Nan Shen

Summary

Publications

  1. doi request reprint MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    Yuanjia Tang
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arthritis Rheum 60:1065-75. 2009
  2. pmc Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
    Nan Shen
    Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Proc Natl Acad Sci U S A 107:15838-43. 2010
  3. pmc A novel vector-based method for exclusive overexpression of star-form microRNAs
    Bo Qu
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    PLoS ONE 7:e41504. 2012
  4. pmc A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
    Xiaobing Luo
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS Genet 7:e1002128. 2011
  5. pmc Genomic signatures characterize leukocyte infiltration in myositis muscles
    Wei Zhu
    Translational Sciences, MedImmune, LLC, Gaithersburg, MD 20878, USA
    BMC Med Genomics 5:53. 2012
  6. doi request reprint MicroRNAs--novel regulators of systemic lupus erythematosus pathogenesis
    Nan Shen
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, 145 Shan Dong Middle Road, Shanghai 200001, China
    Nat Rev Rheumatol 8:701-9. 2012
  7. pmc Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population
    Ling Hong Liao
    The Research Base of TCM Syndrom, Fujian University of Traditional Chinese Medicine, Huatuo Road No 1, Fuzhou 350108, PR China
    Arthritis Res Ther 13:R11. 2011
  8. pmc Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients
    Qiong Fu
    Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shan Dong Middle Road, Shanghai 200001, PR China
    Arthritis Res Ther 10:R112. 2008
  9. ncbi request reprint MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
    Wen Pan
    Joint Molecular Rheumatology Laboratory, Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai, China
    J Immunol 184:6773-81. 2010
  10. ncbi request reprint [Variations within OLF1/EBF-associated zinc finger protein gene confer susceptibility to lupus nephritis in Chinese population]
    Dong Liang
    Department of Rheumatology, Renji Hospital, Shanghai 2nd Medical University, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 85:949-54. 2005

Collaborators

Detail Information

Publications37

  1. doi request reprint MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins
    Yuanjia Tang
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arthritis Rheum 60:1065-75. 2009
    ..This study was undertaken to investigate the contribution of microRNA-146a (miR-146a), which was identified in the pilot expression profiling step, to the pathogenesis of systemic lupus erythematosus (SLE)...
  2. pmc Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
    Nan Shen
    Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Proc Natl Acad Sci U S A 107:15838-43. 2010
    ..7-fold higher transcripts of G-allele than C-allele. These data established a functional polymorphism in type I IFN pathway gene TLR7 predisposing to SLE, especially in Chinese and Japanese male subjects...
  3. pmc A novel vector-based method for exclusive overexpression of star-form microRNAs
    Bo Qu
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
    PLoS ONE 7:e41504. 2012
    ..Our novel strategy opens the way for exclusively stable overexpression of miRNA* species and analyzing their unique functions both in vitro and in vivo...
  4. pmc A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
    Xiaobing Luo
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China
    PLoS Genet 7:e1002128. 2011
    ..Our data identified and confirmed an association between a functional promoter variant of miR-146a and SLE. This risk allele had decreased binding to transcription factor Ets-1, contributing to reduced levels of miR-146a in SLE patients...
  5. pmc Genomic signatures characterize leukocyte infiltration in myositis muscles
    Wei Zhu
    Translational Sciences, MedImmune, LLC, Gaithersburg, MD 20878, USA
    BMC Med Genomics 5:53. 2012
    ....
  6. doi request reprint MicroRNAs--novel regulators of systemic lupus erythematosus pathogenesis
    Nan Shen
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, 145 Shan Dong Middle Road, Shanghai 200001, China
    Nat Rev Rheumatol 8:701-9. 2012
    ....
  7. pmc Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population
    Ling Hong Liao
    The Research Base of TCM Syndrom, Fujian University of Traditional Chinese Medicine, Huatuo Road No 1, Fuzhou 350108, PR China
    Arthritis Res Ther 13:R11. 2011
    ..We tried to investigate the possible association of CYP2E1 tag single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese Han population...
  8. pmc Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients
    Qiong Fu
    Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shan Dong Middle Road, Shanghai 200001, PR China
    Arthritis Res Ther 10:R112. 2008
    ..In this study we correlated the combined expression level of multiple interferon-inducible chemokines with disease activity, degree of organ damage and clinical features in SLE, and we investigated their roles as biomarkers...
  9. ncbi request reprint MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
    Wen Pan
    Joint Molecular Rheumatology Laboratory, Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai, China
    J Immunol 184:6773-81. 2010
    ..Together, our data demonstrated a critical functional link between miRNAs and the aberrant DNA hypomethylation in lupus CD4+ T cells and could help to develop new therapeutic approaches...
  10. ncbi request reprint [Variations within OLF1/EBF-associated zinc finger protein gene confer susceptibility to lupus nephritis in Chinese population]
    Dong Liang
    Department of Rheumatology, Renji Hospital, Shanghai 2nd Medical University, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 85:949-54. 2005
    ..To observe whether single nucleotide polymorphisms (SNPs) within the OLF1/EBF-associated zinc finger protein (OAZ) gene are associated with lupus nephritis (LN) susceptibility in Chinese population...
  11. ncbi request reprint [Interferon-inducible genes lymphocyte antigen 6 complex E and tetratricopeptide repeats 1 are correlated with clinical features of patients with systemic lupus erythematosus]
    Jian Ping Tang
    Shanghai Clinical Centre of Rheumatic Diseases and Institute of Rheumatology, Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 84:1157-60. 2004
    ....
  12. ncbi request reprint [Association between Bcl-2 gene polymorphism with systemic lupus erythematosus]
    Hui Wu
    Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 82:467-70. 2002
    ..To study the association between Bcl-2 gene polymorphism and systemic lupus erythematosus (SLE) in Chinese and detect the synergism between IL-10 and Bcl-2 genotypes in determining susceptibility to SLE...
  13. doi request reprint miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells
    Haibo Zhou
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
    Blood 116:5885-94. 2010
    ..Thus, our study identified and validated novel miRNA-protein networks involved in regulating PDC activation...
  14. doi request reprint Expression, localization and clinical application of exogenous Smith proteins D1 in gene transfected HEp-2 cells
    Su Li Wang
    Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Int J Rheum Dis 16:303-9. 2013
    ..To establish an improved substrate for an indirect immunofluorescence test (IIF) to detect anti-Sm antibody...
  15. doi request reprint MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus
    Xia Zhao
    Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai RenJi Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, and Chinese Academy of Sciences, Shanghai, China
    Arthritis Rheum 62:3425-35. 2010
    ..This study aimed to clarify whether miR-125a, which was identified in a pilot expression profiling step, is involved in the inflammatory chemokine pathway in systemic lupus erythematosus (SLE)...
  16. doi request reprint Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus
    Wei Fan
    Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences, Shanghai Jiaotong University School of Medicine, Chinese Academy of Sciences, China
    Arthritis Rheum 64:3715-25. 2012
    ..The miR-31 microRNA has been found to be markedly underexpressed in patients with SLE, and thus the present study was undertaken to investigate the role of miR-31 in IL-2 defects in lupus T cells...
  17. ncbi request reprint Could 2'5'-oligoadenylate synthetase isoforms be biomarkers to differentiate between disease flare and infection in lupus patients? A pilot study
    Shuang Ye
    Department of Rheumatology, Renji Hospital, Clinical Center for Rheumatic Diseases and Institute of Rheumatology, Shanghai Second Medical University, 145, Shandong Rd, 200001, Shanghai, People s Republic of China
    Clin Rheumatol 26:186-90. 2007
    ..77 (p=0.007) for CRP. Therefore, our preliminary data suggest that the pattern of OAS isoform expressions, OASL in particular, may provide useful information in differentiating disease flares from certain infections in SLE...
  18. pmc Association of a functional IRF7 variant with systemic lupus erythematosus
    Qiong Fu
    University of California, Los Angeles, and Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institutes for Biological Sciences, and Chinese Academy of Sciences, Shanghai, China
    Arthritis Rheum 63:749-54. 2011
    ..This study was undertaken to investigate whether genetic polymorphism within IRF7 is a risk factor for the development of SLE...
  19. doi request reprint MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells
    Jia Wang
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Stem Cells Dev 21:1524-37. 2012
    ..These results reveal that the miR-125b/Lin28 axis is an important regulator of early lineage specification and cardiomyocyte differentiation of ESCs...
  20. doi request reprint Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon-α and atherosclerosis in lupus
    Jia Li
    Shanghai Institute of Rheumatology, Renji Hospital, Molecular Rheumatology Laboratory of Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arthritis Rheum 63:492-502. 2011
    ....
  21. ncbi request reprint [Peripheral blood mRNA and interferon gene expression in systemic lupus erythematosus]
    Jian Ping Tang
    Shanghai Clinical Center of Rheumatic Diseases and Institute of Rheumatology, Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Zhonghua Nei Ke Za Zhi 44:106-10. 2005
    ....
  22. ncbi request reprint The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α
    Shu Zhu
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
    Nat Med 18:1077-86. 2012
    ..Thus, IL-17 contributes to autoimmune pathogenesis by suppressing miR-23b expression in radio-resident cells and promoting proinflammatory cytokine expression...
  23. pmc Multidimensional single cell based STAT phosphorylation profiling identifies a novel biosignature for evaluation of systemic lupus erythematosus activity
    Xinfang Huang
    Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    PLoS ONE 6:e21671. 2011
    ..Comprehensively quantifying basal STATs phosphorylation and their signaling response to cytokines should help us to better understand the etiology of SLE...
  24. ncbi request reprint Transfection, overexpression and clinical application of human 60 kDa Ro/SSA autoantigens in HEp-2 cells
    Liangjing Lu
    Shanghai Rheumatology Institute, and Department of Rheumatology, Renji Hospital of Shanghai Second Medical University, Shanghai 200001, China
    Chin Med J (Engl) 116:350-3. 2003
    ..To develop an improved substrate for indirect immunofluorescence test (IIF) for detecting anti-Ro60/Sjogren's syndrome A (Ro/SSA) autoantibodies...
  25. ncbi request reprint Single nucleotide polymorphisms of deoxyribonuclease I and their expression in Chinese systemic lupus erythematosus patients
    Xue Bing Feng
    Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Chin Med J (Engl) 117:1670-6. 2004
    ....
  26. doi request reprint MicroRNA involvement in lupus: the beginning of a new tale
    Dong Liang
    Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai RenJi Hospital, Shanghai Jiaotong University School of Medicine, Chinese Academy of Sciences, Shanghai, China
    Curr Opin Rheumatol 24:489-98. 2012
    ..In this review, we discuss the major progress made in understanding of miRNA biology, as well as novel insights into SLE pathogenesis mediated by miRNAs...
  27. ncbi request reprint Chest imaging manifestations in lupus nephritis
    Hui Qin
    Department of Rheumatology and Respiratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
    Clin Rheumatol 33:817-23. 2014
    ..124, p = 0.042). LN patients were more likely to suffer from lung/pleural disease. The patients with hyaline thrombi in renal biopsy were more prone to have ground glass opacity on CTs. ..
  28. ncbi request reprint [Using GST-tag to capture protein interaction of an interferon-inducible systemic lupus associated gene, IFIT1]
    Shuang Ye
    Department of Rheumatology, Renji Hospital, Clinical Center of Rheumatic Diseases and Institute of Rheumatology, Shanghai 2nd Medical University, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 83:770-3. 2003
    ..To investigate the protein-to-protein interaction of interferon-induced protein with tetratricopeptide repeats 1 (IFIT1), a newly discovered systemic lupus erythematosus (SLE) related up-regulated gene, and its possible function...
  29. doi request reprint Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer
    Yan Wei Lin
    Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Institution of Digestive Disease, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, State Key Laboratory of Oncogene and Related Genes, Shanghai Jiao Tong University School of Medicine, 145 Middle Shandong Road, Shanghai, 200001, China
    J Pathol 230:277-90. 2013
    ..EZH2 expression may be directly regulated by STAT3, and STAT3 may play an important role in EZH2-mediated VDR down-regulation in CRC. This pathway may provide potential targets in aggressive CRC...
  30. pmc New insights into the role and mechanism of macrophage migration inhibitory factor in steroid-resistant patients with systemic lupus erythematosus
    Fang Fang Wang
    Department of Rheumatology, Renji Hospital, Shanghai Jiaotong University School of Medicine, 145 Middle Shan Dong Road, Shanghai 200001, China
    Arthritis Res Ther 14:R103. 2012
    ..In the present study, we investigated for the first time whether MIF correlated with steroid resistance in SLE and explored potential mechanisms of action...
  31. ncbi request reprint Dysregulated expression of interleukin-23 and interleukin-12 subunits in systemic lupus erythematosus patients
    Xinfang Huang
    Joint Molecular Rheumatology Laboratory of Shanghai Ren Ji Hospital and Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University, Shanghai, China
    Mod Rheumatol 17:220-3. 2007
    ..000, 0.000, and 0.017, respectively). These results suggest that deficiency of IL-12 and possibly upregulation of IL-23 may contribute to SLE pathogenesis and both cytokines may be therapeutic targets in SLE...
  32. doi request reprint Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells
    Bing Yan
    Joint Molecular Rheumatology Laboratory of Renji Hospital, Shanghai JiaoTong University School of Medicine and Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Shanghai, China
    Arthritis Rheum 58:801-12. 2008
    ..To explore whether there are extrinsic factors that impair the suppressive function of CD4+,CD25+ regulatory T cells in patients with untreated active systemic lupus erythematosus (SLE)...
  33. doi request reprint miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression
    Dehua Yang
    Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
    J Cell Sci 125:1673-82. 2012
    ..Collectively, our data provide the first evidence that miR-132 is an important molecule regulating ES cell differentiation into dopamine neurons by directly targeting Nurr1 gene expression...
  34. doi request reprint Alterations in the microbiota drive interleukin-17C production from intestinal epithelial cells to promote tumorigenesis
    Xinyang Song
    The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    Immunity 40:140-52. 2014
    ..Thus, IL-17C promotes cancer development by increasing IEC survival, and the microbiota can mediate cancer pathogenesis through regulation of IL-17C. ..
  35. pmc Calcium prevents tumorigenesis in a mouse model of colorectal cancer
    Ji Lin Wang
    Division of Gastroenterology, Shanghai Jiao Tong University School of Medicine, Renji Hospital, Shanghai Institute of Digestive Disease, Shanghai, China
    PLoS ONE 6:e22566. 2011
    ..Hence, we conducted this study to evaluate the possible roles and mechanisms of calcium-mediated prevention of CRC induced by 1,2-dimethylhydrazine (DMH) in mice...
  36. ncbi request reprint [Association between Bcl-2 gene polymorphism with systemic lupus erythematosus]
    Hui Wu
    Department of Rhumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
    Zhonghua Yi Xue Za Zhi 82:515-8. 2002
    ..To study the association between bcl-2 gene polymorphism and systemic lupus erythematosus (SLE) in Chinese and detect the synergism between IL-10 and bcl-2 genotypes in determining susceptibility to SLE...
  37. pmc Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells
    Xiangyang Huang
    Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
    Arthritis Res Ther 10:R91. 2008
    ..Among these IFN-inducible genes, IFN-induced protein with tetratricopeptide repeats 4 (IFIT4) is a novel gene whose function is unknown...