schizophrenia...
  5. doi request reprint A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1
    Yongyong Shi
    Bio X Institutes, Ministry of Education Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, China
    Nat Genet 43:1215-8. 2011
    ..7 × 10(-9)). Imputation analyses also confirmed previously reported associations of rs2294008 and rs2976392 on 8q24, rs4072037 on 1q22 and rs13042395 on 20p13 with non-cardia gastric cancer susceptibility in the Han Chinese population...
  6. pmc No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis
    Ronglin Che
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    BMC Med Genet 10:31. 2009
    ..The present study aims to investigate the relationship between CNP and schizophrenia in the Chinese population and the effect of different factors on the expression level of CNP in schizophrenia...
  7. ncbi request reprint An association study between the genetic polymorphisms within TBX1 and schizophrenia in the Chinese population
    Gang Ma
    Bio X Center, PO Box 501, Hao Ran Building, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030, China
    Neurosci Lett 425:146-50. 2007
    ..Our data suggest that the genetic polymorphisms within TBX1 do not confer an increased susceptibility to schizophrenia in the Chinese population...
  8. doi request reprint The Val/Met functional polymorphism in COMT confers susceptibility to bipolar disorder: evidence from an association study and a meta-analysis
    Zhao Zhang
    Bio X Center, Shanghai Jiao Tong University, PO Box 501, Haoran Building, 1954 Huashan Road, 200030, Shanghai, People s Republic of China
    J Neural Transm 116:1193-200. 2009
    ..In conclusion, the low-activity allele (Met) of rs4680 in COMT gene possibly confers risk for bipolar disorder in the Han population, while it needs further evidence for concluding its association with BP in the Caucasian population...
  9. doi request reprint Association study between RGS4 and bipolar disorder in the Chinese Han population
    You Li
    Bio X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong University, Jiulong, Matang District, Wuhu, China
    Psychiatr Genet 20:130-2. 2010
    ..0078), and in addition, a haplotype containing this T allele was also protective for bipolar disorder (P=0.02). Our results provide further evidence to support RGS4 as a potential susceptible gene for bipolar disorder...
  10. doi request reprint CTLA-4 confers a risk of recurrent schizophrenia, major depressive disorder and bipolar disorder in the Chinese Han population
    Jie Liu
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Brain Behav Immun 25:429-33. 2011
    ..0201, bipolar disorder: P(allele)=0.0008, P(genotype)=0.0125). Our results suggest that shared common risk factors for schizophrenia, major depressive disorder and bipolar disorder exist in the CTLA-4 gene in the Chinese Han population...
  11. doi request reprint Evidence for association between the 5' flank of the NOS1 gene and schizophrenia in the Chinese population
    Wei Tang
    Bio X Center, Shanghai Jiao Tong University, Shanghai, PR China
    Int J Neuropsychopharmacol 11:1063-71. 2008
    ..Our results strongly support a previous hypothesis that NOS1 contributes to the genetic risk of schizophrenia and suggest that further research on more NOS1 variants and its regular elements are warranted...
  12. doi request reprint Positive association between ALDH1A2 and schizophrenia in the Chinese population
    Chunling Wan
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China
    Prog Neuropsychopharmacol Biol Psychiatry 33:1491-5. 2009
    ..In addition, our results suggest a positive association between ALDH1A2 and schizophrenics in the Chinese population and support the retinoid hypothesis of schizophrenia...
  13. doi request reprint Common variants in the BCL9 gene conferring risk of schizophrenia
    Junyan Li
    Bio X Center and affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, China
    Arch Gen Psychiatry 68:232-40. 2011
    ..Rare recurrent microdeletions at 1q21.1 were reported to be associated with schizophrenia, and the BCL9 gene at 1q21.1 was also a functional candidate gene for mental disorders...
  14. doi request reprint Common SNPs in CSF2RB are associated with major depression and schizophrenia in the Chinese Han population
    Peng Chen
    Bio X Center and affiliated Changning Mental Health Center, Key Laboratory for Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    World J Biol Psychiatry 12:233-8. 2011
    ..It locates in the linkage region 22q12.3 of both bipolar disorder and schizophrenia, and is expressed in most cells...
  15. ncbi request reprint Positive association between PDLIM5 and schizophrenia in the Chinese Han population
    Chao Li
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China
    Int J Neuropsychopharmacol 11:27-34. 2008
    ..00019, even after strict Bonferroni correction). Our results provide further evidence to support PDLIM5 as a potential susceptible gene for schizophrenia...
  16. doi request reprint The MDGA1 gene confers risk to schizophrenia and bipolar disorder
    Junyan Li
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China
    Schizophr Res 125:194-200. 2011
    ..To further investigate whether the MDGA1 gene is a shared risk factor of schizophrenia, bipolar disorder and major depressive disorder in Chinese Han population, we conducted this study...
  17. doi request reprint Investigation of variants in the promoter region of PIK3C3 in schizophrenia
    Ruqi Tang
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Neurosci Lett 437:42-4. 2008
    ..Though we cannot exclude the possibility that susceptibility of -432C-/T is caused by its linkage disequilibrium with other causal variants, our results do support PIK3C3 play a significant role in the etiology of schizophrenia...
  18. doi request reprint FoxP2 is significantly associated with schizophrenia and major depression in the Chinese Han population
    Tao Li
    Bio X Center and affiliated Changning Mental Health Center, Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    World J Biol Psychiatry 14:146-50. 2013
    ....
  19. doi request reprint The Ser9Gly polymorphism of the dopamine D3 receptor gene and risk of schizophrenia: an association study and a large meta-analysis
    Gang Ma
    Bio X Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Schizophr Res 101:26-35. 2008
    ..Our study does not support the contention that the Ser9Gly polymorphism of the DRD3 gene plays a major role in schizophrenia in the Chinese population...
  20. doi request reprint No association found between the promoter variations of QKI and schizophrenia in the Chinese population
    Ke Huang
    Institute of Neuropsychiatric Science and Systems Biological Medicine, Shanghai Jiao Tong University, China
    Prog Neuropsychopharmacol Biol Psychiatry 33:33-6. 2009
    ..Several recent published studies have reported that the mRNA expression level of quaking homolog, KH domain RNA binding (QKI) is down regulated in individuals diagnosed with schizophrenia...
  21. ncbi request reprint Positive association between OLIG2 and schizophrenia in the Chinese Han population
    Ke Huang
    Bio X Center, Shanghai Jiao Tong University, PO Box 501, Haoran Building, 1954 Huashan Road, Shanghai, 200030, People s Republic of China
    Hum Genet 122:659-60. 2008
    ..The results provide further evidence that the SNP rs762178 in OLIG2 seems to be a potential candidate in altering risk for schizophrenia in the Chinese Han population and worthy of further replication and functional study...
  22. doi request reprint Association study between GNB1L and three major mental disorders in Chinese Han populations
    You Li
    Bio X Center and affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, China
    Psychiatry Res 187:457-9. 2011
    ..Among 1135 cases and 1135 controls, findings suggests that GNB1L is linked with bipolar disorder and schizophrenia and not with major depressive disorder...
  23. doi request reprint No association of the YWHAE gene with schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population
    Jie Liu
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, The Central White Building, 1954 Huashan Road, Shanghai, 200030, People s Republic of China
    Behav Genet 41:557-64. 2011
    ..Considering the size of our sample sets (power > 90%), our results suggest that the YWHAE does not play a major role in schizophrenia, major depressive disorder or bipolar disorder in the Han Chinese population...
  24. ncbi request reprint Significant association between the genetic variations in the 5' end of the N-methyl-D-aspartate receptor subunit gene GRIN1 and schizophrenia
    Xinzhi Zhao
    Bio X Center, Shanghai Jiao Tong University, China
    Biol Psychiatry 59:747-53. 2006
    ..Evidence from previous studies indicate that NMDA receptors contribute to the pathophysiology of schizophrenia. Two NMDA receptor subunit genes, GRIN1 and GRIN2A, are both good candidate genes for schizophrenia...
  25. ncbi request reprint Systematic study of association of four GABAergic genes: glutamic acid decarboxylase 1 gene, glutamic acid decarboxylase 2 gene, GABA(B) receptor 1 gene and GABA(A) receptor subunit beta2 gene, with schizophrenia using a universal DNA microarray
    Xu Zhao
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, Shanghai 200030, China
    Schizophr Res 93:374-84. 2007
    ..001). These findings suggest that the GABRB2 and GAD1 genes alone and the combined effects of the polymorphisms in the four GABAergic system genes may confer susceptibility to the development of schizophrenia in the Chinese population...
  26. doi request reprint Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population
    Peng Chen
    Bio X Center and affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 36:17-21. 2012
    ..No significant association between ErbB4 and the two other psychiatric disorders was observed, nor did haplotype analysis reveal any positive signal...
  27. doi request reprint Common variants in major histocompatibility complex region and TCF4 gene are significantly associated with schizophrenia in Han Chinese
    Tao Li
    Bio X Center, Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, People s Republic of China
    Biol Psychiatry 68:671-3. 2010
    ..examined 7662 schizophrenic cases and 29053 normal control subjects and reported seven common single nucleotide polymorphisms (SNPs) that were significantly (>10(-8)) associated with schizophrenia...
  28. doi request reprint Haplotype analysis confirms association of the serotonin transporter (5-HTT) gene with schizophrenia in the Han Chinese population
    Chuwen Lin
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Neurosci Lett 453:210-3. 2009
    ..No association was found in the single locus, but haplotype-based analyses revealed significant association between two haplotypes with schizophrenia even after Bonferroni correction (P=0.00000538 and 0.011)...
  29. doi request reprint FGFR2 is associated with bipolar disorder: a large-scale case-control study of three psychiatric disorders in the Chinese Han population
    Ti Wang
    Bio X Institutes and Affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    World J Biol Psychiatry 13:599-604. 2012
    ..The nearest gene to this SNP is fibroblast growth factor receptor 2 (FGFR2)...
  30. ncbi request reprint Brain-derived neurotrophic factor and risk of schizophrenia: an association study and meta-analysis
    Lulu Qian
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Biochem Biophys Res Commun 353:738-43. 2007
    ..However, haplotype analysis found a common four-locus haplotype is protective against schizophrenia (Case 3.1% vs Control 7%, p=0.0011). Our data provides evidence that BDNF is a susceptibility gene for schizophrenia in Chinese subjects...
  31. pmc Rare CNVs and tag SNPs at 15q11.2 are associated with schizophrenia in the Han Chinese population
    Qian Zhao
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Changning Mental Health Center, Bio X Institutes Affiliated Hospital, Shanghai, People s Republic of China
    Schizophr Bull 39:712-9. 2013
    ..In the current study, we investigated the role of both rare CNVs and common single nucleotide polymorphisms (SNPs) at 15q11.2 in schizophrenia in the Chinese Han population...
  32. ncbi request reprint Positive association of the human GABA-A-receptor beta 2 subunit gene haplotype with schizophrenia in the Chinese Han population
    Jixia Liu
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China
    Biochem Biophys Res Commun 334:817-23. 2005
    ..These two independent studies highlighting linkage disequilibrium support the potential involvement of GABRB2 or a nearby gene in the genetic etiology of schizophrenia...
  33. pmc Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis
    Lishan Wang
    Bio X Institutes and Affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    PLoS ONE 8:e59556. 2013
    ..To assess the association between the variant of Cytochrome P450 2A6 whole gene deletion (CYP2A6*4) polymorphism and risk of lung cancer...
  34. pmc Schizophrenia is not associated with the ERBB3 gene in a Han Chinese population sample: Results from case-control and family-based studies
    Dawei Li
    Bio X Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Shanghai Jiao Tong University, Shanghai China
    Genet Mol Biol 32:729-30. 2009
    ..Our results failed to show any evidence of significant association between the ERBB3 rs2292238 polymorphism and schizophrenia...
  35. pmc Functional variants in the promoter region of Chitinase 3-like 1 (CHI3L1) and susceptibility to schizophrenia
    Xinzhi Zhao
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Am J Hum Genet 80:12-8. 2007
    ....
  36. doi request reprint Comparison of hepatocellular carcinoma (HCC), cholangiocarcinoma (CC), and combined HCC-CC (CHC) with each other based on microarray dataset
    Lishan Wang
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, 200030, People s Republic of China
    Tumour Biol 34:1679-84. 2013
    ..However, further validation is required since our results were based on microarray data derived from a small sample size...
  37. pmc Drug-eluting stents for acute coronary syndrome: a meta-analysis of randomized controlled trials
    Lishan Wang
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, P R China FengHe ShangHai Information Technology Co, Ltd, Shanghai, P R China
    PLoS ONE 8:e72895. 2013
    ..We therefore evaluated clinical utility of second-generation and first-generation DES in patients with ACS by conducting a meta-analysis...
  38. pmc Association study of 15q14 and 15q25 with high myopia in the Han Chinese population
    Yu Qiang
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, P, R China
    BMC Genet 15:51. 2014
    ..To validate whether the same variations conferred risk to high myopia in the Han Chinese population, we genotyped 1,461 individuals (940 controls and 521 cases samples) recruited of Han Chinese origin...
  39. ncbi request reprint Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
    Yongyong Shi
    Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Bio X Institutes, Ministry of Education, Shanghai Jiao Tong University, China
    Nat Genet 44:1020-5. 2012
    ..Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS...
  40. doi request reprint ITIH family genes confer risk to schizophrenia and major depressive disorder in the Han Chinese population
    Kuanjun He
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai 200030, PR China College of Life Science, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia, PR China
    Prog Neuropsychopharmacol Biol Psychiatry 51:34-8. 2014
    ..012, OR [95% CI] = 1.193 [1.010-1.410]). Our results revealed that the shared genetic risk factors of both schizophrenia and major depressive disorder exist in ITIH family genes in the Han Chinese population...
  41. doi request reprint First evidence of association between G72 and bipolar disorder in the Chinese Han population
    Zhao Zhang
    Changing Institute of Mental Health, Institute of Neuropsychiatric Science and Systems Biological Medicine, Xiehe Road 299, Bio X Center Hospital, Bio X Center, Shanghai Jiao Tong University, Shanghai, PR China
    Psychiatr Genet 19:151-3. 2009
    ..The results provide first evidence for the single nucleotide polymorphism rs778293 in G72 as a potential candidate in altering risk for BPD in the Chinese Han population...
  42. doi request reprint Association between the PDE4D gene and ischaemic stroke in the Chinese Han population
    Yun Sun
    Institute for Nutritional Sciences, Chinese Academy of Sciences, Shanghai, China
    Clin Sci (Lond) 117:265-72. 2009
    ..In conclusion, our present findings show that polymorphisms in the PDE4D gene are associated with an increased risk of ischaemic stroke in the Chinese Han population. The present study adds further support to the role of PDE4D in stroke...
  43. doi request reprint The endothelial nitric oxide synthase gene is associated with coronary artery disease: a meta-analysis
    Junyan Li
    Bio X Center and affiliated Changning Mental Health Center, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai, PR China
    Cardiology 116:271-8. 2010
    ..However, other studies do not confirm these relationships. The objective was to assess these relationships using meta-analysis...
  44. doi request reprint Common variants in the CDH7 gene are associated with major depressive disorder in the Han Chinese population
    Xingwang Li
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, The Central Little White House, 1954 Huashan Road, Shanghai, 200030, People s Republic of China
    Behav Genet 44:97-101. 2014
    ..000199, OR 1.255). Our results support CDH7 to be a risk factor of MDD in the Han Chinese population. However, further studies with more markers and independent samples were suggested to validate our findings...
  45. doi request reprint A meta-analysis of three polymorphisms in the endothelial nitric oxide synthase gene (NOS3) and their effect on the risk of diabetic nephropathy
    Zhen Zeng
    Bio X Center, Shanghai Jiao Tong University, Central Little White House, Shanghai, People s Republic of China
    Hum Genet 127:373-81. 2010
    ..16, 1.01-1.34, 95% CI) with little heterogeneity. In summary, our meta-analysis of the effect of NOS3 gene polymorphisms on the risk of DN supports the involvement of the NOS3 gene in the pathogenesis of DN...
  46. ncbi request reprint Positive association between POU1F1 and mental retardation in young females in the Chinese Han population
    Yun Sun
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Shanghai, China
    Hum Mol Genet 15:1237-43. 2006
    ..0397 for the haplotype combination of rs300996-snp-7057-rs300977 in the analysis of the quantitative effects of the alleles and haplotypes on IQ in females. Our data suggest that POU1F1 may affect MR through a gender-specific mechanism...
  47. ncbi request reprint Systematic polymorphism analysis of the CYP2D6 gene in four different geographical Han populations in mainland China
    Shengying Qin
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, Shanghai 200030, China
    Genomics 92:152-8. 2008
    ..Tag SNP selection and haplotype distributions showed differences across the four populations. This is the first large-scale study to analyze polymorphisms systematically across the whole CYP2D6 gene in the Chinese Han population...
  48. ncbi request reprint SNPs and haplotypes in the S100B gene reveal association with schizophrenia
    Jixia Liu
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai, PR China
    Biochem Biophys Res Commun 328:335-41. 2005
    ..Our results suggest that S100B could be a susceptible gene for schizophrenia and provide indirect evidence for the GGF/SD hypothesis...
  49. doi request reprint Gold nanoparticles for high-throughput genotyping of long-range haplotypes
    Peng Chen
    Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Bio X Institutes, Shanghai Jiao Tong University, Shanghai 200030, China
    Nat Nanotechnol 6:639-44. 2011
    ..Our method is accurate and promising for large-scale and high-throughput genetic analysis of susceptibility towards disease and drug resistance...
  50. doi request reprint Proteome alteration of U251 human astrocytoma cell after inhibiting retinoic acid synthesis
    Ming Zhang
    Bio X Center, Shanghai Jiao Tong University, Huashan Road 1954, Shanghai, 200030, China
    Mol Cell Biochem 323:185-93. 2009
    ..These data provide some clues for explaining the behavioral changes caused by Ra deficiency, and support the hypothesis that Ra signaling is associated with some symptoms of neurodegenerative disorders and schizophrenia...
  51. doi request reprint CACNA1C, schizophrenia and major depressive disorder in the Han Chinese population
    Kuanjun He
    Kuanjun He, PhD, Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai and College of Life Science, Inner Mongolia University for Nationalities, Tongliao, Inner Mongolia Zhiguo An, MS, Department of Psychiatry, The First Teaching Hospital of Xinjiang Medical University, Urumqi Qingzhong Wang, PhD, Tao Li, PhD, Zhiqiang Li, PhD, Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai Jianhua Chen, PhD, Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, Shanghai and Schizophrenia Program, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai Wenjin Li, PhD, Ti Wang, PhD, Jue Ji, BM, Bio X Institutes
    Br J Psychiatry 204:36-9. 2014
    ..The CACNA1C gene, which codes for subunit alpha-1C of the Cav1.2 voltage-dependent L-type calcium channel, has been consistently found to be the shared risk gene for several kinds of mental disorder...
  52. ncbi request reprint An investigation of the dihydropyrimidinase-like 2 (DPYSL2) gene in schizophrenia: genetic association study and expression analysis
    Xinzhi Zhao
    Bio X Center, Shanghai Jiao Tong University, Shanghai, China
    Int J Neuropsychopharmacol 9:705-12. 2006
    ....
  53. doi request reprint A genome-wide association study reveals association between common variants in an intergenic region of 4q25 and high-grade myopia in the Chinese Han population
    Zhiqiang Li
    Bio X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders Ministry of Education, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai, P R China
    Hum Mol Genet 20:2861-8. 2011
    ..Although there is insufficient evidence to indicate that expressed EST and the predicted gene play an important role in developing HM, this region merits further study as a candidate for the disease...
  54. doi request reprint CNTNAP2 is significantly associated with schizophrenia and major depression in the Han Chinese population
    Weidong Ji
    Shanghai Changning Mental Health Center, 299 XieHe Road, Shanghai 200042, PR China
    Psychiatry Res 207:225-8. 2013
    ..According to the location of significant signals, our study indicated that exon 13-15 of CNTNAP2 may play important roles in both schizophrenia and major depression in the Han Chinese population...
  55. pmc A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese
    Pengfei Qin
    1 Max Planck Independent Research Group on Population Genomics, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institute for Biological Sciences, Shanghai, China 2 Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Eur J Hum Genet 22:248-53. 2014
    ....
  56. pmc Genetic structure adds power to detect schizophrenia susceptibility at SLIT3 in the Chinese Han population
    Yongyong Shi
    Bio X Life Science Research Center, Shanghai Jiao Tong University, Shanghai 200030, China
    Genome Res 14:1345-9. 2004
    ..Our results imply that identifying the hidden genetic substructure adds power when detecting association, and suggest that SLIT3 or a nearby gene is associated with schizophrenia...