K J Shaw

Summary

Publications

  1. doi The oxazolidinones: past, present, and future
    Karen Joy Shaw
    Trius Therapeutics, Inc, Department of Biology, San Diego, California 92121, USA
    Ann N Y Acad Sci 1241:48-70. 2011
  2. pmc In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains
    K J Shaw
    Trius Therapeutics, Inc, 6310 Nancy Ridge Drive, Suite 105, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 52:4442-7. 2008
  3. pmc Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05
    Jeffrey B Locke
    Trius Therapeutics, Inc, San Diego, California, USA
    Antimicrob Agents Chemother 56:332-40. 2012

Collaborators

Detail Information

Publications3

  1. doi The oxazolidinones: past, present, and future
    Karen Joy Shaw
    Trius Therapeutics, Inc, Department of Biology, San Diego, California 92121, USA
    Ann N Y Acad Sci 1241:48-70. 2011
    ..However, maintaining potency against strains carrying the mobile cfr gene poses a challenge for the oxazolidinone class, as well as other 50S ribosome inhibitors that target the peptidyl transferase center...
  2. pmc In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains
    K J Shaw
    Trius Therapeutics, Inc, 6310 Nancy Ridge Drive, Suite 105, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 52:4442-7. 2008
    ..A model of TR-700 binding to 23S rRNA suggests that the increased potency of TR-700 is due to additional target site interactions and that TR-700 binding is less reliant on target residues associated with resistance to LZD...
  3. pmc Genetic environment and stability of cfr in methicillin-resistant Staphylococcus aureus CM05
    Jeffrey B Locke
    Trius Therapeutics, Inc, San Diego, California, USA
    Antimicrob Agents Chemother 56:332-40. 2012
    ..Minicircles resulting from the ermB recombination event and the novel association of cfr with the pSM19035 plasmid system support the potential for the continued dissemination of cfr...