Cloning, physical mapping and structural characterization of the human alpha(A)-adaptin geneAndreas Scorilas
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ont M5G 1X5, Canada
Gene 289:191-9. 2002
..It is also ubiquitously expressed in tissues and in ZR-75-1 breast cancer cells and LNCaP prostate carcinoma cells as a smaller variant generated by splicing out of an exon encoding 22 amino acids in the hinge region of the protein...
- Human kallikrein 13 protein in ovarian cancer cytosols: a new favorable prognostic marker
Andreas Scorilas
Department of Biochemistry and Molecular Biology, University of Athens, Greece
J Clin Oncol 22:678-85. 2004
..007 and P =.002, respectively). CONCLUSION: These results indicate that hK13 is an independent marker of favorable prognosis in ovarian cancer...
- Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors
Andreas Scorilas
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, M5G 1X5, Toronto, ON, Canada
Gene 310:79-89. 2003
..The CEAL1 gene was found to be down-regulated by dexamethasone in BT-474 breast cancer cell lines. Our data suggest that this gene is overexpressed in a subset of ovarian cancers which are clinically more aggressive...
- Polyadenylate polymerase (PAP) and 3' end pre-mRNA processing: function, assays, and association with disease
Andreas Scorilas
National Center for Scientific Research Demokritos, IPC, Athens, Greece
Crit Rev Clin Lab Sci 39:193-224. 2002
..This review summarizes the recently accumulated knowledge on PAP including its function, assays, and association with various human diseases, and proposes future avenues for research...
- Human kallikrein 8 protein is a favorable prognostic marker in ovarian cancer
Carla A Borgono
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, University of Toronto, Ontario, Canada
Clin Cancer Res 12:1487-93. 2006
..001 and P = 0.014, respectively). These results indicate that hK8 is an independent marker of favorable prognosis in ovarian cancer...
- Human kallikrein 5: a potential novel serum biomarker for breast and ovarian cancer
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
Cancer Res 63:3958-65. 2003
..Our preliminary data indicate that hK5 is a potential biomarker in patients with ovarian and breast cancer...
Evaluation and prognostic significance of human tissue kallikrein-related peptidase 10 (KLK10) in colorectal cancerConstantina Petraki
Departments of Pathology, Metropolitan Hospital, Athens, Greece
Tumour Biol 33:1209-14. 2012
..057 and p = 0.001, respectively) and overall survival (p = 0.009 and p = 0.001, respectively). In conclusion, KLK10 immunostaining is an independent prognostic marker in patients with CRC...
- Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinoma
Carla A Borgono
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
Int J Cancer 106:605-10. 2003
..These results indicate that hK11 is a novel, independent marker of favorable prognosis in patients with ovarian cancer...
- Human kallikrein 6 (hK6): a new potential serum biomarker for diagnosis and prognosis of ovarian carcinoma
Eleftherios P Diamandis
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
J Clin Oncol 21:1035-43. 2003
..The discovery of new ovarian cancer biomarkers that are suitable for early disease diagnosis and prognosis may ultimately lead to improved patient management and outcomes...
- Immunofluorometric quantification of human kallikrein 5 expression in ovarian cancer cytosols and its association with unfavorable patient prognosis
Eleftherios P Diamandis
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
Tumour Biol 24:299-309. 2003
..297; p < 0.001). Our findings provide evidence for an association between hK5 and more aggressive forms of epithelial ovarian cancer...
- Differential expression of the human kallikrein gene 14 (KLK14) in normal and cancerous prostatic tissues
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Canada
Prostate 56:287-92. 2003
..Since KLK14 was found to be regulated by steroid hormones in prostate cancer cell lines, we hypothesized that it will be differentially expressed in prostate cancer tissues compared to their normal counterparts...
- Clinical significance of kallikrein-related peptidase 7 (KLK7) in colorectal cancer
Maroulio Talieri
Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savas Hospital, Athens, Greece
Thromb Haemost 101:741-7. 2009
..Present data suggest that KLK7 gene is up-regulated in colon cancer and its expression predicts poor prognosis for colon cancer patients...
- Steroid hormone regulation and prognostic value of the human kallikrein gene 14 in ovarian cancer
George M Yousef
Dept of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, Canada M5G 1X5
Am J Clin Pathol 119:346-55. 2003
..43 and 0.53; P = .027 and .014). A weak negative correlation was found between KLK14 expression and serum CA-125. KLK14 is a new, independent, and favorable prognostic marker for ovarian cancer...
- Prognostic value of the human kallikrein gene 15 expression in ovarian cancer
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
J Clin Oncol 21:3119-26. 2003
..KLK15 is upregulated mainly by androgens and to a lesser extent by progestins. The purpose of this study was to examine the prognostic value of KLK15 in ovarian cancer tissues...
- The prognostic value of the human kallikrein gene 9 (KLK9) in breast cancer
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
Breast Cancer Res Treat 78:149-58. 2003
..Similar results were obtained for overall survival. CONCLUSIONS: KLK9 is a new potential independent marker of favorable prognosis in breast cancer...
- Evaluation and prognostic significance of human tissue kallikrein-related peptidase 6 (KLK6) in colorectal cancer
Constantina Petraki
Department of Pathology, Metropolitan Hospital, Athens, Greece
Pathol Res Pract 208:104-8. 2012
..041). Kaplan-Meier survival curves showed that KLK6-positive patients have statistically significant lower disease-free and overall survival. In conclusion, KLK6 immunostaining is an independent prognostic marker in patients with CRC...
- Expression analysis and clinical evaluation of kallikrein-related peptidase 10 (KLK10) in colorectal cancer
Maroulio Talieri
Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Cancer Hospital, 171, Alexandras Avenue, Athens, 11522, Greece
Tumour Biol 32:737-44. 2011
..As the epigenetics of cancer are unraveled, KLK10 may represent not only a novel biomarker, but also a promising future therapeutic target for the disease...
- p27(kip1) and Ki-67 (MIB1) immunohistochemical expression in radical prostatectomy specimens of patients with clinically localized prostate cancer
Kyriakos Revelos
Department of Pathology, Evangelismos General Hospital, Athens, Greece
In Vivo 19:911-20. 2005
....
- Differential expression of Kallikrein gene 5 in cancerous and normal testicular tissues
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
Urology 60:714-8. 2002
..Previous investigations have established that the expression of KLK5 is estrogen and progestin driven in the BT-474 breast cancer cell line. In this study, we focused on KLK5 expression in normal and cancerous testicular tissue...
- Association between kallikrein-related peptidases (KLKs) and macroscopic indicators of semen analysis: their relation to sperm motility
Nashmil Emami
Department of Laboratory Medicine and Pathobiology, University of Toronto, ON, Canada
Biol Chem 390:921-9. 2009
..In conclusion, the expression level of several seminal plasma KLKs correlates with liquefaction and viscosity indicators of semen quality and may aid in their differential diagnosis and etiology...
- Kallikreins as markers of disseminated tumour cells in ovarian cancer-- a pilot study
Katerina Oikonomopoulou
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada
Tumour Biol 27:104-14. 2006
..Kallikrein expression may have some value for differentiating ovarian cancer from other types of cancer or from non-malignant diseases that lead to ascites accumulation...
- Alterations in mRNA expression of apoptosis-related genes BCL2, BAX, FAS, caspase-3, and the novel member BCL2L12 after treatment of human leukemic cell line HL60 with the antineoplastic agent etoposide
Kostas V Floros
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, and G. Papanicolaou Research Center for Oncology, Saint Sava's Hospital, Athens, Greece
Ann N Y Acad Sci 1090:89-97. 2006
..Since, the main anticarcinogenic effect of etoposide is due to the induction of apoptosis, these changes observed in the mRNA expression levels of the genes may be an underlying mechanism...
- Molecular response of HL-60 cells to mitotic inhibitors vincristine and taxol visualized with apoptosis-related gene expressions, including the new member BCL2L12
Hellinida Thomadaki
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
Ann N Y Acad Sci 1171:276-83. 2009
....
- Assessment of the prognostic significance of endoglin (CD105) in clear cell renal cell carcinoma using automated image analysis
William Dubinski
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada, M5S 1A8
Hum Pathol 43:1037-43. 2012
..Our automated approach overcomes many limitations of manual quantification. Advances in digital assessment of immunohistochemical markers can be helpful in standardizing the evaluation of tumor biomarkers...
- Correlation of androgen receptor status, neuroendocrine differentiation and angiogenesis with time-to-biochemical failure after radical prostatectomy in clinically localized prostate cancer
Kyriakos Revelos
Department of Pathology, Evangelismos Hospital, Athens, Greece
Anticancer Res 27:3651-60. 2007
..Patients and..
- Effect of bleomycin and cisplatin on the expression profile of SRA1, a novel member of pre-mRNA splicing factors, in HL-60 human promyelocytic leukemia cells
Maria E Katsarou
National Center for Scientific Research Demokritos, IPC, GR 15310 Athens, Greece
Biol Chem 388:773-8. 2007
..Our results support the hypothesis that mRNA expression analysis of SRA1 may serve as a new prospective molecular marker, playing an important role in chemotherapy outcome in human leukemia...
- Unfavorable prognostic value of human kallikrein 7 quantified by ELISA in ovarian cancer cytosols
Shannon J C Shan
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
Clin Chem 52:1879-86. 2006
..CONCLUSIONS: hK7 is associated with other unfavorable characteristics of ovarian cancer, but it is not an independent prognosticator for ovarian cancer...
- Human kallikrein 11: an indicator of favorable prognosis in ovarian cancer patients
Eleftherios P Diamandis
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada
Clin Biochem 37:823-9. 2004
..Our preliminary studies indicate that hK11 may represent a diagnostic and prognostic biomarker for ovarian cancer. The aim of the present study was to examine the prognostic value of hK11 expression in ovarian tumors...
- Expression analysis and prognostic significance of the SRA1 gene, in ovarian cancer
Theoni Leoutsakou
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, 15711 Panepistimioupoli, Athens, Greece
Biochem Biophys Res Commun 344:667-74. 2006
..Our results suggest that SRA1 is associated with cancer progression and may possibly be characterized as a new marker of unfavorable prognosis for ovarian cancer...
- The usefulness of serum human kallikrein 11 for discriminating between prostate cancer and benign prostatic hyperplasia
Terukazu Nakamura
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Cancer Res 63:6543-6. 2003
..69). These preliminary data suggest that the hK11:total PSA ratio could be a useful tumor marker for CaP and could be combined with percentage of PSA to further reduce the number of unnecessary prostatic biopsies...
- Parallel overexpression of seven kallikrein genes in ovarian cancer
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
Cancer Res 63:2223-7. 2003
....
- Overexpression of the novel member of the BCL2 gene family, BCL2L12, is associated with the disease outcome in patients with acute myeloid leukemia
Hellinida Thomadaki
Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
Clin Biochem 45:1362-7. 2012
..It is a novel member of the BCL2 gene family, members of which are implicated in different hematological malignancies. In the present study, we investigated and studied the expression profile of BCL2L12 in acute myeloid leukemia (AML)...
- Quantitative analysis of hippostasin/KLK11 gene expression in cancerous and noncancerous prostatic tissues
Terukazu Nakamura
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, Canada
Urology 61:1042-6. 2003
..4. Hippostasin has two alternative splicing isoforms, known as the brain type and prostate type. We have previously reported that the prostate-type isoform is not expressed in human prostate cancer cell lines...
- Quantitative analysis of human kallikrein 5 (KLK5) expression in prostate needle biopsies: an independent cancer biomarker
Dimitrios Korbakis
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
Clin Chem 55:904-13. 2009
..We performed an expression analysis and clinical evaluation of the KLK5 gene, at the mRNA level, in prostate needle biopsies...
- L-dopa decarboxylase (DDC) gene expression is related to outcome in patients with prostate cancer
Georgios Koutalellis
1st Department of Urology, Laiko General Hospital, University of Athens, School of Medicine, Athens, Greece
BJU Int 110:E267-73. 2012
..Moreover, DDC expression was shown to be an unfavourable prognostic marker of biochemical recurrence and disease-free survival in patients with PCa treated by radical prostatectomy...
- Expression analysis and clinical utility of L-Dopa decarboxylase (DDC) in prostate cancer
Margaritis Avgeris
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
Clin Biochem 41:1140-9. 2008
..The aim of this study was to investigate the mRNA expression levels of DDC in prostate tissues and to evaluate its clinical utility in prostate cancer (CaP)...
- Altered kallikrein 7 and 10 concentrations in cerebrospinal fluid of patients with Alzheimer's disease and frontotemporal dementia
Eleftherios P Diamandis
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada
Clin Biochem 37:230-7. 2004
..Some of these enzymes can be measured in cerebrospinal fluid (CSF) by using ELISA-type methodologies...
- Expression analysis and study of the KLK15 mRNA splice variants in prostate cancer and benign prostatic hyperplasia
Konstantinos Mavridis
Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
Cancer Sci 101:693-9. 2010
..017). These results suggest that KLK15 expression analysis could be employed as a valuable tool for the discrimination between BPH and CaP tissue specimens and as an unfavorable prognostic marker for prostate cancer...
The immunohistochemical expression of growth hormone-releasing hormone receptor splice variant 1 is a favorable prognostic marker in colorectal cancerElena Theophanous
Department of Pathology, Evangelismos Hospital, Athens, Greece
Mol Med 15:242-7. 2009
..The immunohistochemical expression of SV-1 seems to be a favorable prognostic factor in CRC...
- Human kallikrein 8, a novel biomarker for ovarian carcinoma
Tadaaki Kishi
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada
Cancer Res 63:2771-4. 2003
..These data suggest that hK8 protein is detectable in ovarian cancer tissue extracts, serum, and ascites fluid, indicating that it may serve as a new ovarian cancer marker...
- Effect of testosterone administration on serum and urine kallikrein concentrations in female-to-male transsexuals
Margrita H Slagter
Department of Endocrinology, Vrije Universiteit University Medical Centre, Amsterdam, The Netherlands, and Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
Clin Chem 52:1546-51. 2006
....
- Significant alterations in the expression pattern of kallikrein-related peptidase genes KLK4, KLK5 and KLK14 after treatment of breast cancer cells with the chemotherapeutic agents epirubicin, docetaxel and methotrexate
Georgia Papachristopoulou
Department of Biochemistry and Molecular Biology, University of Athens, 15701, Panepistimiopolis, Athens, Greece
Tumour Biol 34:369-78. 2013
....
- The clinical utility of miR-21 as a diagnostic and prognostic marker for renal cell carcinoma
Hala Faragalla
Department of Laboratory Medicine, and the Keenan Research Center in the Li Ka Shing Knowledge Institute, St Michael s Hospital, Toronto, Ontario, Canada
J Mol Diagn 14:385-92. 2012
..Moreover, it has potential as a prognostic marker in RCC, although it is not independent of tumor stage and grade...
- Quantitative expression analysis and study of the novel human kallikrein-related peptidase 14 gene (KLK14) in malignant and benign breast tissues
Georgia Papachristopoulou
Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens, Greece
Thromb Haemost 105:131-7. 2011
..024). In accordance with logistic regression models (p=0.012) and receiver-operating-characteristics analysis (p<0.001), KLK14 gene expression could be evaluated as a putative independent diagnostic biomarker in breast tumour biopsies...
- Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells
Kostas V Floros
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR-15701, Athens, Greece
Biol Chem 387:1629-33. 2006
..Our results support the significance of mRNA modulations in the expression of apoptosis-related genes during treatment of human leukemic cells with anticancer drugs...
- The miR-17-92 cluster is over expressed in and has an oncogenic effect on renal cell carcinoma
Tsz fung F Chow
Department of Laboratory Medicine and Keenan Research Centre, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada
J Urol 183:743-51. 2010
..We also elucidated the role of miRNA in clear cell renal cell carcinoma pathogenesis with bioinformatics...
- Molecular profile of the BCL2 family of the apoptosis related genes in breast cancer cells after treatment with cytotoxic/cytostatic drugs
Hellinida Thomadaki
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
Connect Tissue Res 49:261-4. 2008
..In the present review, we describe current knowledge of the molecular profile of the classical and novel members of the BCL2 family of genes as a response of breast cancer cells to cytotoxic/cytostatic drugs...
- The effect of the polyadenylation inhibitor cordycepin on human Molt-4 and Daudi leukaemia and lymphoma cell lines
Hellinida Thomadaki
Institute of Biology, NCSR Demokritos, Aghia Paraskevi Attikis, 15310, Athens, Greece
Cancer Chemother Pharmacol 61:703-11. 2008
....
- Human kallikrein gene 5 (KLK5) expression by quantitative PCR: an independent indicator of poor prognosis in breast cancer
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5 Canada
Clin Chem 48:1241-50. 2002
..006) and OS (P = 0.004) in the subgroup of patients with grade I and II tumors. CONCLUSIONS: KLK5 expression as assessed by quantitative RT-PCR is an independent and unfavorable prognostic marker for breast carcinoma...
- Detection of human kallikrein 4 in healthy and cancerous prostatic tissues by immunofluorometry and immunohistochemistry
Christina V Obiezu
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Ave, Toronto, Ontario, M5G 1X5 Canada
Clin Chem 48:1232-40. 2002
..We propose that the protein either is not synthesized efficiently or is degraded very quickly...
- Human tissue kallikreins: from gene structure to function and clinical applications
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Adv Clin Chem 39:11-79. 2005
- Total and free PSA kinetics in patients without prostate cancer undergoing radical cystoprostatectomy
Alkibiades K Gregorakis
Department of Urology, Attikon General Hospital, University of Athens, Athens, Greece
Prostate 68:759-65. 2008
..Radical cystoprostatectomy is usually performed in patients with invasive bladder cancer. The aim of the study was to examine Total PSA, Free PSA, and Free/Total Ratio elimination kinetics after radical cystoprostatectomy...
- Kallikrein-related peptidase 6 (KLK6)gene expression in intracranial tumors
Maroulio Talieri
Department of Cellular Physiology, G Papanicolaou Research Center of Oncology, Saint Savvas Cancer Hospital, 171, Alexandras Avenue, Athens, 11522, Greece
Tumour Biol 33:1375-83. 2012
..032). KLK6 gene expression may have clinical utility as a marker of unfavorable prognosis for intracranial tumors, and consequently, it could be used as target for therapeutic intervention...
- Molecular cloning of novel alternatively spliced variants of BCL2L12, a new member of the BCL2 gene family, and their expression analysis in cancer cells
Christos K Kontos
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Athens, Greece
Gene 505:153-66. 2012
..The remaining three novel splice variants of BCL2L12 are nonsense-mediated mRNA decay (NMD) candidates...
- Treatment of gastric cancer cells with 5-fluorouracil/leucovorin and irinotecan induces distinct alterations in the mRNA expression of the apoptosis-related genes, including the novel gene BCL2L12
Dimitrios Korbakis
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, Athens, Greece
Tumour Biol 30:100-7. 2009
..Our experimental data demonstrate that the molecular profile mainly of BCL2 and BCL2L12 genes may serve as a new potential molecular biomarker predicting treatment response in gastric cancer cells...
- The serum concentration of human kallikrein 10 represents a novel biomarker for ovarian cancer diagnosis and prognosis
Liu-Ying Luo
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5 Canada
Cancer Res 63:807-11. 2003
..Serum hK10 represents a novel biomarker for ovarian cancer. We conclude that preoperative serum hK10 concentration is a strong and independent unfavorable prognostic marker for ovarian cancer...
- Kallikrein-related peptidase 4 gene (KLK4) in prostate tumors: quantitative expression analysis and evaluation of its clinical significance
Margaritis Avgeris
Department of Biochemistry and Molecular Biology, University of Athens, Panepistimiopolis, Athens, Greece
Prostate 71:1780-9. 2011
..The aim of this study is to investigate the expression status of KLK4 in PCa patients in order to reveal its utility in PCa establishment and clinical management...
- Treatment of MCF-7 cells with taxol and etoposide induces distinct alterations in the expression of apoptosis-related genes BCL2, BCL2L12, BAX, CASPASE-9 and FAS
Hellinida Thomadaki
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, and Department of Biochemistry and Molecular Biology, Papanikolaou Cancer Research Centre, St. Savas Hospital, Athens, Greece
Biol Chem 387:1081-6. 2006
..Our results support the idea that after long-term clinical studies, mRNA expression analysis of BCL2L12 and other members of the BCL2 gene family may serve as useful molecular markers predicting chemotherapy response in breast cancer...
- Immunohistochemical expression of Bcl2 is an independent predictor of time-to-biochemical failure in patients with clinically localized prostate cancer following radical prostatectomy
Kyriakos Revelos
Department of Pathology, Evangelismos General Hospital, Athens, Greece
Anticancer Res 25:3123-33. 2005
..06, 3.31 and 3.15; p = 0.048, p = 0.031 and p = 0.031 for SVI, PLNM and bcl2 IHCE, respectively). CONCLUSION: Bcl2 immunohistochemical overexpression in specimens of RP suggests high risk for BF in clinically localized PC...
- Erlotinib monotherapy in patients with advanced non-small cell lung cancer: an effective approach with low toxicity
Alexandros Ardavanis
First Department of Medical Oncology, St Savvas Anticancer Hospital, Athens, Greece
Anticancer Res 28:2409-15. 2008
..This retrospective study was conducted to assess the efficacy of erlotinib and its impact on survival...
- Differential protein expressions in renal cell carcinoma: new biomarker discovery by mass spectrometry
K W Michael Siu
Department of Chemistry and Centre for Research in Mass Spectrometry, York University, Toronto, Canada
J Proteome Res 8:3797-807. 2009
..We performed an in silico validation of our results using different tools and databases including Serial Analysis of Gene Expression (SAGE), UniGene EST ProfileViewer, Cancer Genome Anatomy Project, and Gene Ontology consortium analysis...
- Serum human glandular kallikrein (hK2) and insulin-like growth factor 1 (IGF-1) improve the discrimination between prostate cancer and benign prostatic hyperplasia in combination with total and %free PSA
Andreas Scorilas
National Center for Scientific Research Demokritos, IPC, Athens, Greece
Prostate 54:220-9. 2003
..CONCLUSIONS: hK2/free PSA and IGF-1/free PSA ratios may be useful adjuncts in improving patient selection for prostate biopsy...
- Free/Total PSA (F/T ratio) kinetics in patients with clinically localized prostate cancer undergoing radical prostatectomy
Alkiviades K Gregorakis
Urology Department, Attikon General Hospital, University of Athens, Athens, Greece
Clin Chim Acta 357:196-201. 2005
..In this paper we study the Free/Total PSA kinetics in patients with clinically localized prostate cancer undergoing radical prostatectomy...
- Prognostic value and biological role of the kallikrein-related peptidases in human malignancies
Konstantinos Mavridis
Department of Biochemistry and Molecular Biology, University of Athens, Athens, Greece
Future Oncol 6:269-85. 2010
..It is believed that KLKs might be employed in future clinical practice as novel and effective tumor markers...
- Safety and efficacy of trastuzumab every 3 weeks combined with cytotoxic chemotherapy in patients with HER2-positive recurrent breast cancer: findings from a case series
Alexandros Ardavanis
First Department of Medical Oncology, St Savas Anticancer Hospital, Athens, Greece
Onkologie 28:558-64. 2005
..Trastuzumab is currently licensed as a weekly treatment, although a 3-weekly schedule could be used conveniently in combination with other cytotoxic agents that are administered on a 3-weekly basis in metastatic breast cancer...
- Cisplatin-induced apoptosis in HL-60 human promyelocytic leukemia cells: differential expression of BCL2 and novel apoptosis-related gene BCL2L12
Kostas V Floros
National Center for Scientific Research Demokritos, Athens 15310, Greece
Ann N Y Acad Sci 1010:153-8. 2003
..It is known that the main anti-carcinogenic effect of cisplatin is due to the induction of cell apoptosis. Present results indicate that downregulation of the BCL2 and upregulation of the BCL2L12 gene may be the underlying mechanisms...
- Effects of long-term androgen administration on breast tissue of female-to-male transsexuals
Margrita H Slagter
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, ON, M5G 1X5, Canada
J Histochem Cytochem 54:905-10. 2006
..These changes are similar to those observed at the end-stage of menopausal mammary involution...
- Phosphatidylinositol 3'-kinase catalytic subunit alpha gene amplification contributes to the pathogenesis of mantle cell lymphoma
Amanda Psyrri
Second Department of Internal Medicine, Propaedeutic, University of Athens, University General Hospital Attikon, Haidari, Athens, Greece
Clin Cancer Res 15:5724-32. 2009
..Activation of phosphatidylinositol 3'-kinase pathway is implicated in the pathogenesis of mantle cell lymphoma (MCL). The genetic change in phosphatidylinositol 3'-kinase catalytic subunit alpha (PIK3CA) in MCL has not been identified...
- Down-regulation of the human kallikrein gene 5 (KLK5) in prostate cancer tissues
George M Yousef
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada
Prostate 51:126-32. 2002
..4. Like KLK2 and KLK3, the KLK5 gene is regulated by steroid hormones in the BT-474 breast cancer cell line. We have previously shown that KLK5 is differentially expressed in ovarian and breast cancer...
- Determination of cathepsin B expression may offer additional prognostic information for ovarian cancer patients
Andreas Scorilas
NCSR Demokritos IPC, Athens, Greece
Biol Chem 383:1297-303. 2002
..Accordingly, cathepsin B can be regarded as unfavorable and as an independent tumor marker for progression-free survival and overall survival in ovarian cancer patients with long follow-up...
- Decreased concentration of human kallikrein 6 in brain extracts of Alzheimer's disease patients
Maryam Zarghooni
Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, Ontario M5G 1X5, Canada
Clin Biochem 35:225-31. 2002
..Our objective was to develop a highly sensitive immunoassay for hK6 and use it to examine the levels of hK6 in brain tissue extracts from Alzheimer's disease patients and control subjects...
- Comparative study of balloon and metal olive dilators for endoscopic management of benign anastomotic rectal strictures: clinical and cost-effectiveness outcomes
Dimitrios Xinopoulos
Department of Gastroenterology, Saint Savvas Hospital, Athens, Greece
Surg Endosc 25:756-63. 2011
....
- Multidisciplinary therapy of locally far-advanced or inflammatory breast cancer with fixed perioperative sequence of epirubicin, vinorelbine, and Fluorouracil chemotherapy, surgery, and radiotherapy: long-term results
Alexandros Ardavanis
First Department of Medical Oncology, St Savas Anticancer Hospital, 171 Alexandras Avenue, 115 22 Athens, Greece
Oncologist 11:563-73. 2006
..Based on phase II data in advanced breast cancer (BC), the fluorouracil, epirubicin, and vinorelbine (FEN) combination was assessed as perioperative chemotherapy, integrated in a multidisciplinary treatment for locally advanced BC...
- Expression analysis and prognostic significance of human kallikrein 11 in prostate cancer
Panagiota Stavropoulou
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, 157 01 Athens, Greece
Clin Chim Acta 357:190-5. 2005
..KLK11 has two alternative splicing isoforms, known as the brain type and prostate type. Many members of the human kallikrein gene family are differentially expressed in cancer and a few have potential as diagnostic/prognostic markers...
- Polyadenylate polymerase modulations in human epithelioid cervix and breast cancer cell lines, treated with etoposide or cordycepin, follow cell cycle rather than apoptosis induction
Hellinida Thomadaki
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, GR-15701 Athens, Greece
Biol Chem 386:471-80. 2005
..Our results suggest, for the first time, that in the epithelial cancer cell lines used, PAP modulations follow cell cycle progression rather than the course of apoptosis...
- Structure and biological properties of the copper(II) complex with the quinolone antibacterial drug N-propyl-norfloxacin and 2,2'-bipyridine
Eleni K Efthimiadou
Institute of Physical Chemistry, NCSR Demokritos, GR 15310 Aghia Paraskevi Attikis, Greece
J Inorg Biochem 101:64-73. 2007
..Complex 1 shows an increased antiproliferative and necrotic effect on both HL-60 and K562 human leukemia cells in comparison to the free pr-norfloxacin...
- Prognostic significance of the expression of SR-A1, encoding a novel SR-related CTD-associated factor, in breast cancer
Theoni Leoutsakou
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, GR-15711 Athens, Greece
Biol Chem 387:1613-8. 2006
..Our results suggest that SR-A1 may possibly be characterized as a new marker of unfavorable prognosis for breast cancer...
- Prognostic value of the apoptosis related genes BCL2 and BCL2L12 in breast cancer
Hellinida Thomadaki
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Greece 15711 Athens, Greece
Cancer Lett 247:48-55. 2007
..Multivariate analysis revealed that BCL2 and BCL2L12 might be used as independent prognostic biomarkers in breast cancer...
- Primary tumor levels of human tissue kallikreins affect surgical success and survival in ovarian cancer patients
Julia Dorn
Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Clin Cancer Res 13:1742-8. 2007
....
- Prognostic value of quantitatively assessed KLK7 expression in ovarian cancer
Lianna G Kyriakopoulou
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, M5G 1X5 Canada
Clin Biochem 36:135-43. 2003
..6). CONCLUSIONS: We conclude that higher KLK7 expression in ovarian cancer tissue is associated with poorer prognosis of ovarian cancer patients, especially those with lower grade disease and those who have been optimally debulked...
- SR-A1, a member of the human pre-mRNA splicing factor family, and its expression in colon cancer progression
Konstantina Mathioudaki
G Papanicolaou Research Center of Oncology, Saint Savas Hospital, GR 11522 Athens, Greece
Biol Chem 385:785-90. 2004
..To the best of our knowledge, this is the first study examining the expression of the novel gene SR-A1 in colon cancer progression...
- Trastuzumab plus paclitaxel or docetaxel in HER-2-negative/HER-2 ECD-positive anthracycline- and taxane-refractory advanced breast cancer
Alexandros Ardavanis
First Department of Medical Oncology, Saint Savas Oncology Hospital, 171 Alexandras Avenue, 115 22 Athens, Hellas
Oncologist 13:361-9. 2008
....
- B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression
Iris Simon
diaDexus, Inc, 343 Oyster Point Blvd, South San Francisco, CA, USA
Gynecol Oncol 106:334-41. 2007
..This study characterizes the expression of the novel biomarker B7-H4 in ovarian cancer tissue, normal ovaries, and benign ovarian tumors, and evaluates its relationship to CA125...
- The role of cordycepin in cancer treatment via induction or inhibition of apoptosis: implication of polyadenylation in a cell type specific manner
Hellinida Thomadaki
Institute of Biology, NCSR Demokritos, Aghia Paraskevi Attikis, 15310 Athens, Greece
Cancer Chemother Pharmacol 61:251-65. 2008
..In the present study we assessed the implication and role of cordycepin, a polyadenylation-specific inhibitor and a well-known chemotherapeutic drug, in apoptosis, induced by the anticancer drug etoposide...
- Expression analysis of the human kallikrein 7 (KLK7) in breast tumors: a new potential biomarker for prognosis of breast carcinoma
Maroulio Talieri
G Papanicolaou Research Center of Oncology, Saint Savas Hospital, Athens Greece
Thromb Haemost 91:180-6. 2004
..These data suggest that KLK7 gene expression may be used as a marker of unfavorable prognosis for breast cancer patients...
- Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12
Hellinida Thomadaki
Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Athens, Panepistimiopolis, 15701 Athens, Greece
Ann N Y Acad Sci 1095:35-44. 2007
....
- Hepsin is highly over expressed in and a new candidate for a prognostic indicator in prostate cancer
Carsten Stephan
Department of Urology, University Hospital Charit, Humboldt University, Berlin, Germany
J Urol 171:187-91. 2004
..Hepsin expression may be a new prognostic marker that could be used for assessing prostate cancer aggressiveness...
- Expression analysis of BCL2L12, a new member of apoptosis-related genes, in colon cancer
Konstantina Mathioudaki
G Papanicolaou Research Center of Oncology, Saint Savas Hospital, GR 11522 Athens, Greece
Biol Chem 385:779-83. 2004
..The BCL2L12-A transcript appears to be of importance for colon cancer since its expression is associated with disease progression...
- Expression of BCL2L12, a new member of apoptosis-related genes, in breast tumors
Maroulio Talieri
G Papanicolaou Research Center of Oncology, Saint Savas Hospital Athens, Greece
Thromb Haemost 89:1081-8. 2003
..002 and p<0.001 respectively). BCL2L12 expression may be regarded as a new independent favorable prognostic marker for breast cancer...
- mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin
Kostas V Floros
National Center for Scientific Research 'Demokritos, GR-15310 Athens, Greece
Biol Chem 385:1099-103. 2004
..In the case of carboplatin-induced apoptosis we detected down-regulation of BAX , BCL2 and caspase-9, whereas in the case of doxorubicin, BAX and BCL2 remained at control levels and caspase-9 was increased...
- A multiparametric panel for ovarian cancer diagnosis, prognosis, and response to chemotherapy
Yingye Zheng
The Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
Clin Cancer Res 13:6984-92. 2007
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