Kai Hu Shi



  1. Tao H, Dai C, Ding J, Yang J, Ding X, Xu S, et al. Epigenetic aberrations of miR-369-5p and DNMT3A control Patched1 signal pathway in cardiac fibrosis. Toxicology. 2018;410:182-192 pubmed publisher
    ..Together, our results highlight miR-369-5p mediated DNMT3A epigenetic silencing of Patched1 as a mechanism of fibroblast proliferation in cardiac fibrosis. ..
  2. Tao H, Yang J, Shi K. Non-coding RNAs as direct and indirect modulators of epigenetic mechanism regulation of cardiac fibrosis. Expert Opin Ther Targets. 2015;19:707-16 pubmed publisher
    ..The emerging recognition of the diverse functions of ncRNAs in regulating gene expression by epigenetic mechanisms suggests that they may represent new targets for therapeutic intervention. ..
  3. Zhao X, Qin R, Yang J, Xu S, Tao H, Ding X, et al. DNMT3A controls miR-200b in cardiac fibroblast autophagy and cardiac fibrosis. Inflamm Res. 2018;67:681-690 pubmed publisher
    ..Taken together, these findings indicate that DNMT3A regulation of miR-200b controls cardiac fibroblast autophagy during cardiac fibrosis and provide a basis for the development of therapies for cardiac fibrosis. ..
  4. Tao H, Song Z, Ding X, Yang J, Shi K, Li J. LncRNAs and miRs as epigenetic signatures in diabetic cardiac fibrosis: new advances and perspectives. Endocrine. 2018;62:281-291 pubmed publisher
    ..Then, we provide several possible therapeutic strategies and highlight the potentialof molecular mechanisms in which targeting epigenetic regulators are considered as an effective means of treating diabetic cardiac fibrosis. ..
  5. Tao H, Yang J, Zhou X, Deng Z, Shi K, Li J. Emerging role of long noncoding RNAs in lung cancer: Current status and future prospects. Respir Med. 2016;110:12-9 pubmed publisher
    ..From a clinical perspective, the targeting of LncRNAs as a novel therapeutic approach will require a deeper understanding of their function and mechanism of action. ..
  6. Tao H, Chen Z, Yang J, Shi K. MicroRNA-29a suppresses cardiac fibroblasts proliferation via targeting VEGF-A/MAPK signal pathway. Int J Biol Macromol. 2016;88:414-23 pubmed publisher
    ..In conclusion, these results suggested that miRNA-29a suppresses cardiac fibrosis and fibroblasts proliferation via targeting VEGF-A/MAPK signal pathway implicating that miRNA-29a might play a role in the treatment of cardiac fibrosis. ..
  7. Tao H, Yang J, Shi K, Li J. Wnt signaling pathway in cardiac fibrosis: New insights and directions. Metabolism. 2016;65:30-40 pubmed publisher
    ..It seems reasonable to suggest the potential targets of Wnt signaling pathway and it can be developed as a therapeutic target for cardiac fibrosis. ..
  8. Tao H, Yang J, Hu W, Shi K, Deng Z, Li J. Noncoding RNA as regulators of cardiac fibrosis: current insight and the road ahead. Pflugers Arch. 2016;468:1103-11 pubmed publisher
    ..Furthermore, we review the functions and role of ncRNAs in cardiac biology and discuss these reports and the therapeutic potential of ncRNAs for cardiac fibrosis associated with fibroblast activation and proliferation. ..
  9. Tao H, Yang J, Chen Z, Xu S, Zhou X, Zhan H, et al. DNMT3A silencing RASSF1A promotes cardiac fibrosis through upregulation of ERK1/2. Toxicology. 2014;323:42-50 pubmed publisher
    ..Our results have shown that DNMT3A likely plays an essential role in RASSF1A mediated upregulation of ERK1/2 in rat cardiac fibrosis. DNMT3A and RASSF1A may serve as a new mechanism for cardiac fibrosis. ..

More Information


  1. Tao H, Shi K, Yang J, Li J. Epigenetic mechanisms in atrial fibrillation: New insights and future directions. Trends Cardiovasc Med. 2016;26:306-18 pubmed publisher
    ..Further studies are needed to reveal the potential targets of epigenetic mechanisms, and it can be developed as a therapeutic target for AF. ..
  2. Tao H, Cao W, Yang J, Shi K, Zhou X, Liu L, et al. Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis. Cardiovasc Pathol. 2016;25:381-9 pubmed publisher
    ..In a broader perspective, these results demonstrated that LncRNA H19 contributes to cardiac fibroblast proliferation and fibrosis, which act in part through repression of DUSP5/ERK1/2. ..
  3. Tao H, Zhang M, Yang J, Shi K. MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation. Heart Lung Circ. 2018;27:104-113 pubmed publisher
    ..These indicated that miR-21 inhibits cardiac fibroblasts proliferation by inactivating the TGF-?1/Smad2 signaling pathway via up-regulation of WWP-1. ..
  4. Tao H, Zhang J, Qin R, Dai C, Shi P, Yang J, et al. LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway. Toxicology. 2017;386:11-18 pubmed publisher
    ..Taken together, GAS5 plays a suppressive role in cardiac fibrosis via negative regulation of miR-21. These results indicated that GAS5 may be a novel therapeutic target for further research of cardiac fibrosis. ..