Rate of serious adverse effects in a series of bevacizumab and ranibizumab injectionsSanjay Sharma
Department of Ophthalmology, Queen s University, Kingston, Ont
Can J Ophthalmol 47:275-9. 2012
..To compare the rate of serious ocular and systemic adverse effects of intravitreal bevacizumab and ranibizumab in the treatment of a variety of eye diseases...
Converting visual acuity to utilitiesS Sharma
Cost Effective Ocular Health Policy Unit, Hotel Dieu Hospital, Queen s University, Kingston, Ont
Can J Ophthalmol 35:267-72. 2000
....
- Age-related macular degeneration and quality of life: how to interpret a research paper in health-related quality of life
Sanjay Sharma
Cost Effective Ocular Health Policy Unit, Department of Ophthalmology, Queen s University, Hotel Dieu Hospital, Brock II 224B, 116 Brock Street, Kingston, Ontario, Canada K7L 5G2
Curr Opin Ophthalmol 15:227-31. 2004
..To review how to critically appraise a research article pertaining to changes in health-related quality of life (HRQoL) related to interventions for age-related macular degeneration (AMD)...
Utilities associated with diabetic retinopathy: results from a Canadian sampleS Sharma
The Cost Effective Ocular Health Policy Unit, Queen s University, Hotel Dieu Hospital, Kingston, ON, Canada
Br J Ophthalmol 87:259-61. 2003
..In addition, to compare these utility values with a sample collected in a similar manner in a tertiary care practice in the United States...
- Photodynamic therapy with verteporfin for subfoveal choroidal neovascularization in age-related macular degeneration: results of an effectiveness study
Sanjay Sharma
Department of Epidemiology and Ophthalmology, Queen s University, and the Cost Effective Ocular Health Policy Unit, Hotel Dieu Hospital, Kingston, Ontario
Arch Ophthalmol 122:853-6. 2004
..To determine the postapproval effectiveness of photodynamic therapy (PDT) with verteporfin for the treatment of predominantly classic subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration...
- Improvement in quality of life from photodynamic therapy: a Canadian perspective
S Sharma
Cost Effective Ocular Health Policy Unit, Queens s University, Kingston, Ont
Can J Ophthalmol 36:332-8. 2001
..We performed a study to determine the expected gain in quality of life associated with photodynamic therapy for the treatment of subfoveal CNV in a Canadian cohort of patients with age-related macular degeneration...
- The cost-effectiveness of early vitrectomy for the treatment of vitreous hemorrhage in diabetic retinopathy
S Sharma
The Cost Effective Ocular Health Policy Unit, Department of Ophthalmology, Queen s University, Hotel Dieu Hospital, Kingston, Ontario, Canada
Curr Opin Ophthalmol 12:230-4. 2001
..Overall, early vitrectomy for the treatment of vitreous hemorrhage secondary to diabetic retinopathy is highly cost-effective...
- The cost-effectiveness of photodynamic therapy for fellow eyes with subfoveal choroidal neovascularization secondary to age-related macular degeneration
S Sharma
The Cost-Effective Ocular Health Policy Unit, Hotel Dieu Hospital, Queen's University, Kingston, Ontario, Canada
Ophthalmology 108:2051-9. 2001
..It is a cost-ineffective treatment for AMD patients who have poor visual acuities in their affected better-seeing eyes...
- Validity of the time trade-off and standard gamble methods of utility assessment in retinal patients
S Sharma
Cost Effective Ocular Health Policy Unit, Department of Ophthalmology, Queen s University, Hotel Dieu Hospital, Kingston, ON, Canada
Br J Ophthalmol 86:493-6. 2002
..A cross section of eligible patients was studied and validity was determined through their relation with two logical constructs, visual acuity and scores from the Visual Function 14 (VF-14) index...
- Reliability of the time trade-off technique of utility assessment in patients with retinal disease
H Hollands
Department of Ophthalmology, Queen's University, Hotel Dieu Hospital, Kingston, Ont
Can J Ophthalmol 36:202-9. 2001
..7634 (95% confidence interval 0.6655-0.8355). INTERPRETATION: Our results show excellent reliability of the time trade-off technique of utility assessment in patients with ocular diseases of the retina...
- Carotid intima-medial thickness as a marker of disease activity in Takayasu's arteritis
Sandeep Seth
Department of Cardiology, Cardiothoracic Center, All India Institute of Medical Sciences, New Delhi 110029, India
Int J Cardiol 108:385-90. 2006
..Presence of carotid intima-medial thickening has been suggested as a possible marker of inflammation and disease activity...
- Influence of previously ingested wheat on fasting breath hydrogen in celiac patients
S V Rana
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Dig Dis Sci 54:1276-9. 2009
....
- Long-term results of the uncemented low contact stress total knee replacement in patients with rheumatoid arthritis
S Sharma
Southern General Hospital, 1345 Govan Road, Glasgow G51 4TF, UK
J Bone Joint Surg Br 87:1077-80. 2005
..The survival rate was 94% at 16 years but 85.5% of patients lost to follow-up were considered as failures. Radiological evidence of impending failure was noted in one knee...
- Effect of pH on production of virulence factors by biofilm cells of Pseudomonas aeruginosa
K Harjai
Department of Microbiology, Panjab University, Chandigarh, India
Folia Microbiol (Praha) 50:99-102. 2005
..Alginate and proteinase production was higher at pH 8; in contrast, siderophores (pyochelin and pyoverdin) were synthesized more intensively at pH 5...
- Benign esophageal stricture following aluminium phosphide poisoning
S Kapoor
Departments of Gastrointestinal Surgery, Bhopal Memorial Hospital and Research Center, Bhopal, India
Indian J Gastroenterol 24:261-2. 2005
..We report two cases of short-segment esophageal strictures that occurred following ingestion of exposed tablet of aluminium phosphide. Both cases could be successfully managed by endoscopic dilatation...
- Involving users in the design of a system for sharing lessons from adverse incidents in anaesthesia
S Sharma
Department of Anaesthesia, Blackburn Royal Infirmary, Infirmary Road, Blackburn, BB2 3LR, UK
Anaesthesia 61:350-4. 2006
..We suggest that large-scale reporting systems either incorporate such a function or allow other systems that permit such sharing to co-exist...
- Changes in immunolocalisation of beta-dystroglycan and specific degradative enzymes in the osteoarthritic synovium
S Wimsey
Department of Orthopaedic Surgery, Queen Alexandra Hospital, Portsmouth, UK
Osteoarthritis Cartilage 14:1181-8. 2006
....
- A glass foreign body in the knee joint mistaken for ACL avulsion: an unusual case
S Sharma
Rotherham General Hospital, South Yorkshire, UK
Knee Surg Sports Traumatol Arthrosc 15:766-8. 2007
..This case report highlights the fact that diagnosis of a foreign body in the knee joint can sometimes be challenging and almost impossible when there is no history of any injury and when the X-ray mimics ACL avulsion...
- Genetic structure and phylogeography of two freshwater fishes, Rhadinocentrus ornatus and Hypseleotris compressa, in southern Queensland, Australia, inferred from allozymes and mitochondrial DNA
S Sharma
Australian Rivers Institute, Griffith University, Nathan Campus, Queensland, 4111, Australia
J Fish Biol 78:57-77. 2011
..High levels of genetic differentiation were identified between all coastal streams in the area, including those hypothesized to have been recently connected in the Sunshine Coast area in the case of R. ornatus...
- Trend of complete hydatidiform mole
K Thapa
Paropakar Maternity and Women s Hospital, Thapathali, Kathmandu
JNMA J Nepal Med Assoc 49:10-3. 2010
..Complete Hydatidiform mole is one of the most frequent abnormal pregnancies. This review studies the trend of complete mole in Paropakar Maternity and Women's hospital and clinical ability to detect it...
- Conservative treatment of nonarticular fractures of distal third tibia
B K Pandey
Department of Orthopaedic Surgery, Kathmandu Medical College Teaching Hospital, Sinamangal, Kathmandu, Nepal
JNMA J Nepal Med Assoc 48:292-5. 2009
..None of these techniques can be considered the "gold standard" for these injuries. The purpose of this prospective study is to evaluate the results of conservative treatment of these fractures...
- Acute subdural haematoma in the presence of an intrathecal catheter placed for the prevention of post-dural puncture headache
S Sharma
Department of Anaesthesia, Westmead Hospital, Sydney, New South Wales, Australia
Anaesth Intensive Care 38:939-41. 2010
..An intrathecal catheter may not always prevent cerebrospinal fluid efflux, so subdural haematoma remains a potential complication of inadvertent dural puncture...
- An epidemiological study to identify the risk factors with two different types of controls in high-grade cervical lesions including invasive cancer
S Sardana
Division of Biostatistics and Epidemiology, Institute of Cytology and Preventive Oncology ICMR, Noida, India
Eur J Cancer Care (Engl) 18:620-4. 2009
..So it is concluded that in order to remove any bias, normal hospital controls or controls selected from multiple cancers should be taken to study the risk factors involved in cervical carcinogenesis...
- Effect of predominant methanogenic flora on outcome of lactose hydrogen breath test in controls and irritable bowel syndrome patients of north India
S V Rana
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India
Dig Dis Sci 54:1550-4. 2009
..49%) of IBS patients and in 29/154 (20.14%) in controls. PMP affected lactose hydrogen breath tests in 6.49-20.14% subjects. This effect is more apparent in apparently healthy subjects as compared to patients with IBS...
- Orocecal transit time in patients with celiac disease from North India: a case control study
S V Rana
Department of Gastroentrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Trop Gastroenterol 29:98-100. 2008
..Small bowel motor abnormalities may be involved in this pathological condition; however, there is no study addressing small bowel transit in patients of celiac disease from Northern India...
- Incidence of predominant methanogenic flora in irritable bowel syndrome patients and apparently healthy controls from North India
S V Rana
Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India
Dig Dis Sci 54:132-5. 2009
..However, the prevalence of methanogenic flora has not yet been reported in healthy and IBS patients from North India. Therefore, this study was planned...
- Cervical cancer screening in India: strategies revisited
A Juneja
National Institute of Medical Statistics ICMR, Ansari Nagar, New Delhi, India
Indian J Med Sci 61:34-47. 2007
..They all differ with regard to their test characteristics, feasibility and economic considerations. This communication reviews different aspects of these screening modalities and provides different options considering mass application...
- The trabecular meshwork in acute and chronic angle closure glaucoma
R Sihota
Dr Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, Ansari Nagar, New Delhi, India
Indian J Ophthalmol 49:255-9. 2001
..To determine the effect of acute and chronic primary angle closure glaucoma (PACG) on the trabecular meshwork...
- Detection of coronary artery disease by stress thallium scintigraphy in diabetic patients
R Kumar
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi
Nucl Med Commun 22:287-9. 2001
..5% and negative predictive value of 84.2% when compared with coronary angiography. The findings of this study suggest that stress thallium scintigraphy is a useful modality in screening of coronary artery disease in diabetic patients...
- Ectopic goiter masquerading as submandibular gland swelling: a case report and review of the literature
R Kumar
Department of Nuclear Medicine, All India Institute of Medical Sciences Campus, New Delhi
Clin Nucl Med 26:306-9. 2001
..The importance of being aware of the possibility of ectopic thyroid tissue as a submandibular region swelling has an important bearing on disease management. A pertinent review of the literature and its management is included...
- Percutaneous transluminal angioplasty of the aorta in children with nonspecific aortoarteritis: acute and follow-up results with special emphasis on left ventricular function
A Saxena
Cardiothoracic Centre, All India Institute of Medical Sciences, New Delhi, India
Catheter Cardiovasc Interv 49:419-24. 2000
..Small intimal flap is seen in the majority, extensive dissection is more likely in the long diffuse lesions in descending thoracic aorta. Hypertension and left ventricular dysfunction improve after relief of obstruction...
- Mitral valve surgery and maternal and fetal outcome in valvular heart disease
M Malhotra
Department of Obstetrics and Gynaecology and Biostatistics, Maulana Azad Medical College and Associated Lok Nayak Hospital, New Delhi, India
Int J Gynaecol Obstet 81:151-6. 2003
..To compare maternal and fetal outcomes in patients with non-operated valvular heart disease and patients who had surgery before or during pregnancy...
- Recurrent giant cell reparative granuloma of hard palate: role of Tc-99m-MDP three-phase bone scan
R Kumar
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India
Clin Imaging 24:143-5. 2000
..The three-phase bone scan helped in establishing the diagnosis of recurrence, which was confirmed after histological examination of the curettaged tissue...
- Non-ligation of the hernial sac during herniotomy: a prospective study
A Mohta
Pediatr Surg Int 19:451-2. 2003
..It was found that non-ligation has no untoward effect on early complications and recurrence rate on long-term follow-up. It is suggested that it is not necessary to ligate the hernial sac during herniotomy in children...
- Maternal and perinatal outcome in varying degrees of anemia
Monika Malhotra
Department of Obstetrics and Gynaecology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India
Int J Gynaecol Obstet 79:93-100. 2002
..To analyze the maternal and perinatal outcome in varying degrees of anemia...
- Utility of metabolic exercise testing in distinguishing hypertrophic cardiomyopathy from physiologic left ventricular hypertrophy in athletes
S Sharma
St George s Hospital Medical School, London, United Kingdom
J Am Coll Cardiol 36:864-70. 2000
..This study evaluated the role of metabolic (cardiopulmonary gas exchange) exercise testing in differentiating physiologic LVH in athletes from HCM...
- Radiopaque shadow in the lumbar region on plain X-ray abdomen: diagnostic dilemma
P N Dogra
Department of Urology, All India Institute of Medical Sciences, New Delhi, India
Int Urol Nephrol 34:485-7. 2002
..However, it was not possible to locate the lesion and an open exploration was done. During exploration a large fecolith was found trapped in a diverticulum of the cecum...
- Cancer cell adaptation to chemotherapy
Federica Di Nicolantonio
Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
BMC Cancer 5:78. 2005
..Studies of human tumors show that cells adapt to chemotherapy, but it has been largely assumed that clonal selection leads to the resistance of recurrent tumors...
- Athlete's heart--effect of age, sex, ethnicity and sporting discipline
Sanjay Sharma
University Hospital Lewisham, Lewisham High Street, London SE12 6LH, UK
Exp Physiol 88:665-9. 2003
..This review discusses the effects of age, sex, ethnicity and sporting discipline on cardiac dimensions in athletic individuals...
- Thymic cyst causing superior venacava syndrome relieved by mediastinoscopy--a rare presentation
Anand P Iyer
Department of Cardiothoracic Surgery, Fremantle Hospital, Alma Street, Fremantle, WA, Australia
Heart Lung Circ 17:510-2. 2008
..He underwent a mediastinoscopy, which showed a cyst. It was drained following which there was complete resolution of symptoms post-operatively. Histopathology of the lesion confirmed a thymic cyst...
- Images in clinical medicine. Chronic budd-Chiari syndrome and abdominal varices
Sanjay Sharma
All India Institute of Medical Sciences, New Delhi 110 029, India
N Engl J Med 357:e29. 2007
- Electrophysiological effects of intravitreal Avastin (bevacizumab) in the treatment of exudative age-related macular degeneration
R Karanjia
Department of Ophthalmology, Queen s University, Hotel Dieu Hospital, 166 Brock Street, Kingston, ON, Canada, K7L 5G2
Br J Ophthalmol 92:1248-52. 2008
..To examine the sensitivity of the multifocal electroretinogram (mf-ERG) at measuring changes in retinal electrical activity in response to Avastin (bevacizumab) treatment for age-related macular degeneration (ARMD)...
- Drug pricing for a novel treatment for wet macular degeneration: using incremental cost-effectiveness ratios to ensure societal value
Sanjay Sharma
Cost-Effective Ocular Health Policy Unit, Department of Ophthalmology and Community Health and Epidemiology, Queen's University, Hotel Dieu Hospital, Kingston, Ontario, Canada
Can J Ophthalmol 40:369-77. 2005
..INTERPRETATION: In theory, an anecortave cost of $2986/vial is associated with an ICER of $50,000/QALY, the threshold used by many health technology assessment and reimbursement agencies...
- Ophthaproblem. Prepapillary vascular loops
K Punja
Department of Ophthalmology, Queen's University, Kingston, Ont
Can Fam Physician 48:41, 50. 2002
- Quality of life amongst American vs. Canadian patients with retinal diseases
Davin Johnson
Department of Ophthalmology, Queen s University, Kingston, Ontario, Canada
Curr Opin Ophthalmol 21:227-32. 2010
..To compare health-related quality of life (HRQoL) in American vs. Canadian populations suffering from retinal diseases...
- Progression of visual loss and time between initial assessment and treatment of wet age-related macular degeneration
Alejandro Oliver-Fernandez
Department of Ophthalmology, Indiana University, Indianapolis, USA, and Cost-Effective Ocular Health Policy Unit, Queen's University, Hotel Dieu Hospital, Kingston, Ontario, Canada
Can J Ophthalmol 40:313-9. 2005
..INTERPRETATION: Delay in assessment and treatment of new-onset wet AMD by a retinal specialist is associated with a higher risk of visual loss...
- Acute-onset floaters and flashes: is this patient at risk for retinal detachment?
Hussein Hollands
Department of Ophthalmology, Queen s University, Kingston, ON, Canada
JAMA 302:2243-9. 2009
..A significant proportion of patients with acute PVD develop an associated retinal tear that can lead to retinal detachment and permanent vision loss if left untreated...
- Short-term intraocular pressure changes after intravitreal injection of bevacizumab
Hussein Hollands
Department of Ophthalmology, Queen s University, Hotel Dieu Hospital, Kingston, ON K7L 5S9
Can J Ophthalmol 42:807-11. 2007
..A prospective series of consecutive patients undergoing injection of intravitreal bevacizumab was investigated...
- Ophthaproblem. Orbital cellulitis
Khalid Hasanee
Queen's University, Kingston, Ont
Can Fam Physician 50:359, 365, 367. 2004
- Enteroendocrine localization of GLP-2 receptor expression in humans and rodents
B Yusta
Department of Medicine, Toronto General Hospital, Banting and Best Diabetes Centre, University of Toronto, Toronto, Ontario, Canada
Gastroenterology 119:744-55. 2000
..GLP-2 acts via binding to a single G protein-coupled GLP-2 receptor (GLP-2R), but the cellular targets for the diverse actions of GLP-2 remain unknown...
- Dabigatran versus warfarin in patients with atrial fibrillation
Stuart J Connolly
Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada
N Engl J Med 361:1139-51. 2009
..Warfarin reduces the risk of stroke in patients with atrial fibrillation but increases the risk of hemorrhage and is difficult to use. Dabigatran is a new oral direct thrombin inhibitor...
- Incidence and characteristics of acute intraocular inflammation after intravitreal injection of bevacizumab: a retrospective cohort study
Davin Johnson
Department of Ophthalmology, Queen s University, Kingston, Ont
Can J Ophthalmol 45:239-42. 2010
..To determine the incidence and characteristics of acute intraocular inflammation after intravitreal bevacizumab injections from a tertiary care retinal practice...
- Ophthaproblem. Retinopathy of prematurity
Clara Chan
Queen's University, Kingston, Ont
Can Fam Physician 49:1605-7. 2003
- Outcome results in macular hole surgery: an evaluation of internal limiting membrane peeling with and without indocyanine green
Tom G Sheidow
Department of Ophthalmology, University of Western Ontario, London, Ontario, Canada
Ophthalmology 110:1697-701. 2003
....
- The impact of diabetic retinopathy on health-related quality of life
Sanjay Sharma
Department of Ophthalmology, Queen's University, Kingston, Ontario, Canada
Curr Opin Ophthalmol 16:155-9. 2005
....
- Update on utilities and cost-utility analyses
Hussein Hollands
Cost-Effective Ocular Health Policy Unit, Queens University, Kingston, Ontario, Canada
Curr Opin Ophthalmol 17:223-7. 2006
..SUMMARY: Utilities are being used increasingly to measure health-related quality of life. Cost-utility analyses are becoming more readily available for comparing the incremental cost-effectiveness of different ophthalmic interventions...
- Ophthaproblem. Pseudopapilledema
Stephanie Baxter
Department of Ophthalmology at Queen's University, Kingston, Ont
Can Fam Physician 48:881, 889. 2002
- Ophthaproblem
Khalid Hasanee
Department of Ophthalmology at Queen's University, Kingston, Ont
Can Fam Physician 49:972, 977. 2003
- Ophthaproblem. Chloroquine or hydroxychloroquine retinopathy
Wei Liu
Department of Ophthalmology, Queen's University, Kingston, Ont
Can Fam Physician 51:671, 679-80. 2005
- Ophthaproblem. Pseudotumour cerebri
Khalid Hasanee
Department of Ophthalmology at Queen's University, Kingston, Ont
Can Fam Physician 49:580, 592. 2003
- Ophthaproblem. Ocular myasthenia gravis
Stephanie Baxter
Department of Ophthalmology, Queen's University, Kingston, Ont
Can Fam Physician 48:1771, 1776. 2002
- Pharmacologic management of neovascular age-related macular degeneration: systematic review of economic evidence and primary economic evaluation
William Hodge
Department of Ophthalmology, University of Western Ontario, London, Ont
Can J Ophthalmol 45:223-30. 2010
..To examine the economic implications for the Canadian health system of pharmacologic treatment of neovascular age-related macular degeneration (AMD)...
- Ophthaproblem. Retinal arteriovenous malformations (type 2)
Wei Liu
Department of Ophthalmology, Queen's University, Kingston, Ontario
Can Fam Physician 51:203, 209. 2005
- Ophthaproblem. Vitamin supplementation
Sanjay Sharma
Department of Ophthalmology, Department of Epidemiology, Queen's University, Kingston, Ont
Can Fam Physician 48:467, 477-8. 2002
- Quality of life associated with visual loss: a time tradeoff utility analysis comparison with medical health states
Melissa M Brown
The Center for Value Based Medicine, Flourtown, Pennsylvania 19031, USA
Ophthalmology 110:1076-81. 2003
..To assess the visual utility values of patients with ocular disease and to compare these values with those of patients with systemic health states..
- Physiological upper limits of left atrial diameter in highly trained adolescent athletes
Sandeep Basavarajaiah
J Am Coll Cardiol 47:2341-2; author reply 2342. 2006
- Quality of life with visual acuity loss from diabetic retinopathy and age-related macular degeneration
Melissa M Brown
Center for Evidence Based Health Care Economics, Suite 210, 1107 Bethlehem Pike, Flourtown, PA 19031, USA
Arch Ophthalmol 120:481-4. 2002
..To compare the quality of life in patients with visual acuity loss occurring secondary to diabetic retinopathy with visual acuity loss occurring secondary to age-related macular degeneration (ARMD)...
- CME review: A cost-utility analysis of laser photocoagulation for extrafoveal choroidal neovascularization
Brandon G Busbee
Center for Value-Based Medicine, and Department of Ophthalmology, Tufts New England Medical Center, USA
Retina 23:279-87; ; quiz 443-4. 2003
..CONCLUSION: Laser photocoagulation for extrafoveal choroidal neovascularization associated with age-related macular degeneration appears to be cost-effective when compared with interventions across multiple medical specialties...
- Ophthaproblem. Central retinal vein obstruction
Mark A Mandell
University of Toronto, Ontario
Can Fam Physician 51:1627, 1631-2. 2005
- The goal of value-based medicine analyses: comparability. The case for neovascular macular degeneration
Gary C Brown
Center for Value Based Medicine, Flourtown, Pennsylvania, USA
Trans Am Ophthalmol Soc 105:160-9; discussion 169-71. 2007
..To evaluate the comparability of articles in the peer-reviewed literature assessing the (1) patient value and (2) cost-utility (cost-effectiveness) associated with interventions for neovascular age-related macular degeneration (ARMD)...
- A value-based medicine comparison of interventions for subfoveal neovascular macular degeneration
Gary C Brown
Center for Value Based Medicine, Flourtown, Pennsylvania 19031, USA
Ophthalmology 114:1170-8. 2007
....
- Photodynamic therapy for juxtafoveal choroidal neovascularization due to ocular histoplasmosis syndrome
Gaurav K Shah
Barnes Retina Institute, St Louis, MO, 63144, USA
Retina 25:26-32. 2005
..To report the use of photodynamic therapy with verteporfin in patients with juxtafoveal choroidal neovascularization (CNV) for ocular histoplasmosis syndrome (OHS)...
- Visual outcomes and complications after multiple vitrectomies for diabetic vitreous hemorrhage
Blake Cooper
Barnes Retina Institute and Washington University School of Medicine, 1600 South Brentwood Boulevard 8th Floor, St. Louis, MO 63144, USA
Retina 24:19-22. 2004
..CONCLUSION: Multiple vitrectomies for recurrent diabetic vitreous hemorrhage can have a favorable anatomic outcome while maintaining ambulatory vision...
- The ex vivo characterization of XR5944 (MLN944) against a panel of human clinical tumor samples
Federica Di Nicolantonio
Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, United Kingdom
Mol Cancer Ther 3:1631-7. 2004
..These data support the rapid introduction of XR5944 to clinical trials and suggest that it may be effective against a broad spectrum of tumor types, especially ovarian and breast cancer...
- Impact of visual impairment on service and device use by individuals with age-related macular degeneration (AMD)
Jordana K Schmier
Exponent Inc, Alexandria, Virginia 22314, USA
Disabil Rehabil 28:1331-7. 2006
..To assess the patient-reported use of services, supplements, and devices among individuals with age-related macular degeneration (AMD) and evaluate the impact of visual impairment level on this use...
- Quality of life and systemic comorbidities in patients with ophthalmic disease
Melissa M Brown
Center for Evidence Based Health Care Economics, Flourtown, PA 19031, USA
Br J Ophthalmol 86:8-11. 2002
..To ascertain the effect of serious systemic comorbidities upon the quality of life of patients with ophthalmic diseases...
- Incremental cost-effectiveness of laser therapy for visual loss secondary to branch retinal vein occlusion
Gary C Brown
Center for Evidence Based Health Care Economics, Flourtown, PA 19031, USA
Ophthalmic Epidemiol 9:1-10. 2002
..To ascertain the incremental cost-effectiveness of therapeutic interventions for improving visual loss associated with branch retinal vein occlusion...
- Rapid up-regulation of cyclooxygenase-2 by 5-fluorouracil in human solid tumors
Stuart J Mercer
Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
Anticancer Drugs 16:495-500. 2005
..7-fold decrease, p<0.01). These data provide a molecular rationale for clinical trials of combination chemotherapy with COX-2 inhibitors...
- Surgical removal of peripapillary choroidal neovascularization associated with age-related macular degeneration
Kevin J Blinder
Barnes Retina Institute, Washington University School of Medicine, St Louis, Missouri, USA
Ophthalmic Surg Lasers Imaging 36:358-64. 2005
..CONCLUSION: In cases where photodynamic therapy and laser photocoagulation are not indicated, the surgical treatment of peripapillary choroidal neovascularization secondary to age-related macular degeneration may prove beneficial...
- Chemosensitization of solid tumors by modulation of resistance mechanisms
Ian A Cree
Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Cosham, Portsmouth, UK
Curr Opin Investig Drugs 3:634-40. 2002
..Oncologists should take account of potential resistance mechanisms when treating patients: it is often feasible to design combinations with old or new drugs which exploit these apparent weaknesses to the patient's advantage...
- Health insurance coverage and use of eye care services
Xinzhi Zhang
National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailbox K 10, Atlanta, GA 30341 3727, USA
Arch Ophthalmol 126:1121-6. 2008
..To compare realized access or use of eye care services in adults with self-reported vision problems in Canada and the United States...
- Intratumoral injection of GM-CSF in perspective - a review
Stephen Brooks
Department of Surgery, State University of New York at Buffalo and Kaleida Health, Buffalo, NY, USA
J Med 34:149-53. 2003
- Physiological upper limits of left ventricular dimensions in highly trained junior tennis players
Sandeep Basavarajaiah
University Hospital Lewisham, London, UK
Br J Sports Med 41:784-8. 2007
..Currently, there are few data relating to cardiac dimensions in junior elite tennis players. The aim of this study was to define the upper limits of left ventricular dimensions in a large cohort of national adolescent tennis players...
- Heterogeneity of chemosensitivity of colorectal adenocarcinoma determined by a modified ex vivo ATP-tumor chemosensitivity assay (ATP-TCA)
Pauline A Whitehouse
Translational Oncology Research Centre, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
Anticancer Drugs 14:369-75. 2003
..The degree of heterogeneity demonstrated from these results suggests that the ATP-TCA could be used to identify patients who might benefit from specific chemotherapeutic agents alone or in combination...
- Ethnic differences in left ventricular remodeling in highly-trained athletes relevance to differentiating physiologic left ventricular hypertrophy from hypertrophic cardiomyopathy
Sandeep Basavarajaiah
King s College Hospital, London, United Kingdom
J Am Coll Cardiol 51:2256-62. 2008
..The purpose of this study was to evaluate ethnic differences in left ventricular (LV) remodeling between highly-trained athletes of African/Afro-Caribbean (black) and Caucasian (white) athletes...
- Sudden cardiac death in young athletes
Sandeep Basavarajaiah
Department of Cardiology, University Hospital of Lewisham, Lewisham High Street, London, UK
Heart 93:287-9. 2007
..Most cases of sudden cardiac death in young athletes (<35 years) are caused by inherited cardiomyopathies, notably hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy...
- Impact of visual impairment on use of caregiving by individuals with age-related macular degeneration
Jordana K Schmier
Exponent Inc, Alexandria, VA, USA
Retina 26:1056-62. 2006
..To assess the patient-reported use of caregiving among individuals with age-related macular degeneration (AMD) and evaluate the impact of visual impairment level on this use...
- Visual outcomes and complications of epiretinal membrane removal secondary to rhegmatogenous retinal detachment
Matthew D Council
Washington University School of Medicine, St. Louis, Missouri, USA
Ophthalmology 112:1218-21. 2005
..Visual acuity can be improved in these patients by removal of the epiretinal membrane, with excellent results. In this series, recurrent membrane formation is not visually significant. Careful follow-up is needed to detect recurrent RD...
- The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours
Louise A Knight
Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth, UK
BMC Cancer 4:83. 2004
..Gefitinib ('Iressa') is an orally active tyrosine kinase inhibitor (TKI) targeted to the ATP-binding domain of EGFR (HER1; erbB1)...
- Cytokines and chemokines are expressed at different levels in small and large murine colon-26 tumors following intratumoral injections of CpG ODN
Sanjay Sharma
Department of Surgery, SUNY Buffalo and Kaleida Health, Buffalo General Hospital, Buffalo, NY 14203, USA
Neoplasia 6:523-8. 2004
..Similarly, several chemokines (CXCL1, CCL2, and CCL3) were also significantly higher in CpG ODN-treated small tumors compared to control ODN-treated tumors...
- Ophthaproblem. Charles Bonnet's syndrome
Jason Blair
Queen's University in Kingston, Ont
Can Fam Physician 50:1365, 1370-1. 2004
- Unrecognized left ventricular thrombus during reoperative coronary artery bypass grafting
Sanjay Sharma
Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
Ann Thorac Surg 78:e79-80. 2004
..He recovered and was discharged with no neurologic sequelae. Aggressive removal of clot using cardiopulmonary bypass is warranted even for the critically ill patient...
- Ex vivo reversal of chemoresistance by tariquidar (XR9576)
Federica Di Nicolantonio
Translational Oncology Research Centre, Department of Histopathology, Queen Alexandra Hospital, Portsmouth PO6 3LY, UK
Anticancer Drugs 15:861-9. 2004
..These data support the introduction of tariquidar in combination with chemotherapy to clinical trials of patients expressing P-gp...
- Aberrant expression, processing and degradation of dystroglycan in squamous cell carcinomas
Jie Jing
School of Pharmacy and Biomedical Sciences, Institute of Biomedical and Biomolecular Sciences, Molecular Medicine Group, University of Portsmouth, St. Michael's Building, White Swan Road, PO1 2DT, UK
Eur J Cancer 40:2143-51. 2004
..Considering the multifaceted role of DG in epithelial development, it appears that the role of DG degradation in cancer growth and spread, although currently poorly understood, may be important...
- Pars plana vitrectomy with internal limiting membranectomy for refractory diabetic macular edema without a taut posterior hyaloid
Brett J Rosenblatt
Department of Ophthalmology and Visual Sciences, Washington School of Medicine, St Louis, MO 63114, USA
Graefes Arch Clin Exp Ophthalmol 243:20-5. 2005
..Further investigations are warranted to define the role of surgery in the management of persistent diabetic macular edema...
- Cost-utility analysis of cataract surgery in the second eye
Brandon G Busbee
Center for Evidence Based Health Care Economics, Wills Eye Hospital, Jefferson Medical College, Philadelphia, Pennsylvania, USA
Ophthalmology 110:2310-7. 2003
..To perform a reference case cost-utility analysis of second-eye cataract surgery by using the current literature on cataract outcomes and complications...
- Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy: an independent marker of sudden death risk in young patients
Lorenzo Monserrat
Service of Cardiology, Juan Canalejo Hospital, , Spain
J Am Coll Cardiol 42:873-9. 2003
..A relation between the frequency, duration, and rate of NSVT episodes could not be demonstrated...
- Physiologic limits of left ventricular hypertrophy in elite junior athletes: relevance to differential diagnosis of athlete's heart and hypertrophic cardiomyopathy
Sanjay Sharma
Department of Cardiology, University Hospital Lewisham, London, United Kingdom
J Am Coll Cardiol 40:1431-6. 2002
..Hypertrophic cardiomyopathy should be considered strongly in any trained adolescent male athlete with LVWT >12 mm (females >11 mm) and nondilated left ventricle...
- Patient, community and clinician perceptions of the quality of life associated with diabetes mellitus
Jennifer Landy
Center for Evidence-Based Health Care Economics, Flourtown, PA, Retina Vascular Unit, Wills Eye Hospital, Jefferson Medical College, Philadelphia 19031, USA
Med Sci Monit 8:CR543-8. 2002
..We conclude that there is a significant difference in how clinicians, diabetics and the general public perceive the effect diabetes has upon quality of life...
- High accumulation of T regulatory cells prevents the activation of immune responses in aged animals
Sanjay Sharma
Sidney Kimmel Cancer Center, San Diego, CA 92121, USA
J Immunol 177:8348-55. 2006
....
- Current concepts in macular degeneration: introduction
Sanjay Sharma
Can J Ophthalmol 40:254-5. 2005
