Progranulin is expressed within motor neurons and promotes neuronal cell survivalCara L Ryan
Royal Victoria Hospital and Department of Medicine, McGill University Health Centre Research Institute, Montreal, Quebec, Canada
BMC Neurosci 10:130. 2009
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- Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
Christopher A Shaw
Departments of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
J Inorg Biochem 103:1555-62. 2009
..The demonstrated neurotoxicity of aluminum hydroxide and its relative ubiquity as an adjuvant suggest that greater scrutiny by the scientific community is warranted...
- Neurodegenerative diseases: neurotoxins as sufficient etiologic agents?
Christopher A Shaw
Department of Ophthalmology, University of British Columbia, Vancouver, BC, Canada
Neuromolecular Med 10:1-9. 2008
..Finally, we will attempt to put environmental toxins into the context of possible genetically-determined susceptibility...
- The primary locus of motor neuron death in an ALS-PDC mouse model
Grace Lee
Department of Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Neuroreport 20:1284-9. 2009
..These data suggest that neuronal pathology begins at the soma and proceeds distally in a 'dying forward' pattern...
Aluminum adjuvant linked to Gulf War illness induces motor neuron death in miceMichael S Petrik
Department of Ophthalmology and Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada
Neuromolecular Med 9:83-100. 2007
..The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with GWI and possibly an additional role for the combination of adjuvants...
- Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC
Jason M B Wilson
Programme in Neuroscience, University of British Columbia, Vancouver, British Columbia
Neuromolecular Med 3:105-18. 2003
..Deciphering the series of events leading to neurodegeneration in cycad-fed animals may provide clues leading to therapeutic approaches to halt the early stages of disease progression...
In vitro effects of cholesterol β-D-glucoside, cholesterol and cycad phytosterol glucosides on respiration and reactive oxygen species generation in brain mitochondriaAlexander Panov
Carolinas Neuromuscular ALS Research Laboratory, Cannon Research Center, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA
J Membr Biol 237:71-7. 2010
..Unlike heart mitochondria, in activated neurons mitochondria specifically increase ROS production associated with succinate oxidation (Panov et al., J Biol Chem 284:14448-14456, 2009)...
- Lack of behavioral and neuropathological effects of dietary beta-methylamino-L-alanine (BMAA) in mice
Reyniel Cruz-Aguado
Department of Ophthalmology, University of British Columbia, Canada
Pharmacol Biochem Behav 84:294-9. 2006
..No motor, cognitive or neuropathological outcome resulted from this feeding paradigm. Our findings support neither the causal role of BMAA in neurodegeneration nor the specific involvement of this amino acid in ALS-PDC...
- Human papillomavirus (HPV) vaccines as an option for preventing cervical malignancies: (how) effective and safe?
Lucija Tomljenovic
Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W 10th Ave, Vancouver, BC, V5Z 1L8, Canada
Curr Pharm Des 19:1466-87. 2013
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- Human papillomavirus (HPV) vaccine policy and evidence-based medicine: are they at odds?
Lucija Tomljenovic
Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W 10th Ave, Vancouver, BC, V5Z 1L8, Canada
Ann Med 45:182-93. 2013
..Future vaccination policies should adhere more rigorously to evidence-based medicine and ethical guidelines for informed consent...
- HPV vaccines and cancer prevention, science versus activism
Lucija Tomljenovic
Neural Dynamics Research Group, Vancouver General Hospital Research Pavilion, University of British Columbia, 828 W, 10th Ave, Vancouver, BC, V5Z 1L8, Canada
Infect Agent Cancer 8:6. 2013
..Careful analysis of HPV vaccine pre- and post-licensure data shows however that both of these premises are at odds with factual evidence and are largely derived from significant misinterpretation of available data...
- Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
Lucija Tomljenovic
Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W 10th Ave, Vancouver, BC, Canada V5Z 1L8
J Inorg Biochem 105:1489-99. 2011
..Because children represent a fraction of the population most at risk for complications following exposure to Al, a more rigorous evaluation of Al adjuvant safety seems warranted...
- Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour
Jason M B Wilson
Department of Ophthalmology, University of British Columbia, Vancouver, Canada
Neuromolecular Med 1:207-21. 2002
..These data are consistent with a number of major features of ALS-PDC in humans...
