B S Shastry

Summary

Publications

  1. ncbi request reprint Therapeutic options for Parkinson's disease
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, Michigan 48309, USA
    Drugs Today (Barc) 38:445-51. 2002
  2. ncbi request reprint SNP alleles in human disease and evolution
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 47:561-6. 2002
  3. ncbi request reprint Schizophrenia: a genetic perspective (review)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Int J Mol Med 9:207-12. 2002
  4. ncbi request reprint Molecular and cell biological aspects of Alzheimer disease
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:609-18. 2001
  5. ncbi request reprint Parkinson disease: etiology, pathogenesis and future of gene therapy
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurosci Res 41:5-12. 2001
  6. ncbi request reprint SNPs and haplotypes: genetic markers for disease and drug response (review)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Int J Mol Med 11:379-82. 2003
  7. ncbi request reprint Molecular genetics of Rett syndrome
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurochem Int 38:503-8. 2001
  8. ncbi request reprint Recent progress in the genetics of incontinentia pigmenti (Bloch-Sulzberger syndrome)
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 45:323-6. 2000
  9. ncbi request reprint Evaluation of RP2 and RP3 genes in an X-linked RP family manifesting loss of central vision and preserved peripheral function
    M Hiraoka
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:241-3. 2001
  10. ncbi request reprint Cosegregation of two unlinked mutant alleles in some cases of autosomal dominant familial exudative vitreoretinopathy
    B S Shastry
    Department of Biological Sciences, Oakland University Rochester, MI 48309, USA
    Eur J Hum Genet 12:79-82. 2004

Collaborators

  • M T Trese
  • Mark E Samuels
  • M Hiraoka
  • Xiaodong Jiao
  • Sarah Kleinberg
  • Johane Robitaille
  • Valerio Ventruto
  • J Fielding Hejtmancik
  • Scott Garrant
  • Terri Tillen
  • Ajamete Kaykas
  • Jutta Zeisler
  • Randall T Moon
  • Duane L Guernsey
  • Simon N Pimstone
  • Y Paul Goldberg
  • Roshni R Singaraja
  • Michael R Hayden
  • Lin Hua Zhang
  • Marie Pierre Dube
  • Ann Hoskin-Mott
  • Laird C Sheldahl
  • Marcia L E MacDonald
  • Lee F Siebert
  • Binyou Zheng
  • D M Berinstein
  • F Rossi

Detail Information

Publications27

  1. ncbi request reprint Therapeutic options for Parkinson's disease
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, Michigan 48309, USA
    Drugs Today (Barc) 38:445-51. 2002
    ..This understanding may lead to predicting drug response and ultimately to developing preventive medicine at the individual level in the future...
  2. ncbi request reprint SNP alleles in human disease and evolution
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 47:561-6. 2002
    ..Nevertheless, these variants may provide a starting point for further inquiry...
  3. ncbi request reprint Schizophrenia: a genetic perspective (review)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Int J Mol Med 9:207-12. 2002
    ..Meanwhile, treatment with newly developed anti-psychotic drugs combined with educational and cognitive rehabilitation procedure may help the patients to cope with the illness...
  4. ncbi request reprint Molecular and cell biological aspects of Alzheimer disease
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:609-18. 2001
    ..Although we are still lacking the molecular basis and order of events involved in the disease process, the future for AD research, as well as for AD patients, is more promising than ever before...
  5. ncbi request reprint Parkinson disease: etiology, pathogenesis and future of gene therapy
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurosci Res 41:5-12. 2001
    ....
  6. ncbi request reprint SNPs and haplotypes: genetic markers for disease and drug response (review)
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Int J Mol Med 11:379-82. 2003
    ..This newly developed toxicogenomic or pharmacogenomic field is rapidly advancing and may change the practice of medicine in the future, providing personalized medicine for each individual...
  7. ncbi request reprint Molecular genetics of Rett syndrome
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurochem Int 38:503-8. 2001
    ..Since the encoded protein was previously shown to be a global transcriptional repressor, undesired expression of yet unidentified genes that are normally repressed is considered to be pathogenic in Rett syndrome...
  8. ncbi request reprint Recent progress in the genetics of incontinentia pigmenti (Bloch-Sulzberger syndrome)
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 45:323-6. 2000
    ..These maps could be invaluable tools in the identification of genes in the near future...
  9. ncbi request reprint Evaluation of RP2 and RP3 genes in an X-linked RP family manifesting loss of central vision and preserved peripheral function
    M Hiraoka
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:241-3. 2001
    ..Further identification of the X-linked genes may facilitate the elucidation of the molecular basis of the disorder in the family analyzed...
  10. ncbi request reprint Cosegregation of two unlinked mutant alleles in some cases of autosomal dominant familial exudative vitreoretinopathy
    B S Shastry
    Department of Biological Sciences, Oakland University Rochester, MI 48309, USA
    Eur J Hum Genet 12:79-82. 2004
    ....
  11. ncbi request reprint Identification of novel missense mutations in the Norrie disease gene associated with one X-linked and four sporadic cases of familial exudative vitreoretinopathy
    B S Shastry
    Eye Research Institute, Oakland University, Rochester, Michigan 48309 4401, USA
    Hum Mutat 9:396-401. 1997
    ..It also demonstrates that it may be beneficial for clinical diagnosis to screen for mutations in the Norrie disease gene in sporadic FEVR cases...
  12. ncbi request reprint Insertion and deletion mutations in the dinucleotide repeat region of the Norrie disease gene in patients with advanced retinopathy of prematurity
    M Hiraoka
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:178-81. 2001
    ..Although the ND gene is not frequently involved in advanced ROP, the present large-scale study further supports the hypothesis that genetic influences may play an important role in the development of severe ROP in some premature infants...
  13. ncbi request reprint X-linked juvenile retinoschisis: mutations at the retinoschisis and Norrie disease gene loci?
    M Hiraoka
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 46:53-6. 2001
    ..If this proves to be a widespread problem, it will complicate the strategies used to identify the genes involved in diseases and to develop methods for intervention...
  14. ncbi request reprint Recurrent missense (R197C) and nonsense (Y89X) mutations in the XLRS1 gene in families with X-linked retinoschisis
    B S Shastry
    Eye Research Institute, Oakland University, Rochester, Michigan 48309 4410, USA
    Biochem Biophys Res Commun 256:317-9. 1999
    ..These mutations, which are transmitted through three generations, cosegregated with the disease, and are not found in the unaffected family members and 150 normal X-chromosomes, are likely to be pathogenic in these families...
  15. ncbi request reprint Factor V Leiden mutation (R506Q) and the risk of advanced retinopathy of prematurity
    Sarah Kleinberg
    Department of Biological Sciences, Oakland University, Rochester, MI 48309 4401, USA
    Int J Mol Med 12:469-72. 2003
    ..4%). Therefore, statistically factor V mutation on its own is not a major risk factor for the above two disorders. However, it may be associated with other additive factors as might be expected for a complex genetic trait...
  16. ncbi request reprint Assessment of the contribution of insulin-like growth factor I receptor 3174 G-->A polymorphism to the progression of advanced retinopathy of prematurity
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Eur J Ophthalmol 17:950-3. 2007
    ....
  17. ncbi request reprint Linkage and candidate gene analysis of X-linked familial exudative vitreoretinopathy
    B S Shastry
    Eye Research Institute, Oakland University, Rochester, Michigan 48309, USA
    Genomics 27:341-4. 1995
    ..Additionally, a polymorphic missense mutation (H127R) was detected in a severely affected patient...
  18. ncbi request reprint Pharmacogenetics and the concept of individualized medicine
    B S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Pharmacogenomics J 6:16-21. 2006
    ..If it becomes a reality, it delivers benefits to improve public health and allow genetically subgroup diseases thereby avoiding adverse drug reactions (by knowing in advance who should be treated with what drug and how)...
  19. pmc Autosomal recessive familial exudative vitreoretinopathy is associated with mutations in LRP5
    Xiaodong Jiao
    Ophthalmic Genetics and Visual Function Branch, National Eye Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Hum Genet 75:878-84. 2004
    ..Sequencing of LRP5 shows, in all three families, homozygous mutations R570Q, R752G, and E1367K. This suggests that mutations in this gene can cause autosomal recessive as well as autosomal dominant FEVR...
  20. ncbi request reprint Bipolar disorder: an update
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, 316 DHE, Rochester, MI 48309, USA
    Neurochem Int 46:273-9. 2005
    ..Identification of risk genes in the future may provide a better understanding of the nature of pathogenesis that may lead to a better therapeutic target...
  21. ncbi request reprint Genetic diversity and new therapeutic concepts
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 50:321-8. 2005
    ..Despite these limitations, translation of pharmacogenomic data into clinical practice would certainly provide better opportunities to increase the safety and efficacy of medicine in the future...
  22. ncbi request reprint Mutant frizzled-4 disrupts retinal angiogenesis in familial exudative vitreoretinopathy
    Johane Robitaille
    Department of Ophthalmology, Izaak Walton Killam IWK Health Centre, Dalhousie University, Halifax, Nova Scotia B3H 2Y9, Canada
    Nat Genet 32:326-30. 2002
    ..In one of the mutants, altered subcellular trafficking led to defective signaling. These findings support a function for frizzled-4 in retinal angiogenesis and establish the first association between a Wnt receptor and human disease...
  23. ncbi request reprint Further support for the common variants in complement factor H (Y402H) and LOC387715 (A69S) genes as major risk factors for the exudative age-related macular degeneration
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309 4401, USA
    Ophthalmologica 220:291-5. 2006
    ..These results further support the notion that CFH and LOC387715 genes are the major risk factors for ARMD...
  24. ncbi request reprint Developmental dyslexia: an update
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    J Hum Genet 52:104-9. 2007
    ..Interestingly, in spite of genetic heterogeneity, the pathology appears to involve common phonological coding deficits. The condition can be managed by a highly structured educational training exercise...
  25. ncbi request reprint Lack of association of the VEGF gene promoter (-634 G-->C and -460 C-->T) polymorphism and the risk of advanced retinopathy of prematurity
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    Graefes Arch Clin Exp Ophthalmol 245:741-3. 2007
    ..In order to evaluate its general applicability as a screening procedure in clinics and to replicate the above result, we have undertaken the following study...
  26. ncbi request reprint SNPs in disease gene mapping, medicinal drug development and evolution
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI, USA
    J Hum Genet 52:871-80. 2007
    ..Therefore, it is possible that disease-associated SNPs (or pathology) and evolution can be related to one another...
  27. ncbi request reprint Neurodegenerative disorders of protein aggregation
    Barkur S Shastry
    Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
    Neurochem Int 43:1-7. 2003
    ....