Christopher A Shaw

Summary

Publications

  1. ncbi request reprint Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice
    Michael S Petrik
    Department of Ophthalmology and Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada
    Neuromolecular Med 9:83-100. 2007
  2. ncbi request reprint Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes
    C A Shaw
    Dept of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Program in Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada Electronic address
    J Inorg Biochem 128:237-44. 2013
  3. doi request reprint Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity
    C A Shaw
    Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia UBC, 828 W 10th Ave, Vancouver, BC, V5Z 1L8, Canada
    Immunol Res 56:304-16. 2013
  4. pmc Progranulin is expressed within motor neurons and promotes neuronal cell survival
    Cara L Ryan
    Royal Victoria Hospital and Department of Medicine, McGill University Health Centre Research Institute, Montreal, Quebec, Canada
    BMC Neurosci 10:130. 2009
  5. pmc Neurodegenerative diseases: neurotoxins as sufficient etiologic agents?
    Christopher A Shaw
    Department of Ophthalmology, University of British Columbia, Vancouver, BC, Canada
    Neuromolecular Med 10:1-9. 2008
  6. pmc Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
    Christopher A Shaw
    Departments of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    J Inorg Biochem 103:1555-62. 2009
  7. pmc The primary locus of motor neuron death in an ALS-PDC mouse model
    Grace Lee
    Department of Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Neuroreport 20:1284-9. 2009
  8. ncbi request reprint Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC
    Jason M B Wilson
    Programme in Neuroscience, University of British Columbia, Vancouver, British Columbia
    Neuromolecular Med 3:105-18. 2003
  9. ncbi request reprint Lack of behavioral and neuropathological effects of dietary beta-methylamino-L-alanine (BMAA) in mice
    Reyniel Cruz-Aguado
    Department of Ophthalmology, University of British Columbia, Canada
    Pharmacol Biochem Behav 84:294-9. 2006
  10. doi request reprint In vitro effects of cholesterol β-D-glucoside, cholesterol and cycad phytosterol glucosides on respiration and reactive oxygen species generation in brain mitochondria
    Alexander Panov
    Carolinas Neuromuscular ALS Research Laboratory, Cannon Research Center, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA
    J Membr Biol 237:71-7. 2010

Research Grants

Collaborators

  • Lucija Tomljenovic
  • Michael S Petrik
  • Y Li
  • Richard Smith
  • David V Pow
  • Grace Lee
  • Reyniel Cruz-Aguado
  • Jason M B Wilson
  • Alexander Panov
  • Cara L Ryan
  • Iraj Khabazian
  • Benjamin R Brooks
  • Nataliya Kubalik
  • Mingju Cao
  • David C Baranowski
  • Sandra Minotti
  • Andrew Bateman
  • Heather D Durham
  • Suneil Malik
  • Denis G Kay
  • Babykumari P Chitramuthu
  • Zhi Li
  • Hugh P J Bennett
  • Ulla K Craig
  • David E Williams
  • Ulla Kate Craig
  • Rebecca J Simpson
  • Arash Seyedalikhani
  • Bryce A Pasqualotto
  • Leonard T Kurland
  • Raymond J Andersen
  • Jaswinder S Bains
  • Margaret C Wong

Detail Information

Publications16

  1. ncbi request reprint Aluminum adjuvant linked to Gulf War illness induces motor neuron death in mice
    Michael S Petrik
    Department of Ophthalmology and Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada
    Neuromolecular Med 9:83-100. 2007
    ..The findings suggest a possible role for the aluminum adjuvant in some neurological features associated with GWI and possibly an additional role for the combination of adjuvants...
  2. ncbi request reprint Administration of aluminium to neonatal mice in vaccine-relevant amounts is associated with adverse long term neurological outcomes
    C A Shaw
    Dept of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada Program in Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada Program in Neuroscience, University of British Columbia, Vancouver, British Columbia, Canada Electronic address
    J Inorg Biochem 128:237-44. 2013
    ..These current data implicate Al injected in early postnatal life in some CNS alterations that may be relevant for a better understanding of the aetiology of ASD...
  3. doi request reprint Aluminum in the central nervous system (CNS): toxicity in humans and animals, vaccine adjuvants, and autoimmunity
    C A Shaw
    Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia UBC, 828 W 10th Ave, Vancouver, BC, V5Z 1L8, Canada
    Immunol Res 56:304-16. 2013
    ..Many of the features of aluminum-induced neurotoxicity may arise, in part, from autoimmune reactions, as part of the ASIA syndrome...
  4. pmc Progranulin is expressed within motor neurons and promotes neuronal cell survival
    Cara L Ryan
    Royal Victoria Hospital and Department of Medicine, McGill University Health Centre Research Institute, Montreal, Quebec, Canada
    BMC Neurosci 10:130. 2009
    ....
  5. pmc Neurodegenerative diseases: neurotoxins as sufficient etiologic agents?
    Christopher A Shaw
    Department of Ophthalmology, University of British Columbia, Vancouver, BC, Canada
    Neuromolecular Med 10:1-9. 2008
    ..Finally, we will attempt to put environmental toxins into the context of possible genetically-determined susceptibility...
  6. pmc Aluminum hydroxide injections lead to motor deficits and motor neuron degeneration
    Christopher A Shaw
    Departments of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    J Inorg Biochem 103:1555-62. 2009
    ..The demonstrated neurotoxicity of aluminum hydroxide and its relative ubiquity as an adjuvant suggest that greater scrutiny by the scientific community is warranted...
  7. pmc The primary locus of motor neuron death in an ALS-PDC mouse model
    Grace Lee
    Department of Experimental Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Neuroreport 20:1284-9. 2009
    ..These data suggest that neuronal pathology begins at the soma and proceeds distally in a 'dying forward' pattern...
  8. ncbi request reprint Decrease in glial glutamate transporter variants and excitatory amino acid receptor down-regulation in a murine model of ALS-PDC
    Jason M B Wilson
    Programme in Neuroscience, University of British Columbia, Vancouver, British Columbia
    Neuromolecular Med 3:105-18. 2003
    ..Deciphering the series of events leading to neurodegeneration in cycad-fed animals may provide clues leading to therapeutic approaches to halt the early stages of disease progression...
  9. ncbi request reprint Lack of behavioral and neuropathological effects of dietary beta-methylamino-L-alanine (BMAA) in mice
    Reyniel Cruz-Aguado
    Department of Ophthalmology, University of British Columbia, Canada
    Pharmacol Biochem Behav 84:294-9. 2006
    ..No motor, cognitive or neuropathological outcome resulted from this feeding paradigm. Our findings support neither the causal role of BMAA in neurodegeneration nor the specific involvement of this amino acid in ALS-PDC...
  10. doi request reprint In vitro effects of cholesterol β-D-glucoside, cholesterol and cycad phytosterol glucosides on respiration and reactive oxygen species generation in brain mitochondria
    Alexander Panov
    Carolinas Neuromuscular ALS Research Laboratory, Cannon Research Center, Carolinas Medical Center, 1000 Blythe Blvd, Charlotte, NC 28203, USA
    J Membr Biol 237:71-7. 2010
    ..Unlike heart mitochondria, in activated neurons mitochondria specifically increase ROS production associated with succinate oxidation (Panov et al., J Biol Chem 284:14448-14456, 2009)...
  11. ncbi request reprint Behavioral and neurological correlates of ALS-parkinsonism dementia complex in adult mice fed washed cycad flour
    Jason M B Wilson
    Department of Ophthalmology, University of British Columbia, Vancouver, Canada
    Neuromolecular Med 1:207-21. 2002
    ..These data are consistent with a number of major features of ALS-PDC in humans...
  12. pmc HPV vaccines and cancer prevention, science versus activism
    Lucija Tomljenovic
    Neural Dynamics Research Group, Vancouver General Hospital Research Pavilion, University of British Columbia, 828 W, 10th Ave, Vancouver, BC, V5Z 1L8, Canada
    Infect Agent Cancer 8:6. 2013
    ..Careful analysis of HPV vaccine pre- and post-licensure data shows however that both of these premises are at odds with factual evidence and are largely derived from significant misinterpretation of available data...
  13. doi request reprint Human papillomavirus (HPV) vaccine policy and evidence-based medicine: are they at odds?
    Lucija Tomljenovic
    Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W 10th Ave, Vancouver, BC, V5Z 1L8, Canada
    Ann Med 45:182-93. 2013
    ..Future vaccination policies should adhere more rigorously to evidence-based medicine and ethical guidelines for informed consent...
  14. ncbi request reprint Human papillomavirus (HPV) vaccines as an option for preventing cervical malignancies: (how) effective and safe?
    Lucija Tomljenovic
    Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W 10th Ave, Vancouver, BC, V5Z 1L8, Canada
    Curr Pharm Des 19:1466-87. 2013
    ....
  15. doi request reprint Do aluminum vaccine adjuvants contribute to the rising prevalence of autism?
    Lucija Tomljenovic
    Neural Dynamics Research Group, Department of Ophthalmology and Visual Sciences, University of British Columbia, 828 W 10th Ave, Vancouver, BC, Canada V5Z 1L8
    J Inorg Biochem 105:1489-99. 2011
    ..Because children represent a fraction of the population most at risk for complications following exposure to Al, a more rigorous evaluation of Al adjuvant safety seems warranted...

Research Grants7

  1. Neurotoxicity of sterol glucosides: role in ALS-PDC
    Christopher Shaw; Fiscal Year: 2007
    ..Our long-term Aims are to identify the causative molecule(s) in ALS-PDC which can share common basis with the rest of the neurodegenerative diseases. ..
  2. Time-lines of neural degeneration in ALS-PDC mouse model
    Christopher Shaw; Fiscal Year: 2006
    ..In a second series of experiments, we will determine if an early exposure to cycad toxins can exacerbate a late adult exposure. These data will provide therapeutic targets to prevent or halt the progression of neurodegeneration. ..
  3. Time-lines of neural degeneration in ALS-PDC mouse model
    Christopher Shaw; Fiscal Year: 2007
    ..In a second series of experiments, we will determine if an early exposure to cycad toxins can exacerbate a late adult exposure. These data will provide therapeutic targets to prevent or halt the progression of neurodegeneration. ..
  4. Time-lines of neural degeneration in ALS-PDC mouse model
    Christopher Shaw; Fiscal Year: 2009
    ..These data will provide therapeutic targets to prevent or halt the progression of neurodegeneration. ..
  5. Time-lines of neural degeneration in ALS-PDC mouse model
    Christopher A Shaw; Fiscal Year: 2010
    ..These data will provide therapeutic targets to prevent or halt the progression of neurodegeneration. ..