N J Sebire

Summary

Publications

  1. pmc Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London GU21 2FB, UK
    J Clin Pathol 56:412-6. 2003
  2. ncbi request reprint Updated diagnostic criteria for partial and complete hydatidiform moles in early pregnancy
    N J Sebire
    Trophoblastic Disease Unit, Department of Histopathology, Charing Cross Hospital, Fulham Palace Road, London, U K
    Anticancer Res 23:1723-8. 2003
  3. ncbi request reprint Pathology teach and tell: pediatric gastrointestinal stromal tumor
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom
    Pediatr Pathol Mol Med 22:259-64. 2003
  4. ncbi request reprint Placental pathology, antiphospholipid antibodies, and pregnancy outcome in recurrent miscarriage patients
    N J Sebire
    Department of Histopathology, Imperial College School of Medicine at St Mary s, London, United Kingdom
    Obstet Gynecol 101:258-63. 2003
  5. ncbi request reprint Routine uterine artery Doppler screening in twin pregnancies?
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol 20:532-4. 2002
  6. doi request reprint Histological examination in sudden unexpected death in infancy: evidence base for histological sampling
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, UK and UCL Institute of Child Health, London, UK
    J Clin Pathol 65:58-63. 2012
  7. doi request reprint Intrauterine growth in multiple pregnancies in relation to fetal number, chorionicity and gestational age
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Ultrasound Obstet Gynecol 32:890-3. 2008
  8. doi request reprint Role of routine neuropathological examination for determining cause of death in sudden unexpected deaths in infancy (SUDI)
    J W Pryce
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    J Clin Pathol 65:257-61. 2012
  9. ncbi request reprint Pseudo-partial moles: placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles
    F J Paradinas
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    Histopathology 39:447-54. 2001
  10. doi request reprint Virological investigations in sudden unexpected deaths in infancy (SUDI)
    M A Weber
    Department of Paediatric Histopathology, Great Ormond Street Hospital For Children and UCL Institute of Child Health, Great Ormond Street, London WC1N 3JH, UK
    Forensic Sci Med Pathol 6:261-7. 2010

Detail Information

Publications106 found, 100 shown here

  1. pmc Myogenin and MyoD1 expression in paediatric rhabdomyosarcomas
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London GU21 2FB, UK
    J Clin Pathol 56:412-6. 2003
    ..This review examines the use of the immunohistochemical markers, MyoD1 and myogenin, in the diagnosis of paediatric rhabdomyosarcoma, including its subtypes...
  2. ncbi request reprint Updated diagnostic criteria for partial and complete hydatidiform moles in early pregnancy
    N J Sebire
    Trophoblastic Disease Unit, Department of Histopathology, Charing Cross Hospital, Fulham Palace Road, London, U K
    Anticancer Res 23:1723-8. 2003
    ..Diagnosis of both complete and partial hydatidiform mole at this early stage of pregnancy requires the use of appropriate, updated histopathological features which are different from those described in later pregnancy...
  3. ncbi request reprint Pathology teach and tell: pediatric gastrointestinal stromal tumor
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom
    Pediatr Pathol Mol Med 22:259-64. 2003
  4. ncbi request reprint Placental pathology, antiphospholipid antibodies, and pregnancy outcome in recurrent miscarriage patients
    N J Sebire
    Department of Histopathology, Imperial College School of Medicine at St Mary s, London, United Kingdom
    Obstet Gynecol 101:258-63. 2003
    ....
  5. ncbi request reprint Routine uterine artery Doppler screening in twin pregnancies?
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol 20:532-4. 2002
  6. doi request reprint Histological examination in sudden unexpected death in infancy: evidence base for histological sampling
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, UK and UCL Institute of Child Health, London, UK
    J Clin Pathol 65:58-63. 2012
    ..This study establishes the frequency with which histological examination of visceral organs determines cause of death and examines associations between clinical, macroscopic and microscopic findings...
  7. doi request reprint Intrauterine growth in multiple pregnancies in relation to fetal number, chorionicity and gestational age
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital, Denmark Hill, London, UK
    Ultrasound Obstet Gynecol 32:890-3. 2008
    ..To examine birth weight in dichorionic and monochorionic twins and trichorionic triplets, and to estimate the relative independent importance on growth of fetal number, chorionicity and gestational age...
  8. doi request reprint Role of routine neuropathological examination for determining cause of death in sudden unexpected deaths in infancy (SUDI)
    J W Pryce
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    J Clin Pathol 65:257-61. 2012
    ..This study examines the frequency of neuropathological findings determining cause of death at postmortem examination in SUDI in relation to clinical and macroscopic features...
  9. ncbi request reprint Pseudo-partial moles: placental stem vessel hydrops and the association with Beckwith-Wiedemann syndrome and complete moles
    F J Paradinas
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    Histopathology 39:447-54. 2001
    ....
  10. doi request reprint Virological investigations in sudden unexpected deaths in infancy (SUDI)
    M A Weber
    Department of Paediatric Histopathology, Great Ormond Street Hospital For Children and UCL Institute of Child Health, Great Ormond Street, London WC1N 3JH, UK
    Forensic Sci Med Pathol 6:261-7. 2010
    ..Application of a broader panel using more sensitive detection techniques may reveal more viruses, although their contribution to the final cause of death requires further exploration...
  11. doi request reprint Salvage chemotherapy of relapsed or high-risk gestational trophoblastic neoplasia (GTN) with paclitaxel/cisplatin alternating with paclitaxel/etoposide (TP/TE)
    J Wang
    Department of Health, Charing Cross Hospital Gestational Trophoblastic Disease Centre, Imperial College School of Medicine, Charing Cross Hospital, London, UK
    Ann Oncol 19:1578-83. 2008
    ..To evaluate the efficacy and toxicity of paclitaxel and cisplatin alternating with paclitaxel and etoposide doublet regimen (TP/TE), for salvage of patients with high-risk gestational trophoblastic neoplasia (GTN)...
  12. ncbi request reprint Extravillus endovascular implantation site trophoblast invasion is abnormal in complete versus partial molar pregnancies
    N J Sebire
    Department of Histopathology, Trophoblastic Disease Surveillance Unit, Charing Ross Hospital, London, UK
    Placenta 22:725-8. 2001
    ..These findings may provide some explanation regarding the mechanism of clinical findings in molar pregnancy...
  13. doi request reprint High quality genomic DNA extraction from postmortem fetal tissue
    S Addison
    Academic Neonatology, Institute for Women s Health, University College London, London, UK
    J Matern Fetal Neonatal Med 25:2467-9. 2012
    ..We examined the yield and quality of genomic deoxyribonucleic acid (DNA) extracted from various postmortem fetal tissues...
  14. pmc Changing patterns of infant death over the last 100 years: autopsy experience from a specialist children's hospital
    J W Pryce
    UCL Institute of Child Health, London, UK
    J R Soc Med 105:123-30. 2012
    ..Postmortem examinations have been performed at Great Ormond Street Hospital for over 100 years, and analysis of cases across this period has been performed to assess changing patterns of infant deaths undergoing autopsy...
  15. doi request reprint The role of post-mortem investigations in determining the cause of sudden unexpected death in infancy
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital For Children and UCL Institute of Child Health, London, UK
    Arch Dis Child 93:1048-53. 2008
    ..The aim of this study is to provide data on the utility of such post-mortem investigations from a large paediatric autopsy series to inform future policy...
  16. doi request reprint Staphylococcal toxins in sudden unexpected death in infancy: experience from a single specialist centre
    M A Weber
    Department of Paediatric Histopathology, Great Ormond Street Hospital For Children and UCL Institute of Child Health, London, UK
    Forensic Sci Med Pathol 7:141-7. 2011
    ..These data are consistent with the hypothesis that a subset of otherwise unexplained SUDI may be related to the presence of S aureus colonization/infection, but do not indicate routine testing for toxin-associated genotypes...
  17. doi request reprint Normal ascent of the conus medullaris: a post-mortem foetal MRI study
    O J Arthurs
    Great Ormond Street Hospital for Children, London, WC1N 3JH, UK
    J Matern Fetal Neonatal Med 26:697-702. 2013
    ..We used magnetic resonance imaging (MRI) to measure the position of the conus in post-mortem foetuses, to investigate the timing of normal ascent...
  18. ncbi request reprint Twin-to-twin transfusion syndrome results from dynamic asymmetrical reduction in placental anastomoses: a hypothesis
    N J Sebire
    Centre for Fetal Care, Department of Maternal-Fetal Medicine, Imperial College School of Medicine at Queen Charlotte's, Hammersmith Hospital Site, Du Cane Road, London, UK
    Placenta 22:383-91. 2001
    ....
  19. ncbi request reprint p57(KIP2) immunohistochemical staining of gestational trophoblastic tumours does not identify the type of the causative pregnancy
    N J Sebire
    Department of Histopathology, Charing Cross Hospital, London, UK
    Histopathology 45:135-41. 2004
    ....
  20. ncbi request reprint Histomorphometric features of hydatidiform moles in early pregnancy: relationship to detectability by ultrasound examination
    D J Fowler
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    Ultrasound Obstet Gynecol 29:76-80. 2007
    ..We measured a microscopic parameter, average villus diameter, of evacuated PHMs and CHMs to ascertain the cause of non-detection on ultrasound...
  21. ncbi request reprint Intraplacental choriocarcinoma: experience from a tertiary referral center and relationship with infantile choriocarcinoma
    N J Sebire
    Department of Histopathology, Trophoblastic Disease Unit, Charing Cross Hospital, London, UK
    Fetal Pediatr Pathol 24:21-9. 2005
    ....
  22. pmc Treatment outcomes for 618 women with gestational trophoblastic tumours following a molar pregnancy at the Charing Cross Hospital, 2000-2009
    A Sita-Lumsden
    Department of Medical Oncology, Gestational Trophoblastic Disease Centre, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London W6 8RF, UK
    Br J Cancer 107:1810-4. 2012
    ..Because of the rarity of the diagnosis, detailed structured information on prognosis, treatment escalations and outcome is limited...
  23. ncbi request reprint Risks of miscarriage and early preterm birth in trichorionic triplet pregnancies with embryo reduction versus expectant management: new data and systematic review
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Hum Reprod 21:1912-7. 2006
    ..Triplet pregnancies are associated with a high risk of miscarriage and early preterm birth. It is uncertain if the outcome is improved by embryo reduction (ER)...
  24. ncbi request reprint The dynamic placenta: I. Hypothetical model of a placental mechanism matching local fetal blood flow to local intervillus oxygen delivery
    D Talbert
    Institute of Reproduction and Developmental Biology, ICSM, Hammersmith Hospital, Du Cane Road, London, UK
    Med Hypotheses 62:511-9. 2004
    ..Intervillus/villus flow matching is likely in the human placenta and this study suggests probable biologically plausible mechanisms for such a phenomenon...
  25. ncbi request reprint Massive perivillous fibrin deposition associated with discordant fetal growth in a dichorionic twin pregnancy
    N Gupta
    Department of Histopathology, Charing Cross Hospital, London, UK
    J Obstet Gynaecol 24:579-80. 2004
  26. ncbi request reprint Histopathological features of testicular regression syndrome: relation to patient age and implications for management
    H Law
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Fetal Pediatr Pathol 25:119-29. 2006
    ..Residual testicular tubules are found in 10% of cases regardless of the presence or absence of a macroscopically identifiable nodule...
  27. ncbi request reprint Testicular and paratesticular pathology in infants and children: the histopathological experience of a tertiary paediatric unit over a 17 year period
    F L Murphy
    Department of Paediatric Urology, Great Ormond Street Children s Hospital, Great Ormond Street, London WC1N 3JH, UK
    Pediatr Surg Int 23:867-72. 2007
    ..Neoplasms represented >20% of the pathology, but the largest clinical group of pathological specimens in this patient population is associated with clinically impalpable or the palpably abnormal testis...
  28. ncbi request reprint Electron microscopy of chorionic villus samples for prenatal diagnosis of lysosomal storage disorders
    D J Fowler
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Ultrastruct Pathol 31:15-21. 2007
    ..In selected cases, one-third of CVS may demonstrate distinctive ultrastructural features allowing prenatal diagnosis of a range of storage diseases...
  29. doi request reprint Clinicopathological features of paediatric deaths due to myocarditis: an autopsy series
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, Great Ormond Street, London, UK
    Arch Dis Child 93:594-8. 2008
    ..Myocarditis is a recognised cause of cardiac failure in childhood but the frequency of myocarditis as a cause of sudden unexpected death across the paediatric age range is uncertain...
  30. ncbi request reprint Placental massive perivillous fibrin deposition associated with antiphospholipid antibody syndrome
    N J Sebire
    Department of Histopathology, Imperial College School of Medicine, St Mary s Hospital, London, UK
    BJOG 109:570-3. 2002
    ....
  31. ncbi request reprint The diagnostic implications of routine ultrasound examination in histologically confirmed early molar pregnancies
    N J Sebire
    Department of Histopathology, Imperial College School of Medicine at Charing Cross Hospital, Fulham Palace Road, London, UK
    Ultrasound Obstet Gynecol 18:662-5. 2001
    ..Early ultrasound examination is being used increasingly in the diagnosis of molar pregnancy. The aim of this study was to examine the diagnostic implications of routine ultrasound examination for histologically confirmed molar pregnancies...
  32. ncbi request reprint Is maternal underweight really a risk factor for adverse pregnancy outcome? A population-based study in London
    N J Sebire
    Department of Obstetrics and Gynaecology, Imperial College School of Medicine, St Mary s Hospital, Paddington, London, UK
    BJOG 108:61-6. 2001
    ..To determine the maternal and fetal risk of adverse outcome during pregnancy in relation to low maternal body mass index in an unselected population...
  33. ncbi request reprint Epstein-Barr virus-associated lymphoproliferative disorder presenting as apparently isolated gastrointestinal lesions in childhood
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London, WC1N 3JH, United Kingdom
    Pediatr Dev Pathol 8:88-91. 2005
    ..The patient responded to therapy with targeted anti-CD20 immunotherapy. PTLD may manifest as apparently isolated gastrointestinal tract lesions in childhood...
  34. ncbi request reprint 'Cor placentale': placental intervillus/intravillus blood flow mismatch is the pathophysiological mechanism in severe intrauterine growth restriction due to uteroplacental disease
    N J Sebire
    Department of Pathology, St Mary's Hospital, Paddington, London, UK
    Med Hypotheses 57:354-7. 2001
    ....
  35. doi request reprint Fetal and placental malignancies: prenatal diagnosis and management
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    Ultrasound Obstet Gynecol 33:235-44. 2009
    ..Placental malignancy is most commonly in the form of gestatational trophoblastic disease, which requires assessment and management in specialist centers...
  36. ncbi request reprint Term preeclampsia is associated with minimal histopathological placental features regardless of clinical severity
    N J Sebire
    Department of Histopathology, St Mary s Hospital Paddington, London, UK
    J Obstet Gynaecol 25:117-8. 2005
    ....
  37. ncbi request reprint Placental site trophoblastic tumour derived from an oocyte donation pregnancy
    S Khan
    Department of Health Gestational Trophoblastic Disease Centre, Charing Cross Hospital, London, UK
    BJOG 113:344-6. 2006
  38. doi request reprint Tandem mass spectrometry findings at autopsy for detection of metabolic disease in infant deaths: postmortem changes and confounding factors
    J W Pryce
    UCL Institute of Child Health, Great Ormond Street Hospital for Children, London, UK
    J Clin Pathol 64:1005-9. 2011
    ..This study investigates postmortem acylcarnitine profiles in a large cohort of infant deaths from a single centre, including those with metabolic disease...
  39. ncbi request reprint Placental pathology of recurrent spontaneous abortion: the role of histopathological examination of products of conception in routine clinical practice: a mini review
    P Jindal
    Recurrent Miscarriage Unit, Department of Obstetrics and Gynaecology, St Mary s Hospital, Imperial College School of Medicine, London, UK
    Hum Reprod 22:313-6. 2007
    ..The extent of additional clinically relevant information provided by this investigation in the setting of recurrent spontaneous abortion remains uncertain...
  40. ncbi request reprint The dynamic placenta: II. Hypothetical model of a fetus driven transplacental water balance mechanism producing low apparent permeability in a highly permeable placenta
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Med Hypotheses 62:520-8. 2004
    ..This may shed new light on disorders such as polyhydramnios and fetal hydrops...
  41. doi request reprint Minimally invasive fetal postmortem examination using magnetic resonance imaging and computerised tomography: current evidence and practical issues
    S Thayyil
    Department of Radiology, Institute of Child Health, University College London, London, UK
    Prenat Diagn 30:713-8. 2010
    ..Here, we review the case for the development of less invasive autopsy using combined investigations including imaging techniques, in particular, magnetic resonance imaging and computerised tomography...
  42. doi request reprint Rhabdomyosarcoma subtyping by immunohistochemical assessment of myogenin: tissue array study and review of the literature
    D A Morgenstern
    Unit of Molecular Haematology and Cancer Biology, Institute of Child Health, London, UK
    Pathol Oncol Res 14:233-8. 2008
    ..0001). This data is consistent with previously published studies identifying strong nuclear myogenin staining in a high proportion of cells as a marker of alveolar histology...
  43. doi request reprint Enteropathic histopathological features may be associated with Shwachman-Diamond syndrome
    N Shah
    Department of Gastroenterology and Haematology, Great Ormond Street Hospital and Institute of Child Health, London, UK
    J Clin Pathol 63:592-4. 2010
    ..To review the gastrointestinal mucosal histological features of biopsies from children with Shwachman-Diamond syndrome (SDS) examined at a single specialist centre...
  44. ncbi request reprint Maternal obesity and pregnancy outcome: a study of 287,213 pregnancies in London
    N J Sebire
    Department of Obstetrics and Gynaecology, Imperial College School of Medicine at St Mary's Hospital, London, UK
    Int J Obes Relat Metab Disord 25:1175-82. 2001
    ..The basis of many of the complications is likely to be related to the altered metabolic state associated with morbid obesity...
  45. ncbi request reprint Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features
    D J Fowler
    Department of Pediatric Histopathology, Great Ormond Street Hospital, London, UK
    Fetal Pediatr Pathol 25:59-72. 2006
    ..At present, the optimal management includes complete surgical excision with clear margins, but there are no reliable histopathological or molecular features to predict the biological behavior in individual cases...
  46. ncbi request reprint Routine pre-evacuation ultrasound diagnosis of hydatidiform mole: experience of more than 1000 cases from a regional referral center
    D J Fowler
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    Ultrasound Obstet Gynecol 27:56-60. 2006
    ....
  47. doi request reprint Prospective parental consent for autopsy research following sudden unexpected childhood deaths: a successful model
    S Thayyil
    UCL Institute of Child Health, London, UK
    Arch Dis Child 94:354-8. 2009
    ..Organ retention issues, recent changes in the Coroners' (Amendment) Rules 2005 and the Human Tissue Act have resulted in pessimism regarding prospective consent for paediatric autopsy research in the UK...
  48. pmc Blood film examination for vacuolated lymphocytes in the diagnosis of metabolic disorders; retrospective experience of more than 2,500 cases from a single centre
    G Anderson
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    J Clin Pathol 58:1305-10. 2005
    ..A range of metabolic diseases can result in abnormal accumulation of metabolic byproducts, resulting in abnormal lymphocyte cytoplasmic vacuolation, identifiable on routine blood film examination...
  49. ncbi request reprint Biology and pathology of the placenta in relation to antiphospholipid antibody-associated pregnancy failure
    N J Sebire
    Department of Obstetrics and Gynaecology, Faculty of Medicine, Imperial College School of Medicine, St Mary s Hospital, London, UK
    Lupus 11:641-3. 2002
    ....
  50. doi request reprint Correlation of placental pathology with prenatal ultrasound findings
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital Institute of Child Health, London, UK
    J Clin Pathol 61:1276-84. 2008
    ....
  51. ncbi request reprint Ultrastructural features of gaucher disease treated with enzyme replacement therapy presenting as mesenteric mass lesions
    D J Fowler
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, London, United Kingdom
    Fetal Pediatr Pathol 25:241-8. 2006
    ..These probably represent incomplete clearance, incomplete/partial enzyme replacement, or possibly an unusual response to a relatively small amount of storage material...
  52. ncbi request reprint Shortened duration of human chorionic gonadotrophin surveillance following complete or partial hydatidiform mole: evidence for revised protocol of a UK regional trophoblastic disease unit
    N J Sebire
    Trophoblastic Disease Unit, Department of Cancer Medicine, Charing Cross Hospital, London, UK
    BJOG 114:760-2. 2007
    ..Therefore, the current revised protocol comprises hCG follow up for 6 months after spontaneous return of hCG levels to normal for all women...
  53. ncbi request reprint Persistent gestational trophoblastic disease is rarely, if ever, derived from non-molar first-trimester miscarriage
    N J Sebire
    Trophoblastic Disease Unit, Charing Cross Hospital, London WC1N 3JH, UK
    Med Hypotheses 64:689-93. 2005
    ....
  54. doi request reprint Morbidity after ganglioneuroma excision: is surgery necessary?
    G Retrosi
    UCL Institute of Child Health and Great Ormond Street Hospital for Children, Department of Surgery, London, United Kingdom
    Eur J Pediatr Surg 21:33-7. 2011
    ..Our aim was to evaluate the incidence of complications after surgical treatment following diagnosis of this tumour...
  55. ncbi request reprint Risk of recurrent hydatidiform mole and subsequent pregnancy outcome following complete or partial hydatidiform molar pregnancy
    N J Sebire
    Trophoblastic Disease Screening and Treatment Centre, Department of Cancer Medicine, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    BJOG 110:22-6. 2003
    ..To determine pregnancy outcome, including the rate of repeat molar pregnancy, following histologically confirmed complete or partial hydatidiform mole...
  56. doi request reprint Capillary apposition and density in the diagnosis of alveolar capillary dysplasia
    L Melly
    Department of Histopathology, Royal Free Hospital, London, UK
    Histopathology 53:450-7. 2008
    ..The aim was to characterise further the histological features of patients suspected of having ACD and to correlate histopathological features with outcome...
  57. doi request reprint Acceptability of a minimally invasive perinatal/paediatric autopsy: healthcare professionals' views and implications for practice
    K Ben-Sasi
    Department of Paediatric Pathology, Great Ormond Street Hospital, London, UK
    Prenat Diagn 33:307-12. 2013
    ..Technology now enables less invasive alternatives to traditional autopsy and may increase the acceptability of post-mortem examination...
  58. doi request reprint Lack of T-cell responses following autologous tumour lysate pulsed dendritic cell vaccination, in patients with relapsed osteosarcoma
    N Himoudi
    Unit of Molecular Haematology and Cancer Biology, University College London Institute of Child Health, London, UK
    Clin Transl Oncol 14:271-9. 2012
    ..We therefore conducted a phase I trial to assess feasibility, safety and tumour-specific immune responses in patients with relapsed disease...
  59. pmc Uterine artery pulsatility index: a predictor of methotrexate resistance in gestational trophoblastic neoplasia
    R Agarwal
    Department of Medical Oncology, Charing Cross Gestational Trophoblastic Disease Centre, Charing Cross Hospital, Imperial College Healthcare NHS Trust, Fulham Palace Road, London W6 8RF, UK
    Br J Cancer 106:1089-94. 2012
    ....
  60. ncbi request reprint Histopathological features of open lung biopsies in children treated with extracorporeal membrane oxygenation (ECMO)
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, Great Ormond Street, London WC1N 3JH, United Kingdom
    Early Hum Dev 81:455-60. 2005
    ..This study describes the histopathological features in a series of 22 children receiving ECMO therapy in whom open lung biopsy was carried out...
  61. ncbi request reprint Challenges to implementation of the new Coroners' (Amendment) Rules 2005: experience from a tertiary paediatric pathology centre
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital, London
    Med Sci Law 47:293-8. 2007
    ....
  62. doi request reprint Histopathological features of Proteus syndrome
    S E H Hoey
    Department of Dermatology, Great Ormond Street Hospital for Children, London, UK
    Clin Exp Dermatol 33:234-8. 2008
    ..Proteus syndrome is a rare, sporadic overgrowth disorder for which the underlying genetic defect remains unknown. Although the clinical course is well-described there is no systematic histopathological description of the lesional pathology...
  63. doi request reprint Gastrointestinal complications of epidermolysis bullosa in children
    E B Freeman
    Department of Paediatric Gastroenterology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London WC1N 3JH, UK
    Br J Dermatol 158:1308-14. 2008
    ..Epidermolysis bullosa (EB) is a group of inherited disorders characterized by skin and mucous membrane fragility. Gastrointestinal (GI) complications have been described in many types of EB and are responsible for significant morbidity...
  64. doi request reprint Infection and sudden unexpected death in infancy: a systematic retrospective case review
    M A Weber
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children and the Institute of Child Health, University College London, London, UK
    Lancet 371:1848-53. 2008
    ..The cause and mechanism of most cases of sudden unexpected death in infancy (SUDI) remain unknown, despite specialist autopsy examination. We reviewed autopsy results to determine whether infection was a cause of SUDI...
  65. ncbi request reprint Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure
    N J Sebire
    Department of Histopathology, Imperial College School of Medicine, St Mary s Hospital, Paddington, London, W2 1PG, UK
    Hum Reprod 17:1067-71. 2002
    ..This study examines products of conception (POC) from early pregnancy failures to investigate the mechanism of pregnancy loss...
  66. ncbi request reprint Overdiagnosis of complete and partial hydatidiform mole in tubal ectopic pregnancies
    N J Sebire
    Department of Histopathology, Trophoblastic Disease Unit, Charing Cross Hospital, London, UK
    Int J Gynecol Pathol 24:260-4. 2005
    ..Molar pregnancy should only be diagnosed when strict criteria regarding morphologic abnormalities previously described in uterine evacuation material are applied...
  67. pmc Light microscopic examination of scalp hair samples as an aid in the diagnosis of paediatric disorders: retrospective review of more than 300 cases from a single centre
    V V Smith
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    J Clin Pathol 58:1294-8. 2005
    ..Microscopic examination of scalp hair can provide important diagnostic information in a range of paediatric conditions. It is a non-invasive and cost effective investigation, which is not widely performed...
  68. ncbi request reprint Risk of germ cell malignancy in children with XY intersex versus isolated cryptorchidism by immunohistochemistry
    H Law
    Department of Pediatric Pathology, Great Ormond Street Hospital, London, UK
    Fetal Pediatr Pathol 25:95-105. 2006
    ..The extent of increased risk of malignancy in XY INT is not simply related to increased numbers of immature PLAP+/CD117+ germ cells present; additional factors play a pathogenic role...
  69. ncbi request reprint Histopathological features of pretreatment neuroblastoma are of limited clinical significance following adjustment for clinical and biological marker status
    N J Sebire
    Consultant in Paediatric Pathology, Great Ormond Street Hospital, London, UK
    Med Hypotheses 66:1078-81. 2006
    ....
  70. ncbi request reprint Primary thoracic myxoid variant of extrarenal rhabdoid tumor in childhood
    D J Fowler
    Department of Pediatric Histopathology, Great Ormond Street Hospital for Children, London, United Kingdom
    Fetal Pediatr Pathol 25:159-68. 2006
    ..The characteristic expression patterns of cytokeratin and vimentin provide strong clues to the diagnosis, and the use of INI1 antibody now makes definitive diagnosis possible even on needle core biopsies...
  71. ncbi request reprint The role of intraplacental vascular smooth muscle in the dynamic placenta: a conceptual framework for understanding uteroplacental disease
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, London, UK
    Med Hypotheses 58:347-51. 2002
    ....
  72. ncbi request reprint Pathophysiological significance of abnormal umbilical cord coiling index
    N J Sebire
    Department of Paediatric Pathology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK
    Ultrasound Obstet Gynecol 30:804-6. 2007
  73. ncbi request reprint Trichorionic triplet pregnancies at 10-14 weeks: outcome after embryo reduction compared to expectant management
    A T Papageorghiou
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    J Matern Fetal Neonatal Med 11:307-12. 2002
    ..To compare the outcome of trichorionic triplet pregnancies managed expectantly with those reduced to twins or singletons...
  74. ncbi request reprint Increased first-trimester fetal nuchal translucency thickness in association with chondroectodermal dysplasia (Ellis-Van Creveld syndrome)
    N Venkat-Raman
    Fetal Medicine Unit, St Mary s Hospital, Praed Street, London, UK
    Ultrasound Obstet Gynecol 25:412-4. 2005
    ..The acetabular roofs were horizontal with medial and lateral spurs. This case adds a further type of severe skeletal dysplasia to the list of genetic syndromes which may present as increased fetal NT in the late first trimester...
  75. ncbi request reprint Umbilical polyp in infants and children
    M Pacilli
    Surgery Unit, Institute of Child Health and Great Ormond Street Hospital, University College London, 30 Guilford Street, London, UK
    Eur J Pediatr Surg 17:397-9. 2007
    ..Exploration of the abdomen to exclude the presence of associated OMD remnants is controversial. The aim of this study was to evaluate the need for peritoneal cavity exploration in children with umbilical polyp...
  76. ncbi request reprint Megacystis at 10-14 weeks of gestation: chromosomal defects and outcome according to bladder length
    A W Liao
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Ultrasound Obstet Gynecol 21:338-41. 2003
    ..To examine the prevalence of chromosomal defects and outcome of fetuses with megacystis at 10-14 weeks of gestation...
  77. ncbi request reprint Myogenin and desmin immunohistochemistry in the assessment of post-chemotherapy genitourinary embryonal rhabdomyosarcoma: prognostic and management implications
    P Godbole
    Department of Paediatric Urology, Great Ormond Street Hospital for Children, London, United Kingdom
    J Urol 176:1751-4. 2006
    ..Therefore, we reviewed our retrospective experience with genitourinary embryonal rhabdomyosarcoma to examine the relationship between immunostain positive undifferentiated cells and subsequent clinical outcome...
  78. ncbi request reprint Outcome for children born after in utero laser ablation therapy for severe twin-to-twin transfusion syndrome
    A G Sutcliffe
    Royal Free and University College Medical School, Department of Paediatrics of Child Health, London, UK
    BJOG 108:1246-50. 2001
    ..3% in the twin survivors group. This pilot data highlights the need for careful long term follow up of children affected by twin-to-twin transfusion syndrome...
  79. ncbi request reprint Risk of partial and complete hydatidiform molar pregnancy in relation to maternal age
    N J Sebire
    Department of Cancer Medicine, Imperial College School of Medicine at Charing Cross Hospital, London, UK
    BJOG 109:99-102. 2002
    ..This study provides, for the first time, data regarding specific risk of partial versus complete hydatidiform mole with maternal age...
  80. pmc Pathology of astrovirus associated diarrhoea in a paediatric bone marrow transplant recipient
    N J Sebire
    Department of Histopathology, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    J Clin Pathol 57:1001-3. 2004
    ..Electron microscopic examination demonstrated viral particles within the cytoplasm of enterocytes, focally forming paracrystalline arrays...
  81. ncbi request reprint Isolated unilateral tuberous sclerosis-associated renal cystic disease in a neonate
    M A Weber
    Department of Pediatric Pathology, Great Ormond Street Hospital, London, UK
    Fetal Pediatr Pathol 24:267-75. 2005
    ....
  82. doi request reprint Histopathological diagnosis of hydatidiform mole: contemporary features and clinical implications
    N J Sebire
    Trophoblastic Disease Unit, Department of Medical Oncology, Charing Cross Hospital, London, UK
    Fetal Pediatr Pathol 29:1-16. 2010
    ....
  83. ncbi request reprint Maternal serum concentrations of pregnancy associated placental protein A and pregnancy specific beta-1-glycoprotein in multifetal pregnancies before and after fetal reduction
    A Abbas
    Harris Birthright Research Centre for Fetal Medicine, King s College Hospital Medical School, London, UK
    Hum Reprod 11:900-2. 1996
    ....
  84. ncbi request reprint Absent/reduced glucose transporter-1 protein expression in infantile subglottic haemangiomas
    D J Purvis
    Department of Dermatology, Great Ormond Street Hospital for Children, London, UK
    Br J Dermatol 155:1041-4. 2006
    ..Positive immunohistochemical staining for glucose transporter-1 protein (GLUT1) is a characteristic of cutaneous infantile haemangiomas...
  85. pmc Histopathological reporting of paediatric cutaneous vascular anomalies in relation to proposed multidisciplinary classification system
    M Al-Adnani
    Department of Paediatric Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, London, UK
    J Clin Pathol 59:1278-82. 2006
    ..This classification is increasingly being accepted as clinically useful and a platform for future studies...
  86. ncbi request reprint Alveolar septal collapse in the transitional infant lung: a possible common mechanism in sudden unexpected death in infancy
    N J Sebire
    Department of Paediatric Pathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Med Hypotheses 63:485-93. 2004
    ..Many epidemiological risk factors for SUDI could influence such a mechanism, leading to the proposal that Alveolar Septal Collapse in Infancy (ASCI) is a core mechanism via which these factors act...
  87. ncbi request reprint Posttransplant de novo membranous nephropathy in childhood
    N J Sebire
    Department of Paediatric Histopathology, Great Ormond Street Hospital, London, United Kingdom
    Fetal Pediatr Pathol 24:95-103. 2005
    ..The presence of posttransplant de novo membranous nephropathy may be associated with an increased risk of graft loss...
  88. ncbi request reprint Sacrococcygeal tumors in infancy and childhood; a retrospective histopathological review of 85 cases
    N J Sebire
    Department of Histopathology, Camelia Botnar Laboratories, Great Ormond Street Hospital, Great Ormond Street, London WC1N 3JH, UK
    Fetal Pediatr Pathol 23:295-303. 2004
    ..59, p = .08). The median age in the group of non-germ-cell sacrococcygeal masses was 3 years (range 5 months to 13 years)...
  89. ncbi request reprint Histomorphometric characterisation of shared and non-shared cotyledonary villus territories of monochorionic placentae in relation to pregnancy complications
    L Y Wee
    Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Campus, London, UK
    Placenta 27:475-82. 2006
    ....
  90. ncbi request reprint The diagnosis of gestational trophoblastic disease in early pregnancy: implications for screening, counseling and management
    N J Sebire
    Ultrasound Obstet Gynecol 25:421-4. 2005
  91. ncbi request reprint Partly molar pregnancies that are not partial moles: additional possibilities and implications
    N J Sebire
    Pediatr Dev Pathol 8:732-3. 2005
  92. ncbi request reprint Umbilical artery Doppler revisited: pathophysiology of changes in intrauterine growth restriction revealed
    N J Sebire
    Ultrasound Obstet Gynecol 21:419-22. 2003
  93. ncbi request reprint Complete hydatidiform mole and normal live birth: a novel case of confined placental mosaicism: case report
    G Makrydimas
    Department of Obstetrics and Gynaecology, Ioannina University Hospital, Ioannina, Greece
    Hum Reprod 17:2459-63. 2002
    ....
  94. ncbi request reprint Fetal loss following ultrasound diagnosis of a live fetus at 6-10 weeks of gestation
    G Makrydimas
    Department of Obstetrics and Gynaecology, Ioannina University Hospital, Ioannina, Greece
    Ultrasound Obstet Gynecol 22:368-72. 2003
    ..To examine prospectively the value of demographic characteristics and ultrasound findings in the prediction of subsequent fetal loss in pregnancies with live fetuses at 6-10 weeks of gestation...
  95. ncbi request reprint Placental villus morphology in relation to maternal hypoxia at high altitude
    J Espinoza
    Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London SE5 9RS, UK
    Placenta 22:606-8. 2001
    ..The predominant morphological alteration is an increase in villus capillary diameter and therefore of the proportion of villus cross-sectional area occupied by capillary lumens...
  96. ncbi request reprint Early trophoblast invasion and fetal loss in chromosomally abnormal conceptions
    N J Sebire
    Ultrasound Obstet Gynecol 19:529-30. 2002
  97. ncbi request reprint Peripartum cardiomyopathy and diandric triploidy
    N J Sebire
    Ultrasound Obstet Gynecol 24:104; author reply 104. 2004
  98. ncbi request reprint Fetal lung lesions: a new classification of fetal lung dysplasia
    N J Sebire
    Ultrasound Obstet Gynecol 24:590-1. 2004
  99. ncbi request reprint Fetal postmortem weight loss in utero
    N J Sebire
    BJOG 110:86-7. 2003
  100. ncbi request reprint Early onset discordant growth in a successful monochorionic twin pregnancy
    N J Sebire
    BJOG 109:1426. 2002
  101. ncbi request reprint Postmortem magnetic resonance imaging as an adjunct to the diagnosis of skeletal dysplasias: short-rib polydactyly syndrome
    A M Taylor
    Ultrasound Obstet Gynecol 27:585-6. 2006