Andreas Scorilas

Summary

Publications

  1. ncbi Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene
    Andreas Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont M5G 1X5, Canada
    Gene 289:191-9. 2002
  2. ncbi Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker
    Andreas Scorilas
    Department of Biochemistry and Molecular Biology, University of Athens, Greece
    J Clin Oncol 22:678-85. 2004
  3. pmc Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer
    A Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Br J Cancer 85:190-8. 2001
  4. ncbi Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors
    Andreas Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, ON, Canada
    Gene 310:79-89. 2003
  5. ncbi Polyadenylate polymerase (PAP) and 3' end pre-mRNA processing: function, assays, and association with disease
    Andreas Scorilas
    National Center for Scientific Research Demokritos, IPC, Athens, Greece
    Crit Rev Clin Lab Sci 39:193-224. 2002
  6. ncbi Human kallikrein 8 protein is a favorable prognostic marker in ovarian cancer
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Clin Cancer Res 12:1487-93. 2006
  7. ncbi Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 106:605-10. 2003
  8. ncbi Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 21:1035-43. 2003
  9. doi Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer
    Constantina Petraki
    Departments of Pathology, Metropolitan Hospital, Athens, Greece
    Tumour Biol 33:1209-14. 2012
  10. ncbi Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 63:3958-65. 2003

Collaborators

Detail Information

Publications100

  1. ncbi Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin gene
    Andreas Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont M5G 1X5, Canada
    Gene 289:191-9. 2002
    ..It is also ubiquitously expressed in tissues and in ZR-75-1 breast cancer cells and LNCaP prostate carcinoma cells as a smaller variant generated by splicing out of an exon encoding 22 amino acids in the hinge region of the protein...
  2. ncbi Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker
    Andreas Scorilas
    Department of Biochemistry and Molecular Biology, University of Athens, Greece
    J Clin Oncol 22:678-85. 2004
    ..We hypothesized that hK13 may represent a potential biomarker for ovarian carcinomas...
  3. pmc Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer
    A Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Br J Cancer 85:190-8. 2001
    ..Furthermore, the mRNA of the SR-A1 gene in these cell lines appears to increase by estrogens, androgens and glucocorticoids, and to a lesser extend by progestins...
  4. ncbi Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors
    Andreas Scorilas
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, ON, Canada
    Gene 310:79-89. 2003
    ..The CEAL1 gene was found to be down-regulated by dexamethasone in BT-474 breast cancer cell lines. Our data suggest that this gene is overexpressed in a subset of ovarian cancers which are clinically more aggressive...
  5. ncbi Polyadenylate polymerase (PAP) and 3' end pre-mRNA processing: function, assays, and association with disease
    Andreas Scorilas
    National Center for Scientific Research Demokritos, IPC, Athens, Greece
    Crit Rev Clin Lab Sci 39:193-224. 2002
    ..This review summarizes the recently accumulated knowledge on PAP including its function, assays, and association with various human diseases, and proposes future avenues for research...
  6. ncbi Human kallikrein 8 protein is a favorable prognostic marker in ovarian cancer
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada
    Clin Cancer Res 12:1487-93. 2006
    ..001 and P = 0.014, respectively). These results indicate that hK8 is an independent marker of favorable prognosis in ovarian cancer...
  7. ncbi Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma
    Carla A Borgono
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Int J Cancer 106:605-10. 2003
    ..These results indicate that hK11 is a novel, independent marker of favorable prognosis in patients with ovarian cancer...
  8. ncbi Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 21:1035-43. 2003
    ..The discovery of new ovarian cancer biomarkers that are suitable for early disease diagnosis and prognosis may ultimately lead to improved patient management and outcomes...
  9. doi Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancer
    Constantina Petraki
    Departments of Pathology, Metropolitan Hospital, Athens, Greece
    Tumour Biol 33:1209-14. 2012
    ..057 and p = 0.001, respectively) and overall survival (p = 0.009 and p = 0.001, respectively). In conclusion, KLK10 immunostaining is an independent prognostic marker in patients with CRC...
  10. ncbi Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 63:3958-65. 2003
    ..Our preliminary data indicate that hK5 is a potential biomarker in patients with ovarian and breast cancer...
  11. ncbi Prognostic value of the human kallikrein gene 15 expression in ovarian cancer
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    J Clin Oncol 21:3119-26. 2003
    ..KLK15 is upregulated mainly by androgens and to a lesser extent by progestins. The purpose of this study was to examine the prognostic value of KLK15 in ovarian cancer tissues...
  12. ncbi Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Tumour Biol 24:299-309. 2003
    ..297; p < 0.001). Our findings provide evidence for an association between hK5 and more aggressive forms of epithelial ovarian cancer...
  13. ncbi Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
    Prostate 56:287-92. 2003
    ..Since KLK14 was found to be regulated by steroid hormones in prostate cancer cell lines, we hypothesized that it will be differentially expressed in prostate cancer tissues compared to their normal counterparts...
  14. ncbi Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer
    Maroulio Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savas Hospital, Athens, Greece
    Thromb Haemost 101:741-7. 2009
    ..Present data suggest that KLK7 gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients...
  15. ncbi Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer
    George M Yousef
    Dept of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
    Am J Clin Pathol 119:346-55. 2003
    ..43 and 0.53; P = .027 and .014). A weak negative correlation was found between KLK14 expression and serum CA-125. KLK14 is a new, independent, and favorable prognostic marker for ovarian cancer...
  16. ncbi Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer
    Lianna G Kyriakopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5G 1X5 Canada
    Clin Biochem 36:135-43. 2003
    ..Recent evidence has indicated that expression of KLK7 appears to be increased in ovarian cancer. We hypothesized that overexpression of the KLK7 gene in ovarian cancer may serve as a prognostic marker of the disease...
  17. ncbi p27(kip1) and Ki-67 (MIB1) immunohistochemical expression in radical prostatectomy specimens of patients with clinically localized prostate cancer
    Kyriakos Revelos
    Department of Pathology, Evangelismos General Hospital, Athens, Greece
    In Vivo 19:911-20. 2005
    ....
  18. ncbi The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Breast Cancer Res Treat 78:149-58. 2003
    ..Like other kallikreins, the KLK9 gene was found to be regulated by steroid hormones, mainly estrogens and progestins, in cancer cell lines...
  19. doi Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Ann N Y Acad Sci 1171:276-83. 2009
    ....
  20. ncbi Alterations in mRNA expression of apoptosis-related genes BCL2, BAX, FAS, caspase-3, and the novel member BCL2L12 after treatment of human leukemic cell line HL60 with the antineoplastic agent etoposide
    Kostas V Floros
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, and G Papanicolaou Research Center for Oncology, Saint Sava s Hospital, Athens, Greece
    Ann N Y Acad Sci 1090:89-97. 2006
    ..Since, the main anticarcinogenic effect of etoposide is due to the induction of apoptosis, these changes observed in the mRNA expression levels of the genes may be an underlying mechanism...
  21. doi Quantification and study of the L-DOPA decarboxylase expression in gastric adenocarcinoma cells treated with chemotherapeutic substances
    Dimitrios Korbakis
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis 15701, Athens, Greece
    Anticancer Drugs 24:291-9. 2013
    ..Our experimental data show that the DDC gene might serve as a new potential molecular biomarker predicting treatment response in gastric cancer cells...
  22. doi Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer
    Constantina Petraki
    Department of Pathology, Metropolitan Hospital, Athens, Greece
    Pathol Res Pract 208:104-8. 2012
    ..041). Kaplan-Meier survival curves showed that KLK6-positive patients have statistically significant lower disease-free and overall survival. In conclusion, KLK6 immunostaining is an independent prognostic marker in patients with CRC...
  23. ncbi Differential expression of Kallikrein gene 5 in cancerous and normal testicular tissues
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Urology 60:714-8. 2002
    ..Previous investigations have established that the expression of KLK5 is estrogen and progestin driven in the BT-474 breast cancer cell line. In this study, we focused on KLK5 expression in normal and cancerous testicular tissue...
  24. doi Expression analysis and clinical evaluation of kallikrein-related peptidase 10 (KLK10) in colorectal cancer
    Maroulio Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Cancer Hospital, 171, Alexandras Avenue, Athens, 11522, Greece
    Tumour Biol 32:737-44. 2011
    ..As the epigenetics of cancer are unraveled, KLK10 may represent not only a novel biomarker, but also a promising future therapeutic target for the disease...
  25. ncbi Expression analysis and prognostic significance of the SRA1 gene, in ovarian cancer
    Theoni Leoutsakou
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, 15711 Panepistimioupoli, Athens, Greece
    Biochem Biophys Res Commun 344:667-74. 2006
    ..Our results suggest that SRA1 is associated with cancer progression and may possibly be characterized as a new marker of unfavorable prognosis for ovarian cancer...
  26. ncbi Effect of bleomycin and cisplatin on the expression profile of SRA1, a novel member of pre-mRNA splicing factors, in HL-60 human promyelocytic leukemia cells
    Maria E Katsarou
    National Center for Scientific Research Demokritos, IPC, GR 15310 Athens, Greece
    Biol Chem 388:773-8. 2007
    ..Our results support the hypothesis that mRNA expression analysis of SRA1 may serve as a new prospective molecular marker, playing an important role in chemotherapy outcome in human leukemia...
  27. ncbi Kallikreins as markers of disseminated tumour cells in ovarian cancer-- a pilot study
    Katerina Oikonomopoulou
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
    Tumour Biol 27:104-14. 2006
    ..We hypothesized that KLK6 and KLK10 can be utilized to monitor dissemination of ovarian cancer cells in blood and ascites fluid of ovarian cancer patients...
  28. doi Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility
    Nashmil Emami
    Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
    Biol Chem 390:921-9. 2009
    ..In conclusion, the expression level of several seminal plasma KLKs correlates with liquefaction and viscosity indicators of semen quality and may aid in their differential diagnosis and etiology...
  29. doi Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
    Clin Biochem 45:1362-7. 2012
    ..It is a novel member of the BCL2 gene family, members of which are implicated in different hematological malignancies. In the present study, we investigated and studied the expression profile of BCL2L12 in acute myeloid leukemia (AML)...
  30. doi Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis
    William Dubinski
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada, M5S 1A8
    Hum Pathol 43:1037-43. 2012
    ..Our automated approach overcomes many limitations of manual quantification. Advances in digital assessment of immunohistochemical markers can be helpful in standardizing the evaluation of tumor biomarkers...
  31. ncbi The usefulness of serum human kallikrein 11 for discriminating between prostate cancer and benign prostatic hyperplasia
    Terukazu Nakamura
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Cancer Res 63:6543-6. 2003
    ..69). These preliminary data suggest that the hK11:total PSA ratio could be a useful tumor marker for CaP and could be combined with percentage of PSA to further reduce the number of unnecessary prostatic biopsies...
  32. ncbi Parallel overexpression of seven kallikrein genes in ovarian cancer
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 63:2223-7. 2003
    ....
  33. ncbi Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
    Clin Biochem 37:823-9. 2004
    ..Our preliminary studies indicate that hK11 may represent a diagnostic and prognostic biomarker for ovarian cancer. The aim of the present study was to examine the prognostic value of hK11 expression in ovarian tumors...
  34. ncbi Correlation of androgen receptor status, neuroendocrine differentiation and angiogenesis with time-to-biochemical failure after radical prostatectomy in clinically localized prostate cancer
    Kyriakos Revelos
    Department of Pathology, Evangelismos Hospital, Athens, Greece
    Anticancer Res 27:3651-60. 2007
    ..Patients and..
  35. ncbi Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols
    Shannon J C Shan
    Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
    Clin Chem 52:1879-86. 2006
    ..The aim of this study was to determine whether hK7, measured quantitatively by ELISA in ovarian cancer cytosols, is a prognostic biomarker for ovarian cancer...
  36. ncbi mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin
    Kostas V Floros
    National Center for Scientific Research Demokritos, GR 15310 Athens, Greece
    Biol Chem 385:1099-103. 2004
    ..In the case of carboplatin-induced apoptosis we detected down-regulation of BAX , BCL2 and caspase-9, whereas in the case of doxorubicin, BAX and BCL2 remained at control levels and caspase-9 was increased...
  37. ncbi Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues
    Terukazu Nakamura
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
    Urology 61:1042-6. 2003
    ..4. Hippostasin has two alternative splicing isoforms, known as the brain type and prostate type. We have previously reported that the prostate-type isoform is not expressed in human prostate cancer cell lines...
  38. doi Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker
    Dimitrios Korbakis
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
    Clin Chem 55:904-13. 2009
    ..We performed an expression analysis and clinical evaluation of the KLK5 gene, at the mRNA level, in prostate needle biopsies...
  39. pmc Effect of doxorubicin, oxaliplatin, and methotrexate administration on the transcriptional activity of BCL-2 family gene members in stomach cancer cells
    Dimitra Florou
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
    Cancer Biol Ther 14:587-96. 2013
    ....
  40. ncbi Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry
    Christina V Obiezu
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5 Canada
    Clin Chem 48:1232-40. 2002
    ..Because the protein has not been detected in any human tissue, we attempted to develop immunologic methods for hK4 analysis and use them to detect hK4 in healthy and cancerous tissue extracts and biological fluids...
  41. ncbi Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells
    Kostas V Floros
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR 15701, Athens, Greece
    Biol Chem 387:1629-33. 2006
    ..Our results support the significance of mRNA modulations in the expression of apoptosis-related genes during treatment of human leukemic cells with anticancer drugs...
  42. doi L-dopa decarboxylase (DDC) gene expression is related to outcome in patients with prostate cancer
    Georgios Koutalellis
    1st Department of Urology, Laiko General Hospital, University of Athens, School of Medicine, Athens, Greece
    BJU Int 110:E267-73. 2012
    ..Moreover, DDC expression was shown to be an unfavourable prognostic marker of biochemical recurrence and disease-free survival in patients with PCa treated by radical prostatectomy...
  43. doi Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer
    Margaritis Avgeris
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
    Clin Biochem 41:1140-9. 2008
    ..The aim of this study was to investigate the mRNA expression levels of DDC in prostate tissues and to evaluate its clinical utility in prostate cancer (CaP)...
  44. ncbi Effect of testosterone administration on serum and urine kallikrein concentrations in female-to-male transsexuals
    Margrita H Slagter
    Department of Endocrinology, Vrije Universiteit University Medical Centre, Amsterdam, The Netherlands, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Clin Chem 52:1546-51. 2006
    ..To gain insight into in vivo kallikrein regulation we measured kallikrein concentrations in serum and urinary tissue in female-to-male transsexuals before and after testosterone administration...
  45. pmc The immunohistochemical expression of growth hormone-releasing hormone receptor splice variant 1 is a favorable prognostic marker in colorectal cancer
    Elena Theophanous
    Department of Pathology, Evangelismos Hospital, Athens, Greece
    Mol Med 15:242-7. 2009
    ..The immunohistochemical expression of SV-1 seems to be a favorable prognostic factor in CRC...
  46. doi Expression analysis and study of the KLK15 mRNA splice variants in prostate cancer and benign prostatic hyperplasia
    Konstantinos Mavridis
    Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
    Cancer Sci 101:693-9. 2010
    ..017). These results suggest that KLK15 expression analysis could be employed as a valuable tool for the discrimination between BPH and CaP tissue specimens and as an unfavorable prognostic marker for prostate cancer...
  47. ncbi Human kallikrein 8, a novel biomarker for ovarian carcinoma
    Tadaaki Kishi
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
    Cancer Res 63:2771-4. 2003
    ..These data suggest that hK8 protein is detectable in ovarian cancer tissue extracts, serum, and ascites fluid, indicating that it may serve as a new ovarian cancer marker...
  48. doi Quantified KLK15 gene expression levels discriminate prostate cancer from benign tumors and constitute a novel independent predictor of disease progression
    Konstantinos Mavridis
    Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
    Prostate 73:1191-201. 2013
    ..Our aim in this present study was the specific quantitative expression analysis of the classical KLK15 mRNA transcript in prostate tumors and the examination of its clinical significance in prostate cancer...
  49. ncbi Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia
    Eleftherios P Diamandis
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
    Clin Biochem 37:230-7. 2004
    ..Some of these enzymes can be measured in cerebrospinal fluid (CSF) by using ELISA-type methodologies...
  50. ncbi Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, and Department of Biochemistry and Molecular Biology, Papanikolaou Cancer Research Centre, St Savas Hospital, Athens, Greece
    Biol Chem 387:1081-6. 2006
    ..Our results support the idea that after long-term clinical studies, mRNA expression analysis of BCL2L12 and other members of the BCL2 gene family may serve as useful molecular markers predicting chemotherapy response in breast cancer...
  51. doi Treatment of gastric cancer cells with 5-fluorouracil/leucovorin and irinotecan induces distinct alterations in the mRNA expression of the apoptosis-related genes, including the novel gene BCL2L12
    Dimitrios Korbakis
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Tumour Biol 30:100-7. 2009
    ..Our experimental data demonstrate that the molecular profile mainly of BCL2 and BCL2L12 genes may serve as a new potential molecular biomarker predicting treatment response in gastric cancer cells...
  52. doi Significant alterations in the expression pattern of kallikrein-related peptidase genes KLK4, KLK5 and KLK14 after treatment of breast cancer cells with the chemotherapeutic agents epirubicin, docetaxel and methotrexate
    Georgia Papachristopoulou
    Department of Biochemistry and Molecular Biology, University of Athens, 15701, Panepistimiopolis, Athens, Greece
    Tumour Biol 34:369-78. 2013
    ....
  53. doi The clinical utility of miR-21 as a diagnostic and prognostic marker for renal cell carcinoma
    Hala Faragalla
    Department of Laboratory Medicine, and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
    J Mol Diagn 14:385-92. 2012
    ..Moreover, it has potential as a prognostic marker in RCC, although it is not independent of tumor stage and grade...
  54. doi Total and free PSA kinetics in patients without prostate cancer undergoing radical cystoprostatectomy
    Alkibiades K Gregorakis
    Department of Urology, Attikon General Hospital, University of Athens, Athens, Greece
    Prostate 68:759-65. 2008
    ..Radical cystoprostatectomy is usually performed in patients with invasive bladder cancer. The aim of the study was to examine Total PSA, Free PSA, and Free/Total Ratio elimination kinetics after radical cystoprostatectomy...
  55. doi Molecular profile of the BCL2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Connect Tissue Res 49:261-4. 2008
    ..In the present review, we describe current knowledge of the molecular profile of the classical and novel members of the BCL2 family of genes as a response of breast cancer cells to cytotoxic/cytostatic drugs...
  56. doi Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues
    Georgia Papachristopoulou
    Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Thromb Haemost 105:131-7. 2011
    ..024). In accordance with logistic regression models (p=0.012) and receiver-operating-characteristics analysis (p<0.001), KLK14 gene expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies...
  57. doi The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma
    Tsz fung F Chow
    Department of Laboratory Medicine and Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada
    J Urol 183:743-51. 2010
    ..We also elucidated the role of miRNA in clear cell renal cell carcinoma pathogenesis with bioinformatics...
  58. ncbi The effect of the polyadenylation inhibitor cordycepin on human Molt-4 and Daudi leukaemia and lymphoma cell lines
    Hellinida Thomadaki
    Institute of Biology, NCSR Demokritos, Aghia Paraskevi Attikis, 15310, Athens, Greece
    Cancer Chemother Pharmacol 61:703-11. 2008
    ....
  59. ncbi Human tissue kallikreins: from gene structure to function and clinical applications
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Adv Clin Chem 39:11-79. 2005
  60. ncbi Kallikrein-related peptidase-6 (KLK6) mRNA expression is an independent prognostic tissue biomarker of poor disease-free and overall survival in colorectal adenocarcinoma
    Spyridon Christodoulou
    Fourth Surgery Department, University General Hospital Attikon, Haidari, Athens, 12462, Greece
    Tumour Biol 35:4673-85. 2014
    ..Thus, KLK6 mRNA expression could be considered as an independent, unfavorable molecular prognostic biomarker in colorectal adenocarcinoma, with additional prognostic value in patients without regional or distant metastases. ..
  61. ncbi Human kallikrein gene 5 (KLK5) expression by quantitative PCR: an independent indicator of poor prognosis in breast cancer
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5 Canada
    Clin Chem 48:1241-50. 2002
    ..Like the genes that encode PSA and other kallikreins, the KLK5 gene was found to be regulated by steroid hormones in the BT-474 breast cancer cell line...
  62. doi Quantitative expression analysis of the apoptosis-related gene, BCL2L12, in head and neck squamous cell carcinoma
    Panagiota Aikaterini Geomela
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
    J Oral Pathol Med 42:154-61. 2013
    ..The aim of this study was to analyze the mRNA expression of the novel apoptosis-related gene BCL2L12 in patients with HNSCC...
  63. doi Kallikrein-related peptidase 6 (KLK6)gene expression in intracranial tumors
    Maroulio Talieri
    Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Cancer Hospital, 171, Alexandras Avenue, Athens, 11522, Greece
    Tumour Biol 33:1375-83. 2012
    ..032). KLK6 gene expression may have clinical utility as a marker of unfavorable prognosis for intracranial tumors, and consequently, it could be used as target for therapeutic intervention...
  64. doi Molecular cloning of novel alternatively spliced variants of BCL2L12, a new member of the BCL2 gene family, and their expression analysis in cancer cells
    Christos K Kontos
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
    Gene 505:153-66. 2012
    ..The remaining three novel splice variants of BCL2L12 are nonsense-mediated mRNA decay (NMD) candidates...
  65. doi Kallikrein-related peptidase 4 gene (KLK4) in prostate tumors: quantitative expression analysis and evaluation of its clinical significance
    Margaritis Avgeris
    Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens, Greece
    Prostate 71:1780-9. 2011
    ..The aim of this study is to investigate the expression status of KLK4 in PCa patients in order to reveal its utility in PCa establishment and clinical management...
  66. ncbi The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis
    Liu Ying Luo
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
    Cancer Res 63:807-11. 2003
    ..Serum hK10 represents a novel biomarker for ovarian cancer. We conclude that preoperative serum hK10 concentration is a strong and independent unfavorable prognostic marker for ovarian cancer...
  67. doi Kallikrein-related peptidase 4 (KLK4) mRNA predicts short-term relapse in colorectal adenocarcinoma patients
    Christos K Kontos
    Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
    Cancer Lett 330:106-12. 2013
    ..In conclusion, KLK4 mRNA expression can be regarded as a novel potential tissue biomarker in colorectal adenocarcinoma...
  68. doi Downregulation and prognostic performance of microRNA 224 expression in prostate cancer
    Konstantinos Mavridis
    Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
    Clin Chem 59:261-9. 2013
    ..The aim of this study was to analyze the expression pattern of miR-224, a cancer-related miRNA, in prostate tumors and investigate its clinical utility...
  69. doi The chromatin remodeling gene ARID1A is a new prognostic marker in clear cell renal cell carcinoma
    Zsuzsanna Lichner
    Department of Laboratory Medicine and Keenan Research Centre, Li Ka Shing Knowledge Institute of St Michael s Hospital, Toronto, Ontario M5B 1WB, Canada
    Am J Pathol 182:1163-70. 2013
    ..BAF250a IHC is easy to perform and represents a potential biomarker that could be incorporated in laboratory practice to enhance the accuracy of the existing prognostic models...
  70. ncbi Immunohistochemical expression of Bcl2 is an independent predictor of time-to-biochemical failure in patients with clinically localized prostate cancer following radical prostatectomy
    Kyriakos Revelos
    Department of Pathology, Evangelismos General Hospital, Athens, Greece
    Anticancer Res 25:3123-33. 2005
    ....
  71. ncbi Erlotinib monotherapy in patients with advanced non-small cell lung cancer: an effective approach with low toxicity
    Alexandros Ardavanis
    First Department of Medical Oncology, St Savvas Anticancer Hospital, Athens, Greece
    Anticancer Res 28:2409-15. 2008
    ..This retrospective study was conducted to assess the efficacy of erlotinib and its impact on survival...
  72. ncbi Serum human glandular kallikrein (hK2) and insulin-like growth factor 1 (IGF-1) improve the discrimination between prostate cancer and benign prostatic hyperplasia in combination with total and %free PSA
    Andreas Scorilas
    National Center for Scientific Research Demokritos, IPC, Athens, Greece
    Prostate 54:220-9. 2003
    ....
  73. ncbi Free/Total PSA (F/T ratio) kinetics in patients with clinically localized prostate cancer undergoing radical prostatectomy
    Alkiviades K Gregorakis
    Urology Department, Attikon General Hospital, University of Athens, Athens, Greece
    Clin Chim Acta 357:196-201. 2005
    ..In this paper we study the Free/Total PSA kinetics in patients with clinically localized prostate cancer undergoing radical prostatectomy...
  74. doi Differential protein expressions in renal cell carcinoma: new biomarker discovery by mass spectrometry
    K W Michael Siu
    Department of Chemistry and Centre for Research in Mass Spectrometry, York University, Toronto, Canada
    J Proteome Res 8:3797-807. 2009
    ..We performed an in silico validation of our results using different tools and databases including Serial Analysis of Gene Expression (SAGE), UniGene EST ProfileViewer, Cancer Genome Anatomy Project, and Gene Ontology consortium analysis...
  75. ncbi Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12
    Kostas V Floros
    National Center for Scientific Research Demokritos, Athens 15310, Greece
    Ann N Y Acad Sci 1010:153-8. 2003
    ..It is known that the main anti-carcinogenic effect of cisplatin is due to the induction of cell apoptosis. Present results indicate that downregulation of the BCL2 and upregulation of the BCL2L12 gene may be the underlying mechanisms...
  76. doi Prognostic value and biological role of the kallikrein-related peptidases in human malignancies
    Konstantinos Mavridis
    Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
    Future Oncol 6:269-85. 2010
    ..It is believed that KLKs might be employed in future clinical practice as novel and effective tumor markers...
  77. ncbi Effects of long-term androgen administration on breast tissue of female-to-male transsexuals
    Margrita H Slagter
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada
    J Histochem Cytochem 54:905-10. 2006
    ..These changes are similar to those observed at the end-stage of menopausal mammary involution...
  78. ncbi Safety and efficacy of trastuzumab every 3 weeks combined with cytotoxic chemotherapy in patients with HER2-positive recurrent breast cancer: findings from a case series
    Alexandros Ardavanis
    First Department of Medical Oncology, St Savas Anticancer Hospital, Athens, Greece
    Onkologie 28:558-64. 2005
    ..Trastuzumab is currently licensed as a weekly treatment, although a 3-weekly schedule could be used conveniently in combination with other cytotoxic agents that are administered on a 3-weekly basis in metastatic breast cancer...
  79. ncbi Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients
    Andreas Scorilas
    NCSR Demokritos IPC, Athens, Greece
    Biol Chem 383:1297-303. 2002
    ..Accordingly, cathepsin B can be regarded as unfavorable and as an independent tumor marker for progression-free survival and overall survival in ovarian cancer patients with long follow-up...
  80. doi Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma
    Amanda Psyrri
    Second Department of Internal Medicine, Propaedeutic, University of Athens, University General Hospital Attikon, Haidari, Athens, Greece
    Clin Cancer Res 15:5724-32. 2009
    ..Activation of phosphatidylinositol 3'-kinase pathway is implicated in the pathogenesis of mantle cell lymphoma (MCL). The genetic change in phosphatidylinositol 3'-kinase catalytic subunit alpha (PIK3CA) in MCL has not been identified...
  81. doi Comparative study of balloon and metal olive dilators for endoscopic management of benign anastomotic rectal strictures: clinical and cost-effectiveness outcomes
    Dimitrios Xinopoulos
    Department of Gastroenterology, Saint Savvas Hospital, Athens, Greece
    Surg Endosc 25:756-63. 2011
    ....
  82. ncbi Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients
    Maryam Zarghooni
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
    Clin Biochem 35:225-31. 2002
    ..Our objective was to develop a highly sensitive immunoassay for hK6 and use it to examine the levels of hK6 in brain tissue extracts from Alzheimer's disease patients and control subjects...
  83. ncbi Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues
    George M Yousef
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
    Prostate 51:126-32. 2002
    ..4. Like KLK2 and KLK3, the KLK5 gene is regulated by steroid hormones in the BT-474 breast cancer cell line. We have previously shown that KLK5 is differentially expressed in ovarian and breast cancer...
  84. ncbi B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression
    Iris Simon
    diaDexus, Inc, 343 Oyster Point Blvd, South San Francisco, CA, USA
    Gynecol Oncol 106:334-41. 2007
    ..This study characterizes the expression of the novel biomarker B7-H4 in ovarian cancer tissue, normal ovaries, and benign ovarian tumors, and evaluates its relationship to CA125...
  85. ncbi Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece
    Ann N Y Acad Sci 1095:35-44. 2007
    ....
  86. ncbi A multiparametric panel for ovarian cancer diagnosis, prognosis, and response to chemotherapy
    Yingye Zheng
    The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Clin Cancer Res 13:6984-92. 2007
    ....
  87. ncbi Primary tumor levels of human tissue kallikreins affect surgical success and survival in ovarian cancer patients
    Julia Dorn
    Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
    Clin Cancer Res 13:1742-8. 2007
    ....
  88. ncbi Prognostic significance of the expression of SR-A1, encoding a novel SR-related CTD-associated factor, in breast cancer
    Theoni Leoutsakou
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR 15711 Athens, Greece
    Biol Chem 387:1613-8. 2006
    ..Our results suggest that SR-A1 may possibly be characterized as a new marker of unfavorable prognosis for breast cancer...
  89. ncbi Structure and biological properties of the copper(II) complex with the quinolone antibacterial drug N-propyl-norfloxacin and 2,2'-bipyridine
    Eleni K Efthimiadou
    Institute of Physical Chemistry, NCSR Demokritos, GR 15310 Aghia Paraskevi Attikis, Greece
    J Inorg Biochem 101:64-73. 2007
    ..Complex 1 shows an increased antiproliferative and necrotic effect on both HL-60 and K562 human leukemia cells in comparison to the free pr-norfloxacin...
  90. doi Trastuzumab plus paclitaxel or docetaxel in HER-2-negative/HER-2 ECD-positive anthracycline- and taxane-refractory advanced breast cancer
    Alexandros Ardavanis
    First Department of Medical Oncology, Saint Savas Oncology Hospital, 171 Alexandras Avenue, 115 22 Athens, Hellas
    Oncologist 13:361-9. 2008
    ....
  91. ncbi Multidisciplinary therapy of locally far-advanced or inflammatory breast cancer with fixed perioperative sequence of epirubicin, vinorelbine, and Fluorouracil chemotherapy, surgery, and radiotherapy: long-term results
    Alexandros Ardavanis
    First Department of Medical Oncology, St Savas Anticancer Hospital, 171 Alexandras Avenue, 115 22 Athens, Greece
    Oncologist 11:563-73. 2006
    ..Based on phase II data in advanced breast cancer (BC), the fluorouracil, epirubicin, and vinorelbine (FEN) combination was assessed as perioperative chemotherapy, integrated in a multidisciplinary treatment for locally advanced BC...
  92. ncbi SR-A1, a member of the human pre-mRNA splicing factor family, and its expression in colon cancer progression
    Konstantina Mathioudaki
    G Papanicolaou Research Center of Oncology, Saint Savas Hospital, GR 11522 Athens, Greece
    Biol Chem 385:785-90. 2004
    ..To the best of our knowledge, this is the first study examining the expression of the novel gene SR-A1 in colon cancer progression...
  93. ncbi Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer
    Konstantina Mathioudaki
    G Papanicolaou Research Center of Oncology, Saint Savas Hospital, GR 11522 Athens, Greece
    Biol Chem 385:779-83. 2004
    ..The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression...
  94. ncbi Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, GR 15701 Athens, Greece
    Biol Chem 386:471-80. 2005
    ..Our results suggest, for the first time, that in the epithelial cancer cell lines used, PAP modulations follow cell cycle progression rather than the course of apoptosis...
  95. ncbi Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma
    Maroulio Talieri
    G Papanicolaou Research Center of Oncology, Saint Savas Hospital, Athens Greece
    Thromb Haemost 91:180-6. 2004
    ..These data suggest that KLK7 gene expression may be used as a marker of unfavorable prognosis for breast cancer patients...
  96. ncbi Hepsin is highly over expressed in and a new candidate for a prognostic indicator in prostate cancer
    Carsten Stephan
    Department of Urology, University Hospital Charite, Humboldt University, Berlin, Germany
    J Urol 171:187-91. 2004
    ..We quantitatively analyzed hepsin gene expression with real-time polymerase chain reaction and calculated its relationships with clinicopathological parameters in a large cohort of samples...
  97. ncbi Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors
    Maroulio Talieri
    G Papanicolaou Research Center of Oncology, Saint Savas Hospital Athens, Greece
    Thromb Haemost 89:1081-8. 2003
    ..002 and p<0.001 respectively). BCL2L12 expression may be regarded as a new independent favorable prognostic marker for breast cancer...
  98. ncbi Prognostic value of the apoptosis related genes BCL2 and BCL2L12 in breast cancer
    Hellinida Thomadaki
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Greece 15711 Athens, Greece
    Cancer Lett 247:48-55. 2007
    ..Multivariate analysis revealed that BCL2 and BCL2L12 might be used as independent prognostic biomarkers in breast cancer...
  99. ncbi The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner
    Hellinida Thomadaki
    Institute of Biology, NCSR Demokritos, Aghia Paraskevi Attikis, 15310 Athens, Greece
    Cancer Chemother Pharmacol 61:251-65. 2008
    ..In the present study we assessed the implication and role of cordycepin, a polyadenylation-specific inhibitor and a well-known chemotherapeutic drug, in apoptosis, induced by the anticancer drug etoposide...
  100. ncbi Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer
    Panagiota Stavropoulou
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, 157 01 Athens, Greece
    Clin Chim Acta 357:190-5. 2005
    ..KLK11 has two alternative splicing isoforms, known as the brain type and prostate type. Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers...