Xianyi Sha

Summary

Publications

  1. ncbi request reprint Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells
    Xianyi Sha
    Department of Pharmaceutics, School of Pharmacy, Fudan University, No 138 Yixueyuan Road, Shanghai 200032, China
    Eur J Pharm Sci 24:477-86. 2005
  2. doi request reprint PEGylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel for the treatment of advanced glioma: in vitro and in vivo evaluation
    Xinyi Jiang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Rd, Shanghai 201203, People s Republic of China
    Int J Pharm 420:385-94. 2011
  3. doi request reprint Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel
    Xinyi Jiang
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China
    Biomaterials 34:2969-79. 2013
  4. doi request reprint Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors
    Xinyi Jiang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, People s Republic of China
    Biomaterials 32:9457-69. 2011
  5. pmc Pluronic mixed micelles overcoming methotrexate multidrug resistance: in vitro and in vivo evaluation
    Yanzuo Chen
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    Int J Nanomedicine 8:1463-76. 2013
  6. doi request reprint The brain targeting mechanism of Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles
    Hongliang Xin
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai, China
    Biomaterials 33:1673-81. 2012
  7. ncbi request reprint Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment
    Xinyi Jiang
    Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, China Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang 212013, China
    Biomaterials 35:518-29. 2014
  8. doi request reprint Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel
    Xinyi Jiang
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China
    Biomaterials 34:1739-46. 2013
  9. doi request reprint Enhanced anti-tumor effect of 9-nitro-camptothecin complexed by hydroxypropyl-β-cyclodextrin and safety evaluation
    Ye Jiang
    School of Pharmacy, Fudan University, 826, Zhangheng Road, Shanghai 201203, PR China
    Int J Pharm 415:252-8. 2011
  10. doi request reprint Enhanced antitumor efficacy by methotrexate conjugated Pluronic mixed micelles against KBv multidrug resistant cancer
    Yanzuo Chen
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
    Int J Pharm 452:421-33. 2013

Collaborators

  • Wei Zhang
  • Xiao Wang
  • Yuan Shi
  • Shuo Chen
  • Min Han
  • Li Yu
  • Xiaoling Fang
  • Yanzuo Chen
  • Xinyi Jiang
  • Hongliang Xin
  • Jijin Gu
  • Liangcen Chen
  • Ye Jiang
  • Qiuyue Ren
  • Zhiwen Zhang
  • Zhuoyang Fan
  • Kitki Law
  • Junguo Hao
  • Yongzhong Wang
  • Yajuan Li
  • Xinyi Chen
  • Yike Xie
  • Zhang Wei
  • Weitong Zhong
  • Ximing Xu
  • Weiyi Xia
  • Xiaoqing Ren
  • Limei Han
  • Lingjun Zhu
  • Fengyi Du
  • Chunli Deng
  • Lin Meng
  • Chunlai Feng
  • Juan Wu
  • Hangting Hu
  • Baisong Chang
  • Wuli Yang
  • Xihui Gao
  • Jieqi Luo
  • Wu Juan
  • Yuanjia Tang
  • Shi Yuan
  • Anle Shen
  • Zhaogui Sun
  • Zheng Gu

Detail Information

Publications35

  1. ncbi request reprint Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells
    Xianyi Sha
    Department of Pharmaceutics, School of Pharmacy, Fudan University, No 138 Yixueyuan Road, Shanghai 200032, China
    Eur J Pharm Sci 24:477-86. 2005
    ..1 and 1% was shown to increase the permeability of mannitol by 4.6-fold and 33.8-fold, respectively. The mechanism of opening of tight junctions was found to involve F-actin-related changes and redistribution of ZO-1...
  2. doi request reprint PEGylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel for the treatment of advanced glioma: in vitro and in vivo evaluation
    Xinyi Jiang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Rd, Shanghai 201203, People s Republic of China
    Int J Pharm 420:385-94. 2011
    ..Therefore, our results suggested that PTX-loaded MPEG-PTMC nanoparticles significantly enhanced the anti-glioblastoma activity of PTX and may be a potential vehicle in the treatment of high-grade glioma...
  3. doi request reprint Integrin-facilitated transcytosis for enhanced penetration of advanced gliomas by poly(trimethylene carbonate)-based nanoparticles encapsulating paclitaxel
    Xinyi Jiang
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China
    Biomaterials 34:2969-79. 2013
    ..Therefore, our results suggested that cyclic RGD-conjugated PEG-PTMC nanoparticle could be a promising vehicle for enhancing the penetration and cxhemotherapy of high-grade malignant gliomas...
  4. doi request reprint Self-aggregated pegylated poly (trimethylene carbonate) nanoparticles decorated with c(RGDyK) peptide for targeted paclitaxel delivery to integrin-rich tumors
    Xinyi Jiang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, People s Republic of China
    Biomaterials 32:9457-69. 2011
    ..Therefore, the results demonstrated that c(RGDyK)-decorated PEG-PTMC MNP developed in this study could be a potential vehicle for delivering hydrophobic chemotherapeutic agents to integrin-rich tumors...
  5. pmc Pluronic mixed micelles overcoming methotrexate multidrug resistance: in vitro and in vivo evaluation
    Yanzuo Chen
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    Int J Nanomedicine 8:1463-76. 2013
    ..Collectively, Pluronic P105/F127 mixed micelles could significantly enhance the antitumor activity of MTX and might be a promising drug delivery platform for multidrug resistance modulation...
  6. doi request reprint The brain targeting mechanism of Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles
    Hongliang Xin
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai, China
    Biomaterials 33:1673-81. 2012
    ..Understanding these issues is important for the future development of ANG-PEG-NP as a brain targeting drug delivery system for neurodegenerative disorders including glioma and Alzheimer's disease...
  7. ncbi request reprint Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment
    Xinyi Jiang
    Key Laboratory of Smart Drug Delivery, Ministry of Education, School of Pharmacy, Fudan University, Shanghai 201203, China Department of Pharmaceutics, School of Pharmacy, Center for Nano Drug Gene Delivery and Tissue Engineering, Jiangsu University, Zhenjiang 212013, China
    Biomaterials 35:518-29. 2014
    ..Therefore, these results indicated that dGlu-NP developed in this study could be a potential dual-targeted vehicle for brain glioma therapy...
  8. doi request reprint Solid tumor penetration by integrin-mediated pegylated poly(trimethylene carbonate) nanoparticles loaded with paclitaxel
    Xinyi Jiang
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China
    Biomaterials 34:1739-46. 2013
    ..In conclusion, cyclic RGD peptide-conjugated PEG-PTMC nanoparticle could facilitate drug penetration and accumulation in tumor tissues and may be a promising vehicle for enhancing the chemotherapy of solid cancers...
  9. doi request reprint Enhanced anti-tumor effect of 9-nitro-camptothecin complexed by hydroxypropyl-β-cyclodextrin and safety evaluation
    Ye Jiang
    School of Pharmacy, Fudan University, 826, Zhangheng Road, Shanghai 201203, PR China
    Int J Pharm 415:252-8. 2011
    ..Taken together, the results suggested that the 9-NC complexed in HP-β-CD, instead of dissolved in the organic solvent, presented significant anti-tumor activity and low toxicity for the treatment of cancer...
  10. doi request reprint Enhanced antitumor efficacy by methotrexate conjugated Pluronic mixed micelles against KBv multidrug resistant cancer
    Yanzuo Chen
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
    Int J Pharm 452:421-33. 2013
    ..Therefore, MTX-conjugated mixed micelles might be an effective platform for delivering chemotherapeutic agents to MDR tumors...
  11. pmc Pluronic P105/F127 mixed micelles for the delivery of docetaxel against Taxol-resistant non-small cell lung cancer: optimization and in vitro, in vivo evaluation
    Liangcen Chen
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
    Int J Nanomedicine 8:73-84. 2013
    ..43% for Taxotere (P < 0.01). Therefore, it could be concluded from the results that DTX-loaded P105/F127 mixed micelles might serve as a potential antitumor drug delivery system to overcome multidrug resistance in lung cancer...
  12. ncbi request reprint Anti-glioblastoma efficacy and safety of paclitaxel-loading Angiopep-conjugated dual targeting PEG-PCL nanoparticles
    Hongliang Xin
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
    Biomaterials 33:8167-76. 2012
    ..Results indicate that Angiopep-conjugated dual targeting PEG-PCL nanoparticle is a potential brain targeting drug delivery system for glioma treatment...
  13. doi request reprint Poly(caprolactone)-modified Pluronic P105 micelles for reversal of paclitaxcel-resistance in SKOV-3 tumors
    Yongzhong Wang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, China
    Biomaterials 33:4741-51. 2012
    ....
  14. doi request reprint Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma
    Hongliang Xin
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, School of Pharmacy, Fudan University, Shanghai 201203, China
    Biomaterials 32:4293-305. 2011
    ..In conclusion, Angiopep-conjugated PEG-PCL nanoparticles were prospective in dual-targeting drug delivery system for targeting therapy of brain glioma...
  15. pmc Triolein-based polycation lipid nanocarrier for efficient gene delivery: characteristics and mechanism
    Zhiwen Zhang
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    Int J Nanomedicine 6:2235-44. 2011
    ..The captured images verified that the fluorescent PDC was localized in the lysosomes and nuclei after endocytosis. Thus, PLN represents a novel efficient nonviral gene delivery vector...
  16. doi request reprint Self-assembled carboxymethyl poly (L-histidine) coated poly (β-amino ester)/DNA complexes for gene transfection
    Jijin Gu
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 201203, PR China
    Biomaterials 33:644-58. 2012
    ..Our approach and the gene delivery system fabrication could potentially be useful for effective gene delivery and therapies to targeted cells...
  17. doi request reprint Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization
    Zhang Wei
    School of Pharmacy, Fudan University, Shanghai, China
    Int J Pharm 376:176-85. 2009
    ..4 microg/ml) and the free PTX (1.7 microg/ml). Therefore, PTX-loaded P123/F127 mixed micelles may be considered as an effective anticancer drug delivery system for cancer chemotherapy...
  18. doi request reprint Enhanced antitumor efficacy by paclitaxel-loaded pluronic P123/F127 mixed micelles against non-small cell lung cancer based on passive tumor targeting and modulation of drug resistance
    Wei Zhang
    School of Pharmacy, Fudan University, Shanghai, China
    Eur J Pharm Biopharm 75:341-53. 2010
    ..At 28days, tumor volume in PF-PTX group was only 31.8% that of the Taxol. Therefore, PF-PTX significantly enhanced the anti-cancer activity of PTX and might be considered a promising drug delivery system to overcome MDR in lung cancer...
  19. doi request reprint The potential of Pluronic polymeric micelles encapsulated with paclitaxel for the treatment of melanoma using subcutaneous and pulmonary metastatic mice models
    Wei Zhang
    School of Pharmacy, Fudan University, Shanghai, China
    Biomaterials 32:5934-44. 2011
    ..In summary, the simple Pluronic-based nanocarrier could be harnessed for the delivery of anticancer drug to melanoma, with increased therapeutic index...
  20. doi request reprint Multifunctional Pluronic P123/F127 mixed polymeric micelles loaded with paclitaxel for the treatment of multidrug resistant tumors
    Wei Zhang
    School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
    Biomaterials 32:2894-906. 2011
    ..In conclusion, folate-conjugated Pluronic micelles could be a potential vehicle for delivering hydrophobic chemotherapeutic drugs to MDR tumors...
  21. doi request reprint Complex of 9-nitro-camptothecin in hydroxypropyl-beta-cyclodextrin: in vitro and in vivo evaluation
    Ye Jiang
    School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
    Int J Pharm 397:116-21. 2010
    ..m. administration and 385.39 ng h/ml vs. 538.05 ng h/ml for i.v. administration, respectively) and ratio of lactone form. These results demonstrated that 9-NC/HP-beta-CD complex is an attractive parenteral formulation for cancer therapy...
  22. doi request reprint Enhanced anti-glioblastoma efficacy by PTX-loaded PEGylated poly(ɛ-caprolactone) nanoparticles: In vitro and in vivo evaluation
    Hongliang Xin
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
    Int J Pharm 402:238-47. 2010
    ..Therefore, MPEGylated poly(ɛ-caprolactone) nanoparticles significantly enhanced the anti-glioblastoma activity of PTX and might be considered a promising drug delivery system against advanced glioblastoma...
  23. ncbi request reprint Enhanced transfection of polyplexes based on pluronic-polypropylenimine dendrimer for gene transfer
    Junguo Hao
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China
    Arch Pharm Res 32:1045-54. 2009
    ..Therefore, P123-PPI/DNA complex nanoparticles may be a safe, efficient and promising cationic conjugate for gene delivery...
  24. doi request reprint A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: enhancing the secretion of chylomicrons
    Zhuoyang Fan
    Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Lane 826, Zhangheng Road, Shanghai 201203, China
    Int J Pharm 445:141-7. 2013
    ..These studies first demonstrate the function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs, which can significantly promote the secretion of chylomicrons by the intestinal epithelial cells...
  25. doi request reprint Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f
    Xiao Wang
    Key Laboratory of Smart Drug Delivery, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China
    Fitoterapia 83:690-8. 2012
    ..Various pharmacodynamics parameters proved that TWHF microemulsion can reduce the male reproductive toxicity and hepatotoxicity of rats. All these suggested that TMDDS could be a suitable delivery system for TWHF...
  26. pmc Self-microemulsifying drug-delivery system for improved oral bioavailability of probucol: preparation and evaluation
    Xianyi Sha
    Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
    Int J Nanomedicine 7:705-12. 2012
    ..22-fold that of oil solution and suspension, respectively. It was concluded that bioavailability of probucol was enhanced greatly by SMEDDS. Improved solubility and lymphatic transport may contribute to the enhancement of bioavailability...
  27. ncbi request reprint In vitro, ex vivo, and in vivo evaluation of the effect of saturated fat Acid chain length on the transdermal behavior of ibuprofen-loaded microemulsions
    Qiuyue Ren
    Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, 201203, China
    J Pharm Sci 103:1680-91. 2014
    ..MFA was found to be an optimal oil phase with appropriate FA chain length for IBU-loaded transdermal ME, which exhibited excellent physicochemical properties, low toxicity, and good permeability profile...
  28. doi request reprint Serum-resistant complex nanoparticles functionalized with imidazole-rich polypeptide for gene delivery to pulmonary metastatic melanoma
    Jijin Gu
    Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, PR China Laboratory for Drug Delivery and Biomaterials, Faculty of Pharmacy, University of Manitoba, 750 McDermot Avenue, Winnipeg, Manitoba R3E 0T5, Canada
    Int J Pharm 461:559-69. 2014
    ..These results suggested that CM-PLH/PbAE/pDNA ternary complex nanoparticles were promising and challenging gene vector for practical application...
  29. ncbi request reprint Oral absorption of ginsenoside Rb1 using in vitro and in vivo models
    Min Han
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, People s Republic of China
    Planta Med 72:398-404. 2006
    ..In summary, elimination in the stomach, large intestine and liver contributed to the poor absorption of Rb1, but the low membrane permeability might be a more important factor dominating the extent of absorption...
  30. pmc Retro-inverso carbohydrate mimetic peptides with annexin1-binding selectivity, are stable in vivo, and target tumor vasculature
    Xinyi Chen
    Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
    PLoS ONE 8:e80390. 2013
    ..Experimental results indicate that RIF7 had significantly increased stability and an increased receptor binding affinity than IF7, and this new moiety may represent a clinically relevant vehicle for anticancer drugs. ..
  31. doi request reprint Polycation nanostructured lipid carrier, a novel nonviral vector constructed with triolein for efficient gene delivery
    Zhiwen Zhang
    School of Pharmacy, Fudan University, Lane 138, Yi Xue Yuan Road, Shanghai 200032, China
    Biochem Biophys Res Commun 370:478-82. 2008
    ..Thus, PNLC is an effective nonviral gene transfer vector and the gene delivery activity of PNLC was enhanced after triolein was included into the PNLC formulation...
  32. doi request reprint In vivo distribution and antitumor activity of doxorubicin-loaded N-isopropylacrylamide-co-methacrylic acid coated mesoporous silica nanoparticles and safety evaluation
    Yanzuo Chen
    Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
    Eur J Pharm Biopharm 85:406-12. 2013
    ..This finding was correlated with both in vitro and in vivo. Subacute toxicity tests revealed a low P-MSN-DOX toxicity in vivo, as well. Thus, P-MSN-DOX appears to be an efficacious and safe cancer treatment strategy...
  33. doi request reprint Effect of phospholipid composition on pharmacokinetics and biodistribution of epirubicin liposomes
    Xianyi Sha
    Key Laboratory of Smart Drug Delivery Fudan University, Ministry of Education and PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai, China
    J Liposome Res 22:80-8. 2012
    ....
  34. ncbi request reprint Difunctional Pluronic copolymer micelles for paclitaxel delivery: synergistic effect of folate-mediated targeting and Pluronic-mediated overcoming multidrug resistance in tumor cell lines
    Yongzhong Wang
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Int J Pharm 337:63-73. 2007
    ....
  35. ncbi request reprint Transport characteristics of 9-nitrocamptothecin in the human intestinal cell line Caco-2 and everted gut sacs
    Xianyi Sha
    Department of Pharmaceutics, School of Pharmacy, Fudan University, Shanghai 200032, PR China
    Int J Pharm 272:161-71. 2004
    ..05). Overall, the current study suggests that pH and efflux transporters are capable of mediating the absorption and efflux of 9-NC, and they may play significant roles in limiting the oral absorption of 9-NC...