MaryJane K Selgrade

Summary

Publications

  1. doi request reprint Potential risk of asthma associated with in utero exposure to xenobiotics
    MaryJane K Selgrade
    ICF International, Fairfax Virginia, Durham, North Carolina 27713, USA
    Birth Defects Res C Embryo Today 99:1-13. 2013
  2. doi request reprint Decision trees for evaluating skin and respiratory sensitizing potential of chemicals in accordance with European regulations
    MaryJane K Selgrade
    ICF International, Fairfax, VA, USA
    Regul Toxicol Pharmacol 63:371-80. 2012
  3. doi request reprint Suppression of pulmonary host defenses and enhanced susceptibility to respiratory bacterial infection in mice following inhalation exposure to trichloroethylene and chloroform
    MaryJane K Selgrade
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S EPA, Research Triangle Park, NC, USA
    J Immunotoxicol 7:350-6. 2010
  4. ncbi request reprint Ultraviolet radiation downregulates allergy in BALB/c mice
    Marsha D W Ward
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, 109 T W Alexander Drive, Mail Drop B143 04, Research Triangle Park, NC 27711, USA
    J Toxicol Environ Health A 67:73-85. 2004
  5. ncbi request reprint Assessing the health effects and risks associated with children's inhalation exposures--asthma and allergy
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, North California, USA
    J Toxicol Environ Health A 71:196-207. 2008
  6. doi request reprint Utility of rodent models for evaluating protein allergenicity
    Christal C Bowman
    Immunotoxicology Branch, Experimental Toxicology Division, US EPA National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Regul Toxicol Pharmacol 54:S58-61. 2009
  7. doi request reprint Failure to induce oral tolerance in mice is predictive of dietary allergenic potency among foods with sensitizing capacity
    Christal C Bowman
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 106:435-43. 2008
  8. pmc Induction of asthma and the environment: what we know and need to know
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 114:615-9. 2006
  9. ncbi request reprint Immunotoxicity: the risk is real
    MaryJane K Selgrade
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD B143 01, Research Triangle Park, NC 27711, USA
    Toxicol Sci 100:328-32. 2007
  10. ncbi request reprint Animal models for protein respiratory sensitizers
    Marsha D W Ward
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 2771, USA
    Methods 41:80-90. 2007

Collaborators

Detail Information

Publications18

  1. doi request reprint Potential risk of asthma associated with in utero exposure to xenobiotics
    MaryJane K Selgrade
    ICF International, Fairfax Virginia, Durham, North Carolina 27713, USA
    Birth Defects Res C Embryo Today 99:1-13. 2013
    ..Genetic predisposition and epigenetic changes have been explored. The developing immune, respiratory, and nervous systems are potential targets. Oxidative stress and modulation of inflammation are thought to be involved...
  2. doi request reprint Decision trees for evaluating skin and respiratory sensitizing potential of chemicals in accordance with European regulations
    MaryJane K Selgrade
    ICF International, Fairfax, VA, USA
    Regul Toxicol Pharmacol 63:371-80. 2012
    ..g., documentation, change management, version control), as well as consistency in chemical hazard assessment for REACH, EC Regulation No. 1272/2008 Classification, Labeling, and Packaging of Substances and the GHS...
  3. doi request reprint Suppression of pulmonary host defenses and enhanced susceptibility to respiratory bacterial infection in mice following inhalation exposure to trichloroethylene and chloroform
    MaryJane K Selgrade
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S EPA, Research Triangle Park, NC, USA
    J Immunotoxicol 7:350-6. 2010
    ..Collectively, these endpoints are among the most sensitive health effects reported for TCE...
  4. ncbi request reprint Ultraviolet radiation downregulates allergy in BALB/c mice
    Marsha D W Ward
    Office of Research and Development, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, 109 T W Alexander Drive, Mail Drop B143 04, Research Triangle Park, NC 27711, USA
    J Toxicol Environ Health A 67:73-85. 2004
    ..Consequently, there is no evidence that exposure to UVR enhances the induction or expression of allergic lung disease...
  5. ncbi request reprint Assessing the health effects and risks associated with children's inhalation exposures--asthma and allergy
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, North California, USA
    J Toxicol Environ Health A 71:196-207. 2008
    ..Because asthma is a complex (multiple genes, phenotypes, organ systems) disease, this area is ripe for systems biology approaches...
  6. doi request reprint Utility of rodent models for evaluating protein allergenicity
    Christal C Bowman
    Immunotoxicology Branch, Experimental Toxicology Division, US EPA National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Regul Toxicol Pharmacol 54:S58-61. 2009
    ..A subcutaneous exposure model did not distinguish allergenic from non-allergenic foods and does not appear useful for assessing potential allergenicity...
  7. doi request reprint Failure to induce oral tolerance in mice is predictive of dietary allergenic potency among foods with sensitizing capacity
    Christal C Bowman
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 106:435-43. 2008
    ..This model represents a complementary method of assessing potential allergenicity. Also, the conditions under which the test protein is encountered may impact experimental outcome...
  8. pmc Induction of asthma and the environment: what we know and need to know
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Environ Health Perspect 114:615-9. 2006
    ..Research to address these questions could have a significant public health and economic impact that would be well worth the investment...
  9. ncbi request reprint Immunotoxicity: the risk is real
    MaryJane K Selgrade
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, MD B143 01, Research Triangle Park, NC 27711, USA
    Toxicol Sci 100:328-32. 2007
    ..There is evidence that in utero exposure to cigarette smoke and arsenic but not PCBs is associated with increased risk of allergic disease as well. There is clearly potential for designing studies that could address both issues...
  10. ncbi request reprint Animal models for protein respiratory sensitizers
    Marsha D W Ward
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, NC 2771, USA
    Methods 41:80-90. 2007
    ..As an example, data are presented from an experiment designed to compare the allergenicity of a fungal biopesticide Metarhizium anisopliae (MACA) crude extract with the one of its components, conidia (CON) extract...
  11. ncbi request reprint Kinetic profile of influenza virus infection in three rat strains
    Mary J Daniels
    Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA
    Comp Med 53:293-8. 2003
    ..The results indicate that F344 and SD rats respond in similar manner to viral infection, whereas viral replication was more limited in BN rats and was associated with a different profile of pulmonary cells...
  12. ncbi request reprint A murine model for low molecular weight chemicals: differentiation of respiratory sensitizers (TMA) from contact sensitizers (DNFB)
    Denise M Sailstad
    United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mail Code B143 04, Research Triangle Park, NC 27711, USA
    Toxicology 194:147-61. 2003
    ....
  13. ncbi request reprint Differences in allergenic potential of food extracts following oral exposure in mice reflect differences in digestibility: potential approaches to safety assessment
    Christal C Bowman
    Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 102:100-9. 2008
    ..Moreover, those foods containing digestion-resistant proteins provoke allergic responses in this model, supporting the current use of pepsin resistance in the decision tree for potential allergenicity assessment...
  14. doi request reprint Human serum IgE reacts with a Metarhizium anisopliae fungal catalase
    Marsha D W Ward
    United States Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711, USA
    Int Arch Allergy Immunol 150:343-51. 2009
    ..anisopliae mycelia extract (MYC) proteins that are recognized by mouse serum IgE, (2) to determine if human serum IgE reacts with these proteins, and (3) to determine if these IgE-reactive proteins are found in other fungi...
  15. pmc Safety assessment of biotechnology products for potential risk of food allergy: implications of new research
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Office of Research and Development, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 110:31-9. 2009
    ..Finally, basic research continues to elucidate the etiology of food allergy...
  16. doi request reprint Immunotoxicology and its application in risk assessment
    Andrew A Rooney
    National Toxicology Program, Office of Health Assessment and Translation, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    EXS 101:251-87. 2012
    ..However, since xenobiotics may have effects on more than one aspect of immune function, immunotoxicity data should be evaluated separately for evidence of suppression, stimulation, hypersensitivity, and autoimmunity...
  17. pmc Assessment of allergenic potential of genetically modified foods: an agenda for future research
    MaryJane K Selgrade
    National Health and Environmental Effects Research Laboratory, Office of Research and Development, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Environ Health Perspect 111:1140-1. 2003
    ..These groups agreed that research should progress quickly in the area of hazard identification and that a need exists for more basic research to understand the mechanisms underlying food allergy. A list of research needs was developed...
  18. ncbi request reprint Systemic administration of Bordetella pertussis enhances pulmonary sensitization to house dust mite in juvenile rats
    Wumin Dong
    Immunotoxicology Branch, MD 92, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina, USA
    Toxicol Sci 72:113-21. 2003
    ..These results suggest that simultaneous exposure to Th2-inducing vaccine components and allergenic proteins may be a risk factor for allergic sensitization and the development of asthma in susceptible individuals...