Prostate pathology of genetically engineered mice: definitions and classification. The consensus report from the Bar Harbor meeting of the Mouse Models of Human Cancer Consortium Prostate Pathology CommitteeScott B Shappell
Department of Pathology and Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37210, USA
Cancer Res 64:2270-305. 2004
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- Expression and role of Foxa proteins in prostate cancer
Janni Mirosevich
Vanderbilt Prostate Cancer Center, AA 1302 Medical Center North, Nashville, Tennessee 37232 2765, USA
Prostate 66:1013-28. 2006
..In particular, Foxa2 may be involved in progression of prostate cancer to androgen independence. As such, Foxa proteins may represent novel targets for therapeutic intervention...
Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancerHarold D Love
Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
PLoS ONE 4:e8384. 2009
..Our results demonstrate the feasibility, and some of the problems, of using a mouse xenograft model to characterize the androgen regulated expression profiles of intact human prostate tissues...
- NE-10 neuroendocrine cancer promotes the LNCaP xenograft growth in castrated mice
Ren Jie Jin
Department of Urologic Surgery, Vanderbilt University Medical Center, A-1302 Medical Center North, Nashville, TN 37232-2765, USA
Cancer Res 64:5489-95. 2004
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- An allograft model of androgen independent prostatic neuroendocrine carcinoma derived from a large probasin promoter-T antigen transgenic mouse line
Naoya Masumori
Department of Urologic Survey, Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Urol 171:439-42. 2004
..CONCLUSIONS: This allograft model may give insight into the mechanism by which human prostate cancer progresses to an androgen independent state and provide a system for testing drugs that can inhibit this disease...
- Forkhead box A1 regulates prostate ductal morphogenesis and promotes epithelial cell maturation
Nan Gao
Department of Cell and Developmental Biology, Vanderbilt University, Nashville, TN 37232, USA
Development 132:3431-43. 2005
..These data indicate that Foxa1 plays a pivotal role in controlling prostate morphogenesis and cell differentiation...
- Tumour volume is an independent predictor of prostate-specific antigen recurrence in patients undergoing radical prostatectomy for clinically localized prostate cancer
Bradford A Nelson
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232 2765, USA
BJU Int 97:1169-72. 2006
..In a large series of patients they found that residual tumour after initial resection was commoner than might be expected, and that the second resection indicated the way to earlier radical treatment and a better prognosis...
- Adverse prognostic significance of capsular incision with radical retropubic prostatectomy
Matthew D Shuford
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Urol 172:119-23. 2004
..However, the prognostic significance of CPI as defined appears similar to that of pT3a with positive margins...
- Use of tissue recombination to predict phenotypes of transgenic mouse models of prostate carcinoma
Kenichiro Ishii
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232-2765, USA
Lab Invest 85:1086-103. 2005
..This comparison of tissue recombination to existing models shows that this approach can elicit new information on well-characterized models...
- 15-Lipoxygenase-2 expression in benign and neoplastic lung: an immunohistochemical study and correlation with tumor grade and proliferation
Adriana L Gonzalez
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232-2561, USA
Hum Pathol 35:840-9. 2004
..0001). These findings suggest a possible role of 15-LOX-2 in regulating secretory differentiation and proliferation in benign lung and NSCLCs, particularly adenocarcinomas...
- The loss of TGF-beta signaling promotes prostate cancer metastasis
William H Tu
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Neoplasia 5:267-77. 2003
..Our study demonstrates for the first time that a disruption of TGF-beta signaling in prostate cancer plays a causal role in promoting tumor metastasis...
- Significance of atypical and suspicious small acinar proliferations, and high grade prostatic intraepithelial neoplasia on prostate biopsy: implications for cancer detection and biopsy strategy
Christopher R Girasole
OUR Lab and Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Urol 175:929-33; discussion 933. 2006
..Repeat biopsy may be indicated in any patient with HGPIN, or atypical or suspicious lesions and this biopsy should not be limited to the site or side of the original pathological findings...
- Elevated expression of 12/15-lipoxygenase and cyclooxygenase-2 in a transgenic mouse model of prostate carcinoma
Scott B Shappell
Department of Pathology, Vanderbilt Prostate Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2561, USA
Cancer Res 63:2256-67. 2003
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- The free/total prostate-specific antigen ratio (%fPSA) is the best predictor of tumor involvement in the radical prostatectomy specimen among men with an elevated PSA
David J Grossklaus
Department of Urologic Surgery, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
Urol Oncol 7:195-8. 2002
..We evaluated the use of %fPSA to predict CaP pathology including percent of tumor involvement in the radical prostatectomy (RP) specimen...
- Incidence and location of prostate and urothelial carcinoma in prostates from cystoprostatectomies: implications for possible apical sparing surgery
Monica P Revelo
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Urol 171:646-51. 2004
..The impact on functional outcomes and cancer control also require additional study...
- Bioluminescence imaging of vascular endothelial growth factor promoter activity in murine mammary tumorigenesis
Shannon L Faley
Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA
Mol Imaging 6:331-9. 2007
..The model should facilitate understanding of the molecular controls and pathways that regulate VEGF transcription in vivo...
- Detection and subcellular localization of two 15S-lipoxygenases in human cornea
Min S Chang
Department of Ophthalmology and Visual Sciences, Vanderbilt Eye Institute, 8000 MCE, Vanderbilt University Medical Center, Nashville, TN 37232, USA
Invest Ophthalmol Vis Sci 46:849-56. 2005
..The presence of both 15-LOXs in the human cornea prompted this study to delineate their roles in the human corneal epithelium...
- Transgenic mouse models for prostate cancer. Identification of an androgen-dependent promoter and creation and characterization of the long probasin promoter-Large T antigen (LPB-Tag) model
Susan Kasper
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA
Methods Mol Med 81:113-47. 2003
Comparative analysis of whole mount processing and systematic sampling of radical prostatectomy specimens: pathological outcomes and risk of biochemical recurrenceShady Salem
Department of Urologic Surgery, Vanderbilt University Medical Center, Nashville, Tennessee 37205, USA
J Urol 184:1334-40. 2010
..We compared whole mount and systematic sampling for detecting pathological outcomes, and compared the prognostic value of pathological findings across pathological methods...
- Approaches to understanding the importance and clinical implications of peroxisome proliferator-activated receptor gamma (PPARgamma) signaling in prostate cancer
Ming Jiang
Vanderbilt Prostate Cancer Center, Department of Urologic Surgery, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Cell Biochem 91:513-27. 2004
..In particular, it seems reasonable to suggest that the patients most likely to benefit may be those with relatively indolent low stage disease for whom this line of therapy could be a useful additive to watchful waiting...
- Pathological parameters of radical prostatectomy for clinical stages T1c versus T2 prostate adenocarcinoma: decreased pathological stage and increased detection of transition zone tumors
Gregory S Jack
Department of Pathology, Vanderbilt Prostate Cancer Center and Vanderbilt Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
J Urol 168:519-24. 2002
..If such transition zone tumors prove to be biologically distinct, improved strategies to identify these lesions preoperatively may result in more conservative treatment recommendations...
- Percent of cancer in the biopsy set predicts pathological findings after prostatectomy
David J Grossklaus
Department of Urologic Surgery and Pathology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
J Urol 167:2032-5; discussion 2036. 2002
..This finding adds additional credence to the inclusion of percent of tumor in the biopsy set in models for the preoperative prediction of pathological stage and should be factored into discussions with patients on treatment options...
- Conditional expression of human 15-lipoxygenase-1 in mouse prostate induces prostatic intraepithelial neoplasia: the FLiMP mouse model
Uddhav P Kelavkar
Department of Urology and Cancer Institute, University of Pittsburgh, Pittsburgh, PA, USA
Neoplasia 8:510-22. 2006
..The FLiMP mouse model should also be useful in crosses with other GEM models to further define the combinations of molecular alterations necessary for PCa progression...
- Overexpression of 12/15-lipoxygenase, an ortholog of human 15-lipoxygenase-1, in the prostate tumors of TRAMP mice
Uddhav P Kelavkar
Department of Urology, University of Pittsburgh and Cancer Institute UPCI, Pittsburgh, PA 15232, USA
Neoplasia 6:821-30. 2004
..In addition, the TRAMP model will serve as a tool for testing the suitability of 12/15-LO-and ultimately human 15-LO--as a therapeutic target during PCa progression...
- Primary culture model of peroxisome proliferator-activated receptor gamma activity in prostate cancer cells
Yue Xu
Department of Urology, Stanford University School of Medicine, Stanford, California, USA
J Cell Physiol 196:131-43. 2003
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- Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants
Bobby Bhatia
Department of Carcinogenesis, The University of Texas M D Anderson Cancer Center, Science Park Research Division, Smithville 78957, USA
J Biol Chem 278:25091-100. 2003
..Together, these results suggest that both 15-LOX2 and 15-LOX2sv-b suppress prostate tumor development, and the tumor-suppressive functions apparently do not necessarily depend on AA-metabolizing activity and nuclear localization...
- Development and characterization of efficient xenograft models for benign and malignant human prostate tissue
Yuzhuo Wang
Department of Cancer Endocrinology, BC Cancer Agency, Vancouver, Canada
Prostate 64:149-59. 2005
..CONCLUSIONS: These data suggest that sub-renal capsule and orthotopic grafting of human prostate tissue can be used for many basic scientific and translational studies...
