P J Schwartz

Summary

Publications

  1. ncbi The long QT syndrome: a clinical counterpart of hERG mutations
    Peter J Schwartz
    Department of Cardiology, University of Pavia and Policlinico S. Matteo IRCCS, V.le Golgi 19, 27100 Pavia, Italy
    Novartis Found Symp 266:186-98; discussion 198-203. 2005
  2. ncbi Management of long QT syndrome
    Peter J Schwartz
    Department of Cardiology, IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy
    Nat Clin Pract Cardiovasc Med 2:346-51. 2005
  3. ncbi The congenital long QT syndromes from genotype to phenotype: clinical implications
    Peter J Schwartz
    Department of Cardiology, IRCCS Policlinico S Matteo and University of Pavia, Pavia, Italy
    J Intern Med 259:39-47. 2006
  4. ncbi Cardiac potassium channel dysfunction in sudden infant death syndrome
    Troy E Rhodes
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    J Mol Cell Cardiol 44:571-81. 2008
  5. ncbi Ion channel diseases in children: manifestations and management
    Peter J Schwartz
    Department of Cardiology and Molecular Cardiology Laboratory, IRCCS Fondazione Policlinico S Matteo and University of Pavia, Pavia, Italy
    Curr Opin Cardiol 23:184-91. 2008
  6. ncbi How really rare are rare diseases?: the intriguing case of independent compound mutations in the long QT syndrome
    Peter J Schwartz
    Department of Cardiology, IRCCS Policlinico S Matteo, Pavia, Italy
    J Cardiovasc Electrophysiol 14:1120-1. 2003
  7. ncbi Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome
    Peter J Schwartz
    Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy
    Circulation 109:1826-33. 2004
  8. ncbi [New ways to become embroiled in a medico-legal suit. Encounters of the third type between cardiologists and lawyers in the era of guidelines and of molecular biology]
    Peter J Schwartz
    Dipartimento di Cardiologia, , Pavia
    Ital Heart J Suppl 5:215-7. 2004
  9. ncbi Stillbirths, sudden infant deaths, and long-QT syndrome: puzzle or mosaic, the pieces of the Jigsaw are being fitted together
    Peter J Schwartz
    Department of Cardiology, IRCCS Policlinico S. Matteo, V.le Golgi, 19 27100 Pavia, Italy
    Circulation 109:2930-2. 2004
  10. ncbi Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias
    P J Schwartz
    Department of Cardiology, Policlinico S Matteo IRCCS and University of Pavia, Pavia, Italy
    Circulation 103:89-95. 2001

Detail Information

Publications77

  1. ncbi The long QT syndrome: a clinical counterpart of hERG mutations
    Peter J Schwartz
    Department of Cardiology, University of Pavia and Policlinico S. Matteo IRCCS, V.le Golgi 19, 27100 Pavia, Italy
    Novartis Found Symp 266:186-98; discussion 198-203. 2005
    ..Presentation and discussion of the different phenotypes is followed by a number of still unanswered questions related to specific features of the LQT2 patients...
  2. ncbi Management of long QT syndrome
    Peter J Schwartz
    Department of Cardiology, IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy
    Nat Clin Pract Cardiovasc Med 2:346-51. 2005
    ..The data presented here illustrate how the treatment of LQTS is rapidly evolving toward a highly individually tailored approach on the basis of patient-specific genetic information...
  3. ncbi The congenital long QT syndromes from genotype to phenotype: clinical implications
    Peter J Schwartz
    Department of Cardiology, IRCCS Policlinico S Matteo and University of Pavia, Pavia, Italy
    J Intern Med 259:39-47. 2006
    ..The recent identification of modifier genes which amplify the effect of an LQTS mutation may change the approach to risk stratification...
  4. ncbi Cardiac potassium channel dysfunction in sudden infant death syndrome
    Troy E Rhodes
    Department of Medicine, Vanderbilt University, Nashville, TN, USA
    J Mol Cell Cardiol 44:571-81. 2008
    ....
  5. ncbi Ion channel diseases in children: manifestations and management
    Peter J Schwartz
    Department of Cardiology and Molecular Cardiology Laboratory, IRCCS Fondazione Policlinico S Matteo and University of Pavia, Pavia, Italy
    Curr Opin Cardiol 23:184-91. 2008
    ..Hence, there is a growing need to know more about the management of these complex and often lethal diseases. The present review addresses these practical issues...
  6. ncbi How really rare are rare diseases?: the intriguing case of independent compound mutations in the long QT syndrome
    Peter J Schwartz
    Department of Cardiology, IRCCS Policlinico S Matteo, Pavia, Italy
    J Cardiovasc Electrophysiol 14:1120-1. 2003
  7. ncbi Left cardiac sympathetic denervation in the management of high-risk patients affected by the long-QT syndrome
    Peter J Schwartz
    Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy
    Circulation 109:1826-33. 2004
    ..We assessed the long-term efficacy of left cardiac sympathetic denervation (LCSD) in a group of high-risk patients...
  8. ncbi [New ways to become embroiled in a medico-legal suit. Encounters of the third type between cardiologists and lawyers in the era of guidelines and of molecular biology]
    Peter J Schwartz
    Dipartimento di Cardiologia, , Pavia
    Ital Heart J Suppl 5:215-7. 2004
  9. ncbi Stillbirths, sudden infant deaths, and long-QT syndrome: puzzle or mosaic, the pieces of the Jigsaw are being fitted together
    Peter J Schwartz
    Department of Cardiology, IRCCS Policlinico S. Matteo, V.le Golgi, 19 27100 Pavia, Italy
    Circulation 109:2930-2. 2004
  10. ncbi Genotype-phenotype correlation in the long-QT syndrome: gene-specific triggers for life-threatening arrhythmias
    P J Schwartz
    Department of Cardiology, Policlinico S Matteo IRCCS and University of Pavia, Pavia, Italy
    Circulation 103:89-95. 2001
    ..Preliminary observations suggested that the conditions ("triggers") associated with cardiac events may in large part be gene specific...
  11. ncbi Pro: Newborn ECG screening to prevent sudden cardiac death
    Peter J Schwartz
    Department of Cardiology, IRCCS Fondazione Policlinico S. Matteo and University of Pavia, Pavia, Italy
    Heart Rhythm 3:1353-5. 2006
  12. ncbi A molecular link between the sudden infant death syndrome and the long-QT syndrome
    P J Schwartz
    Department of Cardiology, University of Pavia and Policlinico San Matteo Istituto di Ricovero e Cura a Carattere Scientifico, Italy
    N Engl J Med 343:262-7. 2000
  13. ncbi The Jervell and Lange-Nielsen syndrome: natural history, molecular basis, and clinical outcome
    Peter J Schwartz
    Department of Cardiology, University of Pavia, IRCCS Policlinico S Matteo, Pavia, Italy
    Circulation 113:783-90. 2006
    ....
  14. ncbi Gene symbol: SCN5A
    L Crotti
    Department of Cardiology, Policlinico San Matteo, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy
    Hum Genet 120:913. 2007
  15. ncbi Clinical and genetic heterogeneity of right bundle branch block and ST-segment elevation syndrome: A prospective evaluation of 52 families
    S G Priori
    Molecular Cardiology Laboratories, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy
    Circulation 102:2509-15. 2000
    ..As a consequence, aggressive management (implantable cardioverter defibrillator) is recommended for both groups...
  16. ncbi Gene symbol: KCNQ1
    L Crotti
    Department of Cardiology, Policlinico San Matteo, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy
    Hum Genet 120:912. 2007
  17. ncbi The elusive link between LQT3 and Brugada syndrome: the role of flecainide challenge
    S G Priori
    Department of Molecular Cardiology, Fondazione Salvatore Maugeri, IRCCS, Pavia, Italy
    Circulation 102:945-7. 2000
    ....
  18. ncbi Gene symbol: KCNH2
    L Crotti
    Department of Cardiology, Policlinico San Matteo, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy
    Hum Genet 120:912. 2007
  19. ncbi Gene symbol: SCN5A
    L Crotti
    Department of Cardiology, Policlinico San Matteo, University of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy
    Hum Genet 120:911-2. 2007
  20. ncbi [Long QT syndrome and Brugada syndrome: 2 aspects of the same disease?]
    M Cerrone
    Dipartimento di Cardiologia, IRCCS Policlinico San Matteo, Pavia
    Ital Heart J Suppl 2:253-7. 2001
    ..Only deepened understanding of the genotype-phenotype correlation will allow the definition of the individual patient's risk and the development of guidelines for clinical management...
  21. ncbi A molecular basis for the therapy of the long QT syndrome
    S G Priori
    Dipartimento di Cardiologia, Facolta di Medicina e Chirurgla, , Policlinico San Matteo IRCCS, Italy
    Arch Mal Coeur Vaiss 89:1185-7. 1996
    ..Conversely, LQT2 patients are at higher risk to develop syncope under stressful conditions, because of the combined arrhythmogenic effect of cathecolamines with the insufficient adaptation of their QT interval when heart rate increases...
  22. ncbi Significance of QT dispersion in the long QT syndrome
    C Napolitano
    Molecular Cardiology Laboratories Fondazione Salvatore Maugeri, IRCCS, Pavia, Italy
    Prog Cardiovasc Dis 42:345-50. 2000
    ....
  23. ncbi Low penetrance in the long-QT syndrome: clinical impact
    S G Priori
    Molecular Cardiology and Electrophysiology Laboratory, Fondazione Salvatore Maugeri IRCCS, Pavia, Italy
    Circulation 99:529-33. 1999
    ..We had previously suggested that a larger-than-anticipated number of LQTS patients might be affected without showing clinical signs. We have now exploited the availability of molecular diagnosis to test this hypothesis...
  24. ncbi Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
    S G Priori
    Molecular Cardiology and Electrophysiology Laboratory, Fondazione S Maugeri, IRCCS, Pavia, Italy
    Circulation 99:518-28. 1999
    ....
  25. ncbi Guidelines for the interpretation of the neonatal electrocardiogram. A task force of the European Society of Cardiology
    P J Schwartz
    Department of Cardiology, University of Pavia and IRCCS Policlinico S Matteo, Italy
    Eur Heart J 23:1329-44. 2002
  26. ncbi Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials
    M T La Rovere
    Centro Medico di Montescano, Fondazione Salvatore Maugeri IRCCS, Pavia, Italy
    Circulation 103:2072-7. 2001
    ....
  27. ncbi Gene symbol: KCNH2
    L Crotti
    Department of Cardiology, Policlinico San Matteo, Univeristy of Pavia, Piazzale Golgi 19, 27100 Pavia, Italy
    Hum Genet 120:911. 2007
  28. ncbi Silent myocardial ischemia in diabetic and nondiabetic patients with coronary artery disease
    C Falcone
    Department of Cardiology, IRCCS San Matteo Hospital, University of Pavia, Piazzale Golgi 2, 27100 Pavia, Italy
    Int J Cardiol 90:219-27. 2003
    ..The aim of the present study was to evaluate the prevalence of silent ischemia in diabetic and nondiabetic patients with assessed CAD...
  29. ncbi Task Force on Sudden Cardiac Death, European Society of Cardiology
    S G Priori
    Task Force on Sudden Cardiac Death of the European Society of Cardiology, Fondazione Salvatore Maugeri, University of Pavia, Italy
    Europace 4:3-18. 2002
    ....
  30. ncbi Does pregnancy increase cardiac risk for LQT1 patients with the KCNQ1-A341V mutation?
    Marshall J Heradien
    Department of Internal Medicine, University of Stellenbosch, Stellenbosch, South Africa
    J Am Coll Cardiol 48:1410-5. 2006
    ..The purpose of this study was to assess the pregnancy-related cardiovascular risk in LQT1 patients...
  31. ncbi Cardiac sodium channel dysfunction in sudden infant death syndrome
    Dao W Wang
    Departments of Pharmacology, Vanderbilt University, Nashville, Tenn, USA
    Circulation 115:368-76. 2007
    ..We present functional characterization of 7 missense variants (S216L, R680H, T1304M, F1486L, V1951L, F2004L, and P2006A) and 1 in-frame deletion allele (delAL586-587) identified by these efforts...
  32. ncbi Can a message from the dead save lives?
    Peter J Schwartz
    J Am Coll Cardiol 49:247-9. 2007
  33. ncbi Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
    ....
  34. ncbi Genetic testing in the long QT syndrome: development and validation of an efficient approach to genotyping in clinical practice
    Carlo Napolitano
    Molecular Cardiology, IRCCS Fondazione S Maugeri Foundation, Pavia, Italy
    JAMA 294:2975-80. 2005
    ..In long QT syndrome (LQTS), disease severity and response to therapy vary according to the genetic loci. There exists a critical need to devise strategies to expedite genetic analysis...
  35. ncbi Prevalence of long-QT syndrome gene variants in sudden infant death syndrome
    Marianne Arnestad
    Institute of Forensic Medicine, University of Oslo, Oslo, Norway
    Circulation 115:361-7. 2007
    ..Given the importance and potential implications of these observations, we performed a study to more accurately quantify the contribution to SIDS of LQTS gene mutations and rare variants...
  36. ncbi Long-QT syndrome after age 40
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2192-201. 2008
    ....
  37. ncbi Neural control of heart rate is an arrhythmia risk modifier in long QT syndrome
    Peter J Schwartz
    Section of Cardiology, Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy
    J Am Coll Cardiol 51:920-9. 2008
    ....
  38. ncbi Two cases of sudden unexpected death in epilepsy in a GEFS+ family with an SCN1A mutation
    Neeti Hindocha
    Epilepsia 49:360-5. 2008
  39. ncbi The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome
    Naomasa Makita
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Clin Invest 118:2219-29. 2008
    ....
  40. ncbi Left cardiac sympathetic denervation for catecholaminergic polymorphic ventricular tachycardia
    Arthur A M Wilde
    University of Amsterdam, Amsterdam
    N Engl J Med 358:2024-9. 2008
    ....
  41. ncbi Risk of death in the long QT syndrome when a sibling has died
    Elizabeth S Kaufman
    Heart and Vascular Research Center, MetroHealth Campus, Case Western Reserve University, Cleveland, Ohio, USA
    Heart Rhythm 5:831-6. 2008
    ..Sudden death of a sibling is thought to be associated with greater risk of death in long QT syndrome (LQTS). However, there is no evidence of such an association...
  42. ncbi Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2184-91. 2008
    ..However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified...
  43. ncbi Congenital long QT syndrome
    Lia Crotti
    Section of Cardiology, Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy
    Orphanet J Rare Dis 3:18. 2008
    ....
  44. ncbi Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists
    Princy Thottathil
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 102:871-4. 2008
    ..14, p = 0.05). In conclusion, beta(2)-agonist therapy was associated with an increased risk for cardiac events in patients with asthma with LQTS, and this risk was diminished in patients receiving beta blockers...
  45. ncbi Long QT syndrome and pregnancy
    Rahul Seth
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 49:1092-8. 2007
    ..This study was designed to investigate the clinical course of women with long QT syndrome (LQTS) throughout their potential childbearing years...
  46. ncbi Phenotypic variability and unusual clinical severity of congenital long-QT syndrome in a founder population
    Paul A Brink
    Department of Internal Medicine, University of Stellenbosch, South Africa
    Circulation 112:2602-10. 2005
    ..We are investigating one such founder effect, originating in South Africa in approximately ad 1700 and segregating the same KCNQ1 mutation (A341V)...
  47. ncbi Modulating effects of age and gender on the clinical course of long QT syndrome by genotype
    Wojciech Zareba
    Department of Medicine, Heart Research Follow Up Program, Medical Center, University of Rochester School of Medicine, Rochester, NY 14642 8653, USA
    J Am Coll Cardiol 42:103-9. 2003
    ..We aimed to determine whether long QT syndrome (LQTS) genotype has a differential effect on clinical course of disease in male and female children and adults after adjustment for QTc duration...
  48. ncbi Risk stratification in the long-QT syndrome
    Silvia G Priori
    Department of Molecular Cardiology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione S Maugeri, University of Pavia, Pavia, Italy
    N Engl J Med 348:1866-74. 2003
    ..We stratified risk according to the genotype, in conjunction with other clinical variables such as sex and the length of the QT interval...
  49. ncbi The efficacy of azimilide in the treatment of atrial fibrillation in the presence of left ventricular systolic dysfunction: results from the Azimilide Postinfarct Survival Evaluation (ALIVE) trial
    Craig M Pratt
    The Methodist DeBakey Heart Center and Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Am Coll Cardiol 43:1211-6. 2004
    ....
  50. ncbi Cost-effectiveness of neonatal ECG screening for the long QT syndrome
    Silvana Quaglini
    Department of Computer Science and Systems, University of Pavia, Italy
    Eur Heart J 27:1824-32. 2006
    ..Appropriate therapy will prevent unnecessary deaths in infants, children, and young adults...
  51. ncbi Prevalent low-frequency oscillation of heart rate: novel predictor of mortality after myocardial infarction
    Dan Wichterle
    Department of Cardiological Sciences, St George's Hospital Medical School, London, UK
    Circulation 110:1183-90. 2004
    ..02), respectively. CONCLUSIONS: An innovative analysis of frequency-domain HRV, which characterizes the distribution of spectral power within the low-frequency band, is a potent and independent risk stratifier in postinfarction patients...
  52. ncbi Counting heart beats: a peephole into prediction of sudden and nonsudden cardiac death
    Maria Teresa La Rovere
    J Cardiovasc Electrophysiol 14:174-5. 2003
  53. ncbi Association of long QT syndrome loci and cardiac events among patients treated with beta-blockers
    Silvia G Priori
    Molecular Cardiology, IRCCS Fondazione Maugeri, University of Pavia, Pavia, Italy
    JAMA 292:1341-4. 2004
    ..Data on the efficacy of beta-blockers in the 3 most common genetic long QT syndrome (LQTS) loci are limited...
  54. ncbi Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism
    Igor Splawski
    Department of Cardiology, Children s Hospital, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115, USA
    Cell 119:19-31. 2004
    ..These discoveries establish the importance of Ca(V)1.2 in human physiology and development and implicate Ca(2+) signaling in autism...
  55. ncbi 25th anniversary of the International Long-QT Syndrome Registry: an ongoing quest to uncover the secrets of long-QT syndrome
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 111:1199-201. 2005
  56. ncbi Increased risk of arrhythmic events in long-QT syndrome with mutations in the pore region of the human ether-a-go-go-related gene potassium channel
    Arthur J Moss
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 105:794-9. 2002
    ..We investigated the clinical features and prognostic implications of mutations involving pore and nonpore regions of the HERG channel in the LQT2 form of this disorder...
  57. ncbi KCNH2-K897T is a genetic modifier of latent congenital long-QT syndrome
    Lia Crotti
    Department of Cardiology, University of Pavia, IRCCS Policlinico S. Matteo, Pavia, Italy
    Circulation 112:1251-8. 2005
    ..CONCLUSIONS: We have provided evidence that a common KCNH2 polymorphism may modify the clinical expression of a latent LQT2 mutation. A similar mechanism may contribute to the risk for sudden death in more prevalent cardiac diseases...
  58. ncbi Allelic variants in long-QT disease genes in patients with drug-associated torsades de pointes
    Ping Yang
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tenn 37232, USA
    Circulation 105:1943-8. 2002
    ..We have previously identified functionally important DNA variants in genes encoding K+ channel ancillary subunits in 11% of an aLQTS cohort...
  59. ncbi Electrocardiographic features in Andersen-Tawil syndrome patients with KCNJ2 mutations: characteristic T-U-wave patterns predict the KCNJ2 genotype
    Li Zhang
    LDS Hospital, 324 10th Ave, Suite 130, Salt Lake City, Utah 84103, USA
    Circulation 111:2720-6. 2005
    ..The normal QTc, distinct ECG, and other clinical features distinguish ATS1 from long-QT syndrome, and it is best designated as ATS1 rather than LQT7...
  60. ncbi Location of mutation in the KCNQ1 and phenotypic presentation of long QT syndrome
    Wojciech Zareba
    Cardiology Unit of the Department of Medicine, Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 14:1149-53. 2003
    ..The aim of this study was to determine whether there is an association between the location of mutations in the KCNQ1 gene and cardiac events in LQT1 patients...
  61. ncbi Combined sodium and calcium channel blockade in prevention of lethal arrhythmias
    Philip B Adamson
    Department of Physiology, Cardiovascular Diseases Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    J Cardiovasc Pharmacol 41:665-70. 2003
    ..The combination of I(Na) and I(Ca(L)) channel blockade coupled with partial beta-adrenergic blockade was equally effective in preventing VF as propranolol...
  62. ncbi Favourable effects of heart rate reduction with intravenous administration of ivabradine in patients with advanced heart failure
    Gaetano M De Ferrari
    Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    Eur J Heart Fail 10:550-5. 2008
    ..Heart rate (HR) reduction may be useful in treatment of patients with heart failure (HF). There are no data on the haemodynamic effects of ivabradine (a selective I(f) current inhibitor) in advanced HF patients...
  63. ncbi Report from the Task Force of the European Society of Cardiology for the interpretation of the neonatal electrocardiogram
    Peter J Schwartz
    Cardiol Young 12:592-608. 2002
  64. ncbi Exercise-induced increase in baroreflex sensitivity predicts improved prognosis after myocardial infarction
    Maria Teresa La Rovere
    Centro Medico di Montescano, Fondazione Salvatore Maugeri IRCCS, Montescano, Pavia, Italy
    Circulation 106:945-9. 2002
    ..04). CONCLUSIONS: Post-MI exercise training can favorably modify long-term survival, provided that it is associated with a clear shift of the autonomic balance toward an increase in vagal activity...
  65. ncbi Heterogeneous regional endocardial repolarization is associated with increased risk for ischemia-dependent ventricular fibrillation after myocardial infarction
    Michael H Swann
    Physiology and Medicine Cardiology Cardiac Arrhythmia Research Institute WK Warren Medical Research Institute, Oklahoma University Health Sciences Center, Oklahoma City, Oklahoma 73190, USA
    J Cardiovasc Electrophysiol 14:873-9. 2003
    ....
  66. ncbi Prediction of unexpected sudden death among healthy dogs by a novel marker of autonomic neural activity
    Emilio Vanoli
    Section of Cardiology, Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy
    Heart Rhythm 5:300-5. 2008
    ..We have previously shown that autonomic modulation of cardiac arrhythmias and autonomic markers, such as baroreflex sensitivity (BRS) and heart rate variability (HRV), carry predictive power after myocardial infarction...
  67. ncbi Baroreflex sensitivity predicts long-term cardiovascular mortality after myocardial infarction even in patients with preserved left ventricular function
    Gaetano M De Ferrari
    Department of Cardiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
    J Am Coll Cardiol 50:2285-90. 2007
    ..This study sought to assess the long-term predictive power of depressed baroreflex sensitivity (BRS) among post-myocardial infarction (MI) patients with preserved left ventricular function...
  68. ncbi Rapid heart rate increase at onset of exercise predicts adverse cardiac events in patients with coronary artery disease
    Colomba Falcone
    Department of Lung, Blood, and Heart, University of Pavia, Pavia, Italy
    Circulation 112:1959-64. 2005
    ....
  69. ncbi Atrial fibrillation requiring urgent medical care. Approach and outcome in the various departments of admission. Data from the atrial Fibrillation/flutter Italian REgistry (FIRE)
    Massimo Santini
    Department of Cardiology, San Filippo Neri Hospital, Rome, Italy
    Ital Heart J 5:205-13. 2004
    ..One out of three discharged patients is not in sinus rhythm. There is still a wide gap between evidence-based medicine and real practice in the treatment of patients with AF...
  70. ncbi Cumulative experience of azimilide-associated torsades de pointes ventricular tachycardia in the 19 clinical studies comprising the azimilide database
    Craig M Pratt
    Department of Cardiology, Methodist DeBakey Heart Center, Houston, Texas 77030, USA
    J Am Coll Cardiol 48:471-7. 2006
    ..The purpose of this study was to assess the incidence, temporal characteristics, and risk factors associated with azimilide-associated torsades de pointes (TdP) ventricular tachycardia...
  71. ncbi Heart-rate profile during exercise as a predictor of sudden death
    Xavier Jouven
    Service de cardiologie, Faculté René Descartes, Universite Paris 5, Hopital Europeen Georges Pompidou, Paris, France
    N Engl J Med 352:1951-8. 2005
    ....
  72. ncbi Mortality due to sudden infant death syndrome in Northern Italy, 1990-2000: a baseline for the assessment of prevention campaigns
    Cristina Montomoli
    University of Pavia, Department of Health Sciences, Section of Medical Statistics and Epidemiology, Pavia, Italy
    Paediatr Perinat Epidemiol 18:336-43. 2004
    ..54 per 1000 live births. The incidence of SIDS in Northern Italy appears much lower than anticipated. SIDS remains the single leading cause of death in the first year of life after the early neonatal period...
  73. ncbi [Infant mortality and sudden crib death in Lombardy]
    Maria Cristina Monti
    Dipartimento di Scienze Sanitarie Applicate e Psicocomportamentali, Cattedra di cardiologia Università di Pavia, Dipartimento di Cardiologia, IRCCS Policlinico San Matteo, Pavia
    Epidemiol Prev 28:13-9. 2004
    ..To estimate the infant mortality rate and the incidence of Sudden Infant Death Syndrome (SIDS) which is not known in Italy...
  74. ncbi Mortality in patients after a recent myocardial infarction: a randomized, placebo-controlled trial of azimilide using heart rate variability for risk stratification
    A John Camm
    Department of Cardiology, St George s Hospital, London, UK
    Circulation 109:990-6. 2004
    ..Azimilide, a novel class III antiarrhythmic drug, was investigated for its effects on mortality in patients with depressed LVF after recent MI and in a subpopulation of patients with low HRV...
  75. ncbi Cardiac arrhythmias of genetic origin are important contributors to sudden infant death syndrome
    Peter J Schwartz
    Heart Rhythm 4:740-2. 2007
  76. ncbi The common long-QT syndrome mutation KCNQ1/A341V causes unusually severe clinical manifestations in patients with different ethnic backgrounds: toward a mutation-specific risk stratification
    Lia Crotti
    Section of Cardiology, Department of Lung, Blood and Heart, University of Pavia, Pavia, Italy
    Circulation 116:2366-75. 2007
    ..We tested whether the arrhythmic risk was caused directly by A341V or by its presence in the specific ethnic setting of the SA families...
  77. ncbi Heart rate turbulence-based predictors of fatal and nonfatal cardiac arrest (The Autonomic Tone and Reflexes After Myocardial Infarction substudy)
    Azad Ghuran
    Department of Cardiological and Public Health Sciences, St. George's Hospital Medical School, London, United Kingdom
    Am J Cardiol 89:184-90. 2002
    ..By combining HR turbulence, BRS, and SDNN, a comprehensive assessment of cardiac autonomic reflexes and modulation can be obtained...