Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cellsXianyi Sha
Department of Pharmaceutics, School of Pharmacy, Fudan University, No 138 Yixueyuan Road, Shanghai 200032, China
Eur J Pharm Sci 24:477-86. 2005
..1 and 1% was shown to increase the permeability of mannitol by 4.6-fold and 33.8-fold, respectively. The mechanism of opening of tight junctions was found to involve F-actin-related changes and redistribution of ZO-1...
- PEGylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel for the treatment of advanced glioma: in vitro and in vivo evaluation
Xinyi Jiang
Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Rd, Shanghai 201203, People s Republic of China
Int J Pharm 420:385-94. 2011
..Therefore, our results suggested that PTX-loaded MPEG-PTMC nanoparticles significantly enhanced the anti-glioblastoma activity of PTX and may be a potential vehicle in the treatment of high-grade glioma...
- Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors
Xinyi Jiang
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, People s Republic of China
Biomaterials 32:9457-69. 2011
..Therefore, the results demonstrated that c(RGDyK)-decorated PEG-PTMC MNP developed in this study could be a potential vehicle for delivering hydrophobic chemotherapeutic agents to integrin-rich tumors...
- The brain targeting mechanism of Angiopep-conjugated poly(ethylene glycol)-co-poly(ɛ-caprolactone) nanoparticles
Hongliang Xin
Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China Department of Pharmaceutics, School of Pharmacy, Nanjing Medical University, Nanjing 210029, China
Biomaterials 33:1673-81. 2012
..Understanding these issues is important for the future development of ANG-PEG-NP as a brain targeting drug delivery system for neurodegenerative disorders including glioma and Alzheimer's disease...
- Enhanced anti-tumor effect of 9-nitro-camptothecin complexed by hydroxypropyl-β-cyclodextrin and safety evaluation
Ye Jiang
School of Pharmacy, Fudan University, 826, Zhangheng Road, Shanghai 201203, PR China
Int J Pharm 415:252-8. 2011
..Taken together, the results suggested that the 9-NC complexed in HP-β-CD, instead of dissolved in the organic solvent, presented significant anti-tumor activity and low toxicity for the treatment of cancer...
- Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors
Yongzhong Wang
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
Biomaterials 33:4741-51. 2012
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- Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma
Hongliang Xin
Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China
Biomaterials 32:4293-305. 2011
..In conclusion, Angiopep-conjugated PEG-PCL nanoparticles were prospective in dual-targeting drug delivery system for targeting therapy of brain glioma...
- Self-assembled carboxymethyl poly (l-histidine) coated poly (β-amino ester)/DNA complexes for gene transfection
Jijin Gu
Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China
Biomaterials 33:644-58. 2012
..Our approach and the gene delivery system fabrication could potentially be useful for effective gene delivery and therapies to targeted cells...
Triolein-based polycation lipid nanocarrier for efficient gene delivery: characteristics and mechanismZhiwen Zhang
Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People s Republic of China
Int J Nanomedicine 6:2235-44. 2011
..The captured images verified that the fluorescent PDC was localized in the lysosomes and nuclei after endocytosis. Thus, PLN represents a novel efficient nonviral gene delivery vector...
- Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance
Wei Zhang
School of Pharmacy, Fudan University, Shanghai, China
Eur J Pharm Biopharm 75:341-53. 2010
..At 28days, tumor volume in PF-PTX group was only 31.8% that of the Taxol. Therefore, PF-PTX significantly enhanced the anti-cancer activity of PTX and might be considered a promising drug delivery system to overcome MDR in lung cancer...
- Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization
Zhang Wei
School of Pharmacy, Fudan University, Shanghai, China
Int J Pharm 376:176-85. 2009
..4 microg/ml) and the free PTX (1.7 microg/ml). Therefore, PTX-loaded P123/F127 mixed micelles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
- The potential of Pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models
Wei Zhang
School of Pharmacy, Fudan University, Shanghai, China
Biomaterials 32:5934-44. 2011
..In summary, the simple Pluronic-based nanocarrier could be harnessed for the delivery of anticancer drug to melanoma, with increased therapeutic index...
- Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors
Wei Zhang
School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
Biomaterials 32:2894-906. 2011
..In conclusion, folate-conjugated Pluronic micelles could be a potential vehicle for delivering hydrophobic chemotherapeutic drugs to MDR tumors...
- Complex of 9-nitro-camptothecin in hydroxypropyl-beta-cyclodextrin: in vitro and in vivo evaluation
Ye Jiang
School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
Int J Pharm 397:116-21. 2010
..m. administration and 385.39 ng h/ml vs. 538.05 ng h/ml for i.v. administration, respectively) and ratio of lactone form. These results demonstrated that 9-NC/HP-beta-CD complex is an attractive parenteral formulation for cancer therapy...
- Enhanced anti-glioblastoma efficacy by PTX-loaded PEGylated poly(ɛ-caprolactone) nanoparticles: In vitro and in vivo evaluation
Hongliang Xin
Department of Pharmaceutics, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
Int J Pharm 402:238-47. 2010
..Therefore, MPEGylated poly(ɛ-caprolactone) nanoparticles significantly enhanced the anti-glioblastoma activity of PTX and might be considered a promising drug delivery system against advanced glioblastoma...
- Enhanced transfection of polyplexes based on pluronic-polypropylenimine dendrimer for gene transfer
Junguo Hao
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China
Arch Pharm Res 32:1045-54. 2009
..Therefore, P123-PPI/DNA complex nanoparticles may be a safe, efficient and promising cationic conjugate for gene delivery...
- Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f
Xiao Wang
Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
Fitoterapia 83:690-8. 2012
..Various pharmacodynamics parameters proved that TWHF microemulsion can reduce the male reproductive toxicity and hepatotoxicity of rats. All these suggested that TMDDS could be a suitable delivery system for TWHF...
- Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation
Xianyi Sha
Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
Int J Nanomedicine 7:705-12. 2012
..22-fold that of oil solution and suspension, respectively. It was concluded that bioavailability of probucol was enhanced greatly by SMEDDS. Improved solubility and lymphatic transport may contribute to the enhancement of bioavailability...
Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticlesHongliang Xin
Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
Biomaterials 33:8167-76. 2012
..Results indicate that Angiopep-conjugated dual targeting PEG-PCL nanoparticle is a potential brain targeting drug delivery system for glioma treatment...
- Oral absorption of ginsenoside Rb1 using in vitro and in vivo models
Min Han
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People's Republic of China
Planta Med 72:398-404. 2006
..In summary, elimination in the stomach, large intestine and liver contributed to the poor absorption of Rb1, but the low membrane permeability might be a more important factor dominating the extent of absorption...
- Polycation nanostructured lipid carrier, a novel nonviral vector constructed with triolein for efficient gene delivery
Zhiwen Zhang
School of Pharmacy, Fudan University, Lane 138, Yi Xue Yuan Road, Shanghai 200032, China
Biochem Biophys Res Commun 370:478-82. 2008
..Thus, PNLC is an effective nonviral gene transfer vector and the gene delivery activity of PNLC was enhanced after triolein was included into the PNLC formulation...
- Effect of phospholipid composition on pharmacokinetics and biodistribution of epirubicin liposomes
Xianyi Sha
Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
J Liposome Res 22:80-8. 2012
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- Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines
Yongzhong Wang
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
Int J Pharm 337:63-73. 2007
....
- Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs
Xianyi Sha
Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
Int J Pharm 272:161-71. 2004
..05). Overall, the current study suggests that pH and efflux transporters are capable of mediating the absorption and efflux of 9-NC, and they may play significant roles in limiting the oral absorption of 9-NC...
