Intrauterine growth restriction in humans is associated with abnormalities in placental insulin-like growth factor signalingLuigi Laviola
Department of Emergency and Organ Transplantation, Section of Internal Medicine, Endocrinology and Metabolic Diseases, University of Bari, Piazza Giulio Cesare 11, I 70124 Bari, Italy
Endocrinology 146:1498-505. 2005
..The observed abnormalities in IGF-I signaling may contribute to altered fetal growth and development in human IUGR...
- Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitus
M Scioscia
Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College Medical School, London, UK
Diabet Med 24:1300-4. 2007
..An increase during normal pregnancy, in maternal and fetal compartments, has recently been reported...
- Social determinants of the increasing caesarean section rate in Italy
M Scioscia
Department of Gynaecology, University of Medical Science of Bari, Bari, Italy
Minerva Ginecol 60:115-20. 2008
..This increasing trend has been reported in many countries and its relationship with social modifications is widely accepted, though poorly supported by published data...
Inositol phosphoglycan P-type in infants of preeclamptic mothersMarco Scioscia
Department of Obstetrics and Gynaecology, Sacro Cuore Don Calabria, Verona, Negrar, Italy
J Matern Fetal Neonatal Med 25:193-5. 2012
..This multicenter prospective cross-sectional case-control study evaluated the fetus/newborn as the source of P-IPG...
- Laparoscopic management of ureteral endometriosis
Marco Scioscia
Department of Obstetrics and Gynecology, Sacro Cuore Don Calabria General Hospital, Via Don A Sempreboni, 5, Negrar 37024, Verona, Italy
Curr Opin Obstet Gynecol 21:325-8. 2009
..Laparoscopic management of these lesions is considered the treatment of choice...
- Altered urinary release of inositol phosphoglycan A-type in women with gestational diabetes mellitus
Marco Scioscia
Department of Molecular Pathology, Molecular Medicine Unit, Royal Free and University College Medical School, London, UK
Gynecol Obstet Invest 64:217-23. 2007
..Inositol phosphoglycan A-type (A-IPG), a putative second messenger of insulin, was reported to regulate lipogenesis in adipose tissue. IPGs have recently been shown to increase during normal pregnancy, in maternal and fetal compartments...
- Release of inositol phosphoglycan P-type by the human placenta following insulin stimulus: a multiple comparison between preeclampsia, intrauterine growth restriction, and gestational hypertension
Marco Scioscia
Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College London Medical School, London, UK
J Matern Fetal Neonatal Med 21:581-5. 2008
..This study was undertaken to assess the release of this mediator in intrauterine growth restriction (IUGR) and hypertensive disorders other than preeclampsia...
- Estimation of birth weight by two-dimensional ultrasonography: a critical appraisal of its accuracy
Marco Scioscia
Department of Gynaecology, Obstetrics and Neonatology, University of Medical Science of Bari, Bari, Italy
Obstet Gynecol 111:57-65. 2008
..To assess the accuracy and characterize two-dimensional ultrasonographic formulas for the estimation of birth weight according to the type of fetal biometric parameters these formulas rely on to make fetal weight predictions...
- Estimation of fetal weight by measurement of fetal thigh soft-tissue thickness in the late third trimester
M Scioscia
Department of Gynaecology, Obstetrics and Neonatology, University of Medical Science of Bari, Italy
Ultrasound Obstet Gynecol 31:314-20. 2008
..The aim of this study was to assess the reliability of the linear measurement of mid-thigh soft-tissue thickness (STT) and to derive a novel formula for EFW...
- Characterization of endometrial growth in proliferative and early luteal phase in IVF cycles
Marco Scioscia
Department of Gynaecology, Obstetrics and Neonatology, University of Medical Science of Bari, Bari, Italy
Reprod Biomed Online 18:73-8. 2009
..This supports the hypothesis that individual factors (intrinsic properties of the endometrium) significantly affect endometrial growth...
- Is there a link between insulin resistance and inflammatory activation in preeclampsia?
Marco Scioscia
Department of Obstetrics and Gynaecology, Sacro Cuore Don Calabria General Hospital, Negrar, Verona, Italy
Med Hypotheses 73:813-7. 2009
..In this article we propose a new working theory on insulin resistance and preeclampsia...
- The link between insulin resistance and preeclampsia: new perspectives
Marco Scioscia
Department of Obstetrics and Gynaecology, Sacro Cuore Don Calabria, 37024 Negrar, Verona, Italy
J Reprod Immunol 82:100-5. 2009
....
- Increased inositol phosphoglycan P-type in the second trimester in pregnant women with type 2 and gestational diabetes mellitus
Marco Scioscia
Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College Medical School, London, UK
J Perinat Med 37:469-71. 2009
..05). A higher P-IPG urinary excretion occurs during the second trimester in pregnant women with clinically evident insulin resistance with a positive association with poor glycemic control...
- Inositol phosphoglycan P-type in healthy and preeclamptic pregnancies
Marco Scioscia
Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College London Medical School, London, UK
J Reprod Immunol 76:85-90. 2007
..Cord blood of infants of preeclamptic mothers showed an increased content of soluble P-IPG compared to controls and to the mother...
- Proposal for a systematic preoperative assessment of pelvic endometriosis
M Scioscia
Department of Obstetrics and Gynecology, Sacro Cuore Don Calabria General Hospital, Negrar, Verona, Italy
Minerva Ginecol 63:189-94. 2011
..Preoperative assessment of the extension of the disease is of key relevance to opt for medical or surgical therapy and, sometimes, to plan a multidisciplinary approach...
- Inositol phosphoglycans and preeclampsia: from bench to bedside
Marco Scioscia
Department of Obstetrics and Gynaecology, Sacro Cuore Don Calabria General Hospital, Negrar, Verona, Italy
J Reprod Immunol 89:173-7. 2011
....
- Four-dimensional and Doppler sonography in the diagnosis and surveillance of a true cord knot
Marco Scioscia
Department of Obstetrics and Gynecology, Sacro Cuore Don Calabria General Hospital, Negrar, Verona, Italy
J Clin Ultrasound 39:157-9. 2011
..We report the importance of color Doppler and four-dimensional ultrasound for the differential diagnosis in the case of true cord knot and the role of Doppler flow velocimetry in the management of that case...
- Distribution of endometriotic lesions in endometriosis stage IV supports the menstrual reflux theory and requires specific preoperative assessment and therapy
Marco Scioscia
Department of Obstetrics and Gynecology, Sacro Cuore Don Calabria General Hospital, Negrar, Verona, Italy
Acta Obstet Gynecol Scand 90:136-9. 2011
..The extent of anatomical sites suggests the opportunity to plan a proper preoperative instrumental study for patients with clinical suspect of severe endometriosis possibly to set a multidisciplinary clinical or surgical management...
- Preeclampsia, insulin signalling and immunological dysfunction: a fetal, maternal or placental disorder?
Thomas W Rademacher
Department of Immunology and Molecular Pathology, Molecular Medicine Unit, Royal Free and University College London Medical School, London, UK
J Reprod Immunol 76:78-84. 2007
..Besides, the lipidic form of P-IPG was reported to be similar to endotoxins, and may represent the 'danger signa'. We propose here a novel working theory on insulin resistance and preeclampsia...
- The ultrasound assessment of adipose tissue deposition in fetuses of "well controlled" insulin-dependent diabetic pregnancies
P Greco
Chair of Obstetrics and Gynecology, University of Foggia, Bari, Italy
Diabet Med 20:858-62. 2003
..This may be a reflection of higher maternal glucose levels in these women and may explain why even well-controlled diabetic pregnancies are at risk of macrosomia...
- Laparoscopic treatment of bowel endometriosis in infertile women
A Stepniewska
Departments of Obstetrics and Gynecology, Ospedale Sacro Cuore, Via Don Sempreboni 5, Negrar 37024, Verona, Italy
Hum Reprod 24:1619-25. 2009
..The purpose of the study was to determine the influence of bowel endometriosis on fertility, and to study whether its removal improves fecundity in women with endometriosis-associated infertility...
- Perinatal risk factors and mode of delivery correlated to survival and psychomotor disability in extremely low birth weight infants
A Vimercati
Department of Gynaecology, Obstetrics and Neonatology, University of Medical Science of Bari, Bari, Italy
Gynecol Obstet Invest 66:91-7. 2008
..Extreme preterm birth, <28 weeks of gestation, represents a public health concern with major economic implications, being the leading cause of neonatal mortality and morbidity...
- The value of ultrasonographic examination of the uterine cervix in predicting post-term pregnancy
A Vimercati
Institute of Obstetrics and Gynecology, University of Bari, Bari, Italy
J Perinat Med 29:317-21. 2001
..This difference is significant from 39 weeks of gestation onwards. We speculate that targeted transvaginal ultrasound may be useful in predicting the post-term onset of labor and possibly in assisting its active management...
- Insulin resistance in human preeclamptic placenta is mediated by serine phosphorylation of insulin receptor substrate-1 and -2
Marco Scioscia
Department of Obstetrics and Gynaecology, University of Bari, Policlinico di Bari, Piazza Giulio Cesare 11, 70125 Bari, Italy
J Clin Endocrinol Metab 91:709-17. 2006
..Preeclampsia is a severe complication of human pregnancy often associated with maternal risk factors. Insulin resistance represents a major risk for developing preeclampsia during pregnancy...
- Parabolic trend in endometrial thickness at embryo transfer in in vitro fertilization/intracytoplasmic sperm injection cases with clinical pregnancy evidence
Giuseppina Lamanna
Department of Gynecology, Obstetrics, and Neonatology, University of Medical Science of Bari, Bari, Italy
Fertil Steril 90:1272-4. 2008
..Nevertheless, a retrospective analysis of a study population of 606 patients showed a decrease of clinical pregnancy rates in the setting of extreme endometrial thicknesses...
- Placental expression of D-chiro-inositol phosphoglycans in preeclampsia
M Scioscia
Department of Obstetrics and Gynaecology, Sacro Cuore Don Calabria General Hospital, Via Don A Sempreboni, 5, 37024 Negrar, Verona, Italy
Placenta 33:882-4. 2012
..The tendencies of more staining in villous stroma associated with a differential staining of placental vessels only in preeclamptic specimens support a vectoral movement of D-chiro-inositol phosphoglycans from the fetus to the placenta...
- Laparoscopic nerve-sparing transperitoneal approach for endometriosis infiltrating the pelvic wall and somatic nerves: anatomical considerations and surgical technique
Marcello Ceccaroni
Gynecologic Oncology Division, Department of Obstetrics and Gynecology, European Gynaecology Endoscopy School, Sacred Heart Hospital Ospedale Sacro Cuore Don Calabria, Via Don A Sempreboni no 5, 37024, Negrar, Verona, Italy
Surg Radiol Anat 32:601-4. 2010
..for diagnosis and treatment of ano-genital pain caused by pudendal and/or sacral nerve roots lesions and adopted at our institution. In this paper we report our experience and anatomo-surgical consideration regarding this technique...
- Inositol phosphoglycan putative insulin mediator in human amniotic fluid
Marco Scioscia
Department of Molecular Pathology, Molecular Medicine Unit, Royal Free and University College Medical School, London, UK
J Matern Fetal Neonatal Med 19:9-12. 2006
..Inositol phosphoglycans (IPGs), a family of putative second messengers of insulin, are reported to exert several of insulin's metabolic effects...
- Colorectal endometriosis: benefits of long-term follow-up in patients who underwent laparoscopic surgery
Anna Stepniewska
Department of Obstetrics and Gynecology, Ospedale Sacro Cuore, Verona, Italy
Fertil Steril 93:2444-6. 2010
....
- Fibrotic tissue in the endometrioma capsule: surgical and physiopathologic considerations from histologic findings
Mario Vicino
Department of Gynaecology, Obstetrics and Neonatology, University of Medical Science of Bari, Bari, Italy
Fertil Steril 91:1326-8. 2009
..A consecutive series of 91 ovarian endometriotic cysts were studied, and an inverse relationship between serum CA-125 and the thickness of the fibrotic tissue of the endometrioma capsule was demonstrated...
- Do uterine fibroids affect IVF outcomes?
Antonella Vimercati
Department of Gynaecology, Obstetrics and Neonatology, University of Medical Science of Bari, Policlinico of Bari, Piazza Giulio Cesare, 11, 70100 Bari, Italy
Reprod Biomed Online 15:686-91. 2007
..This represents valuable information in the counselling of women with fibroids before reproductive assisted cycles...
- Laparoscopic conservative surgery for stage IV symptomatic endometriosis: short-term surgical complications
Luca Minelli
Department of Obstetrics and Gynecology, Sacro Cuore Don Calabria General Hospital, Negrar, Verona, Italy
Fertil Steril 94:1218-22. 2010
..To study severe endometriosis as a cause of pelvic pain, which represents one of the most challenging disorders in gynecology...
- Inositol phosphoglycan P-type in preeclampsia: a novel marker?
Philip J Williams
Department of Molecular Pathology, Molecular Medicine Unit, Royal Free and University College Medical School, London, United Kingdom
Hypertension 49:84-9. 2007
..Urinary level of inositol phosphoglycan P-type increased after diagnosis indicating a possible pathophysiological threshold level and steeply decreased after delivery...
- [Second trimester termination of pregnancy with gemeprost: a review of 306 cases]
M Scioscia
Dipartimento di Ostetricia e Ginecologia, Universita degli Studi di Bari, Bari, Italy
Minerva Ginecol 55:347-51. 2003
..The clinical outcome and the risk of complications were evaluated in a group of women having a medical termination of pregnancy with gemeprost...
- Correlation between serum levels of CA 125 and follicular loss after laparoscopic cystectomy in women with ovarian endometrioma
Mario Vicino
Department of Obstetrics and Gynecology, University of Bari, Bari, Italy
J Minim Invasive Gynecol 14:223-7. 2007
..To preoperatively predict follicular loss after laparoscopic cystectomy of ovarian endometriomas...
- Prenatal diagnosis of Freeman-Sheldon syndrome and usefulness of an ultrasound fetal lip width normogram
Antonella Vimercati
Department of Obstetrics and Gynaecology, University of Bari, Bari, Italy
Prenat Diagn 26:679-83. 2006
..CONCLUSION: Here we present a standard chart for fetal lip width. We demonstrated its usefulness in cases with fetal face anomalies. Specific charts are fundamental for an objective assessment of the fetal parameters...
- Laparoscopic colorectal resection for deep infiltrating endometriosis: analysis of 436 cases
Giacomo Ruffo
Department of General Surgery, Sacro Cuore Don Calabria General Hospital, Verona, Italy
Surg Endosc 24:63-7. 2010
..Complete removal of all visible lesions is considered the adequate treatment of pelvic endometriosis in order to reduce recurrence. Laparoscopic colorectal resection of bowel endometriosis is still challenging. A large series is reported...
- Are active labour and mode of delivery still a challenge for extremely low birth weight infants? Experience at a tertiary care hospital
Antonella Vimercati
Department of Gynaecology, Obstetrics and Neonatology, University of Medical Science of Bari, Bari, Italy
Eur J Obstet Gynecol Reprod Biol 145:154-7. 2009
..This study was to evaluate the impact of mode of delivery and timing of caesarean section in extremely preterm births, below 28 weeks of gestation, on long-term survival and psychomotor outcomes...
- A short-scheme protocol of gemeprost for midtrimester termination of pregnancy with uterine scar
Marco Scioscia
Department of Obstetrics and Gynaecology, University of Bari, 70125 Bari, Italy
Contraception 71:193-6. 2005
..The purpose of this study is to investigate the safety and effectiveness of a short-scheme protocol of gemeprost for second trimester induction of abortion in women with previous uterine surgery...
- Patients' obstetric history in mid-trimester termination of pregnancy with gemeprost: does it really matter?
Marco Scioscia
Department of Obstetrics and Gynaecology, University of Bari, Policlinico di Bari, Piazza Giulio Cesare 11, 70125 Bari, Italy
Eur J Obstet Gynecol Reprod Biol 130:42-5. 2007
..The objective was to investigate the importance of previous obstetric history for termination of pregnancy in the second-trimester with gemeprost alone...
- Nuchal cords in term and postterm deliveries--do we need to know?
Marco Scioscia
Obstet Gynecol 106:1417; Author reply 1417-8. 2005
- P-type inositol phosphoglycans in serum and amniotic fluid in active pre-eclampsia
M A Paine
Department of Molecular Pathology and Immunology, Middlesex Hospital, 1 Mortimer Street, University College London, London W1T 8AA, UK
J Reprod Immunol 69:165-79. 2006
..Additionally, an abnormal IPG-P sub-fraction, detectable in urine and amniotic fluid, may be present and involved in the pathophysiology of the syndrome, although sites of production of this abnormal form remain unclear...
- Timing of fetal growth acceleration in women with insulin-dependent diabetes
Pantaleo Greco
Obstetrics and Gynaecology, University of Foggia, Foggia, Italy
Fetal Diagn Ther 18:437-41. 2003
..Fluctuations in glucose levels rather than basal levels are probably more determinant in fetal growth acceleration...
- Ultrasound evaluation of the uterine scar after cesarean delivery: a randomized controlled trial of one- and two-layer closure
Oronzo Ceci
Obstet Gynecol 111:452; author reply 452. 2008
- A critical analysis on Italian perinatal mortality in a 50-year span
Marco Scioscia
Department of Obstetrics and, Gynaecology, University of Bari, Policlinico di Bari, Piazza Giulio Cesare 11, 70125 Bari, Italy
Eur J Obstet Gynecol Reprod Biol 130:60-5. 2007
..Perinatal mortality rate is used as an indicator of reproductive health worldwide. In western countries, national mortality registers are usually accurate and reliable...
- Recurrent intermenstrual bleeding secondary to cesarean section scars?
Oronzo Ceci
Fertil Steril 88:757; author reply 757-8. 2007
