Defining the allelic variants of HLA A19 in the western Indian populationUmapathy Shankarkumar
HLA Department, Institute of Immunohaematology ICMR, Parel, Mumbai, Maharastra, India
Hum Immunol 63:779-82. 2002
..Prevalence of HLA A*3303 at very high frequencies among Western Indians may be a consequence of the founder effect, racial admixture, or selection pressure due to environmental factors among this population...
- HLA associations in leprosy patients from Mumbai, India
U Shankarkumar
Institute of Immunohaematology ICMR, 13th Floor, KEM Hospital, Parel, Mumbai 400012, Maharastra, India
Lepr Rev 75:79-85. 2004
..It seems that HLA class I alleles play vital roles in disease association/pathogenesis...
- Xenotransplantation--ethics and immunological hurdles!
U Shankarkumar
HLA Department, Institute of Immunohaematology, 13th Floor, K.E.M. Hospital, Parel, Mumbai-400012, India
Indian J Med Sci 57:311-8. 2003
- HLA diversity among Nadars, a primitive Dravidian caste of South India
U Shankarkumar
HLA Department, Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, India
Tissue Antigens 62:542-7. 2003
..The study suggests that a comparatively lesser degree of genetic admixture occurred between the South Indian and North Indian racial groups than that between South Indian and East Asian groups...
- HLA-B27 allele diversity in Indians: impact of ethnic origin and the caste system
U Shankarkumar
HLA Department, Institute of Immunohaematology ICMR, 13th Floor, KEM Hospital, Parel, Mumbai 400012, India
Br J Biomed Sci 60:223-6. 2003
..The study showed that more extensive subtyping in other Indian caste groups will be necessary to resolve the evolutionary implications of HLA-B27 subtypes and their relationship to disease association in the Indian context...
- MHC non -HLA gene polymorphisms in transplantation
U Shankarkumar
HLA Department, Institute of Immunohaematology, K E M Hospital, Parel, Mumbai
Indian J Pathol Microbiol 50:881-5. 2007
..A scenario can be envisaged where polymorphisms associated with transplant outcome are tested prior to transplantation at the same time as HLA typing...
- Human leukocyte antigens in hypertrophic cardiomyopathy patients in South India
Umapathy Shankarkumar
Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
Asian Cardiovasc Thorac Ann 12:107-10. 2004
..Hypertrophic cardiomyopathy may be associated with genes in the human leukocyte antigen region, and immunogenetic factors linked to human leukocyte antigens appear to play a major role in the pathogenesis...
- HLA DRB1* and DQB1* allelic diversity among Nadars: a primitive south Indian Dravidian caste group
Umapathy Shankarkumar
HLA Department, Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, India
Hum Immunol 65:847-54. 2004
..The present study shows that the Nadar caste has several unique alleles and haplotypes at high frequency that are rare or absent in other populations of India and the world...
- Human leukocyte antigen allele associations in type-1 autoimmune hepatitis patients from western India
Umapathy Shankarkumar
HLA Department, Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai 400 012, Maharashtra, India
J Gastroenterol Hepatol 20:193-7. 2005
..The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type-1 autoimmune hepatitis (AIH) among patients from western India...
- Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India
U Shankarkumar
Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400012, Maharashtra, India
J Autoimmun 24:227-33. 2005
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- Molecular diversity of HLA-Cw alleles in the Maratha community of Mumbai, Maharashtra, western India
U Shankarkumar
Institute of Immunohaematology, Indian Council of Medical Research, 13th Floor KEM Hospital Campus, Parel, Mumbai 400 012, Maharashtra, India
Int J Immunogenet 32:223-7. 2005
..Our results will have clinical implications in related and unrelated HLA-matched bone marrow transplantation in India...
- Novel HLA B*2714 and B*2708 allele associations in seronegative spondarthritis patients and haemophilia patients with chronic synovitis in India
U Shankarkumar
HLA Department, Institute of Immunohaematology, K E M Hospital, Mumbai, India
Tissue Antigens 62:175-8. 2003
..We also found a significant association between haemophilia patients with chronic synovitis from India and a hitherto unidentified allele, B*2708...
- HLA A*02 allele and B-associated haplotype diversity in Indians
U Shankarkumar
HLA Department, Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400012, India
Br J Biomed Sci 60:109-12. 2003
..The findings demonstrate a substantial heterogeneity among the groups studied that may be a consequence of founder effect, racial admixture or selection pressure due to environmental factors...
- Role of HLA antigens in Rh (D) alloimmunized pregnant women from Mumbai, Maharashtra, India
U Shankar Kumar
HLA Department, Institute of Immunohaematology, 13th Floor, New MS Building, KEM Hospital, Parel, Mumbai 400 012, India
J Biosci 27:135-41. 2002
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- Seronegative spondarthritis and human leucocyte antigen association
U Shankarkumar
HLA Department, Institute of lmmunohaematology, KEM Hospital, Mumbai, Maharashtra, India
Br J Biomed Sci 59:38-41. 2002
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HLA-DRB1*03 and DQB1*0302 associations in a subset of patients severely affected with systemic lupus erythematosus from western IndiaU Shankarkumar
HLA Department, Institute of Immunohaematology, 13th Floor, KEM Hospital, Parel, Mumbai 400012, Maharastra, India
Ann Rheum Dis 62:92-3. 2003
- HLA A*02 allele frequencies and B haplotype associations in Western Indians
Umapathy Shankarkumar
HLA Department, Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, India
Hum Immunol 64:562-6. 2003
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- Implications of HLA sequence-based typing in transplantation
U Shankarkumar
Institute of Immunohaematology, 13th Floor, K E M Hospital, Parel, Mumbai, Maharashtra, India
J Postgrad Med 54:41-4. 2008
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- HLA associations in P. falciparum malaria patients from Mumbai, western India
U Shankarkumar
HLA Deptt, Institute of Immunohaematology, K E M Hospital Campus, Mumbai 400 012, India
Indian J Malariol 39:76-82. 2002
..Further, when compared to HLA associations of other world populations the present study indicates the relative importance of different HLA alleles that may vary in different populations...
- Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India
U Shankarkumar
National Institute of Immunohaematology, ICMR, KEM Hospital, Parel, Mumbai, India
Int J Immunogenet 37:199-204. 2010
..Our results indicate clearly that there are HLA class II alleles involved in the susceptibility to and protection from HIV-1 infection in our study group and further they vary in different ethnic groups reported in literature...
- HLA B27 polymorphism in Western India
U Shankarkumar
HLA Department, Institute of Immunohaematology ICMR, KEM, Hospital Parel, Mumbia
Tissue Antigens 60:98-101. 2002
..In addition, B*2714 was observed in a patient with ankylosing spondylitis. This association has not been previously reported in ethnic groups from India...
- Comparative case control study of clinical features and human leukocyte antigen susceptibility between familial and nonfamilial vitiligo
Rachita Misri
Department of Dermatology, Seth G S Medical College and KEM Hospital, Parel, Mumbai 400 012, India
Indian J Dermatol Venereol Leprol 75:583-7. 2009
..Various studies worldwide suggest that human leukocyte antigen (HLA) region may be involved in the genetic susceptibility of vitiligo but little information is available from India...
- Common human leucocyte antigen haplotypes in Indians--its implications in finding unrelated compatible bone marrow donors
K Ghosh
HLA Department, Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Mumbai, India
Transfus Med 12:43-8. 2002
..It is hoped that this will give the busy clinician an idea whether a search for prospective unrelated stem cell donor for an Indian patient is likely to succeed or not...
- Increased frequency of HLA-B7 among B27-negative seronegative spondarthritis patients from Mumbai, western India
J P Devraj
HLA Department, National Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400 012, India
Br J Biomed Sci 66:25-7. 2009
..11% vs. 31.86%; P < 0.001) was observed when compared to the controls. These results suggest that HLA-B7 antigen may be associated with B27-negative SSA in patients from western India...
- HLA antigen distribution in Jain population from Mumbai, Maharashtra, India
S U Chhaya
Department of Transfusion Medicine, Tata Memorial Hospital, Mumbai, India
Indian J Med Res 114:25-9. 2001
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- Anti-neutrophil cytoplasmic antibodies (ANCA) in malaria
Vandana Pradhan
Institute of Immunohaematology (ICMR, K.E.M. Hospital, Parel, Mumbai-400 012, India
Indian J Malariol 39:51-9. 2002
..It also alerts us to the fact, whether in cases of repeated malarial infections in susceptible individuals, vasculitic disorders, which through ANCA pathways develop, could lead to renal and other complications...
- The human leucocyte antigen (HLA) system
U Shankarkumar
HLA Department, Institute of Immunohaematology, Parel, Mumbai, India
J Assoc Physicians India 50:916-26. 2002
- HIV and malaria co-infection in Mumbai, western India
U Shankarkumar
National Institute of Immunohaematology, KEM Hospital, Mumbai, India
J Vector Borne Dis 48:155-8. 2011
..A transient almost one-log elevation in HIV viral load occurs during febrile malaria episodes. We prospectively studied malaria patients for HIV infection from Mumbai...
- Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients
U Shankarkumar
Department of Autoimmune, National Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital, Parel, Mumbai, India
Niger Med J 52:163-6. 2011
..An autoimmune cause and related immunological alterations resulting in recurrent spontaneous abortion (RSA) have been suggested in patients with unknown etiology...
- Role of 14-bp deletion/insertion polymorphism in exon 8 of the HLA-G gene in recurrent spontaneous abortion patients
U Shankarkumar
Department of HLA and Transplantation, National Institute of Immunohaematology, KEM Hospital Campus, Parel, Mumbai, India
J Hum Reprod Sci 4:143-6. 2011
..Recent reports indicate that the 14-bp deletion/insertion polymorphism in exon 8 of the 3'UTR region of the HLA-G gene influences the HLA-G mRNA stability and isoform splicing patterns, thus modulating the levels of HLA-G expression...
- Glioma Indian scenario: Is there a human leucocyte antigen association?
U Shankarkumar
Human Leukocyte Antigen and Transplantation Department, Department of Medicine National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
J Nat Sci Biol Med 2:205-8. 2011
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- Human immunodeficiency virus therapeutics and pharmacogenomics
U Shankarkumar
National Institute of Immunohaematology, 13 Floor, KEM Hospital, Parel, Mumbai, Maharashtra, India
Indian J Hum Genet 17:S22-6. 2011
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- A sensitive micro-platelet ELISA technique for screening anti-HLA antibodies
U Shankarkumar
Institute of Immunohaematology (ICMR, KEM Hospital Campus, Parel, Mumbai, India
J Immunoassay Immunochem 23:107-17. 2002
..This technique is, thus, very simple, cost effective, and very much suitable for any developing HLA laboratory, which is in the process of developing indigenous HLA reagents...
- Cytolytic T lymphocytes (CTLs) from HIV-1 subtype C-infected Indian patients recognize CTL epitopes from a conserved immunodominant region of HIV-1 Gag and Nef
Madhuri R Thakar
National AIDS Research Institute, Bhosari, Pune, India
J Infect Dis 192:749-59. 2005
..Three Gag and 4 Nef epitopes were novel. The identification of conserved epitopes will be important in the planning of an HIV-1 vaccine strategy for subtype C-affected regions...
