Quantitative assessment of forward and backward second harmonic three dimensional images of collagen Type I matrix remodeling in a stimulated cellular environmentThomas Abraham
UBC James Hogg Research Centre, Institute for Heart Lung Health, Vancouver, Canada
J Struct Biol 180:17-25. 2012
....
Second harmonic generation analysis of early Achilles tendinosis in response to in vivo mechanical loadingThomas Abraham
James Hogg Research Centre St Paul s Hospital, Vancouver, Canada
BMC Musculoskelet Disord 12:26. 2011
....
- Minimally invasive imaging method based on second harmonic generation and multiphoton excitation fluorescence in translational respiratory research
Thomas Abraham
The James Hogg Research Centre, Heart and Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, Canada
Respirology 16:22-33. 2011
....
- Extracellular matrix remodeling of lung alveolar walls in three dimensional space identified using second harmonic generation and multiphoton excitation fluorescence
Thomas Abraham
The James Hogg Research Centre, Heart Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, Canada V6Z 1Y6
J Struct Biol 171:189-96. 2010
..We conclude that these non-invasive imaging modalities provide spatially resolved 3D images with spectral specificities that are sensitive enough to identity the ECM structural changes associated with emphysematous destruction...
- Deconvolution and chromatic aberration corrections in quantifying colocalization of a transcription factor in three-dimensional cellular space
Thomas Abraham
The James Hogg Research Centre, Heart Lung Institute at St Paul s Hospital University of British Columbia, Vancouver, Canada
Micron 41:633-40. 2010
..The reported imaging and processing methods can be a practical guide for quantitative fluorescence imaging of similar cellular systems and can provide a basis for further development...
- Minimally invasive multiphoton and harmonic generation imaging of extracellular matrix structures in lung airway and related diseases
Thomas Abraham
The James Hogg Research Centre, Heart Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, Canada
Pulm Pharmacol Ther 24:487-96. 2011
....
- Sodium cromolyn reduces expression of CTGF, ADAMTS1, and TIMP3 and modulates post-injury patellar tendon morphology
Aishwariya Sharma
Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, British Columbia, Canada
J Orthop Res 29:678-83. 2011
..This work corroborates previous findings pointing to a role of mast cells in tendon repair...
- Scleraxis expression is coordinately regulated in a murine model of patellar tendon injury
Alexander Scott
Biomedical Research Centre, Vancouver, Canada
J Orthop Res 29:289-96. 2011
..Patellar tendon injury was associated with marked increases in the expression of Scx, Tnmd, and Col1a1. Our data suggest new roles for Scleraxis in coordinating the response to injury in the pathogenesis of tendon disorders...
- Collagen matrix remodeling in 3-dimensional cellular space resolved using second harmonic generation and multiphoton excitation fluorescence
Thomas Abraham
The James Hogg iCAPTURE Centre, Heart Lung Institute at St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, Canada V6Z 1Y6
J Struct Biol 169:36-44. 2010
..Our data suggest second harmonic and multiphoton excitation fluorescence signals can be used in tandem to provide spatially resolved 3-dimensional structural remodeling of a collagen matrix during wound repair...
- Granzyme B contributes to extracellular matrix remodeling and skin aging in apolipoprotein E knockout mice
Paul R Hiebert
Institute for Heart Lung Health, St Paul s Hospital, 166 1081 Burrard Street, Vancouver, British Columbia, Canada
Exp Gerontol 46:489-99. 2011
..In summary, our results provide novel insights into the effects of a high fat diet and apoE deficiency on skin aging and pathology and suggest a role for GrB in age-related skin thinning and frailty...
- Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes
Gloria Fong
Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada
J Orthop Res 31:91-8. 2013
..This study indicates that SP, mediated via NK-1 R, increases collagen remodeling and leads to increased MMP3 mRNA and protein expression that is further enhanced by cyclic mechanical loading...
- Proteomic identification of dysferlin-interacting protein complexes in human vascular endothelium
Cleo Leung
UBC James Hogg Research Centre, Institute for Heart Lung Health, Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia, Canada
Biochem Biophys Res Commun 415:263-9. 2011
..Together, our data further support the claims that dysferlin not only mediates membrane repair but also trafficking of client proteins, ultimately, help bridging dysferlinopathies to aberrant membrane signaling...
- Inducible reprogramming of human T cells into Treg cells by a conditionally active form of FOXP3
Sarah E Allan
Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada
Eur J Immunol 38:3282-9. 2008
..These data represent the first formal evidence that FOXP3 acts as a quantitative regulator rather than a simple molecular switch for Treg...
