S A Sheweita

Summary

Publications

  1. ncbi Narcotic drugs change the expression of cytochrome P450 2E1 and 2C6 and other activities of carcinogen-metabolizing enzymes in the liver of male mice
    Salah A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
    Toxicology 191:133-42. 2003
  2. ncbi Carcinogen-metabolizing enzymes and insecticides
    Salah A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    J Environ Sci Health B 39:805-18. 2004
  3. ncbi Effects of Schistosoma haematobium infection on drug-metabolizing enzymes in human bladder cancer tissues
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
    Cancer Lett 205:15-21. 2004
  4. ncbi Mechanisms of male infertility: role of antioxidants
    Salah A Sheweita
    Department of Clinical Biochemistry, Faculty of Medicine, PO Box 30001, Taibah University, Madinah, Saudi Arabia
    Curr Drug Metab 6:495-501. 2005
  5. ncbi Changes in expression and activity of glutathione S-transferase in different organs of schistosoma haematobium-infected hamster
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    J Biochem Mol Toxicol 17:138-45. 2003
  6. ncbi Calcium metabolism and oxidative stress in bone fractures: role of antioxidants
    S A Sheweita
    Department of Clinical Biochemistry, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia
    Curr Drug Metab 8:519-25. 2007
  7. ncbi Cancer and phase II drug-metabolizing enzymes
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    Curr Drug Metab 4:45-58. 2003
  8. ncbi Changes in the expression of cytochrome P450 2E1 and the activity of carcinogen-metabolizing enzymes in Schistosoma haematobium-infected human bladder tissues
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, 163 Horreya Ave, PO Box 832, Alexandria, Egypt
    Toxicology 162:43-52. 2001
  9. ncbi The hepatoprotective effects of selenium against cadmium toxicity in rats
    A A Newairy
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Toxicology 242:23-30. 2007
  10. ncbi Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, P O Box 832, 163 Horreya Avenue, Alexandria, Egypt
    Toxicology 165:217-24. 2001

Collaborators

Detail Information

Publications21

  1. ncbi Narcotic drugs change the expression of cytochrome P450 2E1 and 2C6 and other activities of carcinogen-metabolizing enzymes in the liver of male mice
    Salah A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
    Toxicology 191:133-42. 2003
    ..benzo(a)pyrene, upon the liver and probably other organs. Such alterations may also change the therapeutic actions of other drugs, which are primarily metabolized by the P450 system, when administered to peoples using hashish or heroin...
  2. ncbi Carcinogen-metabolizing enzymes and insecticides
    Salah A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    J Environ Sci Health B 39:805-18. 2004
    ..It is concluded that modifications in cytochrome P450 system by pesticides could potentiate the toxicity and carcinogenicity of environmental carcinogens such as polycyclic aromatic hydrocarbon and N-nirosodimethylamine (NDMA)...
  3. ncbi Effects of Schistosoma haematobium infection on drug-metabolizing enzymes in human bladder cancer tissues
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
    Cancer Lett 205:15-21. 2004
    ..The present study thus provides new insights into mechanisms for the genesis of bladder cancer initiated in association with schistosomiasis...
  4. ncbi Mechanisms of male infertility: role of antioxidants
    Salah A Sheweita
    Department of Clinical Biochemistry, Faculty of Medicine, PO Box 30001, Taibah University, Madinah, Saudi Arabia
    Curr Drug Metab 6:495-501. 2005
    ....
  5. ncbi Changes in expression and activity of glutathione S-transferase in different organs of schistosoma haematobium-infected hamster
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    J Biochem Mol Toxicol 17:138-45. 2003
    ..This study indicates that low GST expression and high levels of free radicals could provide new evidence for damage to the bladder and other organs as a result of S. haematobium infection...
  6. ncbi Calcium metabolism and oxidative stress in bone fractures: role of antioxidants
    S A Sheweita
    Department of Clinical Biochemistry, Faculty of Medicine, Taibah University, Madinah, Saudi Arabia
    Curr Drug Metab 8:519-25. 2007
    ..In addition, administration of antioxidants might protect bones from osteoporosis and also might help in the acceleration of healing of fractured bones...
  7. ncbi Cancer and phase II drug-metabolizing enzymes
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    Curr Drug Metab 4:45-58. 2003
    ..Determination of glutathione S-transferase isozymes in plasma or serum could be used as a biomarker for cancer in different organs and could give an early detection...
  8. ncbi Changes in the expression of cytochrome P450 2E1 and the activity of carcinogen-metabolizing enzymes in Schistosoma haematobium-infected human bladder tissues
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, 163 Horreya Ave, PO Box 832, Alexandria, Egypt
    Toxicology 162:43-52. 2001
    ..g. benzo(a)pyrene) and N-nitrosamines (e.g. dimethylnitrosamine) through induction of their corresponding bioactivating enzymes in human bladder tissues...
  9. ncbi The hepatoprotective effects of selenium against cadmium toxicity in rats
    A A Newairy
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Toxicology 242:23-30. 2007
    ..In addition, selenium could ameliorate cadmium-induced hepatotoxicity since it reduced MDA levels and increased the activities of antioxidant enzymes in this tissue...
  10. ncbi Carbon tetrachloride-induced changes in the activity of phase II drug-metabolizing enzyme in the liver of male rats: role of antioxidants
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, P O Box 832, 163 Horreya Avenue, Alexandria, Egypt
    Toxicology 165:217-24. 2001
    ..It has been observed that the tested antioxidants were able to antagonize the toxic effects of CCl4, and such counteracting effects were more pronounced when they were administered as repeated doses prior to administration of CCl4...
  11. ncbi Alterations of lipid profile in plasma and liver of diabetic rats: effect of hypoglycemic herbs
    Al Sayeda A Newairy
    Department of Biochemistry, Faculty of Science, Alexandria University, Egypt
    J Environ Sci Health B 37:475-84. 2002
    ..Moreover, the Kammun Quaramany showed the most potent effect...
  12. ncbi N-Nitrosodimethylamine changes the expression of glutathione S-transferase in the liver of male mice: The role of antioxidants
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
    J Biochem Mol Toxicol 22:389-95. 2008
    ..It is concluded that high dose of either gossypol or selenium is a stronger protector than zinc and GSH in ameliorating the toxic effects of DMN...
  13. ncbi Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    J Helminthol 76:71-8. 2002
    ..Such alterations may also change the therapeutic actions of drugs that are primarily metabolized by the P450 system, when administered to patients with schistosomiasis...
  14. ncbi Effect of some hypoglycemic herbs on the activity of phase I and II drug-metabolizing enzymes in alloxan-induced diabetic rats
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    Toxicology 174:131-9. 2002
    ..Such alterations in the activity of phase I and II drug-metabolizing enzymes should be considered when therapeutic drugs are administered to diabetic patients since most of drugs are metabolized mainly by the cytochrome P450 system...
  15. ncbi Changes of drug metabolizing enzymes in the liver of male sheep exposed to either cypermethrin or dimethoate
    S A Sheweita
    Department of Clinical Biochemistry, College of Medicine, PO Box 30001, Al Madinah, Kingdom of Saudi Arabia
    Drug Metab Lett 6:2-6. 2012
    ..Also, such changes should be considered when therapeutic drugs administered to people exposed to such insecticides...
  16. ncbi Carbon tetrachloride changes the activity of cytochrome P450 system in the liver of male rats: role of antioxidants
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, 163 Horreya Ave, PO Box 832, Alexandria, Egypt
    Toxicology 169:83-92. 2001
    ..The mechanisms of antioxidant protection were discussed in the text...
  17. ncbi Different levels of Schistosoma mansoni infection increased the mutagenicity of benzo(a)pyrene, the activity of aryl hydrocarbon hydroxylase and the formation of hepatic microsomal hydrogen peroxide
    H A Awney
    Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt
    Toxicology 163:213-8. 2001
    ..These data clearly demonstrate that S. mansoni infection changes the mutagenicity of B(a)p, AHH activity, as well as enhancing the formation of hepatic H(2)O(2) generated during the metabolic activation of B(a)p in infected mice...
  18. ncbi Protective role of selenium against renal toxicity induced by cadmium in rats
    A S el Sharaky
    Department of Biochemistry, Faculty of Science, Alexandria University, Alexandria, Egypt
    Toxicology 235:185-93. 2007
    ..These results could be important for the further understanding of the complex mechanisms of cadmium toxicity in kidney tissues and in the development of better treatments for people and/or animals exposed to the heavy metal...
  19. ncbi Drug-metabolizing enzymes: mechanisms and functions
    S A Sheweita
    Department of Bioscience and Technology, Institute of Graduate Studies and Research, Alexandria University, Egypt
    Curr Drug Metab 1:107-32. 2000
    ..The mechanisms of modification of drug-metabolizing enzyme activities and their role in the activation and detoxification of xenobiotics and carcinogens have been discussed in the text...
  20. ncbi Can dietary antioxidants reduce the incidence of brain tumors?
    S A Sheweita
    Department of Biosciences and Technology, Alexandria University, Egypt
    Curr Drug Metab 12:587-93. 2011
    ..It is concluded that administration of antioxidants could reduce the incidence of brain tumors and probably other types of cancer...
  21. ncbi Schistosoma mansoni changes the activity of phase II drug-metabolizing enzymes: role of praziquantel as antibilharzial drug
    Salah A Sheweita
    Department of Clinical Biochemistry, Faculty of Medicine, PO Box 30001, Taibah University, Al Madinah, Saudi Arabia
    Drug Metab Lett 4:134-8. 2010
    ..In addition, the present study could provide new evidence to the damage occurred in livers of S. mansoni-infected hosts. Also, it is suggested that praziquantel is the best drug of choice for schistosoma mansoni treatment...