A D Seftel

Summary

Publications

  1. ncbi request reprint Physician perceptions of sexual dysfunction related to benign prostatic hyperplasia (BPH) symptoms and sexual side effects related to BPH medications
    A Seftel
    Department of Urology, Case Western Reserve University, University Hospital of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 19:386-92. 2007
  2. ncbi request reprint The efficacy and safety of tadalafil in United States and Puerto Rican men with erectile dysfunction
    Allen D Seftel
    University Hospitals, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
    J Urol 172:652-7. 2004
  3. ncbi request reprint Challenges in oral therapy for erectile dysfunction
    Allen D Seftel
    Department of Urology, University Hospital of Cleveland, Case Western Reserve University, Cleveland VA Medical Center, Ohio 44106, USA
    J Androl 23:729-36. 2002
  4. ncbi request reprint Testosterone replacement therapy for male hypogonadism: part III. Pharmacologic and clinical profiles, monitoring, safety issues, and potential future agents
    A Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 19:2-24. 2007
  5. ncbi request reprint From aspiration to achievement: assessment and noninvasive treatment of erectile dysfunction in aging men
    Allen D Seftel
    Department of Urology, University Hospital of Cleveland, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Am Geriatr Soc 53:119-30. 2005
  6. ncbi request reprint Male hypogonadism. Part I: Epidemiology of hypogonadism
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 18:115-20. 2006
  7. ncbi request reprint Male hypogonadism. Part II: etiology, pathophysiology, and diagnosis
    A Seftel
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Impot Res 18:223-8. 2006
  8. ncbi request reprint Sildenafil reduces bother associated with erectile dysfunction: pooled analysis of five randomized, double-blind trials
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospital of Cleveland, OH 44106 5046, USA
    Int J Impot Res 19:584-90. 2007
  9. ncbi request reprint Phosphodiesterase type 5 inhibitors: molecular pharmacology and interactions with other phosphodiesterases
    Allen D Seftel
    Professor of Urology and Reproductive Biology, Department of Urology, Case Western Reserve University, School of Medicine, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
    Curr Pharm Des 11:4047-58. 2005
  10. ncbi request reprint The impact of formulary replacement of sildenafil by vardenafil at a local VA hospital
    M Singh
    Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH 44112, USA
    Int J Impot Res 20:188-91. 2008

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Physician perceptions of sexual dysfunction related to benign prostatic hyperplasia (BPH) symptoms and sexual side effects related to BPH medications
    A Seftel
    Department of Urology, Case Western Reserve University, University Hospital of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 19:386-92. 2007
    ..As men with LUTS/BPH are at increased risk for SD, physicians should be especially cognizant of BPH treatment-related sexual side effects...
  2. ncbi request reprint The efficacy and safety of tadalafil in United States and Puerto Rican men with erectile dysfunction
    Allen D Seftel
    University Hospitals, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
    J Urol 172:652-7. 2004
    ..We evaluate the efficacy and safety of tadalafil, taken as needed, in men with mild to severe erectile dysfunction (ED) and assess sexual intercourse attempt patterns...
  3. ncbi request reprint Challenges in oral therapy for erectile dysfunction
    Allen D Seftel
    Department of Urology, University Hospital of Cleveland, Case Western Reserve University, Cleveland VA Medical Center, Ohio 44106, USA
    J Androl 23:729-36. 2002
  4. ncbi request reprint Testosterone replacement therapy for male hypogonadism: part III. Pharmacologic and clinical profiles, monitoring, safety issues, and potential future agents
    A Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 19:2-24. 2007
    ..Investigational agents, including selective androgen receptor modulators, may offer new pharmacodynamic and/or pharmacokinetic properties that enhance outcomes of TRT...
  5. ncbi request reprint From aspiration to achievement: assessment and noninvasive treatment of erectile dysfunction in aging men
    Allen D Seftel
    Department of Urology, University Hospital of Cleveland, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
    J Am Geriatr Soc 53:119-30. 2005
    ..These treatment alternatives include the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil, as well as other oral medications, such as alpha-adrenoceptor antagonists and topical vasoactive or testosterone therapy...
  6. ncbi request reprint Male hypogonadism. Part I: Epidemiology of hypogonadism
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 18:115-20. 2006
    ....
  7. ncbi request reprint Male hypogonadism. Part II: etiology, pathophysiology, and diagnosis
    A Seftel
    Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Impot Res 18:223-8. 2006
    ....
  8. ncbi request reprint Sildenafil reduces bother associated with erectile dysfunction: pooled analysis of five randomized, double-blind trials
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospital of Cleveland, OH 44106 5046, USA
    Int J Impot Res 19:584-90. 2007
    ..The change in EF domain score correlated positively with the change in total transformed EDS score (0.43, P<0.0001). Successful treatment of ED with sildenafil may reduce the bother associated with ED...
  9. ncbi request reprint Phosphodiesterase type 5 inhibitors: molecular pharmacology and interactions with other phosphodiesterases
    Allen D Seftel
    Professor of Urology and Reproductive Biology, Department of Urology, Case Western Reserve University, School of Medicine, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
    Curr Pharm Des 11:4047-58. 2005
    ....
  10. ncbi request reprint The impact of formulary replacement of sildenafil by vardenafil at a local VA hospital
    M Singh
    Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH 44112, USA
    Int J Impot Res 20:188-91. 2008
    ..The substantial cost savings to the VA seem to be justified by the minimal adverse effects on men treated for erectile dysfunction...
  11. ncbi request reprint Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction
    Ridwan Shabsigh
    Department of Urology, Columbia Presbyterian Medical Center, New York, New York 10032, USA
    Urology 68:689-96. 2006
  12. ncbi request reprint Erectile dysfunction: etiology, evaluation, and treatment options
    Allen D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5046, USA
    Med Clin North Am 88:387-416, xi. 2004
    ..Inclusion of the partner in the evaluation and management scheme will provide added benefit and may produce a better outcome...
  13. doi request reprint Standards for clinical trials in male sexual dysfunctions
    Hartmut Porst
    J Sex Med 7:414-44. 2010
    ..Clinical trials in male sexual dysfunction (MSD) are expanding. Consequently, there is a need for consensus standards in this area...
  14. doi request reprint Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily
    A D Seftel
    Department of Urology, Case Medical Center University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Int J Impot Res 21:240-8. 2009
    ..001) correlated with erectile function (EF) improvement (assessed by change from baseline in IIEF-EF score). Tadalafil significantly improved treatment and sexual satisfaction, while improving multiple outcomes measured by SEAR...
  15. ncbi request reprint Medical solutions to sexual problems continue to make sexological care and science essential to the successful treatment of male ED
    Allen D Seftel
    Case Medical Center, Cleveland, Ohio 44106 4920, USA
    J Sex Marital Ther 33:467-8. 2007
  16. ncbi request reprint Restorative increases in serum testosterone levels are significantly correlated to improvements in sexual functioning
    Allen D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland VA Medical Center, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
    J Androl 25:963-72. 2004
    ..We propose that threshold T levels are needed in order to significantly affect improvements in sexual functioning...
  17. ncbi request reprint A three-part study to investigate the incidence and potential etiologies of tadalafil-associated back pain or myalgia
    A D Seftel
    Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
    Int J Impot Res 17:455-61. 2005
    ..Although the mechanism of back pain and/or myalgia remains unknown, these events appear to be self-limiting and a general effect of phosphodiesterase 5 inhibition...
  18. ncbi request reprint Rapid ejaculation
    A D Seftel
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, 1611 S Green Road, Cleveland, OH 44121, USA
    Curr Urol Rep 1:302-6. 2000
    ..This article provides a basic review of the pathophysiology of ejaculatory dysfunction and discusses the current treatment options for rapid ejaculation...
  19. ncbi request reprint Erectile dysfunction in the elderly: epidemiology, etiology and approaches to treatment
    Allen D Seftel
    Case Western Reserve University, Department of Urology, University Hospital of Cleveland, Cleveland VA Medical Center, Cleveland, Ohio, USA
    J Urol 169:1999-2007. 2003
    ..The prevalence of erectile dysfunction is high in men of all ages and increases greatly in the elderly...
  20. ncbi request reprint Computational models for detection of erectile dysfunction
    Moshe Wald
    Department of Urology, University of Illinois at Chicago, 200 Hawkins Drive, Chicago, Illinois 52242, USA
    J Urol 173:167-70. 2005
    ..Using several linear and nonlinear mathematical models we investigated the correlation of age, hypogonadism and depression with ED using the Sexual Health Inventory for Men (SHIM) as a surrogate marker for ED...
  21. ncbi request reprint Prostate-specific antigen changes in hypogonadal men treated with testosterone replacement
    Robert E Gerstenbluth
    Department of Urology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Ohio 44124, USA
    J Androl 23:922-6. 2002
    ....
  22. doi request reprint Benign prostatic hyperplasia evaluation, treatment and association with sexual dysfunction: practice patterns according to physician specialty
    A D Seftel
    Department of Urology, Case Medical Center University Hospitals of Cleveland, Cleveland, OH, USA
    Int J Clin Pract 62:614-22. 2008
    ....
  23. ncbi request reprint Nocturnal penile tumescence activity unchanged after long-term intracavernous injection therapy
    P Maniam
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    J Urol 165:830-2; discussion 832-3. 2001
    ..However, as measured by nocturnal penile tumescence testing, no objective improvement in spontaneous erectile function occurs...
  24. ncbi request reprint The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction
    Allen D Seftel
    School of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    J Urol 171:2341-5. 2004
    ..We quantified the prevalence of diagnosed hypertension, hyperlipidemia, diabetes mellitus and depression in male health plan members with erectile dysfunction (ED)...
  25. ncbi request reprint Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles
    Allen D Seftel
    Dept of Urology and Reproductive Biology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
    Clin Cardiol 27:I14-19. 2004
    ..In addition, in the presence of high-fat food, absorption of sildenafil and vardenafil may be delayed; however, the rate and extent of tadalafil absorption are unaffected by high-fat food...
  26. ncbi request reprint Distribution of chronic prostatitis in radical prostatectomy specimens with up-regulation of bcl-2 in areas of inflammation
    Robert E Gerstenbluth
    Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
    J Urol 167:2267-70. 2002
    ....
  27. ncbi request reprint Erectile dysfunction and symptoms of sleep disorders
    Allen D Seftel
    Department of Urology, Cleveland VA Medical Center, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
    Sleep 25:643-7. 2002
    ..Sleep apnea often is associated with impotence and/or erectile dysfunction (ED). The purpose of this study was to test whether a presentation for ED confers a pretest probability for obstructive sleep apnea hypopnea syndrome (OSAHS)...
  28. ncbi request reprint Erectile dysfunction. Diagnosis and treatment in older men
    Dominick J Carbone
    Department of Urology, Wake Forest University, Winston Salem, North Carolina, USA
    Geriatrics 57:18-24. 2002
    ..Treatments include medical management of multi-drug regimens, oral therapy, intracavernosal injection, testosterone replacement therapy, vacuum erection devices, and penile prostheses...
  29. ncbi request reprint Office evaluation of male sexual dysfunction
    Allen D Seftel
    Department of Urology, Case Medical Center, Cleveland, OH, USA
    Urol Clin North Am 34:463-82, v. 2007
    ..This article provides the rationale for this global assessment paradigm...
  30. ncbi request reprint Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens
    Allen D Seftel
    J Urol 174:1043. 2005
  31. ncbi request reprint Development and validation of four-item version of Male Sexual Health Questionnaire to assess ejaculatory dysfunction
    Raymond C Rosen
    New England Research Institutes, Watertown, Massachusetts 02472, USA
    Urology 69:805-9. 2007
    ..An abridged version of the 25-item Male Sexual Health Questionnaire (MSHQ) was developed and validated (MSHQ-EjD Short Form) for assessing ejaculatory dysfunction (EjD)...
  32. ncbi request reprint Centrally acting mechanisms for the treatment of male sexual dysfunction
    Martin M Miner
    Division of Biology and Medicine, Department of Family Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA
    Urol Clin North Am 34:483-96, v. 2007
    ..Drugs available in Europe include apomorphine. This article focuses on the mechanism of centrally acting agents and reviews clinical data on potential new centrally acting drugs for men who have ED...
  33. ncbi request reprint Male Sexual Health Questionnaire (MSHQ): scale development and psychometric validation
    Raymond C Rosen
    Department of Psychiatry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
    Urology 64:777-82. 2004
    ..To validate a new, self-administered questionnaire for assessing key domains of sexual function and satisfaction in aging men with urogenital health concerns...
  34. ncbi request reprint Editorial commentary on Rochiro, et al
    Allen D Seftel
    J Androl 23:481; discussion 481-2. 2002
  35. ncbi request reprint Association between lower urinary tract symptoms and erectile dysfunction
    Allen D Seftel
    J Urol 173:2077-8. 2005
  36. ncbi request reprint Efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and spinal cord injury: a review
    Fadel Derry
    National Spinal Injuries Center, Stoke Mandeville Hospital, Buckinghamshire, United Kingdom
    Urology 60:49-57. 2002
    ..Symptoms of autonomic dysreflexia were not reported in any study. Existing evidence suggests that oral sildenafil is a highly effective and well-tolerated treatment for ED associated with SCI...
  37. doi request reprint Correlation of the International Prostate Symptom Score bother question with the Benign Prostatic Hyperplasia Impact Index in a clinical practice setting
    MICHAEL P O'LEARY
    Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    BJU Int 101:1531-5. 2008
    ....
  38. ncbi request reprint Psycho-biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions
    Allen D Seftel
    J Urol 173:2078. 2005
  39. ncbi request reprint Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology
    Allen D Seftel
    J Urol 174:1043-4. 2005
  40. ncbi request reprint The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury
    Allen D Seftel
    J Urol 174:1045. 2005
  41. ncbi request reprint 3',5'-Cyclic nucleotide phosphodiesterase 11A: localization in human tissues
    Allen D Seftel
    J Urol 174:1044. 2005
  42. ncbi request reprint Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
    Allen D Seftel
    J Urol 174:1045-6. 2005
  43. ncbi request reprint Erectile dysfunction in obese men
    Allen D Seftel
    JAMA 292:2466; author reply 2467. 2004
  44. ncbi request reprint Incidentally diagnosed Peyronie's disease in men presenting with erectile dysfunction
    Allen D Seftel
    J Urol 173:2076-7. 2005
  45. ncbi request reprint Erectile dysfunction in smokers: a penile dynamic and vascular study
    Allen D Seftel
    J Urol 173:2076. 2005
  46. ncbi request reprint Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation
    Allen D Seftel
    J Urol 173:2077. 2005