Prognostic relevance of Fas (APO-1/CD95) ligand in human colorectal cancerKatherine M Sheehan
Department of Pathology, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland
Eur J Gastroenterol Hepatol 15:375-80. 2003
..The aim of this study was to determine the extent of FasL expression in patients with colorectal cancer and examine its relationship with several prognostic pathological features and survival...
Recurrent aneurysmal fibrous histiocytomaK M Sheehan
Department of Pathology, James Connolly Memorial Hospital, Blanchardstown, Dublin 15, Ireland
J Clin Pathol 57:312-3. 2004
..The histological features of this rare lesion and the importance of the differential diagnosis from other similar appearing malignant lesions will be discussed...
- Unrepresentative astrocytoma biopsy sampling is partly overcome by assessment of the MIB-1-labelled growth fraction
Katherine M Sheehan
Departments of Pathology, Beaumont Hospital and The Royal College of Surgeons in Ireland, Dublin, Ireland
J Clin Pathol 60:945-7. 2007
- Association between cyclooxygenase-2-expressing macrophages, ulceration and microvessel density in colorectal cancer
K M Sheehan
Department of Pathology, Beaumont Hospital, and Royal College of Surgeons in Ireland, Dublin, Ireland
Histopathology 46:287-95. 2005
..Thus they may play an important stromal-epithelial role in carcinogenesis. Tauhe aim of this study was to define the relationship between microvessel density (MVD), tumour COX-2 and macrophage COX-2 expression...
- Cyclooxygenase-2 expression in primary human colorectal cancers and bone marrow micrometastases
K M Sheehan
Department of Pathology, Beaumont Hospital and Royal College of Surgeons, Beaumont Road, Dublin 9, Ireland
Dig Liver Dis 36:392-7. 2004
..Both the expressions of the inducible form of cyclooxygenase-2 and the presence of bone marrow micrometastases are poor prognostic markers in patients with colorectal carcinoma...
- The relationship between cyclooxygenase-2 expression and characteristics of malignant transformation in human colorectal adenomas
Katherine M Sheehan
Department of Pathology, Epidemiology and Clinical Pharmacology, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin, Ireland
Eur J Gastroenterol Hepatol 16:619-25. 2004
..The objective of this study was to evaluate the extent of COX-2 in pre-malignant colorectal polyps and to assess the relationship between COX-2 and the level of dysplasia in these lesions...
- Cyclooxygenase-2 expression in chronic hepatitis C and the effect of interferon alpha treatment
Diarmuid S Manning
Department of Clinical Pharmacology Gastroenterology, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland
J Gastroenterol Hepatol 22:1633-7. 2007
..The aim the present study was to evaluate the extent of COX-2 expression in liver biopsies in patients with HCV infection and to determine the effect of treatment with interferon alpha (IFN)...
- Cyclooxygenase-2 expression in stromal tumors of the gastrointestinal tract
Katherine M Sheehan
Department of Pathology, Beaumont Hospital, Dublin, Ireland
Hum Pathol 34:1242-6. 2003
..The enzyme may play a role in the proliferation of these lesions, suggesting the potential use of nonsteroidal anti-inflammatory drugs in treatment...
Quantitative cell signalling analysis reveals down-regulation of MAPK pathway activation in colorectal cancerChristian Gulmann
Department of Pathology, Beaumont Hospital, Dublin, Ireland
J Pathol 218:514-9. 2009
..It is concluded that MAPK activity may be down-regulated in colorectal cancer and that further exploration of inhibitory therapy in this system should be carefully evaluated if this finding is confirmed in larger series...
- GLUT-1 expression and response to chemoradiotherapy in rectal cancer
Sarah Brophy
Department of Surgery, Beaumont Hospital and Royal College of Surgeons in Ireland, Dublin, Ireland
Int J Cancer 125:2778-82. 2009
..GLUT-1 negative tumors had a 70% probability of good response (TRG3/4) compared to a 31% probability of good response in GLUT-1 positive tumors. GLUT-1 may be a useful predictive marker of response to chemoradiotherapy in rectal cancer...
- Idiopathic cholangiopathy in a biliary cast syndrome necessitating liver transplantation following head trauma
Michael F Byrne
Department of Gastroenterology, Beaumont Hospital, Beaumont Road, Dublin 9, Ireland
Eur J Gastroenterol Hepatol 15:415-7. 2003
..The possible aetiologies of biliary cast formation and subsequently cholangiopathy necessitating transplantation in this patient are described...
- Disabling osteomalacic myopathy as the only presenting feature of coeliac disease
Michael F Byrne
Department of Gastroenterology, Beaumont Hospital, Dublin, Ireland
Eur J Gastroenterol Hepatol 14:1271-4. 2002
..A review of the literature regarding osteomalacia and myopathy in coeliac disease is presented...
- Nonsteroidal anti-inflammatory drug-induced diaphragms and ulceration in the colon
Michael F Byrne
Department of Gastroenterology, Beaumont Hospital Royal College of Surgeons in Ireland, Dublin, Ireland
Eur J Gastroenterol Hepatol 14:1265-9. 2002
..Management usually involves simply stopping the offending NSAID. A review of the literature on this under-recognized entity is presented...
- The relationship between cyclooxygenase-2 expression and colorectal cancer
K M Sheehan
Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin
JAMA 282:1254-7. 1999
..Epidemiological studies have implicated the inducible form of cyclooxygenase (COX-2) in the pathogenesis of colorectal cancer; however, its role is not fully understood...
- Helicobacter pylori induces cyclooxygenase-1 and cyclooxygenase-2 expression in vascular endothelial cells
M F Byrne
Dept of Clinical Pharmacology, Royal College of Surgeons in Ireland, Dublin, Ireland
Scand J Gastroenterol 38:1023-30. 2003
..A potential source is the vascular endothelial cell, which plays a role in regulating mucosal blood flow and inflammatory cell infiltration...
