Comparative evaluation of a simple indirect immunofluorescence test and mouse neutralization test for assaying rabies antibodiesS N Madhusudana
Department of Neurovirology, National Institute of Mental Health and Neuroscience, Bangalore
Indian J Pathol Microbiol 44:309-12. 2001
....
- Evaluation of two intradermal vaccination regimens using purified chick embryo cell vaccine for post-exposure prophylaxis of rabies
S N Madhusudana
National Institute of Mental Health and Neurosciences, PB No 2900, Hosur Road, Bangalore 560029, Karnataka, India
Natl Med J India 14:145-7. 2001
..We evaluated these two regimens--the 2-site and the 8-site regimens--in terms of immunogenicity, safety and tolerance in people with category I exposure to rabies...
- Simulated post-exposure rabies vaccination with purified chick embryo cell vaccine using a modified Thai Red Cross regimen
S N Madhusudana
Department of Neurovirology, National Institute of Mental Health and Neurosciences, PN No 2900, Hosur Road, Bangalore 560029, India
Int J Infect Dis 8:175-9. 2004
..2 ml of purified chick embryo cell vaccine (PCEC). The objective of the present study was to evaluate comparatively the immune response to PCEC and PVRV vaccines administered by the TRC regimen using a uniform dose of 0.1 ml of vaccine...
- Rapid diagnosis of rabies in humans and animals by a dot blot enzyme immunoassay
Shampur Narayan Madhusudana
Department of Neurovirology, National Institute of Mental Health and Neurosciences, PB No 2900, Hosur Road, Bangalore 560029, India
Int J Infect Dis 8:339-45. 2004
..The utility of this test in the ante-mortem diagnosis of human rabies has also been evaluated...
Evaluation of a direct rapid immunohistochemical test (dRIT) for rapid diagnosis of rabies in animals and humansShampur Narayan Madhusudana
Department of Neurovirology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, 560029, India
Virol Sin 27:299-302. 2012
..To conclude, this newly developed dRIT technique promises to be a simple, cost effective diagnostic tool for rabies and will have applicability in field conditions prevalent in developing countries...
N-methylisatin-beta-thiosemicarbazone derivative (SCH 16) is an inhibitor of Japanese encephalitis virus infection in vitro and in vivoLiba Sebastian
Department of Neurovirology, National Institute of Mental Health and Neuro Sciences, Bangalore 560029, India
Virol J 5:64. 2008
..Hence the present study was designed to evaluate the antiviral activity of 14 MIBT derivatives against Flaviviruses that are prevalent in India such as Japanese Encephalitis Virus (JEV), Dengue-2 (Den-2) and West Nile viruses (WNV)...
- Comparison of saftey and immunogenicity of purified chick embryo cell rabies vaccine (PCECV) and purified vero cell rabies vaccine (PVRV) using the Thai Red Cross intradermal regimen at a dose of 0.1 ML
Shampur N Madhusudana
Department of Neurovirology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore, India
Hum Vaccin 2:200-4. 2006
..1 mL as recommended by WHO guidelines. The use of PCECV in this regimen may prove more economical in developing countries like India...
- In vitro inactivation of the rabies virus by ascorbic acid
Shampur Narayan Madhusudana
Department of Neurovirology, National Institute of Mental Health and Neurosciences NIMHANS, Post Box 2900, Hosur Road, Bangalore 560029, India
Int J Infect Dis 8:21-5. 2004
..There is a need to evaluate alternative chemicals, which will inactivate the virus without affecting its antigenicity. In this study the effect of ascorbic acid on the infectivity of the rabies virus has been investigated...
- Rabies: an ancient disease that still prevails
S N Madhusudana
Department of Neurovirology National Institute of Mental Health and Neuro Sciences Bangalore 560029, India
Indian J Med Res 122:4-6. 2005
- Development and evaluation of a latex agglutination test for rabies antibodies
S N Madhusudana
Department of Neurovirology, National Institute of Mental Health and Neurosciences NIMHANS, PB No 2900, Hosur Road, Bangalore, 560029, India
J Clin Virol 27:129-35. 2003
..Simple, rapid and economical tests need to be developed for routine use...
- Economical multi-site intradermal regimen with purified chick embryo cell vaccine (Rabipur) prevents rabies in people bitten by confirmed rabid animals
S N Madhusudana
National Institute of Mental Health and Neuroscience, Bangalore, India
Int J Infect Dis 6:210-4. 2002
..To determine the efficacy of a cost-effective multi-site intradermal regimen with purified chick embryo cell vaccine (PCECV, Rabipur) in preventing rabies in people bitten by confirmed rabid dogs...
- Utility of human embryonic kidney cell line HEK-293 for rapid isolation of fixed and street rabies viruses: comparison with Neuro-2a and BHK-21 cell lines
Shampur Narayan Madhusudana
Department of Neurovirology, WHO Collaborating Centre for Reference and Research on Rabies, National Institute of Mental Health and Neurosciences NIMHANS, Hosur Road, Bangalore, India
Int J Infect Dis 14:e1067-71. 2010
..The human embryonic kidney cell line HEK-293 is known to express several neuronal proteins and is believed to be of neuronal origin. We hypothesized that this cell line could be susceptible to rabies virus, which is highly neurotropic...
- Rabies viral encephalitis: clinical determinants in diagnosis with special reference to paralytic form
Girish Gadre
Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore 560 029, India
J Neurol Neurosurg Psychiatry 81:812-20. 2010
..In contrast, the paralytic form poses a diagnostic dilemma, to distinguish it from Guillain-Barré syndrome. The problem is further compounded in the absence of a history of dog bite, clinical features resembling a psychiatric syndrome...
- Development and evaluation of an enzyme immunoassay for rapid diagnosis of rabies in humans and animals
Joel P Vasanth
Department of Neurovirology, NIMHANS, Bangalore, India
Indian J Pathol Microbiol 47:574-8. 2004
..The utility of this test for ante mortem diagnosis of rabies needs to be further evaluated...
- Boosting effect of purified chick embryo cell rabies vaccine using the intradermal route in persons previously immunized by the intramuscular route or vice versa
M K Sudarshan
Department of Community Medicine, Kempegowda Institute of Medical Sciences, K R Road, V V Puram, Bangalore 560004, Karnataka, India
Natl Med J India 19:192-4. 2006
..As the intradermal route of vaccination is likely to be introduced in the future, we investigated the immune response to a cell culture rabies vaccine after crossing over from the intramuscular to the intradermal route and vice versa...
- Assessing the relationship between antigenicity and immunogenicity of human rabies vaccines. Results of a meta-analysis
M K Sudarshan
Department of Community Medicine and Rabies Epidemiology Unit, Kempegowda Institute of Medical Sciences, Bangalore, India
Hum Vaccin 1:187-90. 2005
..80, p > 0.43, GMR = 1.15, 95% CI of GMR = 0.74, 1.14). However, as there are no reports of meta-analysis of cell culture human rabies vaccine trials, to confirm this observation the authors recommend further studies in this regard...
- Response to purified chick embryo cell rabies vaccine administered intradermally for post-exposure prophylaxis
S N Madhusudana
Department of Neurovirology, Ramiah Medical College, Bangalore, Karnataka, India
Natl Med J India 10:115-6. 1997
..5 i.u./ml. Only minor side-effects were observed in some subjects. CONCLUSION: The feasibility of using this regimen in routine practice needs to be evaluated further...
- Rabies encephalitis following fox bite--histological and immunohistochemical evaluation of lesions caused by virus
M S Suja
Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore, India
Clin Neuropathol 23:271-6. 2004
..Genomic sequence analysis demonstrated close homology with canine virus strain with only minor variations...
- Presence of rabies specific immune complexes in cerebro-spinal fluid can help in ante-mortem diagnosis of human paralytic rabies
K Muhamuda
Department of Neurovirology, National Institute of Mental Health and Neurosciences (NIMHANS, Bangalore 560029, India
J Clin Virol 37:162-7. 2006
..Thus, the results were 100% specific and the sensitivity of this test was 76.6%. CONCLUSIONS: Detection of immune complexes to rabies antigens may be used as one of the techniques for rapid ante-mortem diagnosis of human rabies...
- Ante mortem diagnosis of human rabies using saliva samples: comparison of real time and conventional RT-PCR techniques
T Nagaraj
Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore 560029, India
J Clin Virol 36:17-23. 2006
..0189). This study highlights the utility of molecular diagnostic tests in establishing ante mortem diagnosis of rabies using saliva samples within a few hours...
- Role of apoptosis in rabies viral encephalitis: a comparative study in mice, canine, and human brain with a review of literature
M S Suja
Department of Neuropathology, National Institute of Mental Health and Neurosciences NIMHANS, Bangalore 560 029, India
Patholog Res Int 2011:374286. 2011
..Absence of neuronal apoptosis in wild-type rabies may facilitate intraneuronal survival and replication while apoptosis in inflammatory cells prevents elimination of the virus by abrogation of host inflammatory response...
- Cerebral cysticercosis mimicking rabies in a dog
M S Suja
Department of Neurovirology, National Institute of Mental Health and Neurosciences, Bangalore, India
Vet Rec 153:304-5. 2003
- Intradermal immunization for rabies prophylaxis: issues to be considered in India and other developing countries
S N Madhusudana
Vaccine 21:3095-6. 2003
- Protecting Indian schoolchildren against rabies: pre-exposure vaccination with purified chick embryo cell vaccine (PCECV) or purified verocell rabies vaccine (PVRV)
Preeti Shanbag
Department of Pediatrics, Lokmanya Tilak Municipal College and General Hospital, Sion, Mumbai, India
Hum Vaccin 4:365-9. 2008
..A 1.0 mL dilution volume for PCECV was as well tolerated as PVRV or PCECV reconstituted in half the volume...
- An epidemiological study of animal bites in India: results of a WHO sponsored national multi-centric rabies survey
M K Sudarshan
Association for Prevention and Control of Rabies in India (APCRI
J Commun Dis 38:32-9. 2006
..The people also reported the presence (83%) and menace (22.8%) of stray dogs. It is recommended to initiate appropriate community awareness and dog vaccination campaigns and effective stray dog control measures...
- A passive haemagglutination test for rabies antibodies using rabies glycoprotein coupled erythrocytes
S N Madhusudana
Dept. of Neurovirology, National Institute of Mental Health and Neurosciences PB No. 2900 Hosur Road, Bangalore 560 029
J Commun Dis 35:24-31. 2003
..It may also assist in rapid laboratory confirmation of paralytic rabies cases, based on detection of antibodies in CSF and serum...
- An assessment of rabies free status of the Island of Andaman, Nicobar and Lakshadweep: results of the WHO sponsored national multicentric rabies survey
M K Sudarshan
WHO APCRI, National Multicentric Rabies Survey
Indian J Public Health 50:11-4. 2006
..The Lakshadweep islands, which are free of dogs, however, faced a threat from the lack of vigil on the entry and presence of cats and poor surveillance for rabies in them...
- Partial recovery from rabies in a six-year-old girl
S N Madhusudana
Int J Infect Dis 6:85-6. 2002
- Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey
M K Sudarshan
Association for Prevention and Control of Rabies in India, Kempegowda Institute of Medical Sciences, Bangalore 560004, India
Int J Infect Dis 11:29-35. 2007
..The main objectives of the present study were to estimate the annual incidence of human rabies in India based on a community survey and to describe its salient epidemiological features...
