Research Topics
| Geert MayerSummaryAffiliation: Hephata Klinik Country: Schwalmstadt-Treysa Publications
| Collaborators
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Detail Information
Publications
Narcolepsy increased L-PGDS (beta-trace) levels correlate with excessive daytime sleepiness but not with cataplexyWolfgang Jordan
Dept of Psychiatry and Psychotherapy, Georg August University of Gottingen, von Sieboldstr 5, 37075 Gottingen, Germany
J Neurol 252:1372-8. 2005..The recently demonstrated involvement of the leptomeningeal lipocalin-type prostaglandin-Dsynthase (L-PGDS) (beta-trace) in human physiological sleep encouraged us to investigate its role in the pathophysiology of narcolepsy...
Efficacy and safety of 6-month nightly ramelteon administration in adults with chronic primary insomniaGeert Mayer
Hephata Klinik, Schwalmstadt, Germany
Sleep 32:351-60. 2009..Long-duration (> or = 6 months) polysomnographic studies of insomnia medications are lacking. This study evaluated the long-term efficacy of ramelteon, a selective MT1/MT2 melatonin-receptor agonist used for insomnia treatment...
The use of sodium oxybate to treat narcolepsyGeert Mayer
Hephata Klinik, Schimmelpfengstr 2, 34613 Schwalmstadt Treysa, Germany
Expert Rev Neurother 12:519-29. 2012..This article gives an overview of sodium oxybate, which has been US FDA approved for the treatment of cataplexy and excessive daytime sleepiness in patients with narcolepsy, and EMA approved for the treatment of narcolepsy-cataplexy...- Quantification of tonic and phasic muscle activity in REM sleep behavior disorderGeert Mayer
Department of Neurology, Hephata Klinik, Schwalmstadt Treysa, Germany
J Clin Neurophysiol 25:48-55. 2008.... - Sleep related rhythmic movement disorder revisitedGeert Mayer
Hephata Klinik, Department of Neurology, Schwalmstadt, Germany
J Sleep Res 16:110-6. 2007..In the adult patients it is not associated with mental pathologies and can be triggered by sleep apnea... - Insomnia in central neurologic diseases--occurrence and managementGeert Mayer
Hephata Klinik, Schwalmstadt Treysa, Germany
Sleep Med Rev 15:369-78. 2011.... - [The neurophysiology of cataplexy]G Mayer
Hephata Klinik, Schwalmstadt Treysa
Nervenarzt 76:1464, 1466-9. 2005..An understanding of the neuronal mechanisms responsible for cataplexies is essential for the development of new anticataplectic medications... - [Frequently occurring sleep disorders]G Mayer
Hephata Klinik Schwalmstadt Treysa, Schwalmstadt Treysa, Germany
Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54:1284-95. 2011..The levels of evidence were given according to the recommendations of the Oxford Centre for Evidence-based Medicine... - [Effect of the new drug provisions on the drug treatment of narcolepsy]G Mayer
Hephata Klinik, Schwalmstadt-Treysa
Dtsch Med Wochenschr 129:1198-201. 2004 - Ritanserin improves sleep quality in narcolepsyG Mayer
Hephata Klinik, Schwalmstadt Treysa, Germany
Pharmacopsychiatry 36:150-5. 2003..In conclusion, ritanserin may serve as add-on medication for the treatment of impaired sleep quality in narcoleptic patients, but not as a stimulant or hypnotic type of medication... - Health-related quality of life in patients with narcolepsyRichard Dodel
Department of Neurology, Philipps University, Marburg, Germany
Sleep Med 8:733-41. 2007..To evaluate the health-related quality of life (HRQoL) in patients suffering from narcolepsy... - Patients with idiopathic rapid-eye-movement sleep behavior disorder show normal gastric motility assessed by the 13C-octanoate breath testMarcus M Unger
Department of Neurology, Philipps University Marburg, Marburg, Germany
Mov Disord 26:2559-63. 2011..Few data exist on gastric emptying in early-stage Parkinson's disease. In idiopathic rapid-eye-movement sleep behavior disorder, a presumable pre-motor stage of Parkinson's disease, gastric emptying has not yet been investigated... - Postprandial ghrelin response is reduced in patients with Parkinson's disease and idiopathic REM sleep behaviour disorder: a peripheral biomarker for early Parkinson's disease?Marcus M Unger
Department of Neurology, Philipps Universitat Marburg, Rudolf Bultmann Strasse 8, 35033, Marburg, Germany
J Neurol 258:982-90. 2011..The impaired ghrelin excretion might qualify as a peripheral biomarker and be of diagnostic or therapeutic value... - Diffusion tensor imaging in idiopathic REM sleep behavior disorder reveals microstructural changes in the brainstem, substantia nigra, olfactory region, and other brain regionsMarcus M Unger
Department of Neurology, Philipps Universitat Marburg, Marburg, Germany
Sleep 33:767-73. 2010.... - Transcranial midbrain sonography in narcoleptic subjects with and without concomitant REM sleep behaviour disorderMarcus M Unger
Department of Neurology, Philipps Universitat Marburg, Rudolf Bultmann Str 8, 35039, Marburg, Germany
J Neurol 256:874-7. 2009..Reduced echogenicity of the brainstem raphe might indicate an involvement of the serotonergic system in narcoleptic subjects with RBD... - Unimpaired postprandial pancreatic polypeptide secretion in Parkinson's disease and REM sleep behavior disorderMarcus M Unger
Philipps University Marburg, Department of Neurology, Marburg, Germany Saarland University, Department of Neurology, Homburg, Germany
Mov Disord 28:529-33. 2013..The release is operated by vagal-abdominal projections and has therefore been suggested as a test for vagal nerve integrity. Pathoanatomical and clinical studies indicate vagal dysfunction in early Parkinson's disease (PD)... - Health economic burden of patients with restless legs syndrome in a German ambulatory settingRichard Dodel
Department of Neurology, Philipps University Marburg, Marburg, Germany
Pharmacoeconomics 28:381-93. 2010..RLS places a notable financial burden on society as well as on patients and their families. More detailed studies are needed to evaluate the health economic impact of this disorder... - The REM sleep behavior disorder screening questionnaire--a new diagnostic instrumentKarin Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University, Marburg, Germany
Mov Disord 22:2386-93. 2007..02 +/- 1.78) was significantly lower than in the RBD group (P < 0.0005), revealing a specificity of 0.92. Due to its high sensitivity, the RBDSQ appears to be particularly useful as a screening tool... - Assessment of idiopathic rapid-eye-movement sleep behavior disorder by transcranial sonography, olfactory function test, and FP-CIT-SPECTMarcus M Unger
Department of Neurology, Philipps Universitat Marburg, Germany
Mov Disord 23:596-9. 2008..Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD... - [Comorbidity in narcoleptic patients]G Mayer
Hephata Klinik, Schwalmstadt Treysa
Dtsch Med Wochenschr 127:1942-6. 2002..Narcolepsy is a rare disease which remains undiagnosed in 90 %. The international literature so far has paid little attention to comorbid disorders... - [Differential diagnosis of seizures in sleep]G Mayer
Hephata Klinik, Schwalmstadt-Treysa
Pneumologie 51:698-705. 1997..EEG recordings with at least 16 channels and EMGs from several muscles are necessary for differential diagnosis. Video-documentation often reveals relevant additional information confirming the diagnosis... - The socioeconomic impact of narcolepsyRichard Dodel
Department of Neurology, Friedrich Wilhelms University Bonn, Germany
Sleep 27:1123-8. 2004..To evaluate the economic burden of patients suffering from narcolepsy... - Combination of 'idiopathic' REM sleep behaviour disorder and olfactory dysfunction as possible indicator for alpha-synucleinopathy demonstrated by dopamine transporter FP-CIT-SPECTK Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University of Marburg, Germany
Brain 128:126-37. 2005..Since narcoleptic patients are not known to have an increased risk of developing parkinsonism, the pathophysiology and clinical relevance of hyposmia in RBD/narcolepsy patients requires further research... - From bench to bed: putative animal models of REM sleep behavior disorder (RBD)Martina Krenzer
Department of Neurology, Philipps Universitat Marburg, Marburg, Germany
J Neural Transm 120:683-8. 2013..In order to elucidate these questions, a constant interaction between basic and clinical researchers is required, which might, ultimately, create an early therapeutic window for neurodegenerative disorders... - One year open-label safety and efficacy trial with rotigotine transdermal patch in moderate to severe idiopathic restless legs syndromeWolfgang H Oertel
Department of Neurology, Philipps Universitat, Marburg, Germany
Sleep Med 9:865-73. 2008..Long-term efficacy and tolerability data are not yet available for patch formulations of dopamine agonists in restless legs syndrome... - Efficacy of rotigotine transdermal system in severe restless legs syndrome: a randomized, double-blind, placebo-controlled, six-week dose-finding trial in EuropeWolfgang H Oertel
Department of Neurology, Philipps University, Rudolf Bultmann Strasse 8, D 35039 Marburg, Germany
Sleep Med 9:228-39. 2008..In a pilot placebo-controlled study, low dosages of 0.5-2mg/24h rotigotine showed a dose-dependent beneficial effect in restless legs syndrome (RLS) patients... - Olfactory dysfunction in patients with narcolepsy with and without REM sleep behaviour disorderK Stiasny-Kolster
Department of Neurology, Center of Nervous Diseases, Philipps University of Marburg, Schwalmstadt Treysa, Germany
Brain 130:442-9. 2007..In contrast to patients with idiopathic RBD, hyposmia in patients with RBD associated with narcolepsy is unlikely to be a predictor for developing parkinsonism... - Attention deficits in patients with narcolepsyMartina Rieger
Max Planck Institute for Psychological Research, Munich
Sleep 26:36-43. 2003..Therefore, we conducted a systematic investigation of different aspects of attention and verbal memory in patients with narcolepsy...