Differential gene expression in the T-helper lymphocytes of obstructive sleep apnea patients treated with nasal continuous positive airway pressure (nCPAP)F F Shadan
Scripps Clinic Sleep Center, Molecular and Experimental Medicine, The Scripps Research Institute and General Clinical Research Center, Scripps Clinic, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA
Med Hypotheses 63:630-2. 2004
..e., ICAM-1) in T-helper lymphocytes. An understanding of the underlying inflammatory mechanism could lead to specific interventions that render nCPAP therapy tolerable for these individuals...
- Zolpidem for postanoxic spasticity
Farhad F Shadan
Divisions of Molecular and Experimental Medicine, Hospital Medicine, Neurology, and Chest Medicine, Scripps Clinic Sleep Center, La Jolla, CA, USA
South Med J 97:791-2. 2004
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- A circadian model for viral persistence
Farhad F Shadan
The Scripps Research Institute and Scripps Clinic, 10666 N Torrey Pines Road, 403C, La Jolla, CA 92037, USA
Med Hypotheses 68:546-53. 2007
..This temporal vulnerability to genotoxic stress produces a "mutator phenotype" with inherent genome instability. The proposed model delineates areas of research with implications for viral pathogenesis and therapeutics...
- Circadian tempo: a paradigm for genome stability?
Farhad F Shadan
The Scripps Research Institute and Scripps Clinic, La Jolla, CA 92037, USA
Med Hypotheses 68:883-91. 2007
..The accumulating mutations would lead to accelerated aging, genome instability and neoplasia. The proposed model delineates areas of research with potentially profound implications for carcinogenesis...
- Nasal cytology: a marker of clinically silent inflammation in patients with obstructive sleep apnea and a predictor of noncompliance with nasal CPAP therapy
Farhad F Shadan
Scripps Clinic Sleep Center, La Jolla, CA 92037-1027, USA
J Clin Sleep Med 1:266-70. 2005
..They appear to have subclinical nasal inflammation that cannot be identified from clinical assessment, nasal symptom scores or rhinomanometry...
- Wrist actigraphic scoring for sleep laboratory patients: algorithm development
Daniel F Kripke
Scripps Clinic Sleep Center, La Jolla, CA 92037, USA
J Sleep Res 19:612-9. 2010
..Neither algorithm had fully satisfactory agreement with PSG. Further evaluations of algorithms for these actigraphs are needed, along with controlled comparisons of different actigraphic designs and software...
- CPAP therapy of obstructive sleep apnea in type 2 diabetics improves glycemic control during sleep
Arthur Dawson
Scripps Clinic Sleep Center Division of Chest and Critical Care Medicine, Scripps Clinic, La Jolla, CA 92037, USA
J Clin Sleep Med 4:538-42. 2008
..However, endpoints such as hemoglobin A1c and insulin sensitivity might not reflect short-term changes in glycemic control during sleep...
- Genotyping sleep disorders patients
Daniel F Kripke
Scripps Clinic Sleep Center, La Jolla, California, USA
Psychiatry Investig 7:36-42. 2010
..Several candidate polymorphisms for sleep disorders have been proposed, but there has as yet inadequate replication or validation that the candidates may be useful in the clinical setting...
