Hendrik Schulze-Koops

Summary

Publications

  1. pmc The role of the T cell in autoimmune inflammation
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 7:S4-14. 2005
  2. ncbi request reprint Generation and regulation of human Th1-biased immune responses in vivo: a critical role for IL-4 and IL-10
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 172:6427-34. 2004
  3. ncbi request reprint The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells
    Francis Dodeller
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 35:3631-42. 2005
  4. pmc GATA-3 in human T cell helper type 2 development
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, 91054, Germany
    J Exp Med 199:423-8. 2004
  5. ncbi request reprint The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Erlangen, Germany
    J Immunol 175:6107-16. 2005
  6. ncbi request reprint Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis
    Iryna Prots
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Germany
    Arthritis Rheum 54:1491-500. 2006
  7. ncbi request reprint Regulation of myeloid cell function and major histocompatibility complex class II expression by tumor necrosis factor
    Ruediger B Mueller
    Nikolaus Fiebiger Center for Molecular Medicine and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 52:451-60. 2005
  8. ncbi request reprint Analysis of Th1/Th2 T-cell subsets
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Erlangen, Germany
    Methods Mol Med 136:87-96. 2007
  9. pmc Regulatory T cells in rheumatoid arthritis
    Jan Leipe
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 7:93. 2005
  10. pmc IFNGR1 single nucleotide polymorphisms in rheumatoid arthritis
    Stefan Mattyasovszky
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen, Germany
    Arthritis Res Ther 8:R63. 2006

Collaborators

Detail Information

Publications18

  1. pmc The role of the T cell in autoimmune inflammation
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 7:S4-14. 2005
    ..Here, we review the functional abnormalities and the contribution of different T cell subsets to rheumatoid inflammation...
  2. ncbi request reprint Generation and regulation of human Th1-biased immune responses in vivo: a critical role for IL-4 and IL-10
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 172:6427-34. 2004
    ..The results suggest that both IL-4 and IL-10 contribute to controlling the development of a human Th1-biased immune reaction...
  3. ncbi request reprint The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells
    Francis Dodeller
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Erlangen, Germany
    Eur J Immunol 35:3631-42. 2005
    ..Together, the data suggest that p38 plays a key role in human Th2 cell immune responses...
  4. pmc GATA-3 in human T cell helper type 2 development
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, 91054, Germany
    J Exp Med 199:423-8. 2004
    ..Taken together, the data strongly suggest that GATA-3 is an important transcription factor in regulating human Th2 cell differentiation in vivo...
  5. ncbi request reprint The IL-4 receptor alpha-chain-binding cytokines, IL-4 and IL-13, induce forkhead box P3-expressing CD25+CD4+ regulatory T cells from CD25-CD4+ precursors
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Erlangen, Germany
    J Immunol 175:6107-16. 2005
    ..Moreover, our findings might provide the basis for the design of novel therapeutic approaches for targeted immunotherapy with Tregs to known Ags in autoimmune diseases or graft-vs-host reactions...
  6. ncbi request reprint Association of the IL4R single-nucleotide polymorphism I50V with rapidly erosive rheumatoid arthritis
    Iryna Prots
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Germany
    Arthritis Rheum 54:1491-500. 2006
    ..To examine whether single-nucleotide polymorphisms (SNPs) of the interleukin-4 receptor gene IL4R influence susceptibility to, or radiographic progression in, rheumatoid arthritis (RA)...
  7. ncbi request reprint Regulation of myeloid cell function and major histocompatibility complex class II expression by tumor necrosis factor
    Ruediger B Mueller
    Nikolaus Fiebiger Center for Molecular Medicine and Institute for Clinical Immunology, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 52:451-60. 2005
    ..We undertook this study to analyze the effect of TNF and its neutralization on the expression of major histocompatibility complex class II molecules and on the function of antigen-presenting myeloid cells in rheumatoid arthritis (RA)...
  8. ncbi request reprint Analysis of Th1/Th2 T-cell subsets
    Alla Skapenko
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Erlangen, Germany
    Methods Mol Med 136:87-96. 2007
    ..Here, we briefly discuss the advantages and disadvantages of these methods and describe in detail a standard protocol for the analysis of human Th subsets by means of detection of cytoplasmic cytokines by flow cytometry...
  9. pmc Regulatory T cells in rheumatoid arthritis
    Jan Leipe
    Nikolaus Fiebiger Center for Molecular Medicine, University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Res Ther 7:93. 2005
    ..Here we review existing knowledge of CD4+CD25+ T cells and discuss their role in the pathogenesis of rheumatic diseases...
  10. pmc IFNGR1 single nucleotide polymorphisms in rheumatoid arthritis
    Stefan Mattyasovszky
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen, Germany
    Arthritis Res Ther 8:R63. 2006
    ..Surprisingly, however, neither position was polymorphic in the 364 individuals examined, indicating that IFNGR1 does not contribute to susceptibility to rheumatoid arthritis, at least in Caucasians...
  11. ncbi request reprint Treg cells suppress osteoclast formation: a new link between the immune system and bone
    Mario M Zaiss
    Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen Nuremberg, Krankenhausstrasse 12, Erlangen, Germany
    Arthritis Rheum 56:4104-12. 2007
    ..To investigate whether Treg cells can suppress osteoclast differentiation, and to define a new potential link between the immune system and the skeleton...
  12. doi request reprint Remission of demyelinating polyneuropathy with immunoadsorption, low dose corticosteroids and anti-CD20 monoclonal antibody
    Jürgen Rech
    Medical Department III, University of Erlangen Nuremberg, Erlangen, Germany
    Ther Apher Dial 12:205-8. 2008
    ..Immunoadsorption in combination with a monoclonal anti-CD20 antibody in patients with demyelinating polyneuropathy with anti-MAG is effective and can be used an alternative treatment option in patients with progressive disease...
  13. pmc The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells
    Francis Dodeller
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, and Department of Internal Medicine III, University of Erlangen Nuremberg, Glueckstrasse 6, 91054 Erlangen, Germany
    Arthritis Res Ther 8:205. 2006
    ..These new data suggest that p38 MAPK inhibitors may elicit several unwanted effects in human autoimmune diseases but may be useful for the treatment of allergic disorders...
  14. ncbi request reprint Lack of genetic association of the interleukin-4 receptor single-nucleotide polymorphisms I50V and Q551R with erosive disease in psoriatic arthritis
    Jesus Lascorz
    University of Erlangen Nuremberg, Erlangen, Germany
    Arthritis Rheum 54:4023-4. 2006
  15. ncbi request reprint Induction of cyclooxygenase-2 and enhanced release of prostaglandin E(2) and I(2) in human endothelial cells by engagement of CD40
    Christoph D Garlichs
    Medical Clinic II, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Atherosclerosis 163:9-16. 2002
    ..The hypothesis was tested that CD40-CD154 interaction is involved in the induction of cyclooxygenase-2 and the release of prostanoids in human endothelial cells...
  16. ncbi request reprint Restriction of de novo pyrimidine biosynthesis inhibits Th1 cell activation and promotes Th2 cell differentiation
    Petya Dimitrova
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 169:3392-9. 2002
    ..Moreover, the results further suggest that differentiation of CD4 T cells can be regulated at the level of nucleotide biosynthesis...
  17. pmc Immature and maturation-resistant human dendritic cells generated from bone marrow require two stimulations to induce T cell anergy in vitro
    Thomas G Berger
    Department of Dermatology, University Hospital Erlangen, Erlangen, Germany
    PLoS ONE 4:e6645. 2009
    ..Together, we show the generation of immature, maturation-resistant lowGM-DC for potential clinical use in transplant rejection and propose a two-step-model of T cell anergy induction by immature DC...
  18. pmc Lymphopenia and autoimmune diseases
    Hendrik Schulze-Koops
    Nikolaus Fiebiger Center for Molecular Medicine, Clinical Research Group III, Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen Nuremberg, Germany
    Arthritis Res Ther 6:178-80. 2004