Abnormalities of thalamic volume and shape detected in fetally irradiated rhesus monkeys with high dimensional brain mappingMatthew K Schindler
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA
Biol Psychiatry 51:827-37. 2002
..Low-dose irradiation of the fetal primate may be useful for modeling key features of the pathology described in schizophrenic patients...
Distinct abnormalities of the primate prefrontal cortex caused by ionizing radiation in early or midgestationLynn D Selemon
Department of Neurobiology, Yale University, New Haven, Connecticut
J Comp Neurol 521:1040-53. 2013
..J. Comp. Neurol. 521:1040-1053, 2013. © 2012 Wiley Periodicals, Inc...
- Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages
Lynn D Selemon
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8001, USA
J Comp Neurol 515:454-64. 2009
..Comp. Neurol. 176:23-52). The early gestationally irradiated macaque is discussed as a potentially useful model for studying the neurodevelopmental pathogenesis of schizophrenia...
- Stereologic analysis of the lateral geniculate nucleus of the thalamus in normal and schizophrenic subjects
Lynn D Selemon
Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
Psychiatry Res 151:1-10. 2007
..These findings do not support the hypothesis that early visual processing deficits in schizophrenic subjects are due to reduction of neuronal number in the LGN...
- Amphetamine sensitization alters dendritic morphology in prefrontal cortical pyramidal neurons in the non-human primate
Lynn D Selemon
1Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
Neuropsychopharmacology 32:919-31. 2007
..These findings may also provide key insights into the etiologic origin of the pronounced behavioral disturbances and cognitive dysfunction associated with schizophrenia...
- Direct and indirect effects of fetal irradiation on cortical gray and white matter volume in the macaque
Lynn D Selemon
Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
Biol Psychiatry 57:83-90. 2005
..Exposure of nonhuman primates to x-irradiation in early gestation has previously been shown to decrease thalamic volume and neuronal number. Here we examine whether early gestational irradiation also results in cortical volume reduction...
- Evidence for progression in frontal cortical pathology in late-stage Huntington's disease
Lynn D Selemon
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Comp Neurol 468:190-204. 2004
..Prominent involvement of corticothalamic neurons is discussed in the context of striatal loop circuitry and a possible pathologic cascade of cortical degeneration...
- Cellular pathology in the dorsolateral prefrontal cortex distinguishes schizophrenia from bipolar disorder
L D Selemon
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
Curr Mol Med 3:427-36. 2003
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- Regional specificity in the neuropathologic substrates of schizophrenia: a morphometric analysis of Broca's area 44 and area 9
Lynn D Selemon
Department of Neurobiology, Yale University School of Medicine, 333 Cedar St, Room C 303 SHM, New Haven, CT 06510, USA
Arch Gen Psychiatry 60:69-77. 2003
..Because thought disturbances in schizophrenic patients involve language processing, we have performed a morphometric analysis of Broca's area in the ventral frontal lobe...
- Regionally diverse cortical pathology in schizophrenia: clues to the etiology of the disease
L D Selemon
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
Schizophr Bull 27:349-77. 2001
..A major challenge in contemporary schizophrenia research is to make sense of the patterning of whole brain pathology in schizophrenia, as the mosaic of neuropathologic alterations may provide clues to the disease etiology...
- Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method
L D Selemon
Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Comp Neurol 392:402-12. 1998
..The observed elevation in neuronal density suggests that a reduction in interneuronal neuropil may constitute the anatomical substrate for prefrontal cortical dysfunction in schizophrenia...
- Smaller frontal gray matter volume in postmortem schizophrenic brains
Lynn D Selemon
Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
Am J Psychiatry 159:1983-91. 2002
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- Craniofacial dysmorphogenesis in fetally irradiated nonhuman primates: implications for the neurodevelopmental hypothesis of schizophrenia
Douglas L Gelowitz
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
Biol Psychiatry 52:716-20. 2002
..CONCLUSIONS: These findings indicate that certain features of thalamic neuropathology and craniofacial dysmorphogenesis observed in schizophrenic patients may have a common etiology...
- Fetal irradiation interferes with adult cognition in the nonhuman primate
Harriet R Friedman
Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 68:108-11. 2010
..However, the effect of fetal irradiation on cognitive functions that are vulnerable in schizophrenia (e.g., working memory) has not been examined...
- Increased cortical neuronal density in schizophrenia
Lynn D Selemon
UT Southwestern Medical Center, Department of Psychiatry, 5323 Harry Hines Blvd, NC5.914, Dallas, TX 75390-9070, USA
Am J Psychiatry 161:1564. 2004
- Abnormalities of thalamic volume and shape in schizophrenia
John G Csernansky
Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
Am J Psychiatry 161:896-902. 2004
..However, the pattern of shape change associated with such volume loss has not been investigated. In this study, alterations in thalamic volume, shape, and symmetry were compared in subjects with and without schizophrenia...
- Two-dimensional versus three-dimensional cell counting
Lynn D Selemon
Biol Psychiatry 51:838-40; author reply, 842-6. 2002
