Daniel Sessler

Summary

Publications

  1. doi request reprint The thermoregulation story
    Daniel I Sessler
    Department of Outcomes Research, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesthesiology 118:181-6. 2013
  2. doi request reprint Hospital stay and mortality are increased in patients having a "triple low" of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia
    Daniel I Sessler
    Department of Outcomes Research, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesthesiology 116:1195-203. 2012
  3. ncbi request reprint A randomized controlled study to assess patients' understanding of and consenting for clinical trials using two different consent form presentations
    A A Abd-Elsayed
    Departments of Outcomes Research and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA
    Minerva Anestesiol 78:564-73. 2012
  4. pmc Differential effects of antibiotics in combination with G-CSF on survival and polymorphonuclear granulocyte cell functions in septic rats
    Artur Bauhofer
    Institute of Theoretical Surgery, Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
    BMC Infect Dis 8:55. 2008
  5. doi request reprint Can regional analgesia reduce the risk of recurrence after breast cancer? Methodology of a multicenter randomized trial
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Contemp Clin Trials 29:517-26. 2008
  6. doi request reprint Does regional analgesia reduce the risk of cancer recurrence? A hypothesis
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio, USA
    Eur J Cancer Prev 17:269-72. 2008
  7. pmc Temperature monitoring and perioperative thermoregulation
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic P77, Cleveland, Ohio 44195, USA
    Anesthesiology 109:318-38. 2008
  8. pmc Nitrous oxide may not increase the risk of cancer recurrence after colorectal surgery: a follow-up of a randomized controlled trial
    Edith Fleischmann
    Outcomes Research, The Cleveland Clinic, Cleveland, Ohio, USA
    BMC Anesthesiol 9:1. 2009
  9. doi request reprint Defeating normal thermoregulatory defenses: induction of therapeutic hypothermia
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Stroke 40:e614-21. 2009
  10. doi request reprint Thermoregulatory defense mechanisms
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, OH, USA
    Crit Care Med 37:S203-10. 2009

Research Grants

  1. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2001
  2. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2000
  3. Nitrous Oxide and Wound Infections
    Daniel Sessler; Fiscal Year: 2003
  4. Nitrous Oxide and Wound Infections
    Daniel Sessler; Fiscal Year: 2004
  5. Nitrous Oxide and Wound Infections
    Daniel Sessler; Fiscal Year: 2005
  6. Nitrous Oxide and Wound Infections
    Ozan Akca; Fiscal Year: 2006

Collaborators

Detail Information

Publications82

  1. doi request reprint The thermoregulation story
    Daniel I Sessler
    Department of Outcomes Research, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesthesiology 118:181-6. 2013
    ..Measuring skin-surface temperature gradients is a simple, noninvasive, and quantitative method of determining the thermoregulatory threshold during anesthesia...
  2. doi request reprint Hospital stay and mortality are increased in patients having a "triple low" of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia
    Daniel I Sessler
    Department of Outcomes Research, Cleveland Clinic, Cleveland, OH 44195, USA
    Anesthesiology 116:1195-203. 2012
    ..The authors sought to characterize the effect of the triple low state (low MAP and low BIS during a low MAC fraction) on duration of hospitalization and 30-day all-cause mortality...
  3. ncbi request reprint A randomized controlled study to assess patients' understanding of and consenting for clinical trials using two different consent form presentations
    A A Abd-Elsayed
    Departments of Outcomes Research and Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH 44195, USA
    Minerva Anestesiol 78:564-73. 2012
    ..We therefore tested the hypothesis that presentation of consent documents in an enhanced format improves patients' attention, understanding and therefore willingness to consent for clinical research...
  4. pmc Differential effects of antibiotics in combination with G-CSF on survival and polymorphonuclear granulocyte cell functions in septic rats
    Artur Bauhofer
    Institute of Theoretical Surgery, Philipps University Marburg, Baldingerstrasse, 35033 Marburg, Germany
    BMC Infect Dis 8:55. 2008
    ..We investigated in septic rats the effects of two antibiotic combinations with G-CSF...
  5. doi request reprint Can regional analgesia reduce the risk of recurrence after breast cancer? Methodology of a multicenter randomized trial
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Contemp Clin Trials 29:517-26. 2008
    ..Confirming our hypothesis will indicate that a small modification to anesthetic management, one that can be implemented with little risk or cost, will reduce the risk of cancer recurrence - a complication that is often ultimately lethal...
  6. doi request reprint Does regional analgesia reduce the risk of cancer recurrence? A hypothesis
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio, USA
    Eur J Cancer Prev 17:269-72. 2008
    ..Confirming this hypothesis would indicate that a minor modification to anaesthetic management reduces the risk of cancer recurrence...
  7. pmc Temperature monitoring and perioperative thermoregulation
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic P77, Cleveland, Ohio 44195, USA
    Anesthesiology 109:318-38. 2008
    ..Neuraxial anesthesia also impairs thermoregulatory control, although to a lesser extent than does general anesthesia. Prolonged epidural analgesia is associated with hyperthermia whose cause remains unknown...
  8. pmc Nitrous oxide may not increase the risk of cancer recurrence after colorectal surgery: a follow-up of a randomized controlled trial
    Edith Fleischmann
    Outcomes Research, The Cleveland Clinic, Cleveland, Ohio, USA
    BMC Anesthesiol 9:1. 2009
    ..We therefore tested the hypothesis that colorectal-cancer recurrence risk is augmented by nitrous oxide administration during colorectal surgery...
  9. doi request reprint Defeating normal thermoregulatory defenses: induction of therapeutic hypothermia
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Stroke 40:e614-21. 2009
    ..5 degrees C in doses that maintain adequate ventilation...
  10. doi request reprint Thermoregulatory defense mechanisms
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, Cleveland, OH, USA
    Crit Care Med 37:S203-10. 2009
    ..The combination of buspirone and dexmedetomidine is comparably effective while avoiding the respiratory depression association with opioid administration...
  11. doi request reprint Broadly applicable risk stratification system for predicting duration of hospitalization and mortality
    Daniel I Sessler
    Department of Outcomes Research, Cleveland Clinic, Cleveland, OH, USA
    Anesthesiology 113:1026-37. 2010
    ..We sought to develop a risk-adjustment method using administrative claims data to assess both national-level and hospital-specific performance...
  12. pmc Design and Organization of the Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT) Trial: a factorial trial evaluating the effects of corticosteroids, glucose control, and depth-of-anesthesia on perioperative inflammation and morbidity from
    Basem Abdelmalak
    Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio, USA
    BMC Anesthesiol 10:11. 2010
    ..We are studying three interventions that potentially modulate perioperative inflammation: corticosteroids, tight glucose control, and light anesthesia...
  13. doi request reprint Operation timing and 30-day mortality after elective general surgery
    Daniel I Sessler
    Department of Outcomes Research, The Cleveland Clinic, 9500 Euclid Avenue, Desk P 77, Cleveland, OH 44195, USA
    Anesth Analg 113:1423-8. 2011
    ..A secondary outcome of composite in-hospital complications was also evaluated...
  14. ncbi request reprint Perioperative thermoregulation and temperature monitoring
    Steven R Insler
    The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Anesthesiol Clin 24:823-37. 2006
    ..Because thermal disturbances are associated with severe consequences, the standard of care is to monitor temperature during general anesthesia and to maintain normothermia unless otherwise specifically indicated...
  15. doi request reprint Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis
    Barbara Biki
    Department of Anaesthesia, Mater Misericordiae University Hospital, The Cleveland Clinic, USA
    Anesthesiology 109:180-7. 2008
    ..Therefore, the authors evaluated prostate cancer recurrence in patients who received either general anesthesia with epidural anesthesia/analgesia or general anesthesia with postoperative opioid analgesia...
  16. doi request reprint An evaluation of a full-access underbody forced-air warming system during near-normothermic, on-pump cardiac surgery
    Steven R Insler
    Department of Cardiothoracic Anesthesia, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Anesth Analg 106:746-50, table of contents. 2008
    ....
  17. doi request reprint Propensity matched comparison of outcomes in older and younger patients after coronary artery bypass graft surgery
    Negmeldeen F Mamoun
    Department of Cardiothoracic Anesthesia, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Ann Thorac Surg 85:1974-9. 2008
    ..2 to 20.8 million. We therefore compared outcomes after isolated coronary artery bypass grafting (CABG) in patients aged 85 years and older with those 55 to 65 years old...
  18. doi request reprint Spinal cord stimulation for chronic visceral abdominal pain
    Leonardo Kapural
    Department of Pain Management, The Cleveland Clinic, Cleveland, Ohio 44195, USA
    Pain Med 11:347-55. 2010
    ..Spinal cord stimulation (SCS) may reduce pain scores and improve function in patients with chronic visceral abdominal pain. We thus present our large clinical experience in SCS for visceral abdominal pain...
  19. pmc Blood storage duration and biochemical recurrence of cancer after radical prostatectomy
    Juan P Cata
    Department of Outcomes Research, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Mayo Clin Proc 86:120-7. 2011
    ..To test the hypothesis that perioperative transfusion of allogeneic and autologous red blood cells (RBCs) stored for a prolonged period speeds biochemical recurrence of prostate cancer after prostatectomy...
  20. ncbi request reprint The effects of mild perioperative hypothermia on blood loss and transfusion requirement
    Suman Rajagopalan
    Division of Anesthesia, Critical Care, and Comprehensive Pain Management, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Anesthesiology 108:71-7. 2008
    ..The objective of this meta-analysis and systematic review was to evaluate the hypothesis that mild perioperative hypothermia increases surgical blood loss and transfusion requirement...
  21. pmc Non-pharmacologic prevention of surgical wound infection
    Daniel I Sessler
    Department of Outcomes Research, Cleveland Clinic, 9500 Euclid Avenue, E30, Cleveland, OH 44195, USA
    Anesthesiol Clin 24:279-97. 2006
    ..The contribution, if any, of other factors including, tight glucose control, fluid management, and mild hypercapnia have yet to be suitably tested...
  22. doi request reprint Duration of red-cell storage and complications after cardiac surgery
    Colleen Gorman Koch
    Department of Cardiothoracic Anesthesia, Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    N Engl J Med 358:1229-39. 2008
    ..We tested the hypothesis that serious complications and mortality after cardiac surgery are increased when transfused red cells are stored for more than 2 weeks...
  23. doi request reprint The effect of aminophylline on loss of consciousness, bispectral index, propofol requirement, and minimum alveolar concentration of desflurane in volunteers
    Alparslan Turan
    Department of Outcomes Research, Cleveland Clinic, Cleveland, Ohio 44195, USA
    Anesth Analg 110:449-54. 2010
    ....
  24. doi request reprint Dosing of remifentanil to prevent movement during craniotomy in the absence of neuromuscular blockade
    Marco A Maurtua
    Department of General Anesthesiology, Case Western Reserve University, Cleveland, OH, USA
    J Neurosurg Anesthesiol 20:221-5. 2008
    ..Our study's objective was to determine the optimal dose of remifentanil required to prevent movement after neurosurgical stimulation...
  25. doi request reprint Operation timing does not affect outcome after coronary artery bypass graft surgery
    Paul J Tan
    Anesthesiology Institute, Department of Quantitative Health Sciences, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Anesthesiology 111:785-9. 2009
    ..This study investigated whether the timing of coronary artery bypass graft surgery affects outcomes...
  26. ncbi request reprint Noninvasive temperature monitoring in postanesthesia care units
    Geoffrey E Langham
    School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA
    Anesthesiology 111:90-6. 2009
    ..This study, therefore, quantified the change in core temperature occurring during emergence and transport and evaluated the accuracy and precision of eight noninvasive thermometers in the PACU...
  27. doi request reprint Resistive polymer versus forced-air warming: comparable heat transfer and core rewarming rates in volunteers
    Oliver Kimberger
    Department of Anesthesiology, General Intensive Care and Pain Medicine, Medical University of Vienna, Vienna, Austria
    Anesth Analg 107:1621-6. 2008
    ..Recently, a polymer-based resistive patient warming system has been developed. We compared the efficacy of a standard forced-air warming system with the resistive polymer system in volunteers...
  28. pmc Estimation of mean body temperature from mean skin and core temperature
    Rainer Lenhardt
    Outcomes Research Institute, Department of Anesthesiology and Perioperative Medicine, Neurosciences Intensive Care Unit, University of Louisville, Louisville, Kentucky 40202, USA
    Anesthesiology 105:1117-21. 2006
    ..Therefore, the authors tested the hypothesis that MBT, as estimated with Burton's formula, poorly estimates measured MBT at a temperature range between 18 degrees and 36.5 degrees C...
  29. pmc Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis?
    Aristomenis K Exadaktylos
    University Department of Anaesthesia and Intensive Care Medicine, Mater Misericordiae University Hospital, National Breast Screening Program Eccles Unit, Dublin 7, Ireland
    Anesthesiology 105:660-4. 2006
    ....
  30. ncbi request reprint Core temperature monitoring with new ventilatory devices
    Takashi Matsukawa
    Department of Anesthesia, University of Yamanashi, Faculty of Medicine, Japan
    Anesth Analg 96:1688-91, table of contents. 2003
    ..5 degrees C was 7% with LMA and 10% with COPA. These results suggest that body temperature measured from the cuffs of COPA or LMAs is sufficiently accurate for routine clinical use...
  31. pmc Cutaneous heat loss with three surgical drapes, one impervious to moisture
    Paul E Maglinger
    The Outcomes Research Institute and the Department of Anesthesiology, University of Louisville, Louisville, Kentucky 40202, USA
    Anesth Analg 100:738-42, table of contents. 2005
    ..Moist skin increased heat loss nearly three-fold, but there were no differences among the drapes. We conclude that loss is comparable with impervious and conventional drapes with either moist or dry skin...
  32. ncbi request reprint Resistive-heating and forced-air warming are comparably effective
    Chiharu Negishi
    Department of Anesthesia, Tokyo Women s Medical University, Tokyo, Japan
    Anesth Analg 96:1683-7, table of contents. 2003
    ..Even during major abdominal surgery, resistive heating maintains core temperature as effectively as forced air...
  33. ncbi request reprint Dexmedetomidine and meperidine additively reduce the shivering threshold in humans
    Anthony G Doufas
    Outcomes Research Institute and the Department of Anesthesiology, Louisville, KY, USA
    Stroke 34:1218-23. 2003
    ..We tested the hypothesis that meperidine and dexmedetomidine synergistically reduce the shivering threshold without producing substantial sedation or respiratory depression...
  34. ncbi request reprint Perioperative hypothermia in the high-risk surgical patient
    Kate Leslie
    Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, Parkville, VIC 3050, Australia
    Best Pract Res Clin Anaesthesiol 17:485-98. 2003
    ..Proper thermal management may reduce complications and improve the outcome in high-risk surgical patients...
  35. ncbi request reprint Upright posture reduces thermogenesis and augments core hypothermia
    Yasufumi Nakajima
    Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Anesth Analg 94:1646-51, table of contents. 2002
    ....
  36. pmc Nefopam, a nonsedative benzoxazocine analgesic, selectively reduces the shivering threshold in unanesthetized subjects
    Pascal Alfonsi
    Department of Anesthesia, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, France
    Anesthesiology 100:37-43. 2004
    ..The authors evaluated the effects of nefopam on the major thermoregulatory responses in humans: sweating, vasoconstriction, and shivering...
  37. pmc Dantrolene reduces the threshold and gain for shivering
    Chun Ming Lin
    Outcomes Research Institute, University of Louisville, Louisville, Kentucky 40202, USA
    Anesth Analg 98:1318-24, table of contents. 2004
    ..It thus seems unlikely to prove more effective than conventional muscle relaxants for treatment of life-threatening hyperthermia...
  38. pmc Effect of amino acid infusion on central thermoregulatory control in humans
    Yasufumi Nakajima
    Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Anesthesiology 100:634-9. 2004
    ..Therefore, the authors tested the hypothesis that amino acid infusion increases the thermoregulatory set point...
  39. ncbi request reprint Active warming during cesarean delivery
    Ernst Peter Horn
    Department of Anesthesiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Anesth Analg 94:409-14, table of contents. 2002
    ..05). Babies of warmed mothers had significantly greater core temperatures (37.1 degrees C +/- 0.5 degrees C vs 36.2 degrees C +/- 0.6 degrees C) and umbilical vein pH (7.32 +/- 0.07 vs 7.24 +/- 0.07)...
  40. ncbi request reprint The threshold and gain of thermoregulatory vasoconstriction differs during anesthesia in the dependent and upper arms in the lateral position
    Robert Greif
    Department of Anesthesiology and Intensive Care Medicine, Donauspital SMZO, Vienna, Austria
    Anesth Analg 94:1019-22, table of contents. 2002
    ..The thermoregulatory system may thus recognize that hydrostatic forces reduce the vasoconstriction threshold and may compensate by sufficiently augmenting gain...
  41. ncbi request reprint Thermoregulatory response to intraoperative head-down tilt
    Yasufumi Nakajima
    Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Anesth Analg 94:221-6, table of contents. 2002
    ..Surprisingly, maintaining a head-down tilt did not increase right atrial pressure...
  42. doi request reprint A prospective, randomized comparison of cobra perilaryngeal airway and laryngeal mask airway unique in pediatric patients
    Peter Szmuk
    Department of Anesthesiology, University of Texas Southwestern Medical School and Children s Medical Center at Dallas, 1935, B3304, Motor St, Dallas, TX 75235, USA
    Anesth Analg 107:1523-30. 2008
    ..The Cobra Perilaryngeal Airway (PLA) provides better sealing pressure than the Laryngeal Mask Airway Unique (LMAU) during positive-pressure ventilation in adults. We compared the performance of the CobraPLA and LMAU in infants and children...
  43. doi request reprint Improving perioperative temperature management
    Alexander A Hannenberg
    Anesth Analg 107:1454-7. 2008
  44. ncbi request reprint The effects of hydration on core temperature in pediatric surgical patients
    Tiberiu Ezri
    Department of Anesthesia, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv, Israel
    Anesthesiology 98:838-41. 2003
    ..We therefore tested the hypothesis that mild hypovolemia helps to prevent intraoperative hypothermia in pediatric patients...
  45. ncbi request reprint Skin-temperature gradients are a validated measure of fingertip perfusion
    Daniel I Sessler
    Eur J Appl Physiol 89:401-2; author reply 403-4. 2003
  46. ncbi request reprint The effects of epidural and general anesthesia on tissue oxygenation
    Tanja A Treschan
    Department of Anesthesia and General Intensive Care, Vienna General Hospital, Austria
    Anesth Analg 96:1553-7, table of contents. 2003
    ..Although epidural anesthesia increased tissue oxygenation significantly with and without general anesthesia, the magnitude of this increase might be of marginal clinical importance in regard to surgical wound infections...
  47. ncbi request reprint Effect-site concentration of propofol for recovery of consciousness is virtually independent of fentanyl effect-site concentration
    Hiroko Iwakiri
    Department of Anesthesiology, Tokyo Women s Medical University, Tokyo, Japan
    Anesth Analg 96:1651-5, table of contents. 2003
    ..Heart rate in one of these women decreased to <40 bpm. These data suggest that the optimal fentanyl effect-site concentration in patients recovering from gynecologic laparoscopy is between 1.4 and 2.0 ng/mL...
  48. ncbi request reprint Safety and efficacy of endovascular cooling and rewarming for induction and reversal of hypothermia in human-sized pigs
    Michael W Dae
    Cardiovascular Research Institute, University of California at San Francisco, San Francisco, CA 94143, USA
    Stroke 34:734-8. 2003
    ..However, current systems transfer insufficient heat to rapidly vary core temperature. We thus evaluated the safety and efficacy of endovascular cooling and rewarming for the induction and reversal of hypothermia...
  49. ncbi request reprint Insufficiency in a new temporal-artery thermometer for adult and pediatric patients
    Mohammad Irfan Suleman
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, 501 East Broadway, Louisville, KY 40202, USA
    Anesth Analg 95:67-71, table of contents. 2002
    ..6. Infrared and bladder temperatures in children differed by only 0.3 degrees C, but the SD of the difference was 0.5 degrees C. Thus, 31% of the values in the infants and children differed by more than 0.5 degrees C...
  50. ncbi request reprint Minute sphere acupressure does not reduce postoperative pain or morphine consumption
    Masatomo Sakurai
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, Louisville, Kentucky 40202, USA
    Anesth Analg 96:493-7, table of contents. 2003
    ..Treatment and control patients received a similar covering. Neither pain nor morphine requirements were different between the groups...
  51. ncbi request reprint Transcutaneous electrical stimulation of an auricular acupuncture point decreases anesthetic requirement
    Robert Greif
    Department of Anesthesia and Perioperative Care, University of California San Francisco, San Francisco, California, USA
    Anesthesiology 96:306-12. 2002
    ..This is known as auricular electrically stimulated analgesia. The authors therefore tested the hypothesis that auricular electrically stimulated analgesia reduces anesthetic requirement...
  52. ncbi request reprint Perioperative shivering: physiology and pharmacology
    Jan De Witte
    Department of Anesthesia and Intensive Care, OLV Hospital, Aalst, Belgium
    Anesthesiology 96:467-84. 2002
  53. ncbi request reprint Hypercapnia improves tissue oxygenation
    Ozan Akca
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
    Anesthesiology 97:801-6. 2002
    ..Since hypercapnia improves cardiac output and peripheral tissue perfusion, we tested the hypothesis that peripheral tissue oxygenation increases as a function of arterial carbon dioxide tension (PaCO(2)) in anesthetized humans...
  54. pmc Doxapram only slightly reduces the shivering threshold in healthy volunteers
    Ryu Komatsu
    Outcomes Research Institute, 501 East Broadway, Suite 210, Louisville, KY 40202, USA
    Anesth Analg 101:1368-73. 2005
    ..5 degrees C is unlikely to markedly facilitate induction of therapeutic hypothermia as a sole drug...
  55. ncbi request reprint Preoperative alprazolam reduces anxiety in ambulatory surgery patients: a comparison with oral midazolam
    Jan L De Witte
    Department of Anesthesiology and Intensive Care, OLV Hospital, Aalst, Belgium
    Anesth Analg 95:1601-6, table of contents. 2002
    ..05). We conclude that alprazolam may be an effective alternative to midazolam for anxiety reduction without causing amnesia. However, it may cause greater impairment of psychomotor function in the early postoperative period...
  56. ncbi request reprint Supplementing desflurane-remifentanil anesthesia with small-dose ketamine reduces perioperative opioid analgesic requirements
    Bruno Guignard
    Department of Anesthesiology, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, 9 avenue Charles de Gaulle, Boulogne Billancourt 92100, France
    Anesth Analg 95:103-8, table of contents. 2002
    ..Thus, intraoperative small-dose ketamine may be a useful adjuvant to intraoperative remifentanil...
  57. ncbi request reprint Electro-acupuncture at the Zusanli, Yanglingquan, and Kunlun points does not reduce anesthetic requirement
    Nobutada Morioka
    Department of Anesthesiology, University of Louisville, 501 East Broadway, Louisville, KY 40202, USA
    Anesth Analg 95:98-102, table of contents. 2002
    ..6% +/- 0.6%, mean +/- SD) and control (4.6% +/- 0.8%) days (P = 0.8). These data provided an 80% power for detecting a difference of 0.35 volume-percent between the groups...
  58. pmc The effects of varying local anesthetic concentration and volume on continuous popliteal sciatic nerve blocks: a dual-center, randomized, controlled study
    Brian M Ilfeld
    Department of Anesthesiology, University of California San Diego, San Diego, CA, USA
    Anesth Analg 107:701-7. 2008
    ..We therefore tested the null hypothesis that providing different concentrations and rates of ropivacaine, but at equal total doses, produces comparable effects when used in a continuous sciatic nerve block in the popliteal fossa...
  59. ncbi request reprint Nonpharmacological prevention of surgical wound infections
    Daniel I Sessler
    Department of Anesthesiology and Outcomes Research Institute, University of Louisville, Louisville, KY 40202, USA
    Clin Infect Dis 35:1397-404. 2002
    ..Available data thus suggest that supplemental perioperative oxygen improves surgical outcome with little or no associated risk...
  60. ncbi request reprint Neither arm nor face warming reduces the shivering threshold in unanesthetized humans
    Anthony G Doufas
    Outcomes Research Institute, Department of Anesthesiology, University of Louisville, Louisville, KY, USA
    Stroke 34:1736-40. 2003
    ..We tested the hypothesis that focal arm (forearm and hand) warming or lower facial warming, combined with inhalation of heated and humidified gas, only minimally reduces the shivering threshold (triggering core temperature)...
  61. ncbi request reprint Physiology and clinical relevance of induced hypothermia
    Anthony G Doufas
    Outcomes Research Institute, Department of Anesthesiology and Perioperative Medicine, University of Louisville, Louisville, KY, USA
    Neurocrit Care 1:489-98. 2004
    ..However, pharmacological induction of thermoregulatory tolerance to cold without excessive sedation, respiratory depression, or other serious toxicity remains a major focus of current therapeutic hypothermia research...
  62. ncbi request reprint Core temperature measurements through a new airway device, perilaryngeal airway (CobraPLA)
    Anupama Wadhwa
    Outcomes Research Institute and Department of Anesthesiology, University of Louisville, KY 40202, USA
    J Clin Anesth 17:358-62. 2005
    ....
  63. ncbi request reprint Hyperthermia after cardiac surgery: mechanism and importance
    Daniel I Sessler
    J Cardiothorac Vasc Anesth 19:423-5. 2005
  64. ncbi request reprint Perioperative hypothermia does not enhance the risk of cancer dissemination
    Yüksel Yücel
    Department of Special Gynaecology Senology, Women s Clinic, Medical University of Vienna, General Hospital, Vienna, Austria
    Am J Surg 189:651-5. 2005
    ..We tested the hypothesis that mild perioperative hypothermia increases the risk of cancer recurrence and subsequent mortality..
  65. pmc A factorial trial of six interventions for the prevention of postoperative nausea and vomiting
    Christian C Apfel
    Julius Maximilians Universitat, Wurzburg, Germany
    N Engl J Med 350:2441-51. 2004
    ..Although many trials have been conducted, the relative benefits of prophylactic antiemetic interventions given alone or in combination remain unknown...
  66. pmc Small-dose ketamine infusion improves postoperative analgesia and rehabilitation after total knee arthroplasty
    Frederic Adam
    Department of Anesthesia and INSERM E 332, Hopital Ambroise Pare, Publique Hôpitaux de Paris, 92100 Boulogne, France
    Anesth Analg 100:475-80. 2005
    ..No patient in either group reported sedation, hallucinations, nightmares, or diplopia, and no differences were noted in the incidence of nausea and vomiting between the two groups...
  67. pmc The timing of acupuncture stimulation does not influence anesthetic requirement
    Grigory Chernyak
    Outcomes Research Institute, 501 East Broadway, Louisville, KY 40202, USA
    Anesth Analg 100:387-92. 2005
    ..2% +/- 0.6%), Preinduction (5.0% +/- 0.8%), and At-induction (4.7% +/- 0.3%; P = 0.125) days. This type of acupuncture is thus unlikely to facilitate general anesthesia or decrease the requirement for anesthetic drugs...
  68. pmc Nefopam and ketamine comparably enhance postoperative analgesia
    Barbara Kapfer
    Department of Anesthesia, Hopital Ambroise Pare, Assistance Publique Hopitaux de Paris, Boulogne 92100, France
    Anesth Analg 100:169-74. 2005
    ..Tachycardia and profuse sweating were more frequent in patients given nefopam, and sedation was more intense with ketamine; however, the incidence of other potential complications did not differ among groups...
  69. pmc Anesthetic requirement is increased in redheads
    Edwin B Liem
    Outcomes Research Institute, University of Louisville, Louisville, Kentucky USA
    Anesthesiology 101:279-83. 2004
    ..Therefore, the authors tested the hypothesis that the requirement for the volatile anesthetic desflurane is greater in natural redheaded than in dark-haired women...
  70. ncbi request reprint Independent risk factors for postoperative shivering
    Leopold H J Eberhart
    Department of Anesthesiology and Critical Care, Philipps University Marburg, Baldingerstr 1, D 35033 Marburg, Germany
    Anesth Analg 101:1849-57. 2005
    ..The presented model may serve as a clinical tool to help clinicians to rationally administer prophylactic antishivering drugs...
  71. ncbi request reprint Mild hypercapnia increases subcutaneous and colonic oxygen tension in patients given 80% inspired oxygen during abdominal surgery
    Edith Fleischmann
    Department of Anesthesia and Intensive Care, Medical University Vienna, Austria
    Anesthesiology 104:944-9. 2006
    ..The authors tested the hypothesis that mild intraoperative hypercapnia increases both subcutaneous tissue and intramural intestinal oxygen tension in patients given supplemental oxygen...
  72. ncbi request reprint Ambulatory continuous interscalene nerve blocks decrease the time to discharge readiness after total shoulder arthroplasty: a randomized, triple-masked, placebo-controlled study
    Brian M Ilfeld
    Department of Anesthesiology, University of Florida, Gainsville, Florida, USA
    Anesthesiology 105:999-1007. 2006
    ..This study investigated the relationship between ambulatory CISB and the time to reach three discharge criteria after shoulder arthroplasty...
  73. ncbi request reprint Ephedrine fails to accelerate the onset of neuromuscular block by vecuronium
    Ryu Komatsu
    Department of Anesthesiology, Tokyo Women s Medical University, Tokyo, Japan
    Anesth Analg 97:480-3, table of contents. 2003
    ..The combination of ephedrine and vecuronium thus cannot be substituted for rapid-acting nondepolarizing muscle relaxants...
  74. ncbi request reprint Doxapram produces a dose-dependent reduction in the shivering threshold in rabbits
    Katsumi Okuyama
    Department of Anesthesia, University of Yamanashi, Faculty of Medicine, Tamaho, Yamanashi, Japan
    Anesth Analg 97:759-62. 2003
    ..50 mg x kg(-1) x h(-1) shivered at 33.7 degrees +/- 0.6 degrees C. All the shivering thresholds significantly (P < 0.001) differed from one another. The magnitude of this inhibition, if similar in humans, would be clinically important...
  75. doi request reprint Lower-body warming mimics the normal epidural-induced reduction in the shivering threshold
    Anthony G Doufas
    Department of Anesthesia, Stanford University School of Medicine, Stanford, CA 94305 5640, USA
    Anesth Analg 106:252-6, table of contents. 2008
    ..We tested the hypothesis that increasing leg skin temperature to 38 degrees C mimics the normal approximately 0.6 degrees C reduction in the shivering threshold during epidural anesthesia...
  76. ncbi request reprint Spinal mechanisms contribute to analgesia produced by epidural sufentanil combined with bupivacaine for postoperative analgesia
    Jean L Joris
    Department of Anesthesia and Intensive Care Medicine, University of Louisville, Louisville, Kentucky, USA
    Anesth Analg 97:1446-51. 2003
    ..05). We conclude that spinal mechanisms contribute to the analgesia produced by epidural sufentanil in combination with a local anesthetic...
  77. ncbi request reprint New circulating-water devices warm more quickly than forced-air in volunteers
    Anupama Wadhwa
    Outcomes Research Institute, University of Louisville, Louisville, Kentucky, USA
    Anesth Analg 105:1681-7, table of contents. 2007
    ..We therefore compared two circulating-water systems with a forced-air system during simulation of upper abdominal or chest surgery in volunteers...
  78. pmc The evolution of primary hyperalgesia in orthopedic surgery: quantitative sensory testing and clinical evaluation before and after total knee arthroplasty
    Valéria Martinez
    Department of Anesthesia, Assistance Publique Hopitaux de Paris, Hopital Raymond Poincare, Garches, France
    Anesth Analg 105:815-21. 2007
    ..Quantitative sensory testing (QST) allows precise characterization of sensory deficits and painful symptoms and may offer additional information on the pathophysiology of postoperative pain...
  79. pmc The influence of timing of administration on the analgesic efficacy of parecoxib in orthopedic surgery
    Valéria Martinez
    Department of Anesthesia, Hopital Raymond Poincare, APHP, France
    Anesth Analg 104:1521-7, table of contents. 2007
    ..Parecoxib, a selective cyclooxygenase-2 inhibitor, may reduce postoperative pain without increasing bleeding when administered before surgery...
  80. pmc Women have the same desflurane minimum alveolar concentration as men: a prospective study
    Anupama Wadhwa
    Department of Anesthesiology, University of Louisville, Kentucky, USA
    Anesthesiology 99:1062-5. 2003
    ..The authors therefore tested the hypothesis that the desflurane concentration required to prevent movement in response to skin incision (MAC) differs between men and women...
  81. ncbi request reprint Perioperative amino acid infusion improves recovery and shortens the duration of hospitalization after off-pump coronary artery bypass grafting
    Takako Umenai
    Anesth Analg 103:1386-93. 2006
    ..004] were significantly shorter in patients given amino acid. Perioperative amino acid infusion in patients undergoing off-pump CABG effectively minimizes intraoperative hypothermia and improves postoperative recovery...
  82. ncbi request reprint Latency of pupillary reflex dilation during general anesthesia
    Merlin D Larson
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, CA 94143 0648, USA
    J Appl Physiol (1985) 97:725-30. 2004
    ..We conclude that pupillary reflex dilation during anesthesia is not initiated by slowly conducting C fibers and that fentanyl depresses the reflex in a stereotypical manner...

Research Grants6

  1. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2001
    ..Since the cost of oxygen is trivial and the risks of oxygen administration are low, clinicians will easily be able to implement this treatment once we have demonstrated its benefits. ..
  2. SUPPLEMENTAL OXYGEN AND SURGICAL WOUND INFECTIONS
    Daniel Sessler; Fiscal Year: 2000
    ..Since the cost of oxygen is trivial and the risks of oxygen administration are low, clinicians will easily be able to implement this treatment once we have demonstrated its benefits. ..
  3. Nitrous Oxide and Wound Infections
    Daniel Sessler; Fiscal Year: 2003
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..
  4. Nitrous Oxide and Wound Infections
    Daniel Sessler; Fiscal Year: 2004
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..
  5. Nitrous Oxide and Wound Infections
    Daniel Sessler; Fiscal Year: 2005
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..
  6. Nitrous Oxide and Wound Infections
    Ozan Akca; Fiscal Year: 2006
    ..Confirming our hypothesis would thus allow clinicians to make a minor modification in anesthetic practice that might reduce the incidence of a complication responsible for considerable perioperative morbidity and cost. ..