Thomas S Seifert

Summary

Publications

  1. pmc Non-selective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans
    Thomas Seifert Larsen
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    J Physiol 586:2807-15. 2008
  2. pmc Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline
    Thomas S Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Physiol 587:285-93. 2009
  3. doi request reprint Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockade
    T Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 196:295-302. 2009
  4. doi request reprint Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males
    T Seifert
    Department of Anesthesia, Section of Systems Biology Research, The Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 297:R867-76. 2009
  5. doi request reprint Endurance training enhances BDNF release from the human brain
    Thomas Seifert
    Department of Anesthesia, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 298:R372-7. 2010
  6. doi request reprint Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans
    Thomas Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen Ø, Denmark
    Exp Physiol 95:1016-25. 2010
  7. doi request reprint Sympathetic influence on cerebral blood flow and metabolism during exercise in humans
    Thomas Seifert
    Department of Anaesthesia and The Copenhagen Muscle Research Centre, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Prog Neurobiol 95:406-26. 2011
  8. doi request reprint Is cerebral oxygenation negatively affected by infusion of norepinephrine in healthy subjects?
    P Brassard
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Br J Anaesth 102:800-5. 2009

Detail Information

Publications8

  1. pmc Non-selective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humans
    Thomas Seifert Larsen
    Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
    J Physiol 586:2807-15. 2008
    ....
  2. pmc Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline
    Thomas S Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
    J Physiol 587:285-93. 2009
    ..05). These results support that non-oxidative carbohydrate consumption for the brain is driven by a beta(2)-adrenergic mechanism, giving neurons an abundant provision of energy when plasma adrenaline increases...
  3. doi request reprint Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockade
    T Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
    Acta Physiol (Oxf) 196:295-302. 2009
    ..Beta-blockers reduce exercise capacity by attenuated increase in cardiac output, but it remains unknown whether performance also relates to attenuated cerebral oxygenation...
  4. doi request reprint Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males
    T Seifert
    Department of Anesthesia, Section of Systems Biology Research, The Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark
    Am J Physiol Regul Integr Comp Physiol 297:R867-76. 2009
    ..05), CMRO(2) did not increase. This study demonstrates that endurance training attenuates the cerebral metabolic response to submaximal exercise, as reflected in a lower carbohydrate uptake and maintained cerebral oxygenation...
  5. doi request reprint Endurance training enhances BDNF release from the human brain
    Thomas Seifert
    Department of Anesthesia, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 298:R372-7. 2010
    ..4.6 + or - 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health...
  6. doi request reprint Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans
    Thomas Seifert
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen Ø, Denmark
    Exp Physiol 95:1016-25. 2010
    ..05). Thus, during both cycling and static handgrip, a cholinergic receptor mechanism is important for the exercise-induced increase in cerebral perfusion without affecting the cerebral metabolic rate for oxygen...
  7. doi request reprint Sympathetic influence on cerebral blood flow and metabolism during exercise in humans
    Thomas Seifert
    Department of Anaesthesia and The Copenhagen Muscle Research Centre, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Prog Neurobiol 95:406-26. 2011
    ..This is possibly related to an attenuated catecholamine response. Finally, exercise promotes brain health as evidenced by increased release of brain-derived neurotrophic factor (BDNF) from the brain...
  8. doi request reprint Is cerebral oxygenation negatively affected by infusion of norepinephrine in healthy subjects?
    P Brassard
    Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
    Br J Anaesth 102:800-5. 2009
    ..The influence of norepinephrine on cerebral oxygenation is not clear. The aim of this study was to evaluate the impact of the infusion of norepinephrine on cerebral oxygenation in healthy subjects...