Surendra K Sharma

Summary

Publications

  1. pmc Tuberculosis: From an incurable scourge to a curable disease - journey over a millennium
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 137:455-93. 2013
  2. pmc Efficacy and safety of thrice weekly DOTS in tuberculosis patients with and without HIV co-infection: an observational study
    Richa Vashishtha
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    BMC Infect Dis 13:468. 2013
  3. ncbi Evaluation of risk factors for antituberculosis treatment induced hepatotoxicity
    Rohit Singla
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 132:81-6. 2010
  4. ncbi Prevalence and risk factors of syndrome Z in urban Indians
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Sleep Med 11:562-8. 2010
  5. pmc Clinical characteristics of tuberculosis-associated immune reconstitution inflammatory syndrome in North Indian population of HIV/AIDS patients receiving HAART
    Suman Karmakar
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Clin Dev Immunol 2011:239021. 2011
  6. pmc Comparative evaluation of GenoType MTBDRplus line probe assay with solid culture method in early diagnosis of multidrug resistant tuberculosis (MDR-TB) at a tertiary care centre in India
    Raj N Yadav
    Department of Internal Medicine Division of Research for Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 8:e72036. 2013
  7. ncbi A study of TB-associated immune reconstitution inflammatory syndrome using the consensus case-definition
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 131:804-8. 2010
  8. doi CPAP for the metabolic syndrome in patients with obstructive sleep apnea
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    N Engl J Med 365:2277-86. 2011
  9. pmc Prevalence of multidrug-resistant tuberculosis among category II pulmonary tuberculosis patients
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 133:312-5. 2011
  10. ncbi Are metabolic syndrome, obstructive sleep apnoea & syndrome Z sequential?--a hypothesis
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 131:455-8. 2010

Collaborators

Detail Information

Publications45

  1. pmc Tuberculosis: From an incurable scourge to a curable disease - journey over a millennium
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 137:455-93. 2013
    ..Quest for newer biomarkers for predicting a durable cure, relapse, discovery/repurposing of newer anti-TB drugs, development of newer vaccines continues to achieve the goal of eliminating TB altogether by 2050...
  2. pmc Efficacy and safety of thrice weekly DOTS in tuberculosis patients with and without HIV co-infection: an observational study
    Richa Vashishtha
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    BMC Infect Dis 13:468. 2013
    ..The present study sets out to compare TB treatment outcomes in these two groups in the Indian national programme, which currently involves thrice-weekly therapy for all, regardless of HIV status...
  3. ncbi Evaluation of risk factors for antituberculosis treatment induced hepatotoxicity
    Rohit Singla
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 132:81-6. 2010
    ..We undertook a prospective case-control study to assess the role of these putative risk factors in the development of DIH in patients receiving anti-TB treatment...
  4. ncbi Prevalence and risk factors of syndrome Z in urban Indians
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Sleep Med 11:562-8. 2010
    ..Syndrome Z is defined as the co-occurrence of obstructive sleep apnea (OSA) and metabolic syndrome. There is a paucity of information on the magnitude of syndrome Z in the community and the factors associated with it...
  5. pmc Clinical characteristics of tuberculosis-associated immune reconstitution inflammatory syndrome in North Indian population of HIV/AIDS patients receiving HAART
    Suman Karmakar
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    Clin Dev Immunol 2011:239021. 2011
    ..The present study was undertaken to describe the pattern of TB-associated IRIS using recently proposed consensus case-definitions for TB-IRIS for its use in resource-limited settings...
  6. pmc Comparative evaluation of GenoType MTBDRplus line probe assay with solid culture method in early diagnosis of multidrug resistant tuberculosis (MDR-TB) at a tertiary care centre in India
    Raj N Yadav
    Department of Internal Medicine Division of Research for Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences, New Delhi, India
    PLoS ONE 8:e72036. 2013
    ....
  7. ncbi A study of TB-associated immune reconstitution inflammatory syndrome using the consensus case-definition
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 131:804-8. 2010
    ....
  8. doi CPAP for the metabolic syndrome in patients with obstructive sleep apnea
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    N Engl J Med 365:2277-86. 2011
    ..It is unclear whether treatment of obstructive sleep apnea syndrome with continuous positive airway pressure (CPAP) would modify these outcomes...
  9. pmc Prevalence of multidrug-resistant tuberculosis among category II pulmonary tuberculosis patients
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 133:312-5. 2011
    ..We carried out this study to ascertain the prevalence of MDR-TB among category II pulmonary TB patients...
  10. ncbi Are metabolic syndrome, obstructive sleep apnoea & syndrome Z sequential?--a hypothesis
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 131:455-8. 2010
    ....
  11. pmc Nevirapine versus efavirenz-based antiretroviral therapy regimens in antiretroviral-naive patients with HIV and tuberculosis infections in India: a pilot study
    Sanjeev Sinha
    Departments of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    BMC Infect Dis 13:482. 2013
    ..Nevirapine is a much cheaper drug than its alternative efavirenz, and might be beneficial in resource constrained settings...
  12. pmc Early versus delayed initiation of antiretroviral therapy for Indian HIV-Infected individuals with tuberculosis on antituberculosis treatment
    Sanjeev Sinha
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
    BMC Infect Dis 12:168. 2012
    ....
  13. pmc Outcomes of antiretroviral therapy in a northern Indian urban clinic
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India
    Bull World Health Organ 88:222-6. 2010
    ..However, whether they would succeed as part of a national programme in a resource-constrained setting such as India is not clear. The outcomes and specific problems encountered in such a setting have not been adequately studied...
  14. pmc Prevalence of metabolic syndrome in a north Indian hospital-based population with obstructive sleep apnoea
    Swastik Agrawal
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 134:639-44. 2011
    ..We investigated the prevalence of MS and its components in a cross-sectional study in patients with and without OSA in a hospital-based population of a tertiary health care centre in New Delhi, India...
  15. ncbi Relevance of latent TB infection in areas of high TB prevalence
    Surendra K Sharma
    Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India
    Chest 142:761-73. 2012
    ..There is ample space for further research in these countries, whose outcomes may strengthen future national guidelines...
  16. pmc Prevalence of multidrug-resistant tuberculosis among newly diagnosed cases of sputum-positive pulmonary tuberculosis
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 133:308-11. 2011
    ..We sought to ascertain the prevalence of MDR-TB among new cases of sputum-positive pulmonary TB...
  17. ncbi Prevalence of extensively drug-resistant tuberculosis among patients with multidrug-resistant tuberculosis: a retrospective hospital-based study
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 130:392-5. 2009
    ..High rates of XDR-TB have been reported from India. We sought to ascertain the prevalence of XDR-TB among patients with MDR-TB treated at a tertiary care centre in New Delhi, India...
  18. ncbi Epidemiology of adult obstructive sleep apnoea syndrome in India
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 131:171-5. 2010
    ..Therefore, future studies on the association of OSA and metabolic syndrome should carefully evaluate confounding effect of obesity on metabolic abnormalities in patients with OSA...
  19. pmc Challenges in the diagnosis & treatment of miliary tuberculosis
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 135:703-30. 2012
    ..However, sparse data are available from randomized controlled trials to define the optimum regimen and duration of treatment in patients with drug-sensitive as well as drug-resistant miliary TB, including those with HIV/AIDS...
  20. doi Recruitment of Th1 effector cells in human tuberculosis: hierarchy of chemokine receptor(s) and their ligands
    Pradip K Saha
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Cytokine 63:43-51. 2013
    ..In vitro chemotaxis assay indicates dominant role of RANTES and IP-10 in the selective recruitment of CXCR3(+)CCR5(+)cells at the tubercular pathologic sites...
  21. pmc Contribution of medical colleges to tuberculosis control in India under the Revised National Tuberculosis Control Programme (RNTCP): lessons learnt & challenges ahead
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 137:283-94. 2013
    ....
  22. doi A study of incidence of AKI in critically ill patients
    Mukesh Sharma Paudel
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Ren Fail 34:1217-22. 2012
    ..There are no new studies from the developing countries looking at AKI in these patients since adoption of uniform Acute Kidney Injury Network (AKIN) criteria...
  23. pmc Clinical profile & predictors of poor outcome of adult HIV-tuberculosis patients in a tertiary care centre in north India
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 139:154-60. 2014
    ..This study was done to assess the frequency and pattern of TB, outcome of anti-tuberculosis treatment, and the factors related to poor outcome of TB treatment in adult patients with HIV infection...
  24. ncbi Pattern & correlates of neurocognitive dysfunction in Asian Indian adults with severe obstructive sleep apnoea
    Hanish Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 132:409-14. 2010
    ..No published data are available on neurocognitive dysfunction in Asian Indians with obstructive sleep apnoea (OSA). We therefore, studied the pattern and correlates of neurocognitive dysfunction in Indian adults with severe OSA...
  25. doi Delayed resolution of inflammatory response compared with clinical recovery in patients with acute exacerbations of chronic obstructive pulmonary disease
    Anant Mohan
    Department of Pulmonary Medicine and Sleep Disorders, All India Institute of Medical Sciences, New Delhi, India
    Respirology 17:1080-5. 2012
    ..The aim was to assess the changes in levels of inflammatory markers in AECOPD and correlate these with clinical and laboratory indices of recovery...
  26. doi Prevalence and risk factors of obstructive sleep apnea among middle-aged urban Indians: a community-based study
    Emmadi V Reddy
    Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    Sleep Med 10:913-8. 2009
    ..The epidemiology of obstructive sleep apnea (OSA) and obstructive sleep apnea syndrome (OSAS) is not well studied among Indians. We sought to determine the prevalence and risk factors of OSA in a middle-aged urban Indian population...
  27. doi Evaluation of the current management protocols for prophylaxis against Pneumocystis jiroveci pneumonia and other opportunistic infections in patients living with HIV/AIDS
    Sheel Bhadra Jain
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
    AIDS Care 23:846-50. 2011
    ..Prophylaxis in AIDS patients seems to be a major problem area and a lot of efforts need to be directed toward it since patients suffering from AIDS are bound to have a downhill course despite provision of all available treatment options...
  28. doi Rifamycins (rifampicin, rifabutin and rifapentine) compared to isoniazid for preventing tuberculosis in HIV-negative people at risk of active TB
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Cochrane Database Syst Rev 7:CD007545. 2013
    ..Rifampicin or rifamycin-combination treatments are shorter and may result in higher completion rates...
  29. doi Safety of 3 different reintroduction regimens of antituberculosis drugs after development of antituberculosis treatment-induced hepatotoxicity
    Surendra K Sharma
    Div of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Clin Infect Dis 50:833-9. 2010
    ..Reintroduction of antituberculosis drugs in patients with DIH has never been studied systematically. We aimed to compare the safety of 3 different reintroduction regimens of antituberculosis drugs in patients with antituberculosis DIH...
  30. ncbi Acute lung injury and acute respiratory distress syndrome in malaria
    Alladi Mohan
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, India
    J Vector Borne Dis 45:179-93. 2008
    ..ARDS in malaria is a disease with a high mortality. Early diagnosis, institution of specific antimalarial treatment and assisted ventilation can be life-saving...
  31. ncbi Proton magnetic resonance spectroscopy of brain in obstructive sleep apnoea in north Indian Asian subjects
    Surendra K Sharma
    Departments of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 132:278-86. 2010
    ..The aim of this study was to determine the absolute concentration of cerebral metabolites in apnoeic and non-apnoeic subjects from different regions of the brain to monitor the regional variation of cerebral metabolites...
  32. doi Epidemiology of nosocomial infections in medicine intensive care unit at a tertiary care hospital in northern India
    Shabina Habibi
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    Trop Doct 38:233-5. 2008
    ..3% of Escherichia coli were resistant to the third generation cephalosporins. An increased duration of the time spent in intensive care units and days of intervention were associated with incident NI...
  33. pmc Rare manifestations of sarcoidosis in modern era of new diagnostic tools
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 135:621-9. 2012
    ..We sought to study the rare clinical and radiological manifestations (<5%) in patients with sarcoidosis...
  34. pmc HIV & immune reconstitution inflammatory syndrome (IRIS)
    Surendra K Sharma
    Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India
    Indian J Med Res 134:866-77. 2011
    ....
  35. pmc Diffuse small bowel thickening in AIDS patient--a case report
    Rohit Singla
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    BMC Infect Dis 10:310. 2010
    ..Diarrhea is common in HIV/AIDS patients, caused by both classic enteric pathogens and different opportunistic agents. Infection with these different pathogens may lead to similar radiological findings, thus causing diagnostic confusion...
  36. pmc Non-invasive ventilation for acute exacerbation of COPD with very high PaCO(2): A randomized controlled trial
    Gopi C Khilnani
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Lung India 27:125-30. 2010
    ..To assess the role of non-invasive positive pressure ventilation (NIPPV) for management of Indian patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD)...
  37. pmc Genetic polymorphisms in TNF genes and tuberculosis in North Indians
    Shilpy Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110029, India
    BMC Infect Dis 10:165. 2010
    ..A number of genes have been identified in studies of diverse origins to be important in tuberculosis. Of these, both tumor necrosis factor alpha (TNF-alpha) and lymphotoxin alpha (LT-alpha) play important immunoregulatory roles...
  38. pmc Medical management of genitourinary tuberculosis
    Tamilarasu Kadhiravan
    Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 608, India
    Indian J Urol 24:362-8. 2008
    ..Standardized treatment regimens at correct doses and assured completion of treatment have made DOTS the present-day standard of care for the management of all forms of TB including GUTB...
  39. doi Management of the patient with HIV disease
    Surendra K Sharma
    Division of Pulmonary and Critical Care Medicine, All India Institute of Medical Sciences, New Delhi, India
    Dis Mon 54:162-95. 2008
  40. pmc Association of Intracellular T(H)1-T(H)2 Balance in CD4+ T-cells and MIP-1α in CD8+ T-cells with Disease Severity in Adults with Dengue
    Tamilarasu Kadhiravan
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Immune Netw 10:164-72. 2010
    ..We tested the hypothesis that dengue haemorrhagic fever (DHF) is associated with a T(H)1-skewed immune response as opposed to dengue fever (DF)...
  41. doi Prevalence and risk factors for wheezing in children from rural areas of north India
    Surendra K Sharma
    Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
    Allergy Asthma Proc 28:647-53. 2007
    ....
  42. pmc The antiretroviral efficacy of highly active antiretroviral therapy and plasma nevirapine concentrations in HIV-TB co-infected Indian patients receiving rifampicin based antituberculosis treatment
    Sanjeev Sinha
    Department of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India
    AIDS Res Ther 8:41. 2011
    ..abstract:..
  43. ncbi Isolated unilateral acute retinal necrosis syndrome as the initial manifestation of HIV infection
    Sujit Gharai
    All India Institute of Medical Sciences, New Delhi, India
    AIDS Read 19:241-4. 2009
    ..This case of an atypical ophthalmic manifestation as initial presentation of HIV infection highlights the need for increased index of suspicion for HIV infection in young patients with acute retinal necrosis syndrome...
  44. ncbi Multidrug-resistant tuberculosis: a menace that threatens to destabilize tuberculosis control
    Surendra K Sharma
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, All India Institute of Medical Sciences, New Delhi 110 029, India
    Chest 130:261-72. 2006
    ..With newer effective anti-TB drugs still a distant dream, innovative approaches such as DOTS-Plus are showing promise for the management of patients with MDR-TB under program conditions and appear to be a hope for future...
  45. pmc Clinical presentation and predictors of outcome in patients with severe acute exacerbation of chronic obstructive pulmonary disease requiring admission to intensive care unit
    Alladi Mohan
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati 517 507, India
    BMC Pulm Med 6:27. 2006
    ..Severe acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) is a common reason for emergency room (ER) visit about which little has been documented from India...