Saame Raza Shaikh

Summary

Publications

  1. ncbi request reprint Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation?
    Saame Raza Shaikh
    Department of Biology, Indiana University, Indianapolis 46202 5132, USA
    Biochemistry 42:12028-37. 2003
  2. ncbi request reprint Membranes are not just rafts
    Saame Raza Shaikh
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Mudd Hall, Baltimore, MD 21218, USA
    Chem Phys Lipids 144:1-3. 2006
  3. ncbi request reprint Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules
    Saame Raza Shaikh
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    J Lipid Res 48:127-38. 2007
  4. pmc Polyunsaturated fatty acids and membrane organization: elucidating mechanisms to balance immunotherapy and susceptibility to infection
    Saame Raza Shaikh
    Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States
    Chem Phys Lipids 153:24-33. 2008
  5. pmc Differential effects of a saturated and a monounsaturated fatty acid on MHC class I antigen presentation
    S R Shaikh
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Mudd Hall Room 45, Baltimore, MD 21218, USA
    Scand J Immunol 68:30-42. 2008
  6. pmc In vivo test of the vertical phase separation hypothesis: the display of major histocompatibility complex (MHC) class I molecules on membranes of B cells from mice fed high-fat diets
    Saame Raza Shaikh
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Br J Nutr 101:804-9. 2009
  7. ncbi request reprint Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation
    Saame Raza Shaikh
    Johns Hopkins University, Baltimore, MD 21218, USA
    Am J Clin Nutr 84:1277-89. 2006
  8. pmc Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study
    Saame Raza Shaikh
    Department of Biology, Indiana University Purdue University, Indianapolis, Indiana 46202 5132, USA
    Biophys J 87:1752-66. 2004
  9. ncbi request reprint Molecular organization of cholesterol in unsaturated phosphatidylethanolamines: X-ray diffraction and solid state 2H NMR reveal differences with phosphatidylcholines
    Saame Raza Shaikh
    Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, Indiana 46202 5132, USA
    J Am Chem Soc 128:5375-83. 2006
  10. pmc Plasma membrane lipid diffusion and composition of sea urchin egg membranes vary with ocean temperature
    Frances E Weaver
    Department of Biology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Chem Phys Lipids 151:62-5. 2008

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Interaction of cholesterol with a docosahexaenoic acid-containing phosphatidylethanolamine: trigger for microdomain/raft formation?
    Saame Raza Shaikh
    Department of Biology, Indiana University, Indianapolis 46202 5132, USA
    Biochemistry 42:12028-37. 2003
    ..Our findings provide further evidence that cholesterol has a low affinity for DHA-containing phospholipids and that this reduced affinity may serve as a mechanism for triggering the formation of lipid microdomains such as rafts...
  2. ncbi request reprint Membranes are not just rafts
    Saame Raza Shaikh
    Department of Biology, The Johns Hopkins University, 3400 North Charles Street, Mudd Hall, Baltimore, MD 21218, USA
    Chem Phys Lipids 144:1-3. 2006
    ....
  3. ncbi request reprint Immunosuppressive effects of polyunsaturated fatty acids on antigen presentation by human leukocyte antigen class I molecules
    Saame Raza Shaikh
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    J Lipid Res 48:127-38. 2007
    ..In addition, PUFA-mediated changes in ER-Golgi trafficking point to a new area of PUFA modulation of immune responses...
  4. pmc Polyunsaturated fatty acids and membrane organization: elucidating mechanisms to balance immunotherapy and susceptibility to infection
    Saame Raza Shaikh
    Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, United States
    Chem Phys Lipids 153:24-33. 2008
    ..In addition, we propose that mechanistic studies with defined experimental protocols will speed the translation of laboratory studies on PUFAs to the clinic...
  5. pmc Differential effects of a saturated and a monounsaturated fatty acid on MHC class I antigen presentation
    S R Shaikh
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Mudd Hall Room 45, Baltimore, MD 21218, USA
    Scand J Immunol 68:30-42. 2008
    ....
  6. pmc In vivo test of the vertical phase separation hypothesis: the display of major histocompatibility complex (MHC) class I molecules on membranes of B cells from mice fed high-fat diets
    Saame Raza Shaikh
    Department of Biology, Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Br J Nutr 101:804-9. 2009
    ..MHC class I surface levels on B cells were not affected by the MUFA-rich diet. This study suggests that the membrane vertical phase separation hypothesis may have limited application in a physiologically relevant setting...
  7. ncbi request reprint Polyunsaturated fatty acids, membrane organization, T cells, and antigen presentation
    Saame Raza Shaikh
    Johns Hopkins University, Baltimore, MD 21218, USA
    Am J Clin Nutr 84:1277-89. 2006
    ..Our data-based models show that membrane modification of both effectors and targets is an important, often overlooked, mechanism of immunomodulation by PUFAs...
  8. pmc Oleic and docosahexaenoic acid differentially phase separate from lipid raft molecules: a comparative NMR, DSC, AFM, and detergent extraction study
    Saame Raza Shaikh
    Department of Biology, Indiana University Purdue University, Indianapolis, Indiana 46202 5132, USA
    Biophys J 87:1752-66. 2004
    ..We conclude that the OA-PE phase separates from rafts far less than DHA-PE, which may have implications for cellular signaling...
  9. ncbi request reprint Molecular organization of cholesterol in unsaturated phosphatidylethanolamines: X-ray diffraction and solid state 2H NMR reveal differences with phosphatidylcholines
    Saame Raza Shaikh
    Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, Indiana 46202 5132, USA
    J Am Chem Soc 128:5375-83. 2006
    ..This distinction may have biological implications reflected by the health benefits of dietary polyunsaturated fatty acids that are often taken up into PE > PC...
  10. pmc Plasma membrane lipid diffusion and composition of sea urchin egg membranes vary with ocean temperature
    Frances E Weaver
    Department of Biology, Johns Hopkins University, 3400 N Charles Street, Baltimore, MD 21218, USA
    Chem Phys Lipids 151:62-5. 2008
    ..We found similar trends comparing DiI diffusion in membranes of eggs from 15 degrees C waters with those from 10 degrees C. Our findings establish a new approach for manipulating and studying membrane organization...
  11. pmc Cutting edge: phosphatidylinositol 4,5-bisphosphate concentration at the APC side of the immunological synapse is required for effector T cell function
    David Robert Fooksman
    Department of Biology, Johns Hopkins University, Baltimore, MD 21218, USA
    J Immunol 182:5179-82. 2009
    ..These findings suggest a new regulatory target for modulating immune function that may be exploited for immune escape by pathogens and tumors...
  12. ncbi request reprint Docosahexaenoic acid affects cell signaling by altering lipid rafts
    William Stillwell
    Department of Biology, Indiana University, Purdue University Indianapolis, 723 West Michigan, Indianapolis, IN 46202, USA
    Reprod Nutr Dev 45:559-79. 2005
    ..We conclude with a proposal of how DHA incorporation into membranes may control cell biochemistry and physiology...
  13. ncbi request reprint Comparison of cis and trans fatty acid containing phosphatidylcholines on membrane properties
    Charles Roach
    Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, Indiana 46202 5132, USA
    Biochemistry 43:6344-51. 2004
    ..e., cis double bonds induce much larger membrane perturbations than trans double bonds...
  14. ncbi request reprint Monounsaturated PE does not phase-separate from the lipid raft molecules sphingomyelin and cholesterol: role for polyunsaturation?
    Saame Raza Shaikh
    Department of Biology, Indiana University Purdue University Indianapolis, 723 West Michigan Street, Indianapolis, IN 46202 5132, USA
    Biochemistry 41:10593-602. 2002
    ..We propose that monounsaturated lipids do not promote formation of stable lipid rafts and that polyunsaturation may be important for raft stability...
  15. ncbi request reprint Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation
    Stephen R Wassall
    Department of Physics, Indiana University Purdue University Indianapolis, 402 N Blackford Street, Indianapolis, IN 46202 3273, USA
    Chem Phys Lipids 132:79-88. 2004
    ..We hypothesize that the enhanced propensity to form SM-/cholesterol-rich rafts as well as PUFA-rich/cholesterol-poor microdomains would modify the function of proteins for which these respective regions provide a platform...