MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteinsYuanjia Tang
Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
Arthritis Rheum 60:1065-75. 2009
..This study was undertaken to investigate the contribution of microRNA-146a (miR-146a), which was identified in the pilot expression profiling step, to the pathogenesis of systemic lupus erythematosus (SLE)...
Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosusNan Shen
Shanghai Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
Proc Natl Acad Sci U S A 107:15838-43. 2010
..7-fold higher transcripts of G-allele than C-allele. These data established a functional polymorphism in type I IFN pathway gene TLR7 predisposing to SLE, especially in Chinese and Japanese male subjects...
- MicroRNAs--novel regulators of systemic lupus erythematosus pathogenesis
Nan Shen
Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, 145 Shan Dong Middle Road, Shanghai 200001, China
Nat Rev Rheumatol 8:701-9. 2012
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- Single-nucleotide polymorphisms and haplotype of CYP2E1 gene associated with systemic lupus erythematosus in Chinese population
Ling Hong Liao
The Research Base of TCM Syndrom, Fujian University of Traditional Chinese Medicine, Huatuo Road No 1, Fuzhou 350108, PR China
Arthritis Res Ther 13:R11. 2011
..We tried to investigate the possible association of CYP2E1 tag single nucleotide polymorphisms (SNPs) with susceptibility to systemic lupus erythematosus (SLE) in a Chinese Han population...
- Association of elevated transcript levels of interferon-inducible chemokines with disease activity and organ damage in systemic lupus erythematosus patients
Qiong Fu
Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shan Dong Middle Road, Shanghai 200001, PR China
Arthritis Res Ther 10:R112. 2008
..In this study we correlated the combined expression level of multiple interferon-inducible chemokines with disease activity, degree of organ damage and clinical features in SLE, and we investigated their roles as biomarkers...
- MicroRNA-21 and microRNA-148a contribute to DNA hypomethylation in lupus CD4+ T cells by directly and indirectly targeting DNA methyltransferase 1
Wen Pan
Joint Molecular Rheumatology Laboratory, Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai JiaoTong University School of Medicine, Shanghai, China
J Immunol 184:6773-81. 2010
..Together, our data demonstrated a critical functional link between miRNAs and the aberrant DNA hypomethylation in lupus CD4+ T cells and could help to develop new therapeutic approaches...
[Interferon-inducible genes lymphocyte antigen 6 complex E and tetratricopeptide repeats 1 are correlated with clinical features of patients with systemic lupus erythematosus]Jian-Ping Tang
Shanghai Clinical Centre of Rheumatic Diseases and Institute of Rheumatology, Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
Zhonghua Yi Xue Za Zhi 84:1157-60. 2004
..The real time expression levels of LY6E and IFIT1 genes are associated with SLE disease activity. To inhibit the expression of LY6E and IFIT1 may become a novel therapeutic approach for SLE...
- [Association between Bcl-2 gene polymorphism with systemic lupus erythematosus]
Hui Wu
Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
Zhonghua Yi Xue Za Zhi 82:467-70. 2002
..To study the association between Bcl-2 gene polymorphism and systemic lupus erythematosus (SLE) in Chinese and detect the synergism between IL-10 and Bcl-2 genotypes in determining susceptibility to SLE...
- [Variations within OLF1/EBF-associated zinc finger protein gene confer susceptibility to lupus nephritis in Chinese population]
Dong Liang
Department of Rheumatology, Renji Hospital, Shanghai 2nd Medical University, Shanghai 200001, China
Zhonghua Yi Xue Za Zhi 85:949-54. 2005
..To observe whether single nucleotide polymorphisms (SNPs) within the OLF1/EBF-associated zinc finger protein (OAZ) gene are associated with lupus nephritis (LN) susceptibility in Chinese population...
- A functional variant in microRNA-146a promoter modulates its expression and confers disease risk for systemic lupus erythematosus
Xiaobing Luo
Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiaotong University School of Medicine, Shanghai, China
PLoS Genet 7:e1002128. 2011
..Our data identified and confirmed an association between a functional promoter variant of miR-146a and SLE. This risk allele had decreased binding to transcription factor Ets-1, contributing to reduced levels of miR-146a in SLE patients...
- miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells
Haibo Zhou
Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
Blood 116:5885-94. 2010
..Thus, our study identified and validated novel miRNA-protein networks involved in regulating PDC activation...
- Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus
Wei Fan
Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences, Shanghai Jiaotong University School of Medicine, Chinese Academy of Sciences, China
Arthritis Rheum 64:3715-25. 2012
..The miR-31 microRNA has been found to be markedly underexpressed in patients with SLE, and thus the present study was undertaken to investigate the role of miR-31 in IL-2 defects in lupus T cells...
- MicroRNA-125a contributes to elevated inflammatory chemokine RANTES levels via targeting KLF13 in systemic lupus erythematosus
Xia Zhao
Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai RenJi Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institutes for Biological Sciences, and Chinese Academy of Sciences, Shanghai, China
Arthritis Rheum 62:3425-35. 2010
..This study aimed to clarify whether miR-125a, which was identified in a pilot expression profiling step, is involved in the inflammatory chemokine pathway in systemic lupus erythematosus (SLE)...
- MicroRNA-125b/Lin28 pathway contributes to the mesendodermal fate decision of embryonic stem cells
Jia Wang
Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
Stem Cells Dev 21:1524-37. 2012
..These results reveal that the miR-125b/Lin28 axis is an important regulator of early lineage specification and cardiomyocyte differentiation of ESCs...
- [Peripheral blood mRNA and interferon gene expression in systemic lupus erythematosus.]
Jian-Ping Tang
Shanghai Clinical Center of Rheumatic Diseases and Institute of Rheumatology, Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
Zhonghua Nei Ke Za Zhi 44:106-10. 2005
..Lower expression level of IFN score has also significance in the determination of SLE disease specificity. Higher protein level of IFN-alpha is helpful to judging SLE disease activity...
- Interferon-α priming promotes lipid uptake and macrophage-derived foam cell formation: a novel link between interferon-α and atherosclerosis in lupus
Jia Li
Shanghai Institute of Rheumatology, Renji Hospital, Molecular Rheumatology Laboratory of Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, China
Arthritis Rheum 63:492-502. 2011
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- The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α
Shu Zhu
The Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai, China
Nat Med 18:1077-86. 2012
..Thus, IL-17 contributes to autoimmune pathogenesis by suppressing miR-23b expression in radio-resident cells and promoting proinflammatory cytokine expression...
- Association of a functional IRF7 variant with systemic lupus erythematosus
Qiong Fu
University of California, Los Angeles, and Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institutes for Biological Sciences, and Chinese Academy of Sciences, Shanghai, China
Arthritis Rheum 63:749-54. 2011
..This study was undertaken to investigate whether genetic polymorphism within IRF7 is a risk factor for the development of SLE...
- A novel vector-based method for exclusive overexpression of star-form microRNAs
Bo Qu
Joint Molecular Rheumatology Laboratory of the Institute of Health Sciences and Shanghai Renji Hospital, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, and Shanghai Jiaotong University School of Medicine, Shanghai, People s Republic of China
PLoS ONE 7:e41504. 2012
..Our novel strategy opens the way for exclusively stable overexpression of miRNA* species and analyzing their unique functions both in vitro and in vivo...
- MicroRNA involvement in lupus: the beginning of a new tale
Dong Liang
Joint Molecular Rheumatology Laboratory of Institute of Health Sciences and Shanghai RenJi Hospital, Shanghai Jiaotong University School of Medicine, Chinese Academy of Sciences, Shanghai, China
Curr Opin Rheumatol 24:489-98. 2012
..In this review, we discuss the major progress made in understanding of miRNA biology, as well as novel insights into SLE pathogenesis mediated by miRNAs...
- Single nucleotide polymorphisms of deoxyribonuclease I and their expression in Chinese systemic lupus erythematosus patients
Xue-Bing Feng
Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
Chin Med J (Engl) 117:1670-6. 2004
..There is a relatively unique transcript band in SLE patients independent of special haplotype, which suggests that other unknown factors might be involved in adjusting gene expression...
- Transfection, overexpression and clinical application of human 60 kDa Ro/SSA autoantigens in HEp-2 cells
Liangjing Lu
Shanghai Rheumatology Institute, and Department of Rheumatology, Renji Hospital of Shanghai Second Medical University, Shanghai 200001, China
Chin Med J (Engl) 116:350-3. 2003
..To develop an improved substrate for indirect immunofluorescence test (IIF) for detecting anti-Ro60/Sjogren's syndrome A (Ro/SSA) autoantibodies...
- miR-132 regulates the differentiation of dopamine neurons by directly targeting Nurr1 expression
Dehua Yang
Key Laboratory of Stem Cell Biology, Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China
J Cell Sci 125:1673-82. 2012
..Collectively, our data provide the first evidence that miR-132 is an important molecule regulating ES cell differentiation into dopamine neurons by directly targeting Nurr1 gene expression...
- Dysregulated expression of interleukin-23 and interleukin-12 subunits in systemic lupus erythematosus patients
Xinfang Huang
Joint Molecular Rheumatology Laboratory of Shanghai Ren Ji Hospital and Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University, Shanghai, China
Mod Rheumatol 17:220-3. 2007
..000, 0.000, and 0.017, respectively). These results suggest that deficiency of IL-12 and possibly upregulation of IL-23 may contribute to SLE pathogenesis and both cytokines may be therapeutic targets in SLE...
- Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-alpha-producing antigen-presenting cells
Bing Yan
Joint Molecular Rheumatology Laboratory of Renji Hospital, Shanghai JiaoTong University School of Medicine and Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Shanghai, China
Arthritis Rheum 58:801-12. 2008
..To explore whether there are extrinsic factors that impair the suppressive function of CD4+,CD25+ regulatory T cells in patients with untreated active systemic lupus erythematosus (SLE)...
- [Using GST-tag to capture protein interaction of an interferon-inducible systemic lupus associated gene, IFIT1]
Shuang Ye
Department of Rheumatology, Renji Hospital, Clinical Center of Rheumatic Diseases and Institute of Rheumatology, Shanghai 2nd Medical University, Shanghai 200001, China
Zhonghua Yi Xue Za Zhi 83:770-3. 2003
..CONCLUSION: IFIT1 may interact with Rho/Rac guanine nucleotide exchange factor, and regulate the activation of Rho/Rac proteins, thus being involved in the pathogenesis of SLE...
- [Association between Bcl-2 gene polymorphism with systemic lupus erythematosus]
Hui Wu
Department of Rhumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China
Zhonghua Yi Xue Za Zhi 82:515-8. 2002
..To study the association between bcl-2 gene polymorphism and systemic lupus erythematosus (SLE) in Chinese and detect the synergism between IL-10 and bcl-2 genotypes in determining susceptibility to SLE...
- Could 2'5'-oligoadenylate synthetase isoforms be biomarkers to differentiate between disease flare and infection in lupus patients? A pilot study
Shuang Ye
Department of Rheumatology, Renji Hospital, Clinical Center for Rheumatic Diseases and Institute of Rheumatology, Shanghai Second Medical University, 145, Shandong Rd, 200001, Shanghai, People s Republic of China
Clin Rheumatol 26:186-90. 2007
..77 (p=0.007) for CRP. Therefore, our preliminary data suggest that the pattern of OAS isoform expressions, OASL in particular, may provide useful information in differentiating disease flares from certain infections in SLE...
- Interferon-induced protein IFIT4 is associated with systemic lupus erythematosus and promotes differentiation of monocytes into dendritic cell-like cells
Xiangyang Huang
Shanghai Institute of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China
Arthritis Res Ther 10:R91. 2008
..Among these IFN-inducible genes, IFN-induced protein with tetratricopeptide repeats 4 (IFIT4) is a novel gene whose function is unknown...
