A M Sharifi

Summary

Publications

  1. ncbi request reprint Study of high glucose-induced apoptosis in PC12 cells: role of bax protein
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    J Pharmacol Sci 104:258-62. 2007
  2. ncbi request reprint Study of correlation between lead-induced cytotoxicity and nitric oxide production in PC12 cells
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Toxicol Lett 160:43-8. 2005
  3. ncbi request reprint Investigation of acute lead poisoning on apoptosis in rat hippocampus in vivo
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Neurosci Lett 329:45-8. 2002
  4. doi request reprint Studying the effect of LPS on cytotoxicity and apoptosis in PC12 neuronal cells: role of Bax, Bcl-2, and Caspase-3 protein expression
    Ali M Sharifi
    Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran
    Toxicol Mech Methods 20:316-20. 2010
  5. ncbi request reprint Isolation, culture, characterization and optimization of human corneal stem cells
    Ali M Sharifi
    Razi Institute for Drug Research, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
    Biocell 34:53-5. 2010
  6. doi request reprint Effect of chronic lead exposure on pro-apoptotic Bax and anti-apoptotic Bcl-2 protein expression in rat hippocampus in vivo
    Ali M Sharifi
    Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
    Cell Mol Neurobiol 30:769-74. 2010
  7. doi request reprint Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Neurosci Lett 459:47-51. 2009
  8. ncbi request reprint Effect of short term treatment of L-carnitine on tissue ACE activity in streptozotocin-induced diabetic rats
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Pathophysiology 16:53-6. 2009
  9. doi request reprint Effect of caloric restriction on nitric oxide production, ACE activity, and blood pressure regulation in rats
    A M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Acta Physiol Hung 95:55-63. 2008
  10. ncbi request reprint Investigation of local ACE activity and structural alterations during development of L-NAME-induced hypertension
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Pharmacol Res 52:438-44. 2005

Detail Information

Publications17

  1. ncbi request reprint Study of high glucose-induced apoptosis in PC12 cells: role of bax protein
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    J Pharmacol Sci 104:258-62. 2007
    ..From our present results, it may be concluded that high glucose can cause PC12 cell death, in which apoptosis plays an important role possibly by the mitochondrial pathway through higher expression of Bax pro-apoptotic protein...
  2. ncbi request reprint Study of correlation between lead-induced cytotoxicity and nitric oxide production in PC12 cells
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Toxicol Lett 160:43-8. 2005
    ..L-NAME, a NOS inhibitor, treatment (2.5 mM) could reverse this cytotoxicity. It can be concluded that lead-induced cytotoxicity in PC12 cells could partly be mediated by higher NO production...
  3. ncbi request reprint Investigation of acute lead poisoning on apoptosis in rat hippocampus in vivo
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Neurosci Lett 329:45-8. 2002
    ..In Western blot analysis, the ratio of Bax/Bcl-2 protein expression in hippocampus was significantly increased compared to controls. In conclusion, the lead induced cell death in hippocampus in vivo may partly be due to apoptosis...
  4. doi request reprint Studying the effect of LPS on cytotoxicity and apoptosis in PC12 neuronal cells: role of Bax, Bcl-2, and Caspase-3 protein expression
    Ali M Sharifi
    Razi Institute for Drug Research, Iran University of Medical Sciences, Tehran, Iran
    Toxicol Mech Methods 20:316-20. 2010
    ..From the present results, it might be concluded that LPS can cause PC12 cell death, in which apoptosis plays an important role, possibly by the mitochondrial pathway through higher expression of the Bax as well as caspase 3 protein...
  5. ncbi request reprint Isolation, culture, characterization and optimization of human corneal stem cells
    Ali M Sharifi
    Razi Institute for Drug Research, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
    Biocell 34:53-5. 2010
    ..The results showed that limbal stem cells proliferate more easily and reach to full confluency in a shorter time if the medium is supplemented with hEGF rather than with mEGF...
  6. doi request reprint Effect of chronic lead exposure on pro-apoptotic Bax and anti-apoptotic Bcl-2 protein expression in rat hippocampus in vivo
    Ali M Sharifi
    Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
    Cell Mol Neurobiol 30:769-74. 2010
    ..In conclusion, these data suggest that neurotoxicity of chronic lead exposure in hippocampus in vivo may partly be due to facilitation of apoptosis...
  7. doi request reprint Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Neurosci Lett 459:47-51. 2009
    ..Based on the current data, it could be concluded that high glucose-induced apoptosis in PC12 cells is mediated, in part, by activation of caspase-8, -9, and -3 dependent pathways...
  8. ncbi request reprint Effect of short term treatment of L-carnitine on tissue ACE activity in streptozotocin-induced diabetic rats
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Pathophysiology 16:53-6. 2009
    ..In conclusion, L-carnitine can reduce tissue ACE activity in aorta, heart and kidney in streptozotocin diabetic rats, which may be due to higher NO production...
  9. doi request reprint Effect of caloric restriction on nitric oxide production, ACE activity, and blood pressure regulation in rats
    A M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Acta Physiol Hung 95:55-63. 2008
    ..The serum NOx was significantly increased compared to the C group. The serum ACE activity was lower in the CR group. Therefore, it may be concluded that CR could reduce blood pressure by elevating NO production and lowering ACE activity...
  10. ncbi request reprint Investigation of local ACE activity and structural alterations during development of L-NAME-induced hypertension
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Pharmacol Res 52:438-44. 2005
    ..These observations highlight the importance of the local ACE particularly in organs regulating hypertension (aorta and heart) during development of L-NAME-induced hypertension...
  11. ncbi request reprint Investigation of circulatory and tissue ACE activity during development of lead-induced hypertension
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183 Tehran, Iran
    Toxicol Lett 153:233-8. 2004
    ..These results emphasize the etiological role of ACE activity in the early phase of lead-induced hypertension...
  12. ncbi request reprint Study of interaction between nitric oxide and ACE activity in STZ-induced diabetic rats: role of insulin
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Pharmacol Res 50:261-6. 2004
    ..It is concluded that ACE reducing activity of insulin in aorta and heart of STZ-induced diabetic rats may be mediated by elevation of NO by insulin treatment...
  13. ncbi request reprint Study of correlation between elevation of blood pressure and tissue ACE activity during development of hypertension in 1K1C rats
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, Iran University of Medical Sciences, P O Box 141555 6183, Tehran, Iran
    Vascul Pharmacol 41:15-20. 2004
    ....
  14. ncbi request reprint Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity
    Ali M Sharifi
    Department of Pharmacology, Razi Institute for Drug Research and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, PO Box 14155 6183 Tehran, Iran
    Life Sci 73:2963-71. 2003
    ..These results indicated that there is a negative correlation between consumption of tribulus and ACE activity in serum and different tissues in 2K1C rats...
  15. ncbi request reprint Investigation of antihypertensive mechanism of garlic in 2K1C hypertensive rat
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    J Ethnopharmacol 86:219-24. 2003
    ....
  16. ncbi request reprint Alteration of local ACE activity and vascular responsiveness during development of 2K1C renovascular hypertension
    Ali M Sharifi
    Department of Pharmacology and Cellular and Molecular Research Center, School of Medicine, Iran University of Medical Sciences, P O Box 14155 6183, Tehran, Iran
    Pharmacol Res 47:201-9. 2003
    ..This study sought to examine the correlation between development of hypertension and local, including; aorta, heart, kidney, lung, as well as circulatory (serum) ACE activity in two kidney one clip (2K1C) renovascular hypertension...
  17. doi request reprint Investigating the effect of lead acetate on rat bone marrow-derived mesenchymal stem cells toxicity: role of apoptosis
    Ali M Sharifi
    Razi Institute for Drug Research, Tehran University of Medical Sciences, Tehran, Iran
    Toxicol Mech Methods 21:225-30. 2011
    ....