Howard J Seeherman

Summary

Publications

  1. doi request reprint Intraosseous injection of rhBMP-2/calcium phosphate matrix improves bone structure and strength in the proximal aspect of the femur in chronic ovariectomized nonhuman primates
    Howard J Seeherman
    Inflammation and Remodeling Research Unit, Pfizer Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 95:36-47. 2013
  2. doi request reprint rhBMP-12 accelerates healing of rotator cuff repairs in a sheep model
    Howard J Seeherman
    Women s Health and Musculoskeletal Biology, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 90:2206-19. 2008
  3. doi request reprint rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model
    Howard J Seeherman
    Musculoskeletal Therapies, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 92:411-26. 2010
  4. doi request reprint rhBMP-2/calcium phosphate matrix induces bone formation while limiting transient bone resorption in a nonhuman primate core defect model
    Howard J Seeherman
    Inflammation and Tissue Repair, Pfizer Discovery Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 94:1765-76. 2012
  5. ncbi request reprint Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model
    Howard J Seeherman
    Women s Health and Bone, Wyeth Discovery Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 86:1961-72. 2004
  6. pmc Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
    Stephen P Berasi
    Tissue Repair, Pfizer Research, Cambridge, MA 02140, USA
    Growth Factors 29:128-39. 2011
  7. pmc Regulation of gene expression in human tendinopathy
    Scott A Jelinsky
    Tissue Repair, Pfizer Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    BMC Musculoskelet Disord 12:86. 2011
  8. pmc Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings
    Nisarg J Shah
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Sci Transl Med 5:191ra83. 2013
  9. ncbi request reprint Protein-based tissue engineering in bone and cartilage repair
    John M Wozney
    Wyeth Research, 87 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Biotechnol 15:392-8. 2004

Collaborators

Detail Information

Publications9

  1. doi request reprint Intraosseous injection of rhBMP-2/calcium phosphate matrix improves bone structure and strength in the proximal aspect of the femur in chronic ovariectomized nonhuman primates
    Howard J Seeherman
    Inflammation and Remodeling Research Unit, Pfizer Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 95:36-47. 2013
    ..Despite systemic therapies, the morbidity and mortality that are associated with hip fractures remain a major consequence of osteoporosis...
  2. doi request reprint rhBMP-12 accelerates healing of rotator cuff repairs in a sheep model
    Howard J Seeherman
    Women s Health and Musculoskeletal Biology, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 90:2206-19. 2008
    ..This study was performed to evaluate the ability of recombinant human bone morphogenetic protein-12 (rhBMP-12), administered in several carriers, to accelerate healing in a sheep model of rotator cuff repair...
  3. doi request reprint rhBMP-2 induces transient bone resorption followed by bone formation in a nonhuman primate core-defect model
    Howard J Seeherman
    Musculoskeletal Therapies, Wyeth Discovery Research, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 92:411-26. 2010
    ..This study characterizes treatment with rhBMP-2/ACS in metaphyseal bone with use of a nonhuman primate core-defect model...
  4. doi request reprint rhBMP-2/calcium phosphate matrix induces bone formation while limiting transient bone resorption in a nonhuman primate core defect model
    Howard J Seeherman
    Inflammation and Tissue Repair, Pfizer Discovery Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 94:1765-76. 2012
    ..The purpose of the present study was to evaluate the efficacy of rhBMP-2/calcium phosphate matrix (CPM) to induce bone formation while limiting transient bone resorption in nonhuman primate core defects...
  5. ncbi request reprint Recombinant human bone morphogenetic protein-2 delivered in an injectable calcium phosphate paste accelerates osteotomy-site healing in a nonhuman primate model
    Howard J Seeherman
    Women s Health and Bone, Wyeth Discovery Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    J Bone Joint Surg Am 86:1961-72. 2004
    ..In this study, we used a nonhuman primate fibular osteotomy model to evaluate injectable rhBMP-2/carrier formulations that can be administered in closed fractures...
  6. pmc Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities
    Stephen P Berasi
    Tissue Repair, Pfizer Research, Cambridge, MA 02140, USA
    Growth Factors 29:128-39. 2011
    ..Such an assay also permits the ability to distinguish between the activities of different BMPs and may prove useful in studies on the molecular mechanisms of BMP tenogenic activity...
  7. pmc Regulation of gene expression in human tendinopathy
    Scott A Jelinsky
    Tissue Repair, Pfizer Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    BMC Musculoskelet Disord 12:86. 2011
    ..These injuries result in a significant amount of morbidity and health care expenditure, yet little is known about the molecular mechanisms leading to tendinopathy...
  8. pmc Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings
    Nisarg J Shah
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA
    Sci Transl Med 5:191ra83. 2013
    ..Collectively, these results suggest that the multilayered coating system promotes biological fixation of orthopedic and dental implants to improve surgical outcomes by preventing loosening and premature failure. ..
  9. ncbi request reprint Protein-based tissue engineering in bone and cartilage repair
    John M Wozney
    Wyeth Research, 87 CambridgePark Drive, Cambridge, Massachusetts 02140, USA
    Curr Opin Biotechnol 15:392-8. 2004
    ..Although a similar rationale exists for the regeneration of articular cartilage with bioactive factors, advancement in this area has not been as substantial...