Scott B Shappell

Summary

Publications

  1. ncbi request reprint Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee
    Scott B Shappell
    Department of Pathology and Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37210, USA
    Cancer Res 64:2270-305. 2004
  2. ncbi request reprint Expression and role of Foxa proteins in prostate cancer
    Janni Mirosevich
    Vanderbilt Prostate Cancer Center, AA 1302 Medical Center North, Nashville, Tennessee 37232 2765, USA
    Prostate 66:1013-28. 2006
  3. pmc Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer
    Harold D Love
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 4:e8384. 2009
  4. ncbi request reprint NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice
    Ren Jie Jin
    Department of Urologic Surgery, Vanderbilt University Medical Center, A 1302 Medical Center North, Nashville, TN 37232 2765, USA
    Cancer Res 64:5489-95. 2004
  5. ncbi request reprint An allograft model of androgen independent prostatic neuroendocrine carcinoma derived from a large probasin promoter-T antigen transgenic mouse line
    Naoya Masumori
    Department of Urologic Survey, Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Urol 171:439-42. 2004
  6. ncbi request reprint Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation
    Nan Gao
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA
    Development 132:3431-43. 2005
  7. ncbi request reprint Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer
    Bradford A Nelson
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
    BJU Int 97:1169-72. 2006
  8. ncbi request reprint Adverse prognostic significance of capsular incision with radical retropubic prostatectomy
    Matthew D Shuford
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Urol 172:119-23. 2004
  9. ncbi request reprint Use of tissue recombination to predict phenotypes of transgenic mouse models of prostate carcinoma
    Kenichiro Ishii
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
    Lab Invest 85:1086-103. 2005
  10. ncbi request reprint 15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation
    Adriana L Gonzalez
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Hum Pathol 35:840-9. 2004

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology Committee
    Scott B Shappell
    Department of Pathology and Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37210, USA
    Cancer Res 64:2270-305. 2004
    ....
  2. ncbi request reprint Expression and role of Foxa proteins in prostate cancer
    Janni Mirosevich
    Vanderbilt Prostate Cancer Center, AA 1302 Medical Center North, Nashville, Tennessee 37232 2765, USA
    Prostate 66:1013-28. 2006
    ..In particular, Foxa2 may be involved in progression of prostate cancer to androgen independence. As such, Foxa proteins may represent novel targets for therapeutic intervention...
  3. pmc Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer
    Harold D Love
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    PLoS ONE 4:e8384. 2009
    ..Our results demonstrate the feasibility, and some of the problems, of using a mouse xenograft model to characterize the androgen regulated expression profiles of intact human prostate tissues...
  4. ncbi request reprint NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice
    Ren Jie Jin
    Department of Urologic Surgery, Vanderbilt University Medical Center, A 1302 Medical Center North, Nashville, TN 37232 2765, USA
    Cancer Res 64:5489-95. 2004
    ....
  5. ncbi request reprint An allograft model of androgen independent prostatic neuroendocrine carcinoma derived from a large probasin promoter-T antigen transgenic mouse line
    Naoya Masumori
    Department of Urologic Survey, Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Urol 171:439-42. 2004
    ..Animal models that mimic this hormone refractory prostate cancer may be useful for developing and testing novel treatment strategies...
  6. ncbi request reprint Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation
    Nan Gao
    Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA
    Development 132:3431-43. 2005
    ..These data indicate that Foxa1 plays a pivotal role in controlling prostate morphogenesis and cell differentiation...
  7. ncbi request reprint Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer
    Bradford A Nelson
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
    BJU Int 97:1169-72. 2006
    ..In a large series of patients they found that residual tumour after initial resection was commoner than might be expected, and that the second resection indicated the way to earlier radical treatment and a better prognosis...
  8. ncbi request reprint Adverse prognostic significance of capsular incision with radical retropubic prostatectomy
    Matthew D Shuford
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Urol 172:119-23. 2004
    ..The prognostic significance of capsular incision (CPI) at radical retropubic prostatectomy remains to be defined. To evaluate this we compared prostate specific antigen recurrence for with CPI to that with established pathological groups...
  9. ncbi request reprint Use of tissue recombination to predict phenotypes of transgenic mouse models of prostate carcinoma
    Kenichiro Ishii
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
    Lab Invest 85:1086-103. 2005
    ..This comparison of tissue recombination to existing models shows that this approach can elicit new information on well-characterized models...
  10. ncbi request reprint 15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation
    Adriana L Gonzalez
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Hum Pathol 35:840-9. 2004
    ..0001). These findings suggest a possible role of 15-LOX-2 in regulating secretory differentiation and proliferation in benign lung and NSCLCs, particularly adenocarcinomas...
  11. pmc The loss of TGF-beta signaling promotes prostate cancer metastasis
    William H Tu
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Neoplasia 5:267-77. 2003
    ..Our study demonstrates for the first time that a disruption of TGF-beta signaling in prostate cancer plays a causal role in promoting tumor metastasis...
  12. ncbi request reprint Significance of atypical and suspicious small acinar proliferations, and high grade prostatic intraepithelial neoplasia on prostate biopsy: implications for cancer detection and biopsy strategy
    Christopher R Girasole
    OUR Lab and Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Urol 175:929-33; discussion 933. 2006
    ..Subsequent CaP findings on repeat biopsy with relevant clinical implications were assessed...
  13. ncbi request reprint Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma
    Scott B Shappell
    Department of Pathology, Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
    Cancer Res 63:2256-67. 2003
    ....
  14. ncbi request reprint The free/total prostate-specific antigen ratio (%fPSA) is the best predictor of tumor involvement in the radical prostatectomy specimen among men with an elevated PSA
    David J Grossklaus
    Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Urol Oncol 7:195-8. 2002
    ..We evaluated the use of %fPSA to predict CaP pathology including percent of tumor involvement in the radical prostatectomy (RP) specimen...
  15. ncbi request reprint Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: implications for possible apical sparing surgery
    Monica P Revelo
    Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Urol 171:646-51. 2004
    ..In this study the pathological features of Pca and Uca, and the frequency of apical involvement were investigated in prostates from cystoprostatectomy specimens...
  16. ncbi request reprint Bioluminescence imaging of vascular endothelial growth factor promoter activity in murine mammary tumorigenesis
    Shannon L Faley
    Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
    Mol Imaging 6:331-9. 2007
    ..The model should facilitate understanding of the molecular controls and pathways that regulate VEGF transcription in vivo...
  17. ncbi request reprint Detection and subcellular localization of two 15S-lipoxygenases in human cornea
    Min S Chang
    Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 8000 MCE, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Invest Ophthalmol Vis Sci 46:849-56. 2005
    ..The presence of both 15-LOXs in the human cornea prompted this study to delineate their roles in the human corneal epithelium...
  18. ncbi request reprint Transgenic mouse models for prostate cancer. Identification of an androgen-dependent promoter and creation and characterization of the long probasin promoter-Large T antigen (LPB-Tag) model
    Susan Kasper
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
    Methods Mol Med 81:113-47. 2003
  19. doi request reprint Comparative analysis of whole mount processing and systematic sampling of radical prostatectomy specimens: pathological outcomes and risk of biochemical recurrence
    Shady Salem
    Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37205, USA
    J Urol 184:1334-40. 2010
    ..We compared whole mount and systematic sampling for detecting pathological outcomes, and compared the prognostic value of pathological findings across pathological methods...
  20. ncbi request reprint Approaches to understanding the importance and clinical implications of peroxisome proliferator-activated receptor gamma (PPARgamma) signaling in prostate cancer
    Ming Jiang
    Vanderbilt Prostate Cancer Center, Department of Urologic Surgery, Vanderbilt Ingram Comprehensive Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Cell Biochem 91:513-27. 2004
    ..In particular, it seems reasonable to suggest that the patients most likely to benefit may be those with relatively indolent low stage disease for whom this line of therapy could be a useful additive to watchful waiting...
  21. ncbi request reprint Pathological parameters of radical prostatectomy for clinical stages T1c versus T2 prostate adenocarcinoma: decreased pathological stage and increased detection of transition zone tumors
    Gregory S Jack
    Department of Pathology, Vanderbilt Prostate Cancer Center and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Urol 168:519-24. 2002
    ..The percent of stage T1c disease represented a stable majority of patients undergoing treatment for clinically localized prostate cancer...
  22. ncbi request reprint Percent of cancer in the biopsy set predicts pathological findings after prostatectomy
    David J Grossklaus
    Department of Urologic Surgery and Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    J Urol 167:2032-5; discussion 2036. 2002
    ....
  23. pmc Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model
    Uddhav P Kelavkar
    Department of Urology and Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
    Neoplasia 8:510-22. 2006
    ..The FLiMP mouse model should also be useful in crosses with other GEM models to further define the combinations of molecular alterations necessary for PCa progression...
  24. pmc Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice
    Uddhav P Kelavkar
    Department of Urology, University of Pittsburgh and Cancer Institute UPCI, Pittsburgh, PA 15232, USA
    Neoplasia 6:821-30. 2004
    ..In addition, the TRAMP model will serve as a tool for testing the suitability of 12/15-LO-and ultimately human 15-LO--as a therapeutic target during PCa progression...
  25. ncbi request reprint Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells
    Yue Xu
    Department of Urology, Stanford University School of Medicine, Stanford, California, USA
    J Cell Physiol 196:131-43. 2003
    ....
  26. ncbi request reprint Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants
    Bobby Bhatia
    Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
    J Biol Chem 278:25091-100. 2003
    ..Together, these results suggest that both 15-LOX2 and 15-LOX2sv-b suppress prostate tumor development, and the tumor-suppressive functions apparently do not necessarily depend on AA-metabolizing activity and nuclear localization...
  27. ncbi request reprint Development and characterization of efficient xenograft models for benign and malignant human prostate tissue
    Yuzhuo Wang
    Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, Canada
    Prostate 64:149-59. 2005
    ..Furthermore, xenografts could only be established using high-grade, advanced stage, but not low- or moderate-grade prostate cancer tissues...