Research Topics
Species | V PopovicSummaryAffiliation: Clinical Center of Serbia Country: Serbia and Montenegro Publications
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Publications
Hypopituitarism as a consequence of traumatic brain injury (TBI) and its possible relation with cognitive disabilities and mental distressV Popovic
Institute of Endocrinology, University Clinical Center, Belgrade, Union of Serbia and Montenegro
J Endocrinol Invest 27:1048-54. 2004..Depression scale showed that nearly half of patients suffered from mild to moderate depression. The benefits of hormone replacement therapy on cognitive functioning and mental distress in TBI patients are eagerly awaited...- Clinical indicators of biochemical remission in acromegaly: does incomplete disease control always mean therapeutic failure?Svetozar S Damjanovic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Dr Subotica 13, 11000 Belgrade, Serbia
Clin Endocrinol (Oxf) 62:410-7. 2005..We investigate whether various biochemical outcomes after transsphenoidal pituitary surgery (TSS) in these patients are associated with clinically relevant differences in cardiac performance, insulin resistance and body composition... - Hypopituitarism following traumatic brain injuryV Popovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Dr Subotic 13, 11000 Belgrade, Serbia
Growth Horm IGF Res 15:177-84. 2005..In conclusion, pituitary failure can occur even in minor head injuries and is poorly recognized... - Changes in neuroendocrine and metabolic hormones induced by atypical antipsychotics in normal-weight patients with schizophreniaVera Popovic
Institutes for Endocrinology, Diabetes and Metabolic Diseases, University Clinical Center Belgrade, Belgrade, Serbia
Neuroendocrinology 85:249-56. 2007..Atypical antipsychotics (SGA) have the propensity to induce weight gain... 
Adaptation of the QoL-AGHDA scale for adults with growth hormone deficiency in four Slavic languagesStephen P McKenna
Galen Research Ltd, Manchester, UK
Health Qual Life Outcomes 9:60. 2011..The present study describes the adaptation of the QoL-AGHDA for use in the following four Slavic languages; Czech, Polish, Serbian and Slovakian...- The impact of cranial irradiation on GH responsiveness to GHRH plus GH-releasing peptide-6Vera Popovic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center, 11000 Belgrade, Yugoslavia
J Clin Endocrinol Metab 87:2095-9. 2002..Impairment of the GH releasable pool in the irradiated patients, with a maximal provocative test, reflects alterations in the hypothalamic-pituitary unit caused by radiotherapy... - Are there alternative tests for diagnosis of acromegaly?V Popovic
Institute of Endocrinology, University Clinical Center, Belgrade, Serbia
J Endocrinol Invest 28:73-4. 2005..Furthermore, some acromegalics may have subtle abnormalities in GH secretion, resulting in post-glucose GH nadir in the designated "normal" range with elevated IGF-I levels... - Circulating and cerebrospinal fluid ghrelin and leptin: potential role in altered body weight in Huntington's diseaseVera Popovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Centre, Belgrade, Serbia
Eur J Endocrinol 151:451-5. 2004..The aim of this study was to investigate the possible involvement of cerebrospinal fluid (CSF) and circulating ghrelin and leptin in the regulation of energy balance in patients with HD... - Acromegaly - evolving strategiesVera Popovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Belgrade Serbia
Pediatr Endocrinol Rev 1:496-500. 2004..The aim of the evolving therapeutic strategies is to produce a normal life expectancy in patients with acromegaly... - Low plasma ghrelin level in gastrectomized patients is accompanied by enhanced sensitivity to the ghrelin-induced growth hormone releaseVera Popovic
Neuroendocrine Unit, Institute of Endocrinology, Diabetes Mellitus and Metabolism, University Clinical Center, Dr Subotic 13, 11000 Belgrade, Serbia
J Clin Endocrinol Metab 90:2187-91. 2005..This is associated with increased GH responsiveness. GASTRX is a state of acquired chronic hypoghrelinemia that may require replacement with ghrelin, and it is tempting to speculate that this may affect the GH-IGF-IGFBP axis... - Leptin TRH and ghrelin: influence on energy homeostasis at rest and during exerciseV Popovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Belgrade, Serbia
Horm Metab Res 37:533-7. 2005..A study within the general population found that activity levels and leptin were significantly negatively associated in both sexes. Circulating ghrelin levels, however, do not change during energy expenditure... - Hypopituitarism following traumatic brain injury (TBI): call for attentionV Popovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Belgrade, Serbia
J Endocrinol Invest 28:61-4. 2005..In conclusion, pituitary failure can occur even in minor head injuries and is poorly recognized... - Hypopituitarism following traumatic brain injuryV Popovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Belgrade, Serbia
Front Horm Res 33:33-44. 2005 - Brain somatic cross-talk: ghrelin, leptin and ultimate challengers of obesityVera Popovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Belgrade, Serbia, Yugoslavia
Nutr Neurosci 8:1-5. 2005..The administration of exogenous satiety hormone peptide YY 3-36 (PYY) may prevent the action of appetite-stimulating hypothalamic circuits on the anorexigenic melanocortin pathways... - The effectiveness of arginine + GHRH test compared with GHRH + GHRP-6 test in diagnosing growth hormone deficiency in adultsVera Popovic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center, Belgrade, Yugoslavia
Clin Endocrinol (Oxf) 59:251-7. 2003..The objective of this study is to investigate the performance of two novel tests in diagnosing growth hormone deficiency in adults... - Leptin and the pituitaryV Popovic
Institute of Endocrinology, University Clinical Center Belgrade, Yugoslavia
Pituitary 4:7-14. 2001.... - A large sellar granular cell tumor in a 21-year-old womanVera Popovic
University Clinical Center, Neuroendocrine Unit, Institute of Endocrinology, Dr Subotica 13, Belgrade, 11000, Serbia
Endocr Pathol 18:91-4. 2007..These tumors are, in most cases, very small and are found incidentally at autopsy of older patients. Our case is exceptional because the tumor developed in a young woman, extended to the suprasellar region, and caused clinical symptoms... - Parathyroid hormone response to vitamin D insufficiency in elderly males with chronic heart failureB Bozic
Institute for Medical Research, Military Medical Academy, Belgrade, Serbia
Physiol Res 60:S155-63. 2011..In conclusion, increased PTH levels, but not low vitamin D, demonstrated close relation to CHF severity... - Ghrelin test for the assessment of GH status in successfully treated patients with acromegalyS Pekic
Institute of Endocrinology, Diabetes and Metabolism, University Clincal Centre, Belgrade, Serbia
Eur J Endocrinol 154:659-66. 2006..CONCLUSIONS: The assessment of residual GH secretory capacity by the GH provocation test is necessary in the long-term follow-up of successfully treated acromegalics since a large proportion of these patients are rendered GH deficient... - Gonadotropin response to clomiphene and plasma leptin levels in weight recovered but amenorrhoeic patients with anorexia nervosaM Djurovic
Institute of Endocrinology, University Clinical Centre, Belgrade, Yugoslavia
J Endocrinol Invest 27:523-7. 2004..It is reasonable to believe that nutritional disturbances, fat intake and persisting psychological factors still affect plasma leptin levels and reproductive functions in weight-recovered patients with amenorrhea... - Plasma ghrelin levels of gastrectomized and vagotomized patients are not affected by glucose administrationS Pekic
Institute of Endocrinology, Diabetes and Metabolism, University Clinical Centre, Belgrade, Serbia
Clin Endocrinol (Oxf) 64:684-8. 2006.... - Glucose metabolism during ghrelin infusion in patients with anorexia nervosaD Miljic
Department of Neuroendocrinology, Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia
J Endocrinol Invest 30:771-5. 2007..In addition to our previous findings of impaired neuroendocrine and appetite responses in patients with AN, we conclude that metabolic responses to ghrelin are attenuated in these patients, which tend to recover with weight gain... - Ghrelin has partial or no effect on appetite, growth hormone, prolactin, and cortisol release in patients with anorexia nervosaD Miljic
Department of Neuroendocrinology, Institute of Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, 11000 Belgrade, Serbia and Montenegro
J Clin Endocrinol Metab 91:1491-5. 2006..Our results suggest that AN patients are less sensitive to ghrelin in terms of GH response and appetite than healthy controls. Ghrelin effects on sleep need further studies... - Serum leptin levels in patients with acromegaly before and after correction of hypersomatotropism by trans-sphenoidal surgeryS S Damjanović
Institute of Endocrinology, Diabetes, and Diseases of Metabolism, School of Medicine, University Clinical Center, Beograd, Yugoslavia
J Clin Endocrinol Metab 85:147-54. 2000.... - Growth-hormone response to combined stimulation with GHRH plus GH-releasing peptide-6 in obese patients with polycystic ovary syndrome before and after short-term fastingD Micic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Beograd, Yugoslavia
J Endocrinol Invest 26:333-40. 2003..Observed changes in insulin and leptin may participate in modulation of enhanced GH response after short-term fasting to GHRH+GHRP-6 in PCOS and obese controls... 
Psychiatric and neuropsychological changes in growth hormone-deficient patients after traumatic brain injury in response to growth hormone therapyN P Maric
Institute of Psychiatry, University Clinical Center Belgrade, Pasterova 2, Belgrade, Serbia
J Endocrinol Invest 33:770-5. 2010..The impact of GH therapy on mental status in TBI patients is still unknown...- Chronic cognitive sequelae after traumatic brain injury are not related to growth hormone deficiency in adultsD Pavlovic
Institute of Neurology, University Clinical Center, Belgrade, Serbia
Eur J Neurol 17:696-702. 2010..Even the patients with favorable outcome after TBI may present with persistent bodily, psychosocial, and cognitive impairments, resembling patients with untreated partial or complete pituitary insufficiency... - Loss of gender difference in serum leptin levels and its slow recovery after successful surgery for Leydig cell tumours in two virilized femalesS Pekic
Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia
Clin Endocrinol (Oxf) 54:693-7. 2001.... - Growth hormone secretion elicited by GHRH, GHRP-6 or GHRH plus GHRP-6 in patients with microprolactinoma and macroprolactinoma before and after bromocriptine therapyV Popovic
Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia
Clin Endocrinol (Oxf) 48:103-8. 1998..We studied the effects of GHRH, GHRP-6 and both secretagogues on GH release in patients harbouring pituitary tumours that may be reduced in size by medical treatment... - Follicle stimulating hormone-secreting pituitary adenoma: inappropriate secretion and effect of pulsatile luteinizing hormone releasing hormone analogue (buserelin) administrationS Damjanovic
University Clinical Center, Institute of Endocrinology, Diabetes and Metabolic Diseases, Beograd, Yugoslavia
J Endocrinol Invest 14:299-304. 1991..Although buserelin may not have a therapeutic effect, it is of use in differential diagnosis of hypergonadotropinemia... - ACTH and cortisol responses to ghrelin and desmopressin in patients with Cushing's disease and adrenal enlargementD Miljic
Institute of Endocrinology, University Clinical Center of Serbia, Belgrade, Serbia
J Endocrinol Invest 33:526-9. 2010..Overexpression of ghrelin and vasopressin (V3) receptors demonstrated on corticotrophe adenomas accounts for exaggerated ACTH and cortisol responses to ghrelin and desmopressin (DDAVP) in patients with Cushing's disease (CD)... - Serum insulin-like growth factor I (IGF-I), IGF-binding proteins 2 and 3, and the risk for development of malignancies in adults with growth hormone (GH) deficiency treated with GH: data from KIMS (Pfizer International Metabolic Database)Vera Popovic
Neuroendocrine Unit, Endocrinology Clinic, University Clinical Center, Dr Subotic 13, 11000 Belgrade, Serbia
J Clin Endocrinol Metab 95:4449-54. 2010..The association between IGFs and cancer in adults with GH deficiency (GHD) receiving GH replacement requires investigation... - GH deficiency as the most common pituitary defect after TBI: clinical implicationsVera Popovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Dr Subotic 13, Belgrade, Serbia
Pituitary 8:239-43. 2005..Improvements in mental-well being and cognitive function with GH replacement therapy in GHD adults have been reported. The effect of GH replacement in posttraumatic GHD needs to be examined in randomized controlled studies... - Adiponectin: novelties in metabolism and hormonal regulationLeonidas H Duntas
Evgenidion Hospital, University of Athens, 11528 Athens, Greece
Nutr Neurosci 7:195-200. 2004..These data show adiponectin to be an important factor in the issue of obesity and its associated disorders, and indicate a potential future utilization of adiponectin as a drug in the treatment of metabolic syndrome... - Effect of obesity and morbid obesity on the growth hormone (GH) secretion elicited by the combined GHRH + GHRP-6 testFahrettin Kelestimur
Department of Endocrinology, Erciyes University, Kayseri, Turkey
Clin Endocrinol (Oxf) 64:667-71. 2006.... - Hypersensitivity reaction with intravenous GnRH after pulsatile subcutaneous GnRH treatment in male hypogonadotrophic hypogonadismV Popovic
Clinic for Endocrinology and Immunology, University Clinic, School of Medicine, Belgrade, Yugoslavia
Postgrad Med J 64:245-6. 1988..We wish to report hypersensitivity reactions with intravenous GnRH after low dose subcutaneous pulsatile GnRH treatment in two men with hypogonadotrophic hypogonadism due to suprasellar disease... - Case report of hypopituitarism with suspected syndrome of inappropriate VP secretion (SIADH) due to a large aneurysm of the internal carotid in the sellar regionD Miljic
Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia
J Endocrinol Invest 26:450-2. 2003..We present a case with unrecognized and untreated hypopituitarism due to a large aneurysm of the internal carotid artery in the sellar region causing the syndrome of inappropriate secretion of antidiuretic hormone (SIADH)... - Multiple pituitary hormone deficiency (MPHD) associated with normal height, absent puberty and obesityMirjana Doknic
Neuroendocrine Unit, Institute of Endocrinology University Clinical Center, Belgrade, Serbia and Montenegro
Pediatr Endocrinol Rev 1:505-7. 2004..Despite severe growth hormone deficiency according to the provocative tests and decreased IGF I level our patient grew normally. On follow up at age 22 she is 174cm tall... - Evolving hypopituitarism as a consequence of traumatic brain injury (TBI) in childhood - call for attentionMilica Medic-Stojanoska
Clinic of Endocrinology, Diabetes and Metabolic Disease, University Clinical Center, Hajduk Veljkova 1 3, Novi Sad, Serbia
Endocrine 31:268-71. 2007.... - Growth hormone response to GHRH + GHRP-6 in type 2 diabetes during euglycemic and hyperglycemic clampDragan Micic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Dr Subotica 13, 11000, Belgrade, Serbia and Montenegro
Diabetes Res Clin Pract 63:37-45. 2004..It is suggested that ambient glucose levels should be taken into account during interpretation of GH response to combined administration of GHRH+GHRP-6 in patients with type 2 diabetes... - Changes in prothrombin and activated partial thromboplastin time during replacement therapy with human recombinant growth hormone in growth hormone deficient adultsDragana Miljic
Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia
Hormones (Athens) 5:187-91. 2006..Changes in PT were more pronounced in female GHD patients, while an increase in aPTT values was observed only in male patients with GHD. The clinical significance of these changes needs further evaluation... - Association of increased parathyroid hormone with neuroendocrine activation and endothelial dysfunction in elderly men with heart failureG Loncar
Cardiology Department, Clinical Medical Center Zvezdara, Belgrade, Serbia
J Endocrinol Invest 34:e78-85. 2011..Future studies are needed to evaluate the predictive value of serum PTH for clinical outcomes as well as beneficial potential of PTH suppression in CHF patients... - Effect of 12 months of recombinant human growth hormone replacement therapy on insulin sensitivity in GH-deficient adults as determined by different methodsD Micic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Serbia, Dr Subotica 13, 11000 Beograd, Yugoslavia
J Postgrad Med 48:260-5; discussion 265. 2002..Controversial results have been obtained in measuring insulin sensitivity (S(I)) during recombinant human growth hormone (rhGH) treatment in adult growth hormone deficient (GH-deficient) patients... - Inhibin B: a potential marker of gonadal activity in patients with anorexia nervosa during weight recoveryVera Popovic
Neuroendocrine Unit, University Clinical Center, and Institute of Medical Investigation VMA D V, 11000 Belgrade, Yugoslavia
J Clin Endocrinol Metab 89:1838-43. 2004.... - Ghrelin-induced GH secretion in normal subjects is partially resistant to homologous desensitization by GH-releasing peptide-6Dragan Micic
Institute of Endocrinology, Belgrade University, Belgrade, Yugoslavia
Eur J Endocrinol 147:761-6. 2002..Ghrelin was completely insensitive to the previous administration of GHRH as well as relatively resistant to the homologous desensitization exerted by GHRP-6... - Dopaminergic tone and obesity: an insight from prolactinomas treated with bromocriptineMirjana Doknic
Institute of Endocrinology, University Clinical Center, Belgrade, Yugoslavia
Eur J Endocrinol 147:77-84. 2002..234, P>0.05). CONCLUSION: The long-acting dopamine agonist BC, by increasing dopaminergic tone, may influence body weight and likely body composition by mechanisms in addition to reducing hyperprolactinemia in patients with prolactinomas... - Hypopituitarism and growth hormone deficiency in adult subjects after traumatic brain injury: who and when to testMonica Lorenzo
Department of Medicine, Endocrine Section, Complejo Hospitalario Universitario de Santiago, Santiago de Compostela University, Santiago de Compostela, Spain
Pituitary 8:233-7. 2005..In the present work a suggestion for screening a subgroup of TBI patients is discussed in order to increase the effectiveness of the whole procedure... - High risk of hypopituitarism in patients who recovered from hemorrhagic fever with renal syndromeMarko Stojanovic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Dr Subotica 13, Belgrade, Serbia
J Clin Endocrinol Metab 93:2722-8. 2008..Pituitary ischemia/infarction and necrosis are known causes of hypopituitarism, often remaining unrecognized due to subtle clinical manifestations. Cases of hypopituitarism after HFRS were previously only sporadically reported... - Neuroendocrine dysfunction in patients recovering from subarachnoid hemorrhageVladimir Jovanovic
Institute of Neurosurgery, Belgrade, Serbia
Hormones (Athens) 9:235-44. 2010..The aim of our study was to identify possible predictor(s) for neuroendocrine dysfunction in SAH survivors... - The role of the aryl hydrocarbon receptor-interacting protein gene in familial and sporadic pituitary adenomasChrysanthia A Leontiou
Department of Endocrinology, Barts and the London School of Medicine, London, United Kingdom
J Clin Endocrinol Metab 93:2390-401. 2008..Mutations have been identified in the aryl hydrocarbon receptor-interacting protein (AIP) gene in familial isolated pituitary adenomas (FIPA). It is not clear, however, how this molecular chaperone is involved in tumorigenesis... - Growth hormone (GH) peaks versus areas under the curve in the diagnosis of adult GH deficiency: analysis of the variables provided by the GHRH + GHRP-6 testHans P F Koppeschaar
Department of Endocrinology, University Medical Center Utrech, Utrech, The Netherlands
Pituitary 7:15-20. 2004..However, on a mathematical basis the area under the secretory curve (AUC) should be more valid for this evaluation... - Evaluation of the reproducibility of the GHRH plus GHRP-6 test of growth hormone reserve in adultsVera Popovic
Institute of Endocrinology, University Clinical Centre, School of Medicine and Complejo Hospitalario de Santiago, Santiago de Compostela University, Spain
Clin Endocrinol (Oxf) 60:185-91. 2004..Furthermore, the repeated tests did not alter the biochemical diagnosis of the subjects, with absence of false-positive values. CONCLUSIONS: The GHRH + GHRP-6 test of GH reserve is reproducible in adult subjects... - Physical activity or food intake prior to testing did not affect the reproducibility of GH secretion elicited by GH releasing hormone plus GH-releasing hexapeptide in normal adult subjectsVera Popovic
Institute of Endocrinology, University Clinical Centre, Belgrade, Yugoslavia
Clin Endocrinol (Oxf) 56:89-94. 2002..Considering that stringent testing conditions are not required and the whole test may be performed in 30 minutes, it may be useful in the clinical setting for the diagnosis of GH deficiency in adults... - Cumulative exposure to estrogen and psychosis: a peak bone mass, case-control study in first-episode psychosisNadja Maric
Institute of Psychiatry, University Clinical Centre, Belgrade, Serbia and Montenegro
Schizophr Res 73:351-5. 2005..3, 95% CI: 1.2, 24.2). The results are compatible with the hypothesis that psychosis in women may be associated causally with a reduced protective effect of estrogen over the course of development... - Low leptin level in an obese hyperandrogenic woman--potential marker for androgen-secreting tumorGoran Cvijovic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Dr Subotica 13, 11000 Belgrade, Serbia
Gynecol Endocrinol 23:112-6. 2007..In conclusion, we speculate that low leptin levels in obese hyperandrogenic women might be a marker for androgen-secreting tumors... - High output heart failure in patients with newly diagnosed acromegalySvetozar S Damjanovic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center for Serbia, Belgrade University School of Medicine, Belgrade, Yugoslavia
Am J Med 112:610-6. 2002..Left ventricular hypertrophy in these patients is characterized by a dilated ventricle and an increased left ventricular mass that is primarily due to the enlarged chamber diameter... - Growth hormone replacement throughout life: insights into age-related responses to treatmentPeter Clayton
Endocrine Science Research Group, Division of Human Development, The Medical School, University of Manchester, UK
Growth Horm IGF Res 17:369-82. 2007..Evidence is growing for improved quality of life with GH therapy in the elderly. This review describes the diagnosis, symptoms and treatment of GHD specific to the different age groups... - Intravascular large B-cell lymphoma as a cause of hypopituitarism: gradual and late reversal of hypopituitarism after long-term remission of lymphoma with immunochemotherapySandra Pekic
Neuroendocrine Unit, Institute of Endocrinology, University Clinical Center, Dr Subotica 13, 11000, Belgrade, Serbia
Endocrine 34:11-6. 2008..This is the first case of IVL complicated with hypopituitarism, treated with immunochemotherapy which resulted in complete hematological remission and gradual and late reversal of hypopituitarism... - Hypopituitarism as a late complication of hemorrhagic feverSandra Pekic
Institute of Endocrinology, Diabetes and Diseases of Metabolism, University Clinical Center, Belgrade, Serbia
Endocrine 26:79-82. 2005..Hemorrhagic fever is endemic in certain regions of the Balkans, and this preliminary report suggests the importance of investigating the endocrine status in every patient who survived HFRS...