Non-selective beta-adrenergic blockade prevents reduction of the cerebral metabolic ratio during exhaustive exercise in humansThomas Seifert Larsen
Department of Anaesthesia, Rigshospitalet 2041, Blegdamsvej 9, DK 2100, Copenhagen Ø, Denmark
J Physiol 586:2807-15. 2008
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- Cerebral non-oxidative carbohydrate consumption in humans driven by adrenaline
Thomas S Seifert
Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Denmark
J Physiol 587:285-93. 2009
..05). These results support that non-oxidative carbohydrate consumption for the brain is driven by a beta(2)-adrenergic mechanism, giving neurons an abundant provision of energy when plasma adrenaline increases...
Cerebral oxygenation decreases during exercise in humans with beta-adrenergic blockadeT Seifert
Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark
Acta Physiol (Oxf) 196:295-302. 2009
..Beta-blockers reduce exercise capacity by attenuated increase in cardiac output, but it remains unknown whether performance also relates to attenuated cerebral oxygenation...
- Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males
T Seifert
Department of Anesthesia, Section of Systems Biology Research, The Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark
Am J Physiol Regul Integr Comp Physiol 297:R867-76. 2009
..05), CMRO(2) did not increase. This study demonstrates that endurance training attenuates the cerebral metabolic response to submaximal exercise, as reflected in a lower carbohydrate uptake and maintained cerebral oxygenation...
- Endurance training enhances BDNF release from the human brain
Thomas Seifert
Department of Anesthesia, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
Am J Physiol Regul Integr Comp Physiol 298:R372-7. 2010
..4.6 + or - 1.4 mRNA/ssDNA) compared with untrained mice. The increased BDNF expression in the hippocampus and the enhanced release of BDNF from the human brain following training suggest that endurance training promotes brain health...
- Glycopyrrolate abolishes the exercise-induced increase in cerebral perfusion in humans
Thomas Seifert
Department of Anaesthesia, The Copenhagen Muscle Research Centre, University of Copenhagen, Copenhagen Ø, Denmark
Exp Physiol 95:1016-25. 2010
..05). Thus, during both cycling and static handgrip, a cholinergic receptor mechanism is important for the exercise-induced increase in cerebral perfusion without affecting the cerebral metabolic rate for oxygen...
- Sympathetic influence on cerebral blood flow and metabolism during exercise in humans
Thomas Seifert
Department of Anaesthesia and The Copenhagen Muscle Research Centre, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
Prog Neurobiol 95:406-26. 2011
..This is possibly related to an attenuated catecholamine response. Finally, exercise promotes brain health as evidenced by increased release of brain-derived neurotrophic factor (BDNF) from the brain...
- Is cerebral oxygenation negatively affected by infusion of norepinephrine in healthy subjects?
P Brassard
Department of Anaesthesia, The Copenhagen Muscle Research Centre, Rigshospitalet 2041, University of Copenhagen, Blegdamsvej 9, 2100 Copenhagen Ø, Denmark
Br J Anaesth 102:800-5. 2009
..The influence of norepinephrine on cerebral oxygenation is not clear. The aim of this study was to evaluate the impact of the infusion of norepinephrine on cerebral oxygenation in healthy subjects...
