Karuna SHanker

Summary

Affiliation: CSIR-Central Institute of Medicinal and Aromatic Plants
Location: Lucknow, India
URL: http://staff.cimap.res.in/show.aspx?empid=57

Publications

  1. ncbi request reprint Uptake and translocation of selenium by maize (Zea mays) from its environmentaly important forms
    K Shanker
    Central Research Institute Ay, Lucknow, UP, India
    J Environ Biol 22:225-8. 2001
  2. pmc Wound induced tanscriptional regulation of benzylisoquinoline pathway and characterization of wound inducible PsWRKY transcription factor from Papaver somniferum
    Sonal Mishra
    Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CSIR CIMAP, Lucknow, India
    PLoS ONE 8:e52784. 2013
  3. ncbi request reprint Liquiritigenin derivatives and their hepatotoprotective activity
    Rashmi Gaur
    Central Institute of Medicinal and Aromatic Plants, P O CIMAP, Lucknow 226015, India
    Nat Prod Commun 5:1243-6. 2010
  4. doi request reprint Influence of Moringa oleifera on pharmacokinetic disposition of rifampicin using HPLC-PDA method: a pre-clinical study
    Anirban Pal
    Division of Molecular Bioprospection, Central Institute of Medicinal and Aromatic Plants, CSIR, Lucknow, India
    Biomed Chromatogr 25:641-5. 2011
  5. doi request reprint Simultaneous determination of three steroidal glycoalkaloids in Solanum xanthocarpum by high performance thin layer chromatography
    Karuna Shanker
    Analytical Chemistry Department, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow 226015, India
    J Pharm Biomed Anal 54:497-502. 2011
  6. doi request reprint Genetic and chemical diversity of high mucilaginous plants of Sida complex by ISSR markers and chemical fingerprinting
    Sanjog T Thul
    Plant Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, Lucknow, 226016, UP, India
    Mol Biotechnol 49:77-81. 2011
  7. doi request reprint 1-Chloro-2-formyl indenes and tetralenes as antitubercular agents
    Debabrata Chanda
    Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, PO CIMAP, Kukrail, Picnic Spot Road, Lucknow 226015, UP, India
    Bioorg Med Chem Lett 21:3966-9. 2011
  8. doi request reprint A simple and convenient synthesis of 2-methoxyestradiol from estrone
    A P Prakasham
    Chemical Sciences Division, Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, P O CIMAP, Kukrail Picnic Spot Road, Lucknow, 226015 UP, India
    Steroids 77:467-70. 2012
  9. doi request reprint HILIC quantification of oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages
    Rashmi Singh
    Analytical Chemistry Department, Central Institute of Medicinal and Aromatic Plants CSIR CIMAP, Lucknow, India
    J Ethnopharmacol 141:357-62. 2012
  10. doi request reprint HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: a study of organic/green solvent and continuous/pulse sonication
    Shikha Gupta
    Analytical Chemistry Department, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research CSIR, Lucknow 226015, India
    J Pharm Biomed Anal 66:33-9. 2012

Collaborators

  • J K Kumar
  • Anirban Pal
  • M M Gupta
  • Sanjog T Thul
  • Dinesh Kumar Agrawal
  • Shalini Gupta
  • Sunil Kumar
  • Chandan S Chanotiya
  • Suaib Luqman
  • Anila Dwivedi
  • Suchitra Banerjee
  • Arvind S Negi
  • Debabrata Chanda
  • Pooja Srivastava
  • Suman P S Khanuja
  • Priyanka Verma
  • A P Prakasham
  • Priyanka Trivedi
  • Dharmendra Saikia
  • Neerja Tiwari
  • Vandana Srivastava
  • Atul Gupta
  • Dnyaneshwar Umrao Bawankule
  • Arvind Singh Negi
  • Atiya Fatima
  • Manju Singh
  • Uzma Faridi
  • Vivek K Gupta
  • Ram K Verma
  • Anil K Gupta
  • M P Darokar
  • Hari Om Saxena
  • Sonal Mishra
  • Ajay K Mathur
  • Swati Parihar
  • Rashmi Singh
  • Jyoti Agarwal
  • Jay Prakash Thakur
  • Rashmi Gaur
  • Pragya Singh
  • Sailendra Singh
  • Suchita Srivastava
  • Narayan P Yadav
  • Akhilesh K Yadav
  • S P S Khanuja
  • Nusrat Masood
  • Rakesh Kumar Shukla
  • Seema Singh
  • Vineeta Triptahi
  • Ujjal J Phukan
  • Amit K Chaturvedi
  • F Khan
  • Santosh K Guru
  • Z A Wani
  • B A Rah
  • Bendangla Changkija
  • A K Saxena
  • Shashi Bhushan
  • Murli Manohar
  • Dilip M Mondhe
  • Ateeque Ahmad
  • D K Yadav
  • Rituraj Konwar
  • Tandeep Kaur
  • Mahender Pandurang Darokar
  • Rajendra Singh Bhakuni
  • Dayanandan Mani
  • Mahendra Pandurang Darokar
  • Anil Kumar Gupta
  • Ram Kishore Verma
  • Vijendra Kumar
  • Dyaneshwar U Bawankule
  • Neha Rahuja
  • Brijesh S Sisodia
  • Richa Malasoni
  • Mahendra P Darokar

Detail Information

Publications32

  1. ncbi request reprint Uptake and translocation of selenium by maize (Zea mays) from its environmentaly important forms
    K Shanker
    Central Research Institute Ay, Lucknow, UP, India
    J Environ Biol 22:225-8. 2001
    ..Selenium does not cause any adverse effect on the maize plants (dry matter yield vs concentration, no significant correlation, p>0.05)...
  2. pmc Wound induced tanscriptional regulation of benzylisoquinoline pathway and characterization of wound inducible PsWRKY transcription factor from Papaver somniferum
    Sonal Mishra
    Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CSIR CIMAP, Lucknow, India
    PLoS ONE 8:e52784. 2013
    ..Preferential expression of PsWRKY in straw and capsule and its interaction with consensus W-box element present in BIAs pathway gene transcripts suggest its possible involvement in the wound induced regulation of BIAs pathway...
  3. ncbi request reprint Liquiritigenin derivatives and their hepatotoprotective activity
    Rashmi Gaur
    Central Institute of Medicinal and Aromatic Plants, P O CIMAP, Lucknow 226015, India
    Nat Prod Commun 5:1243-6. 2010
    ..05) when compared with the GalN/LPS group. The results revealed that isoliquiritigenin exhibited better hepatoprotective activity than liquiritigenin and its derivatives...
  4. doi request reprint Influence of Moringa oleifera on pharmacokinetic disposition of rifampicin using HPLC-PDA method: a pre-clinical study
    Anirban Pal
    Division of Molecular Bioprospection, Central Institute of Medicinal and Aromatic Plants, CSIR, Lucknow, India
    Biomed Chromatogr 25:641-5. 2011
    ..In conclusion, the result of this study suggested that the bioavailability-enhancing property of MoAF may help to lower the dosage level and shorten the treatment course of rifampicin...
  5. doi request reprint Simultaneous determination of three steroidal glycoalkaloids in Solanum xanthocarpum by high performance thin layer chromatography
    Karuna Shanker
    Analytical Chemistry Department, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow 226015, India
    J Pharm Biomed Anal 54:497-502. 2011
    ..Method specificity was confirmed using retention factor (R(f)), Vis spectral correlation and electrospray ionization mass spectra (ESI-MS) of marker compounds in the sample track...
  6. doi request reprint Genetic and chemical diversity of high mucilaginous plants of Sida complex by ISSR markers and chemical fingerprinting
    Sanjog T Thul
    Plant Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, Lucknow, 226016, UP, India
    Mol Biotechnol 49:77-81. 2011
    ..rhombifolia shared most bands making them difficult to identify on chemical fingerprint basis. This report summarizes the genotypic and chemotypic diversity and the use of profiles for authentication of species of Sida complex...
  7. doi request reprint 1-Chloro-2-formyl indenes and tetralenes as antitubercular agents
    Debabrata Chanda
    Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, PO CIMAP, Kukrail, Picnic Spot Road, Lucknow 226015, UP, India
    Bioorg Med Chem Lett 21:3966-9. 2011
    ..Analogue 13 was further modified to some derivatives. The most active analogue 23 showing MIC at 30 μg/mL was further evaluated for acute oral toxicity in Swiss albino mice and was found to be safe up to 300 mg/kg dose...
  8. doi request reprint A simple and convenient synthesis of 2-methoxyestradiol from estrone
    A P Prakasham
    Chemical Sciences Division, Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, P O CIMAP, Kukrail Picnic Spot Road, Lucknow, 226015 UP, India
    Steroids 77:467-70. 2012
    ..A simple and straightforward synthesis of 2-methoxyestradiol have been achieved in nine synthetic steps with 21% of overall yield. Being a convenient process, it can be upscaled to industrial process...
  9. doi request reprint HILIC quantification of oenotheralanosterol A and B from Oenothera biennis and their suppression of IL-6 and TNF-α expression in mouse macrophages
    Rashmi Singh
    Analytical Chemistry Department, Central Institute of Medicinal and Aromatic Plants CSIR CIMAP, Lucknow, India
    J Ethnopharmacol 141:357-62. 2012
    ..The present study demonstrates the in vitro anti-inflammatory activity of three Oenothera biennis compounds...
  10. doi request reprint HPTLC method for the simultaneous determination of four indole alkaloids in Rauwolfia tetraphylla: a study of organic/green solvent and continuous/pulse sonication
    Shikha Gupta
    Analytical Chemistry Department, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research CSIR, Lucknow 226015, India
    J Pharm Biomed Anal 66:33-9. 2012
    ..Method specificity was confirmed using retention factor (R(f)) and visible spectral (post chromatographic scan) correlation of marker compounds in the samples and standard tracks...
  11. doi request reprint Synthesis and anticancer activity of 2-benzylidene indanones through inhibiting tubulin polymerization
    A P Prakasham
    CSIR, Central Institute of Medicinal and Aromatic Plants, Kukrail Picnic Spot Road, Lucknow 226 015, UP, India
    Bioorg Med Chem 20:3049-57. 2012
    ..62-2.04 μM). Compound 9j, the best candidate of the series was found to be non-toxic in acute oral toxicity in Swiss-albino mice up to 1000 mg/kg dose...
  12. doi request reprint Gallic acid based steroidal phenstatin analogues for selective targeting of breast cancer cells through inhibiting tubulin polymerization
    Swati Parihar
    Central Institute of Medicinal and Aromatic Plants CSIR CIMAP, Lucknow, UP, India
    Steroids 77:878-86. 2012
    ..The most active analogue 10 was found to be non-toxic in Swiss albino mice up to 300 mg/kg dose. Gallic acid based phenstatin analogues may further be optimized as selective anti-breast cancer agents...
  13. doi request reprint Tryptophan over-producing cell suspensions of Catharanthus roseus (L) G. Don and their up-scaling in stirred tank bioreactor: detection of a phenolic compound with antioxidant potential
    Priyanka Verma
    Department of Plant Biotechnology, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, PO CIMAP, Kukrail Picnic Spot Road, Lucknow 226015, India
    Protoplasma 250:371-80. 2013
    ..The latter, however, showed 57.47 % better radical scavenging activity (DPPH) than the bioreactor-harvested cells...
  14. doi request reprint Increased availability of tryptophan in 5-methyltryptophan-tolerant shoots of Catharanthus roseus and their postharvest in vivo elicitation induces enhanced vindoline production
    Priyanka Verma
    Department of Plant Biotechnology, Council of Scientific and Industrial Research Central Institute of Medicinal and Aromatic Plants CSIR CIMAP, PO CIMAP, Kukrail Picnic Spot Road, Lucknow 226015, India
    Appl Biochem Biotechnol 168:568-79. 2012
    ..0 mg/l tryptophan registered an eight-to-tenfold increment in their vindoline content within 24-48 h...
  15. doi request reprint Pluchea lanceolata (Rasana): Chemical and biological potential of Rasayana herb used in traditional system of medicine
    Pooja Srivastava
    Analytical Chemistry Department, CSIR Central Institute of Medicinal and Aromatic Plants CIMAP, Lucknow 226015, India
    Fitoterapia 83:1371-85. 2012
    ..Out of about 80 species of Pluchea, some of them are on extinct and only 16 have traditional uses in several countries of Asian, Middle East and North American region. The present review covers the period 1935-2011...
  16. doi request reprint Anticancer activity, toxicity and pharmacokinetic profile of an indanone derivative
    Debabrata Chanda
    Central Institute of Medicinal and Aromatic Plants, Lucknow, UP, India
    Eur J Pharm Sci 47:988-95. 2012
    ..Pharmacokinetic studies in rabbits revealed rate of absorption, half life, volume of distribution with high plasma and blood clearance after i.v. administration. Indanone 1, is a safe and moderately active anticancer agent...
  17. doi request reprint HPLC method development and validation of cytotoxic agent phenyl-heptatriyne in Bidens pilosa with ultrasonic-assisted cloud point extraction and preconcentration
    Priyanka Trivedi
    Analytical Chemistry Department, Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, PO CIMAP, Lucknow, India
    Biomed Chromatogr 25:697-706. 2011
    ..84 and 6.13 µg/mL, respectively. The method was validated following international guidelines and successfully applied for quantitative assays of cytotoxic compound phenyl-1,3,5-heptatriyne in Bidens pilosa...
  18. doi request reprint A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents
    Sailendra Singh
    Plant Tissue Culture Division, Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, Kukrail Picnic Spot Road, P O CIMAP, Lucknow 226015, India
    Eur J Med Chem 45:4379-82. 2010
    ..Two of its semisynthetic analogues also exhibited antitubercular activity at 250-500 microg/mL. It is the first report on isolation and antimycobacterial activity of this dialdehyde from C. amada...
  19. ncbi request reprint Synthesis of gallic acid based naphthophenone fatty acid amides as cathepsin D inhibitors
    Vandana Srivastava
    Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow, India
    Bioorg Med Chem Lett 16:4603-8. 2006
    ..14 microM, respectively, as compared against pepstatin (0.0023 microM), the most potent inhibitor known so far. The study revealed that such attempts on gallic acid based pharmacophores might result in potent inhibitors of cathepsin D...
  20. ncbi request reprint Synthesis of chalcone derivatives on steroidal framework and their anticancer activities
    Hari Om Saxena
    Central Institute of Medicinal and Aromatic Plants CIMAP, P O CIMAP, Kukrail Picnic Spot Road, Lucknow, U P, India
    Steroids 72:892-900. 2007
    ..It was observed that chalcone derivatives showing cytotoxicity against cancer cell lines did not affect the fragility of erythrocytes and hence may be considered as non-toxic to normal cells...
  21. ncbi request reprint Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads
    Arvind S Negi
    Central Institute of Medicinal and Aromatic Plants, PO CIMAP, Lucknow, India
    Med Res Rev 28:746-72. 2008
    ..This review focuses discussion on the chemistry, biological activity, mode of action, toxicity, and future prospects of these leads...
  22. ncbi request reprint Separation and quantification of lignans in Phyllanthus species by a simple chiral densitometric method
    Vandana Srivastava
    Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants, Lucknow, India
    J Sep Sci 31:47-55. 2008
    ..The method reported here is reproducible and applied for the quantitative analysis of the above lignans in the leaves of four Phyllanthus species, i. e., P. amarus, P. maderaspatensis, P. urinaria, and P. virgatus...
  23. doi request reprint Antimicrobial potential of Glycyrrhiza glabra roots
    Vivek K Gupta
    Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CSIR, Kukrail Picnic Spot Road, P O CIMAP, Lucknow 226015, India
    J Ethnopharmacol 116:377-80. 2008
    ..It exhibited antimicrobial activity against both Gram-positive and Gram-negative bacteria. Our results indicate potential use of licorice as antitubercular agent through systemic experiments and sophisticated anti-TB assay...
  24. doi request reprint Iridoid glycosides from Gmelina arborea
    Neerja Tiwari
    Central Institute of Medicinal and Aromatic Plants, Analytical Chemistry Division, P O CIMAP, Kukrail Picnic Spot Road, Lucknow, Uttar Pradesh 226015, India
    Phytochemistry 69:2387-90. 2008
    ..Additionally a known iridoid 6-O-(3'', 4''-O-dibenzoyl)-alpha-L-rhamnopyranosylcatalpol (4) was also isolated and identified...
  25. doi request reprint Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus
    Narayan P Yadav
    In Vivo Testing Facility, Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants, Near Kukrail Picnic Spot, PO CIMAP, Lucknow 226015, India
    Phytomedicine 15:1053-61. 2008
    ..amarus showed better activity due to the higher concentration of phyllanthin in ethanolic extract in comparison to aqueous extract of P. amarus as estimated by HPLC...
  26. ncbi request reprint Simultaneous quantification of withanolides in Withania somnifera by a validated high-performance thin-layer chromatographic method
    Pooja Srivastava
    Central Institute of Medicinal and Aromatic Plants, Analytical Chemistry Division, Lucknow, India
    J AOAC Int 91:1154-61. 2008
    ..Specificity of quantification was confirmed using retention factor (Rf) values, UV-Vis spectral correlation, and electrospray ionization mass spectra of marker compounds in sample tracks...
  27. doi request reprint Demethoxycurcumin and its semisynthetic analogues as antitubercular agents
    Dinesh Kumar Agrawal
    Analytical Chemistry Division, Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, Lucknow, India
    Planta Med 74:1828-31. 2008
    ..8 microg/mL. H (37)Rv:Mycobacterium tuberculosis H (37)Rv strain MIC:minimum inhibitory concentration...
  28. doi request reprint Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin
    Atiya Fatima
    Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CSIR, Kukrail Picnic Spot Road, P O CIMAP, Lucknow 226015, India
    Phytother Res 23:1190-3. 2009
    ..25-250 microg/mL. Although the compound was reported earlier to be active against Candida albicans, but this is the first report of its activity against drug resistant mutants...
  29. ncbi request reprint Safety evaluation of Trikatu, a generic Ayurvedic medicine in Charles Foster rats
    Debabrata Chanda
    Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants CSIR
    J Toxicol Sci 34:99-108. 2009
    ....
  30. ncbi request reprint Design and synthesis of C-ring lactone- and lactam-based podophyllotoxin analogues as anticancer agents
    Pragya Singh
    Central Institute of Medicinal and Aromatic Plants CIMAP CSIR, P O CIMAP, Kukrail Picnic Spot Road, Lucknow 226 015, India
    Chem Pharm Bull (Tokyo) 58:242-6. 2010
    ..These analogues showed toxicity comparable to PDT against human erythrocytes albeit at much higher concentrations (100 microg/ml) than their cytotoxicity values...
  31. doi request reprint Two new lignans from Phyllanthus amarus
    Manju Singh
    Central Institute of Medicinal and Aromatic Plants, Council of Scientific and Industrial Research, Lucknow, India
    J Asian Nat Prod Res 11:562-8. 2009
    ..Additionally, eight known lignans were also isolated and characterized...
  32. ncbi request reprint An evaluation of toxicity of Taxus baccata Linn. (Talispatra) in experimental animals
    K Shanker
    Chemical Research Unit, Central Research Institute Ay, 474 6, Sitapur Road, 226020, Lucknow, India
    J Ethnopharmacol 79:69-73. 2002
    ....