K Sellheyer



  1. Sellheyer K, Krahl D. PHLDA1 (TDAG51) is a follicular stem cell marker and differentiates between morphoeic basal cell carcinoma and desmoplastic trichoepithelioma. Br J Dermatol. 2011;164:141-7 pubmed publisher
    ..We suggest incorporating PHLDA1 in the diagnostic work-up of difficult to differentiate basaloid tumours. ..
  2. Sellheyer K, Nelson P. Follicular stem cell marker PHLDA1 (TDAG51) is superior to cytokeratin-20 in differentiating between trichoepithelioma and basal cell carcinoma in small biopsy specimens. J Cutan Pathol. 2011;38:542-50 pubmed publisher
    ..Rather than searching for CK20-positive Merkel cells, assessing PHLDA1 expression allows the differential diagnosis between trichoepithelioma and basal cell carcinoma to be solved at scanning magnification. ..
  3. Sellheyer K, Nelson P. The concept of the onychodermis (specialized nail mesenchyme): an embryological assessment and a comparative analysis with the hair follicle. J Cutan Pathol. 2013;40:463-71 pubmed publisher
    ..Its function may be related to the anchorage of the overlying nail bed but may also involve a more dynamic role in the induction of hard keratins in the latter, contributing to the formation of the nail plate. ..
  4. Sellheyer K, Nelson P, Patel R. Expression of embryonic stem cell markers SOX2 and nestin in dermatofibrosarcoma protuberans and dermatofibroma. J Cutan Pathol. 2011;38:415-9 pubmed publisher
    ..Also, DFSP may derive from hair follicle-associated mesenchymal stem cells that have lost their SOX2 expression. ..
  5. Sellheyer K, Nelson P, Kutzner H. Fibroepithelioma of Pinkus is a true basal cell carcinoma developing in association with a newly identified tumour-specific type of epidermal hyperplasia. Br J Dermatol. 2012;166:88-97 pubmed publisher
    ..Viewing the anastomosing network as a tumour-specific form of epidermal hyperplasia explains the hitherto enigmatic presence of Merkel cells in FEP. ..
  6. Sellheyer K, Nelson P. The ventral proximal nail fold: stem cell niche of the nail and equivalent to the follicular bulge--a study on developing human skin. J Cutan Pathol. 2012;39:835-43 pubmed publisher
    ..Further studies on adult human nail units are suggested. ..
  7. Sellheyer K, Nelson P, Krahl D. Dermatofibrosarcoma protuberans: a tumour of nestin-positive cutaneous mesenchymal stem cells?. Br J Dermatol. 2009;161:1317-22 pubmed publisher
    ..A population of mesenchymal stem cells has recently been identified in the dermal compartment of the skin. These proposed stem cells are positive for the neuroepithelial stem cell marker nestin...
  8. Sellheyer K, Krahl D. Blimp-1: a marker of terminal differentiation but not of sebocytic progenitor cells. J Cutan Pathol. 2010;37:362-70 pubmed publisher
  9. Sellheyer K, Krahl D. Spatiotemporal expression pattern of neuroepithelial stem cell marker nestin suggests a role in dermal homeostasis, neovasculogenesis, and tumor stroma development: a study on embryonic and adult human skin. J Am Acad Dermatol. 2010;63:93-113 pubmed publisher
    ..We propose that nestin functions as a stem cell marker of the follicular mesenchyme and has a major regulatory role in dermal homeostasis, cutaneous neovasculogenesis, and tumor stroma development. ..

More Information


  1. Sellheyer K, Krahl D. Does the peritumoral stroma of basal cell carcinoma recapitulate the follicular connective tissue sheath?. J Cutan Pathol. 2011;38:551-9 pubmed publisher
    ..This study examines the expression of this neuroepithelial stem cell protein in trichoblastoma/trichoepithelioma and in basal cell carcinoma (BCC), which is increasingly being viewed as follicular in nature...
  2. Sellheyer K, Nelson P, Kutzner H, Patel R. The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. J Cutan Pathol. 2013;40:363-70 pubmed publisher
    ..CK15 and CK19 are helpful adjuncts in the differential diagnosis of sclerosing adnexal neoplasms but are second in line to BerEP4 and PHLDA1. We propose an algorithm for the immunohistochemical work-up of sclerosing adnexal neoplasms. ..
  3. Sellheyer K, Cribier B, Nelson P, Kutzner H, Rutten A. Basaloid tumors in nevus sebaceus revisited: the follicular stem cell marker PHLDA1 (TDAG51) indicates that most are basal cell carcinomas and not trichoblastomas. J Cutan Pathol. 2013;40:455-62 pubmed publisher
    ..This influences clinical care, as it is paramount in the decision of whether to excise these lesions or not. ..