Physician perceptions of sexual dysfunction related to benign prostatic hyperplasia (BPH) symptoms and sexual side effects related to BPH medicationsA Seftel
Department of Urology, Case Western Reserve University, University Hospital of Cleveland, Cleveland, OH 44106 5046, USA
Int J Impot Res 19:386-92. 2007
..As men with LUTS/BPH are at increased risk for SD, physicians should be especially cognizant of BPH treatment-related sexual side effects...
- The efficacy and safety of tadalafil in United States and Puerto Rican men with erectile dysfunction
Allen D Seftel
University Hospitals, Case Western Reserve University, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
J Urol 172:652-7. 2004
..We evaluate the efficacy and safety of tadalafil, taken as needed, in men with mild to severe erectile dysfunction (ED) and assess sexual intercourse attempt patterns...
- Challenges in oral therapy for erectile dysfunction
Allen D Seftel
Department of Urology, University Hospital of Cleveland, Case Western Reserve University, Cleveland VA Medical Center, Ohio 44106, USA
J Androl 23:729-36. 2002
- Testosterone replacement therapy for male hypogonadism: part III. Pharmacologic and clinical profiles, monitoring, safety issues, and potential future agents
A Seftel
Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
Int J Impot Res 19:2-24. 2007
..Investigational agents, including selective androgen receptor modulators, may offer new pharmacodynamic and/or pharmacokinetic properties that enhance outcomes of TRT...
- From aspiration to achievement: assessment and noninvasive treatment of erectile dysfunction in aging men
Allen D Seftel
Department of Urology, University Hospital of Cleveland, Case Western Reserve University, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, USA
J Am Geriatr Soc 53:119-30. 2005
..These treatment alternatives include the phosphodiesterase type 5 inhibitors sildenafil, vardenafil, and tadalafil, as well as other oral medications, such as alpha-adrenoceptor antagonists and topical vasoactive or testosterone therapy...
- Male hypogonadism. Part I: Epidemiology of hypogonadism
A D Seftel
Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
Int J Impot Res 18:115-20. 2006
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- Male hypogonadism. Part II: etiology, pathophysiology, and diagnosis
A Seftel
Department of Urology, Case Western Reserve University, Cleveland, OH 44106, USA
Int J Impot Res 18:223-8. 2006
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- Sildenafil reduces bother associated with erectile dysfunction: pooled analysis of five randomized, double-blind trials
A D Seftel
Department of Urology, Case Western Reserve University, University Hospital of Cleveland, OH 44106 5046, USA
Int J Impot Res 19:584-90. 2007
..The change in EF domain score correlated positively with the change in total transformed EDS score (0.43, P<0.0001). Successful treatment of ED with sildenafil may reduce the bother associated with ED...
- Phosphodiesterase type 5 inhibitors: molecular pharmacology and interactions with other phosphodiesterases
Allen D Seftel
Professor of Urology and Reproductive Biology, Department of Urology, Case Western Reserve University, School of Medicine, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
Curr Pharm Des 11:4047-58. 2005
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- The impact of formulary replacement of sildenafil by vardenafil at a local VA hospital
M Singh
Department of Urology, Case Western Reserve University School of Medicine, Cleveland, OH 44112, USA
Int J Impot Res 20:188-91. 2008
..The substantial cost savings to the VA seem to be justified by the minimal adverse effects on men treated for erectile dysfunction...
- Review of time of onset and duration of clinical efficacy of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction
Ridwan Shabsigh
Department of Urology, Columbia-Presbyterian Medical Center, New York, New York 10032, USA
Urology 68:689-96. 2006
- Erectile dysfunction: etiology, evaluation, and treatment options
Allen D Seftel
Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106 5046, USA
Med Clin North Am 88:387-416, xi. 2004
..Inclusion of the partner in the evaluation and management scheme will provide added benefit and may produce a better outcome...
Standards for clinical trials in male sexual dysfunctionsHartmut Porst
J Sex Med 7:414-44. 2010
..Clinical trials in male sexual dysfunction (MSD) are expanding. Consequently, there is a need for consensus standards in this area...
- Improvements in confidence, sexual relationship and satisfaction measures: results of a randomized trial of tadalafil 5 mg taken once daily
A D Seftel
Department of Urology, Case Medical Center University Hospitals of Cleveland, Cleveland, OH 44106, USA
Int J Impot Res 21:240-8. 2009
..001) correlated with erectile function (EF) improvement (assessed by change from baseline in IIEF-EF score). Tadalafil significantly improved treatment and sexual satisfaction, while improving multiple outcomes measured by SEAR...
- Medical solutions to sexual problems continue to make sexological care and science essential to the successful treatment of male ED
Allen D Seftel
Case Medical Center, Cleveland, Ohio 44106-4920, USA
J Sex Marital Ther 33:467-8. 2007
- Restorative increases in serum testosterone levels are significantly correlated to improvements in sexual functioning
Allen D Seftel
Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland VA Medical Center, 11100 Euclid Ave, Cleveland, OH 44106 5046, USA
J Androl 25:963-72. 2004
..We propose that threshold T levels are needed in order to significantly affect improvements in sexual functioning...
- A three-part study to investigate the incidence and potential etiologies of tadalafil-associated back pain or myalgia
A D Seftel
Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH 44106 5046, USA
Int J Impot Res 17:455-61. 2005
..Although the mechanism of back pain and/or myalgia remains unknown, these events appear to be self-limiting and a general effect of phosphodiesterase 5 inhibition...
- Rapid ejaculation
A D Seftel
Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, 1611 S Green Road, Cleveland, OH 44121, USA
Curr Urol Rep 1:302-6. 2000
..This article provides a basic review of the pathophysiology of ejaculatory dysfunction and discusses the current treatment options for rapid ejaculation...
- Erectile dysfunction in the elderly: epidemiology, etiology and approaches to treatment
Allen D Seftel
Case Western Reserve University, Department of Urology, University Hospital of Cleveland, Cleveland VA Medical Center, Cleveland, Ohio, USA
J Urol 169:1999-2007. 2003
..CONCLUSIONS: Further research into the neural, vascular and molecular mechanisms involved in penile erection will lead to the development of even safer, more effective and more convenient therapies for men with erectile dysfunction...
- Computational models for detection of erectile dysfunction
Moshe Wald
Department of Urology, University of Illinois at Chicago, 200 Hawkins Drive, Chicago, Illinois 52242, USA
J Urol 173:167-70. 2005
..Using several linear and nonlinear mathematical models we investigated the correlation of age, hypogonadism and depression with ED using the Sexual Health Inventory for Men (SHIM) as a surrogate marker for ED...
- Prostate-specific antigen changes in hypogonadal men treated with testosterone replacement
Robert E Gerstenbluth
Department of Urology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Ohio 44124, USA
J Androl 23:922-6. 2002
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- Benign prostatic hyperplasia evaluation, treatment and association with sexual dysfunction: practice patterns according to physician specialty
A D Seftel
Department of Urology, Case Medical Center University Hospitals of Cleveland, Cleveland, OH, USA
Int J Clin Pract 62:614-22. 2008
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- Nocturnal penile tumescence activity unchanged after long-term intracavernous injection therapy
P Maniam
Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
J Urol 165:830-2; discussion 832-3. 2001
..However, as measured by nocturnal penile tumescence testing, no objective improvement in spontaneous erectile function occurs...
- The prevalence of hypertension, hyperlipidemia, diabetes mellitus and depression in men with erectile dysfunction
Allen D Seftel
School of Medicine, Case Western Reserve University and University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
J Urol 171:2341-5. 2004
..This finding suggests that clinicians could include ED in the assessment profile of these concurrent conditions for earlier detection and treatment...
- Phosphodiesterase type 5 inhibitor differentiation based on selectivity, pharmacokinetic, and efficacy profiles
Allen D Seftel
Dept of Urology and Reproductive Biology, Case Western Reserve University School of Medicine, University Hospitals of Cleveland, Cleveland VA Medical Center, Cleveland, Ohio 44106 5046, USA
Clin Cardiol 27:I14-19. 2004
..In addition, in the presence of high-fat food, absorption of sildenafil and vardenafil may be delayed; however, the rate and extent of tadalafil absorption are unaffected by high-fat food...
- Distribution of chronic prostatitis in radical prostatectomy specimens with up-regulation of bcl-2 in areas of inflammation
Robert E Gerstenbluth
Department of Urology, Case Western Reserve University, University Hospitals of Cleveland, Cleveland Veterans Affairs Medical Center, Cleveland, Ohio, USA
J Urol 167:2267-70. 2002
..Bcl-2 was prominently expressed in areas of prostatitis. Our findings indirectly support a potential role for prostatitis in the pathogenesis of BPH...
- Erectile dysfunction and symptoms of sleep disorders
Allen D Seftel
Department of Urology, Cleveland VA Medical Center, University Hospitals of Cleveland, Case Western Reserve University, Ohio 44106, USA
Sleep 25:643-7. 2002
..CONCLUSIONS: Urology patients will report a variety of sleep problems, but neither persistent snoring nor suspected OSAHS is correlated uniquely to ED...
- Erectile dysfunction. Diagnosis and treatment in older men
Dominick J Carbone
Department of Urology, Wake Forest University, Winston-Salem, North Carolina, USA
Geriatrics 57:18-24. 2002
..Treatments include medical management of multi-drug regimens, oral therapy, intracavernosal injection, testosterone replacement therapy, vacuum erection devices, and penile prostheses...
- Office evaluation of male sexual dysfunction
Allen D Seftel
Department of Urology, Case Medical Center, Cleveland, OH, USA
Urol Clin North Am 34:463-82, v. 2007
..This article provides the rationale for this global assessment paradigm...
- Expression and functional activity of phosphodiesterase type 5 in human and rabbit vas deferens
Allen D Seftel
J Urol 174:1043. 2005
- Development and validation of four-item version of Male Sexual Health Questionnaire to assess ejaculatory dysfunction
Raymond C Rosen
New England Research Institutes, Watertown, Massachusetts 02472, USA
Urology 69:805-9. 2007
..An abridged version of the 25-item Male Sexual Health Questionnaire (MSHQ) was developed and validated (MSHQ-EjD Short Form) for assessing ejaculatory dysfunction (EjD)...
- Centrally acting mechanisms for the treatment of male sexual dysfunction
Martin M Miner
Division of Biology and Medicine, Department of Family Medicine, Warren Alpert Medical School of Brown University, Providence, RI, USA
Urol Clin North Am 34:483-96, v. 2007
..Drugs available in Europe include apomorphine. This article focuses on the mechanism of centrally acting agents and reviews clinical data on potential new centrally acting drugs for men who have ED...
- Male Sexual Health Questionnaire (MSHQ): scale development and psychometric validation
Raymond C Rosen
Department of Psychiatry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854, USA
Urology 64:777-82. 2004
..This new instrument has excellent psychometric properties and is well suited for use in clinical and research settings...
- Editorial commentary on Rochiro, et al
Allen D Seftel
J Androl 23:481; discussion 481-2. 2002
- Association between lower urinary tract symptoms and erectile dysfunction
Allen D Seftel
J Urol 173:2077-8. 2005
- Efficacy and safety of sildenafil citrate (Viagra) in men with erectile dysfunction and spinal cord injury: a review
Fadel Derry
National Spinal Injuries Center, Stoke Mandeville Hospital, Buckinghamshire, United Kingdom
Urology 60:49-57. 2002
..Symptoms of autonomic dysreflexia were not reported in any study. Existing evidence suggests that oral sildenafil is a highly effective and well-tolerated treatment for ED associated with SCI...
- Correlation of the International Prostate Symptom Score bother question with the Benign Prostatic Hyperplasia Impact Index in a clinical practice setting
MICHAEL P O'LEARY
Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
BJU Int 101:1531-5. 2008
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- Psycho-biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions
Allen D Seftel
J Urol 173:2078. 2005
- Phosphodiesterase 11 (PDE11) regulation of spermatozoa physiology
Allen D Seftel
J Urol 174:1043-4. 2005
- The effect of neural embryonic stem cell therapy in a rat model of cavernosal nerve injury
Allen D Seftel
J Urol 174:1045. 2005
- 3',5'-Cyclic nucleotide phosphodiesterase 11A: localization in human tissues
Allen D Seftel
J Urol 174:1044. 2005
- Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes
Allen D Seftel
J Urol 174:1045-6. 2005
- Erectile dysfunction in obese men
Allen D Seftel
JAMA 292:2466; author reply 2467. 2004
- Incidentally diagnosed Peyronie's disease in men presenting with erectile dysfunction
Allen D Seftel
J Urol 173:2076-7. 2005
- Erectile dysfunction in smokers: a penile dynamic and vascular study
Allen D Seftel
J Urol 173:2076. 2005
- Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation
Allen D Seftel
J Urol 173:2077. 2005
