Hong Shen

Summary

Publications

  1. ncbi request reprint Cloning and promoter activity of rat Smad1 5'-flanking region in rat hepatic stellate cells
    Yu Sun
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, Canada, R3T 2N2
    Mol Cell Biochem 304:227-34. 2007
  2. pmc Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation
    Hong Shen
    Department of Internal Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    BMC Cell Biol 3:9. 2002
  3. doi request reprint Bone morphogenetic protein-4 induced rat hepatic progenitor cell (WB-F344 cell) differentiation toward hepatocyte lineage
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    J Cell Physiol 220:72-81. 2009
  4. ncbi request reprint Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    J Cell Physiol 207:499-505. 2006
  5. ncbi request reprint Expression of Fc fragment receptors of immunoglobulin G (Fc gammaRs) in rat hepatic stellate cells
    Hong Shen
    Faculty of Pharmacy, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Dig Dis Sci 50:181-7. 2005
  6. ncbi request reprint Transforming growth factor-beta1 downregulation of Smad1 gene expression in rat hepatic stellate cells
    Hong Shen
    Faculty of Pharmacy, University of Manitoba, Winnipeg, MB R3T 2N2 Canada
    Am J Physiol Gastrointest Liver Physiol 285:G539-46. 2003
  7. doi request reprint Extent of extracellular signal-regulated kinases phosphorylation determines the sensitivity of hepatic stellate cells to staurosporine-induced apoptosis
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, Winnipeg Manitoba R3E 0T5, Canada
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 37:11-6. 2012
  8. ncbi request reprint Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, R3T2N2, Canada
    Biochem Cell Biol 85:189-95. 2007
  9. ncbi request reprint Effects of sildenafil citrate on hepatic function and regeneration in normal and alcohol-fed rats
    Hong Ji
    Faculty of Pharmacy, University of Manitoba, Winnipeg, MB, Canada
    Liver Int 25:913-9. 2005
  10. doi request reprint Prospect of bone morphogenetic protein 13 in liver diseases
    Yining Li
    University of Manitoba, Winnipeg Manitoba, Canada
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 37:1-5. 2012

Collaborators

  • Ping Li
  • Hong Ji
  • Yu Sun
  • Xiao Yan Bai
  • Ning Li
  • Xin Li
  • Gerald Minuk
  • Samuel S Lee
  • Yue Wen Gong
  • Michael Namaka
  • Xiaochen Gu
  • Fu Kui Zhang
  • Cheng Wang
  • Jianghong Fan
  • Yanqing Ding
  • Yining Li
  • Frank J Burzynski
  • Qiaomei Dai
  • Jian Geng
  • Wei Kang
  • Li He
  • Pinhui Miao
  • Xia Liu
  • GuQi Wang
  • Frank Burczynski
  • Liang fang Shen
  • Tan shi Li
  • Junjie Cai
  • Huixia Han
  • Desheng Weng
  • Zhuguo Li
  • Huijun Wang
  • Wei Guo Liu
  • Yang Song
  • Rutao Cui
  • Jun xin Zhang
  • Qing Ling Zhang
  • Scott M Ocheltree
  • Yubin Kang
  • Hui Meng
  • Frank J Burczynski
  • Kim Madec
  • David Eisenstat
  • Maria Melanson
  • Meghann Klowak
  • Christine Leong
  • Ping Jiang
  • Tailing Wang
  • Shaohua Gou
  • Haibin Zhu
  • Patrick Choy
  • Ganesh Rajaraman
  • Kai Cui
  • Yaw Siow
  • Michael S Roberts
  • Yuan Le
  • Shan Zeng
  • Xin Wang
  • Yang De Zhang
  • Qingling Zhang
  • Ping Liang
  • Liwen Qiu
  • Quan Ying He
  • Jinlin Hou
  • Di Cheng Yin
  • Zhongxi Huang
  • Xu Hui Wu
  • Yang Li Song
  • Ming Yin
  • Shibo Jiang
  • Xiaoyan Che
  • Ai Shi Ding
  • Lei Yang
  • Jin Hua Zhang
  • Jin Lin Hou
  • Yan qing Ding
  • David E Smith
  • Wen li Zhang
  • Shi ting Lü
  • Bret A Hughes
  • Yong jian Zhu
  • Zhuo guo Li
  • Hui Jun Wang
  • Xiu yi Jiang
  • Hui xia Han
  • Zhong xi Huang
  • Richard F Keep
  • Kaitai Yao
  • Yaodan Lu
  • Jinchun He

Detail Information

Publications35

  1. ncbi request reprint Cloning and promoter activity of rat Smad1 5'-flanking region in rat hepatic stellate cells
    Yu Sun
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, Canada, R3T 2N2
    Mol Cell Biochem 304:227-34. 2007
    ..In conclusion, rat Smad1 promoter was cloned and characterized in hepatocyte and HSC cell line (CFSC-8B cells) at different culture conditions...
  2. pmc Different effects of rat interferon alpha, beta and gamma on rat hepatic stellate cell proliferation and activation
    Hong Shen
    Department of Internal Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    BMC Cell Biol 3:9. 2002
    ..Therefore, our objective in current study is to investigate the effects of rat interferon-alpha, interferon-beta, and interferon-gamma on the proliferation and activation of rat hepatic stellate cells...
  3. doi request reprint Bone morphogenetic protein-4 induced rat hepatic progenitor cell (WB-F344 cell) differentiation toward hepatocyte lineage
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    J Cell Physiol 220:72-81. 2009
    ..Moreover, BMP4 also stimulated expression of transcription factor--C/EBP-alpha, which involved in differentiation of WB-F344 cells toward hepatocytes. BMP4 is able to stimulate WB-F344 cells differentiation toward hepatocyte lineage...
  4. ncbi request reprint Bone morphogenetic protein 4 mediates bile duct ligation induced liver fibrosis through activation of Smad1 and ERK1/2 in rat hepatic stellate cells
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    J Cell Physiol 207:499-505. 2006
    ..In conclusion, BMP4 expression was significantly increased in the liver of BDL rats and HSCs in culture. These findings indicate that BMP4 may mediate HSC activation through activation of Smad1 and ERK1/2...
  5. ncbi request reprint Expression of Fc fragment receptors of immunoglobulin G (Fc gammaRs) in rat hepatic stellate cells
    Hong Shen
    Faculty of Pharmacy, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Dig Dis Sci 50:181-7. 2005
    ..In conclusion, we provided evidence that HSCs expresses receptors for the Fc fragment of IgG, and IgG regulates HSC differentiation and proliferation. Therefore, immunoglobulin G may play a role in HSC activation...
  6. ncbi request reprint Transforming growth factor-beta1 downregulation of Smad1 gene expression in rat hepatic stellate cells
    Hong Shen
    Faculty of Pharmacy, University of Manitoba, Winnipeg, MB R3T 2N2 Canada
    Am J Physiol Gastrointest Liver Physiol 285:G539-46. 2003
    ..In conclusion, Smad1 expression and phosphorylation are increased during the activation of HSCs and TGF-beta1 significantly inhibits the expression of the Smad1 gene...
  7. doi request reprint Extent of extracellular signal-regulated kinases phosphorylation determines the sensitivity of hepatic stellate cells to staurosporine-induced apoptosis
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, Winnipeg Manitoba R3E 0T5, Canada
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 37:11-6. 2012
    ..The purpose of the present study is to determine the effects of extracellular signal-regulated kinases (ERKs) phosphorylation on the apoptosis of HSCs induced by staurosporine...
  8. ncbi request reprint Saikosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury
    Jianghong Fan
    Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, MB, R3T2N2, Canada
    Biochem Cell Biol 85:189-95. 2007
    ..Furthermore, SSd was able to alleviate hepatocyte injury from oxidative stress. In conclusion, SSd could postpone the development of liver fibrosis by attenuating hepatocyte injury...
  9. ncbi request reprint Effects of sildenafil citrate on hepatic function and regeneration in normal and alcohol-fed rats
    Hong Ji
    Faculty of Pharmacy, University of Manitoba, Winnipeg, MB, Canada
    Liver Int 25:913-9. 2005
    ....
  10. doi request reprint Prospect of bone morphogenetic protein 13 in liver diseases
    Yining Li
    University of Manitoba, Winnipeg Manitoba, Canada
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 37:1-5. 2012
    ..However, our recent findings revealed that there was expression of BMP13 in the liver and its expression was modulated during metabolic disorders. The current article is to understand biological function of BMP13 especially in the liver...
  11. ncbi request reprint Mutational analysis of thyroid transcription factor-1 gene (TTF-1) in lung carcinomas
    Xiao Yan Bai
    Department of Pathology, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong Province, People s Republic of China
    In Vitro Cell Dev Biol Anim 44:17-25. 2008
    ..The analyses of TTF-1 gene missense mutation and synonymous mutation and the loss of TTF-1 protein and mRNA can be regarded as the important indexes of molecular pathology of lung carcinoma...
  12. ncbi request reprint [Quantitative analysis of thyroid transcription factor-1 mRNA expressions in primary lung cancer and its metastatic foci]
    Xiao Yan Bai
    Department of Pathology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 28:20-5. 2008
    ....
  13. ncbi request reprint Increased expression of cystic fibrosis transmembrane conductance regulator in rat liver after common bile duct ligation
    Hong Shen
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    J Cell Physiol 203:599-603. 2005
    ..Immunohistochemical staining also demonstrated an increased intensity of CFTR staining in the liver tissue section. In conclusion, there is an increased expression of CFTR in the liver after common BDL...
  14. doi request reprint Axotomy-induced up-regulation of tumor necrosis factor-alpha in the dorsal root ganglia
    Pinhui Miao
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Man, Canada
    Neurol Res 30:623-31. 2008
    ..They play a crucial role in injury and the pathologic development of chronic pain syndromes such as neuropathic pain...
  15. ncbi request reprint Change in lipid profile and impairment of endothelium-dependent relaxation of blood vessels in rats after bile duct ligation
    Hong Ji
    Department of Internal Medicine, Biochemistry and Medical Genetics, Faculty of Medicine, University of Manitoba, A108 Chown Building, 753 McDermot Avenue, Manitoba, Winnipeg, Canada R3E 0W3
    Life Sci 73:1253-63. 2003
    ..We conclude that the alterations of lipid profile and the mild atrophy of the media may lead to the impairment of EDR in the aorta in BDL rats, and these factors may potentiate the development of atherosclerosis...
  16. ncbi request reprint Apoptotic and survival signals in hepatic stellate cells
    Hong Shen
    Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 32:726-34. 2007
    ..These therapeutic strategies to induce HSC apoptosis are current research hotspot and the future for the patients with liver fibrosis and cirrhosis...
  17. ncbi request reprint Effect of transforming growth factor beta and bone morphogenetic proteins on rat hepatic stellate cell proliferation and trans-differentiation
    Hong Shen
    John Buhler Research Centre, 803G 715 McDermot Avenue, Winnipeg, Manitoba, Canada, R3E 3P4
    World J Gastroenterol 9:784-7. 2003
    ..To explore different roles of TGF-beta (transforming growth factor beta) and bone morphogenetic proteins (BMPs) in hepatic stellate cell proliferation and trans-differentiation...
  18. ncbi request reprint [Quantitative study of thyroid transcription factor-1 protein expression in lung carcinoma cell nucleus by tissue microarray]
    Xiao Yan Bai
    Department of Pathology, Southern Medical University, Guangzhou 510515, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1423-6. 2006
    ..To investigate thyroid transcription factor-1 (TTF-1) expression in normal human adult type II alveolar epithelial cells, embryonic pneumocytes, lung carcinoma cells and lymph node metastases of lung cancer...
  19. doi request reprint Farnesoid X receptor induces GLUT4 expression through FXR response element in the GLUT4 promoter
    Hong Shen
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, China
    Cell Physiol Biochem 22:1-14. 2008
    ..All these data thereby implied that FXR is a new transcription factor of GLUT4, further elucidating the potential role for FXR in glucose metabolism...
  20. pmc In vivo gene transfer using a nonprimate lentiviral vector pseudotyped with Ross River Virus glycoproteins
    Yubin Kang
    Program in Gene Therapy, Department of Pediatrics, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    J Virol 76:9378-88. 2002
    ..Our data support the utility of RRV glycoprotein-pseudotyped FIV lentiviral vectors for hepatocyte- and neuroglia-related disease applications...
  21. ncbi request reprint In vitro cytotoxicity study on platinum (II) complexes with epoxysuccinates as leaving groups
    Xia Liu
    State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China
    Bioorg Med Chem Lett 17:3831-4. 2007
    ..Complex 4a shows the most effective among those tested platinum complexes in both cell lines, and its cytotoxicity approached that of cisplatin...
  22. ncbi request reprint Morphological changes in canine lungs perfused with modified Euro-Collins solution
    Hui Meng
    Department of Cardiothoracic Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 22:898-901. 2002
    ..To investigate the structural changes in canine lungs perfused with modified Euro-Collins solution (mECS), thus providing insight into the preservation of the donor lung tissue for transplantation...
  23. ncbi request reprint Increased Smad1 expression and transcriptional activity enhances trans-differentiation of hepatic stellate cells
    Hong Shen
    Medical Research Center, Xiangya Hospital, Central South University, Changsha, Hunan, China
    J Cell Physiol 212:764-70. 2007
    ..In conclusion, there were significantly increases in Smad1 expression and transcriptional activity during in vivo activation of hepatic stellate cells...
  24. ncbi request reprint Expression and antioxidant function of liver fatty acid binding protein in normal and bile-duct ligated rats
    GuQi Wang
    Faculty of Pharmacy, Princess Alexandra Hospital, University of Queensland, Woolloongabba, Queensland, 4102 Australia
    Eur J Pharmacol 560:61-8. 2007
    ..05). Liver fatty acid binding protein likely has important antioxidant function during hepatocellular oxidative stress...
  25. ncbi request reprint [Effects of naloxone on rat cortical neuron apoptosis induced by anoxia]
    Yang Song
    Department of Emergency, General Hospital of People s Liberation Army, Beijing 100853, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:553-6. 2003
    ..To investigate the damage of anoxia on the cultured rat's cortical neurons and the protective effects of naloxone...
  26. ncbi request reprint Preliminary investigation into the expression of proton-coupled oligopeptide transporters in neural retina and retinal pigment epithelium (RPE): lack of functional activity in RPE plasma membranes
    Scott M Ocheltree
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan 48109 1065, USA
    Pharm Res 20:1364-72. 2003
    ..To determine the expression and functional activity of proton-coupled oligopeptide transporters (POT) in retinal pigment epithelial (RPE) cells...
  27. ncbi request reprint [Detection of severe acute respiratory syndrome (SARS)-associated coronavirus RNA in autopsy tissues with in situ hybridization]
    Qing Ling Zhang
    Department of Pathology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 23:1125-7. 2003
    ..To explore the distribution of severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV) in SARS autopsy tissues at the molecular level...
  28. ncbi request reprint [Effect of handportable mobiletelephone microwave radiation on rat central neuron apoptosis]
    Wei Guo Liu
    The Second Hospital, College of Medical Science, Zhejiang University, Hangzhou 310009, China
    Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 21:45-7. 2003
    ..To investigate the effect of handportable mobiletelephone microwave radiation on rat central nervous system by setting up rat model...
  29. ncbi request reprint [Study on apoptosis of lung tissue cells in patients with severe brain injury complicated with aspiration-induced lung injury]
    Tan shi Li
    Department of Emergency, General Hospital of PLA, Beijing 100853, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 16:97-9. 2004
    ..To investigate the role of apoptosis of pulmonary cells in aspiration induced lung injury in patients with severe brain injury with or without aspiration-induced lung injury...
  30. ncbi request reprint Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways
    Yanqing Ding
    Department of Pathology, Nan Fang Hospital, First Military Medical University, Guangzhou, China
    J Pathol 203:622-30. 2004
    ..This data will be useful for designing new strategies for prevention and treatment of SARS...
  31. ncbi request reprint Microsatellite instability and loss of heterozygosity of fragile histidine triad gene in lung hyperplastic lesions
    Jun xin Zhang
    Department of Pathology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 23:313-7. 2003
    ....
  32. ncbi request reprint Suppressive effect of Astragalus membranaceus Bunge on chemical hepatocarcinogenesis in rats
    Rutao Cui
    Molecular Carcinogenesis Unit, International Agency for Research on Cancer IARC, 150 cours Albert Thomas, 69372 Lyon, Cedex 08, France
    Cancer Chemother Pharmacol 51:75-80. 2003
    ..The formation of GST-P-positive foci and the expression of GST-P protein and mRNA caused by DEN-PH-AAF were reduced in the treatment groups, which clearly suggests that AM is effective in delaying DEN-PH-AAF-induced hepatocarcinogenesis...
  33. ncbi request reprint Liver targeting and the delayed drug release of the nanoparticles of adriamycin polybutylcyanoacrylate in mice
    Liang fang Shen
    Department of Tumor, Xiangya Hospital, Central South University of China, Changsha 410008, China
    Chin Med J (Engl) 119:1287-93. 2006
    ....
  34. ncbi request reprint The clinical pathology of severe acute respiratory syndrome (SARS): a report from China
    Yanqing Ding
    Department of Pathology, Nan Fang Hospital, First Military Medical University, Guangzhou, Guangdong Province 510515, PR China
    J Pathol 200:282-9. 2003
    ....
  35. ncbi request reprint Immunolocalization of the proton-coupled oligopeptide transporter PEPT2 in developing rat brain
    Hong Shen
    Department of Pharmaceutical Sciences, The University of Michigan, Ann Arbor, Michigan 48109 0504, USA
    Mol Pharm 1:248-56. 2004
    ..PEPT2 may also play a role in the regulation of neuropeptide concentrations in extracellular fluid, especially during early development...