S K Shankar

..abstract:..

..This review deals with some of the structural, functional and metabolic features of aging nervous system and discusses briefly the functional consequences...

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..Since dopaminergic neurons are preserved in ageing Asian Indians, our study possibly signifies better proteasomal or ER response and partially explains the lower prevalence of PD in them...

..Confocal microscopic evidence of stem cell origin with biphenotypic, glial and neurocytic differentiation is presented with a comprehensive review of literature...

..Several mutations in the PYGM gene and geographic variations have been described. We report three biopsy confirmed cases of McArdle's disease...

..These data highlight the influence of pre and postmortem factors on GSH dynamics and the inherent differences in brain regions, with implications for studies on brain pathophysiology employing human samples...

..Co-localization of glial and neuronal markers was demonstrable on confocal microscopy with expression of stem cell markers (Nestin and CD133) suggesting possible origin from neuroepithelial stem cell with biphenotypic differentiation...

..Nevertheless, inactivation of the p53 tumor suppressor pathway could play a major role in the genesis of these neoplasms...

..The immunohistochemical pattern of supratentorial and infratentorial liponeurocytomas are almost identical, which indicates that these tumors are homologous...

..We also discuss the imaging and intraoperative findings and describe our use of a split calvarial graft in the present case...

..Though there are 3 previous reports of functioning pituitary tumors and gliomas, this is the first report of a thyrotropin secreting pituitary adenoma and an associated low grade glioma...

..As post mortem tissues are influenced by pre- and post mortem factors, we investigated the effect of these variables on mitochondrial function...

..We present a brief review of all cases reported in the medical literature, and describe the clinical symptomatology, associated endocrinological abnormalities, imaging characteristics, behavior and outcome...

..In contrast, the paralytic form poses a diagnostic dilemma, to distinguish it from Guillain-Barré syndrome. The problem is further compounded in the absence of a history of dog bite, clinical features resembling a psychiatric syndrome...

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..05 in CD and Put) activity due to proliferation of astrocytes. We suggest that increased GSH and astrocytic proliferation protects non-SN brain regions from oxidative and mitochondrial damage in PD...

..Our findings highlight the importance of a meticulous systemic examination and systematic laboratory investigations in the diagnosis of POEMS syndrome...

..Awareness of the variants and their relative frequency is essential for accurate diagnosis...

..The presentation of this disease as an isolated spinal extradural mass lesion is quite rare, with only six cases reported in literature...

..Absence of neuronal apoptosis in wild-type rabies may facilitate intraneuronal survival and replication while apoptosis in inflammatory cells prevents elimination of the virus by abrogation of host inflammatory response...

..The latter possibility explains our earlier observation that the melanized nigral neurons are preserved with age in the Asian Indians...

..There was no subsequent history to suggest nonbite exposure to a rabid dog to consider recent event causing the disease, although this cannot be totally excluded...

..We present neuropathological findings at autopsy following medical termination of pregnancy of a 23-week fetus with septo-optic dysplasia (SOD), optic nerve hypoplasia, absent septum pellucidum with aplastic posterior pituitary...

..Antemortem diagnosis of cerebral toxoplasmosis, the second most common opportunistic infection (OI) in HIV-infected individuals in developing countries is a challenge...

..To study the clinical, pathological and prognostic profile of patients with temporal arteritis in India...

..He underwent surgery with decompression of the intradural, and a small part of the extradural, component. To our knowledge this is the first report of a cervical triton tumor presenting with an intratumoral bleed...

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..To the best of our knowledge only 1 case of intratumoral hemorrhage has been reported. We report a rare case of lateral ventricular ganglioglioma with intratumoral hemorrhage in a 27-year-old man...

..We report a patient with multiple metastases from a cardiac myxoma which had an unusual histopathology mimicking an adenocarcinoma...

..Whether this association is like the co-occurrence of retinoblastoma and Wilson's disease due to possible somatic mutation in chromosome 13 needs to be explored...

..Need to carry out CSF cytology of even hemorrhagic CSF is stressed, to diagnose the condition...

..The tumour cells lacked cytological atypia and mitosis was sparse. These features were important in prognostication as low-grade tumours can be cured by complete wide-resection...

..The absence of p53 protein expression suggests that DIG probably has different molecular genetic pathways from other supratentorial astrocytomas...

..The diagnostic value of histopathologic examination of surgically resected blood clots in determining aetiology of intracerebral haemorrhagic masses is highlighted...