L D Selemon

Summary

Publications

  1. ncbi request reprint Abnormalities of thalamic volume and shape detected in fetally irradiated rhesus monkeys with high dimensional brain mapping
    Matthew K Schindler
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Biol Psychiatry 51:827-37. 2002
  2. pmc A role for synaptic plasticity in the adolescent development of executive function
    L D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Transl Psychiatry 3:e238. 2013
  3. pmc Distinct abnormalities of the primate prefrontal cortex caused by ionizing radiation in early or midgestation
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8001, USA
    J Comp Neurol 521:1040-53. 2013
  4. pmc Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8001, USA
    J Comp Neurol 515:454-64. 2009
  5. pmc Stereologic analysis of the lateral geniculate nucleus of the thalamus in normal and schizophrenic subjects
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
    Psychiatry Res 151:1-10. 2007
  6. ncbi request reprint Amphetamine sensitization alters dendritic morphology in prefrontal cortical pyramidal neurons in the non-human primate
    Lynn D Selemon
    1Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Neuropsychopharmacology 32:919-31. 2007
  7. ncbi request reprint Direct and indirect effects of fetal irradiation on cortical gray and white matter volume in the macaque
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
    Biol Psychiatry 57:83-90. 2005
  8. ncbi request reprint Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method
    L D Selemon
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Comp Neurol 392:402-12. 1998
  9. ncbi request reprint Evidence for progression in frontal cortical pathology in late-stage Huntington's disease
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Comp Neurol 468:190-204. 2004
  10. ncbi request reprint Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder
    L D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Curr Mol Med 3:427-36. 2003

Detail Information

Publications18

  1. ncbi request reprint Abnormalities of thalamic volume and shape detected in fetally irradiated rhesus monkeys with high dimensional brain mapping
    Matthew K Schindler
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Biol Psychiatry 51:827-37. 2002
    ..Irradiated monkeys sacrificed as infants demonstrate neuronal losses in specific thalamic nuclei and decreases in cortical neuropil...
  2. pmc A role for synaptic plasticity in the adolescent development of executive function
    L D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Transl Psychiatry 3:e238. 2013
    ..Greater insight into the neurobiology of the adolescent brain is needed to fully understand the molecular basis for heightened vulnerability during adolescence to the injurious effects of substance abuse and stress...
  3. pmc Distinct abnormalities of the primate prefrontal cortex caused by ionizing radiation in early or midgestation
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8001, USA
    J Comp Neurol 521:1040-53. 2013
    ....
  4. pmc Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8001, USA
    J Comp Neurol 515:454-64. 2009
    ..Comp. Neurol. 176:23-52). The early gestationally irradiated macaque is discussed as a potentially useful model for studying the neurodevelopmental pathogenesis of schizophrenia...
  5. pmc Stereologic analysis of the lateral geniculate nucleus of the thalamus in normal and schizophrenic subjects
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
    Psychiatry Res 151:1-10. 2007
    ..These findings do not support the hypothesis that early visual processing deficits in schizophrenic subjects are due to reduction of neuronal number in the LGN...
  6. ncbi request reprint Amphetamine sensitization alters dendritic morphology in prefrontal cortical pyramidal neurons in the non-human primate
    Lynn D Selemon
    1Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Neuropsychopharmacology 32:919-31. 2007
    ..These findings may also provide key insights into the etiologic origin of the pronounced behavioral disturbances and cognitive dysfunction associated with schizophrenia...
  7. ncbi request reprint Direct and indirect effects of fetal irradiation on cortical gray and white matter volume in the macaque
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
    Biol Psychiatry 57:83-90. 2005
    ..Exposure of nonhuman primates to x-irradiation in early gestation has previously been shown to decrease thalamic volume and neuronal number. Here we examine whether early gestational irradiation also results in cortical volume reduction...
  8. ncbi request reprint Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method
    L D Selemon
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Comp Neurol 392:402-12. 1998
    ..The observed elevation in neuronal density suggests that a reduction in interneuronal neuropil may constitute the anatomical substrate for prefrontal cortical dysfunction in schizophrenia...
  9. ncbi request reprint Evidence for progression in frontal cortical pathology in late-stage Huntington's disease
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Comp Neurol 468:190-204. 2004
    ..Prominent involvement of corticothalamic neurons is discussed in the context of striatal loop circuitry and a possible pathologic cascade of cortical degeneration...
  10. ncbi request reprint Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder
    L D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Curr Mol Med 3:427-36. 2003
    ....
  11. ncbi request reprint Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar St, Room C 303 SHM, New Haven, CT 06510, USA
    Arch Gen Psychiatry 60:69-77. 2003
    ..Because thought disturbances in schizophrenic patients involve language processing, we have performed a morphometric analysis of Broca's area in the ventral frontal lobe...
  12. ncbi request reprint Regionally diverse cortical pathology in schizophrenia: clues to the etiology of the disease
    L D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Schizophr Bull 27:349-77. 2001
    ..A major challenge in contemporary schizophrenia research is to make sense of the patterning of whole brain pathology in schizophrenia, as the mosaic of neuropathologic alterations may provide clues to the disease etiology...
  13. ncbi request reprint Smaller frontal gray matter volume in postmortem schizophrenic brains
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
    Am J Psychiatry 159:1983-91. 2002
    ....
  14. ncbi request reprint Craniofacial dysmorphogenesis in fetally irradiated nonhuman primates: implications for the neurodevelopmental hypothesis of schizophrenia
    Douglas L Gelowitz
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biol Psychiatry 52:716-20. 2002
    ..This study investigates whether craniofacial dysmorphology and thalamic neuron loss might be associated manifestations of a disruption in embryonic development...
  15. pmc Fetal irradiation interferes with adult cognition in the nonhuman primate
    Harriet R Friedman
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 68:108-11. 2010
    ..However, the effect of fetal irradiation on cognitive functions that are vulnerable in schizophrenia (e.g., working memory) has not been examined...
  16. ncbi request reprint Two-dimensional versus three-dimensional cell counting
    Lynn D Selemon
    Biol Psychiatry 51:838-40; author reply, 842-6. 2002
  17. ncbi request reprint Increased cortical neuronal density in schizophrenia
    Lynn D Selemon
    UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5 914, Dallas, TX 75390 9070, USA
    Am J Psychiatry 161:1564. 2004
  18. ncbi request reprint Abnormalities of thalamic volume and shape in schizophrenia
    John G Csernansky
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 161:896-902. 2004
    ..However, the pattern of shape change associated with such volume loss has not been investigated. In this study, alterations in thalamic volume, shape, and symmetry were compared in subjects with and without schizophrenia...