U Shankarkumar

Summary

Publications

  1. ncbi Defining the allelic variants of HLA A19 in the western Indian population
    Umapathy Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, Parel, Mumbai, Maharastra, India
    Hum Immunol 63:779-82. 2002
  2. ncbi HLA-B27 allele diversity in Indians: impact of ethnic origin and the caste system
    U Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, 13th Floor, KEM Hospital, Parel, Mumbai 400012, India
    Br J Biomed Sci 60:223-6. 2003
  3. ncbi HLA associations in leprosy patients from Mumbai, India
    U Shankarkumar
    Institute of Immunohaematology ICMR, 13th Floor, KEM Hospital, Parel, Mumbai 400012, Maharastra, India
    Lepr Rev 75:79-85. 2004
  4. ncbi Xenotransplantation--ethics and immunological hurdles!
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, 13th Floor, K E M Hospital, Parel, Mumbai 400012, India
    Indian J Med Sci 57:311-8. 2003
  5. ncbi HLA diversity among Nadars, a primitive Dravidian caste of South India
    U Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, India
    Tissue Antigens 62:542-7. 2003
  6. ncbi MHC non -HLA gene polymorphisms in transplantation
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, K E M Hospital, Parel, Mumbai
    Indian J Pathol Microbiol 50:881-5. 2007
  7. ncbi Human leukocyte antigens in hypertrophic cardiomyopathy patients in South India
    Umapathy Shankarkumar
    Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    Asian Cardiovasc Thorac Ann 12:107-10. 2004
  8. ncbi HLA DRB1* and DQB1* allelic diversity among Nadars: a primitive south Indian Dravidian caste group
    Umapathy Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, India
    Hum Immunol 65:847-54. 2004
  9. ncbi Human leukocyte antigen allele associations in type-1 autoimmune hepatitis patients from western India
    Umapathy Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai 400 012, Maharashtra, India
    J Gastroenterol Hepatol 20:193-7. 2005
  10. ncbi Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India
    U Shankarkumar
    Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400012, Maharashtra, India
    J Autoimmun 24:227-33. 2005

Collaborators

Detail Information

Publications34

  1. ncbi Defining the allelic variants of HLA A19 in the western Indian population
    Umapathy Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, Parel, Mumbai, Maharastra, India
    Hum Immunol 63:779-82. 2002
    ..Prevalence of HLA A*3303 at very high frequencies among Western Indians may be a consequence of the founder effect, racial admixture, or selection pressure due to environmental factors among this population...
  2. ncbi HLA-B27 allele diversity in Indians: impact of ethnic origin and the caste system
    U Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, 13th Floor, KEM Hospital, Parel, Mumbai 400012, India
    Br J Biomed Sci 60:223-6. 2003
    ..The study showed that more extensive subtyping in other Indian caste groups will be necessary to resolve the evolutionary implications of HLA-B27 subtypes and their relationship to disease association in the Indian context...
  3. ncbi HLA associations in leprosy patients from Mumbai, India
    U Shankarkumar
    Institute of Immunohaematology ICMR, 13th Floor, KEM Hospital, Parel, Mumbai 400012, Maharastra, India
    Lepr Rev 75:79-85. 2004
    ..It seems that HLA class I alleles play vital roles in disease association/pathogenesis...
  4. ncbi Xenotransplantation--ethics and immunological hurdles!
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, 13th Floor, K E M Hospital, Parel, Mumbai 400012, India
    Indian J Med Sci 57:311-8. 2003
  5. ncbi HLA diversity among Nadars, a primitive Dravidian caste of South India
    U Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, India
    Tissue Antigens 62:542-7. 2003
    ..The study suggests that a comparatively lesser degree of genetic admixture occurred between the South Indian and North Indian racial groups than that between South Indian and East Asian groups...
  6. ncbi MHC non -HLA gene polymorphisms in transplantation
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, K E M Hospital, Parel, Mumbai
    Indian J Pathol Microbiol 50:881-5. 2007
    ..A scenario can be envisaged where polymorphisms associated with transplant outcome are tested prior to transplantation at the same time as HLA typing...
  7. ncbi Human leukocyte antigens in hypertrophic cardiomyopathy patients in South India
    Umapathy Shankarkumar
    Department of Immunology, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    Asian Cardiovasc Thorac Ann 12:107-10. 2004
    ..Hypertrophic cardiomyopathy may be associated with genes in the human leukocyte antigen region, and immunogenetic factors linked to human leukocyte antigens appear to play a major role in the pathogenesis...
  8. ncbi HLA DRB1* and DQB1* allelic diversity among Nadars: a primitive south Indian Dravidian caste group
    Umapathy Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, India
    Hum Immunol 65:847-54. 2004
    ..The present study shows that the Nadar caste has several unique alleles and haplotypes at high frequency that are rare or absent in other populations of India and the world...
  9. ncbi Human leukocyte antigen allele associations in type-1 autoimmune hepatitis patients from western India
    Umapathy Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, KEM Hospital, Parel, Mumbai 400 012, Maharashtra, India
    J Gastroenterol Hepatol 20:193-7. 2005
    ..The immunogenetic basis of autoimmune diseases has become more and more evident. We have analyzed the human leukocyte antigen (HLA) associations with type-1 autoimmune hepatitis (AIH) among patients from western India...
  10. ncbi Immunogenetic association in patients with antineutrophil cytoplasmic antibodies (ANCA) from Mumbai, Maharashtra, India
    U Shankarkumar
    Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400012, Maharashtra, India
    J Autoimmun 24:227-33. 2005
    ....
  11. ncbi Molecular diversity of HLA-Cw alleles in the Maratha community of Mumbai, Maharashtra, western India
    U Shankarkumar
    Institute of Immunohaematology, Indian Council of Medical Research, 13th Floor KEM Hospital Campus, Parel, Mumbai 400 012, Maharashtra, India
    Int J Immunogenet 32:223-7. 2005
    ..Our results will have clinical implications in related and unrelated HLA-matched bone marrow transplantation in India...
  12. ncbi Novel HLA B*2714 and B*2708 allele associations in seronegative spondarthritis patients and haemophilia patients with chronic synovitis in India
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, K E M Hospital, Mumbai, India
    Tissue Antigens 62:175-8. 2003
    ..We also found a significant association between haemophilia patients with chronic synovitis from India and a hitherto unidentified allele, B*2708...
  13. ncbi HLA A*02 allele and B-associated haplotype diversity in Indians
    U Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400012, India
    Br J Biomed Sci 60:109-12. 2003
    ..The findings demonstrate a substantial heterogeneity among the groups studied that may be a consequence of founder effect, racial admixture or selection pressure due to environmental factors...
  14. ncbi Role of HLA antigens in Rh (D) alloimmunized pregnant women from Mumbai, Maharashtra, India
    U Shankar Kumar
    HLA Department, Institute of Immunohaematology, 13th Floor, New MS Building, KEM Hospital, Parel, Mumbai 400 012, India
    J Biosci 27:135-41. 2002
    ....
  15. ncbi Seronegative spondarthritis and human leucocyte antigen association
    U Shankarkumar
    HLA Department, Institute of lmmunohaematology, KEM Hospital, Mumbai, Maharashtra, India
    Br J Biomed Sci 59:38-41. 2002
    ....
  16. pmc HLA-DRB1*03 and DQB1*0302 associations in a subset of patients severely affected with systemic lupus erythematosus from western India
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, 13th Floor, KEM Hospital, Parel, Mumbai 400012, Maharastra, India
    Ann Rheum Dis 62:92-3. 2003
  17. ncbi HLA A*02 allele frequencies and B haplotype associations in Western Indians
    Umapathy Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai, India
    Hum Immunol 64:562-6. 2003
    ....
  18. ncbi Implications of HLA sequence-based typing in transplantation
    U Shankarkumar
    Institute of Immunohaematology, 13th Floor, K E M Hospital, Parel, Mumbai, Maharashtra, India
    J Postgrad Med 54:41-4. 2008
    ....
  19. ncbi HLA associations in P. falciparum malaria patients from Mumbai, western India
    U Shankarkumar
    HLA Deptt, Institute of Immunohaematology, K E M Hospital Campus, Mumbai 400 012, India
    Indian J Malariol 39:76-82. 2002
    ..Further, when compared to HLA associations of other world populations the present study indicates the relative importance of different HLA alleles that may vary in different populations...
  20. doi Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India
    U Shankarkumar
    National Institute of Immunohaematology, ICMR, KEM Hospital, Parel, Mumbai, India
    Int J Immunogenet 37:199-204. 2010
    ..Our results indicate clearly that there are HLA class II alleles involved in the susceptibility to and protection from HIV-1 infection in our study group and further they vary in different ethnic groups reported in literature...
  21. ncbi HLA B27 polymorphism in Western India
    U Shankarkumar
    HLA Department, Institute of Immunohaematology ICMR, KEM, Hospital Parel, Mumbia
    Tissue Antigens 60:98-101. 2002
    ..In addition, B*2714 was observed in a patient with ankylosing spondylitis. This association has not been previously reported in ethnic groups from India...
  22. doi Comparative case control study of clinical features and human leukocyte antigen susceptibility between familial and nonfamilial vitiligo
    Rachita Misri
    Department of Dermatology, Seth G S Medical College and KEM Hospital, Parel, Mumbai 400 012, India
    Indian J Dermatol Venereol Leprol 75:583-7. 2009
    ..Various studies worldwide suggest that human leukocyte antigen (HLA) region may be involved in the genetic susceptibility of vitiligo but little information is available from India...
  23. ncbi Common human leucocyte antigen haplotypes in Indians--its implications in finding unrelated compatible bone marrow donors
    K Ghosh
    HLA Department, Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Mumbai, India
    Transfus Med 12:43-8. 2002
    ..It is hoped that this will give the busy clinician an idea whether a search for prospective unrelated stem cell donor for an Indian patient is likely to succeed or not...
  24. ncbi Increased frequency of HLA-B7 among B27-negative seronegative spondarthritis patients from Mumbai, western India
    J P Devraj
    HLA Department, National Institute of Immunohaematology ICMR, 13th Floor, K E M Hospital, Parel, Mumbai 400 012, India
    Br J Biomed Sci 66:25-7. 2009
    ..11% vs. 31.86%; P < 0.001) was observed when compared to the controls. These results suggest that HLA-B7 antigen may be associated with B27-negative SSA in patients from western India...
  25. ncbi HLA antigen distribution in Jain population from Mumbai, Maharashtra, India
    S U Chhaya
    Department of Transfusion Medicine, Tata Memorial Hospital, Mumbai, India
    Indian J Med Res 114:25-9. 2001
    ....
  26. ncbi Anti-neutrophil cytoplasmic antibodies (ANCA) in malaria
    Vandana Pradhan
    Institute of Immunohaematology ICMR, K E M Hospital, Parel, Mumbai 400 012, India
    Indian J Malariol 39:51-9. 2002
    ..It also alerts us to the fact, whether in cases of repeated malarial infections in susceptible individuals, vasculitic disorders, which through ANCA pathways develop, could lead to renal and other complications...
  27. ncbi The human leucocyte antigen (HLA) system
    U Shankarkumar
    HLA Department, Institute of Immunohaematology, Parel, Mumbai, India
    J Assoc Physicians India 50:916-26. 2002
  28. ncbi HIV and malaria co-infection in Mumbai, western India
    U Shankarkumar
    National Institute of Immunohaematology, KEM Hospital, Mumbai, India
    J Vector Borne Dis 48:155-8. 2011
    ..A transient almost one-log elevation in HIV viral load occurs during febrile malaria episodes. We prospectively studied malaria patients for HIV infection from Mumbai...
  29. pmc Autoantibody profile and other immunological parameters in recurrent spontaneous abortion patients
    U Shankarkumar
    Department of Autoimmune, National Institute of Immunohaematology, Indian Council of Medical Research, KEM Hospital, Parel, Mumbai, India
    Niger Med J 52:163-6. 2011
    ..An autoimmune cause and related immunological alterations resulting in recurrent spontaneous abortion (RSA) have been suggested in patients with unknown etiology...
  30. pmc Role of 14-bp deletion/insertion polymorphism in exon 8 of the HLA-G gene in recurrent spontaneous abortion patients
    U Shankarkumar
    Department of HLA and Transplantation, National Institute of Immunohaematology, KEM Hospital Campus, Parel, Mumbai, India
    J Hum Reprod Sci 4:143-6. 2011
    ..Recent reports indicate that the 14-bp deletion/insertion polymorphism in exon 8 of the 3'UTR region of the HLA-G gene influences the HLA-G mRNA stability and isoform splicing patterns, thus modulating the levels of HLA-G expression...
  31. pmc Glioma Indian scenario: Is there a human leucocyte antigen association?
    U Shankarkumar
    Human Leukocyte Antigen and Transplantation Department, Department of Medicine National Institute of Immunohaematology, KEM Hospital, Parel, Mumbai, India
    J Nat Sci Biol Med 2:205-8. 2011
    ....
  32. pmc Human immunodeficiency virus therapeutics and pharmacogenomics
    U Shankarkumar
    National Institute of Immunohaematology, 13 Floor, KEM Hospital, Parel, Mumbai, Maharashtra, India
    Indian J Hum Genet 17:S22-6. 2011
    ....
  33. ncbi A sensitive micro-platelet ELISA technique for screening anti-HLA antibodies
    U Shankarkumar
    Institute of Immunohaematology ICMR, KEM Hospital Campus, Parel, Mumbai, India
    J Immunoassay Immunochem 23:107-17. 2002
    ..This technique is, thus, very simple, cost effective, and very much suitable for any developing HLA laboratory, which is in the process of developing indigenous HLA reagents...
  34. ncbi Cytolytic T lymphocytes (CTLs) from HIV-1 subtype C-infected Indian patients recognize CTL epitopes from a conserved immunodominant region of HIV-1 Gag and Nef
    Madhuri R Thakar
    National AIDS Research Institute, Bhosari, Pune, India
    J Infect Dis 192:749-59. 2005
    ..Three Gag and 4 Nef epitopes were novel. The identification of conserved epitopes will be important in the planning of an HIV-1 vaccine strategy for subtype C-affected regions...