U Schonbeck

Summary

Publications

  1. ncbi request reprint The CD40/CD154 receptor/ligand dyad
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 58:4-43. 2001
  2. ncbi request reprint Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis
    K Shimizu
    Departments ofMedicine and Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 165:3506-18. 2000
  3. ncbi request reprint Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    F Mach
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 394:200-3. 1998
  4. pmc Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
    U Schonbeck
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 309, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:7458-63. 2000
  5. ncbi request reprint CD154 (CD40 ligand)
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Int J Biochem Cell Biol 32:687-93. 2000
  6. ncbi request reprint CD40 signaling and plaque instability
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:1092-103. 2001
  7. pmc The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
    J L Young
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1535-44. 2000
  8. pmc Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis
    F Mach
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:1931-6. 1997
  9. ncbi request reprint Ligation of CD40 onvascular smooth muscle cells mediates loss of interstitial collagen via matrix metalloproteinase activity
    D B Horton
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann N Y Acad Sci 947:329-36. 2001
  10. ncbi request reprint Soluble CD40L and cardiovascular risk in women
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circulation 104:2266-8. 2001

Collaborators

Detail Information

Publications10

  1. ncbi request reprint The CD40/CD154 receptor/ligand dyad
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Cell Mol Life Sci 58:4-43. 2001
    ....
  2. ncbi request reprint Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis
    K Shimizu
    Departments ofMedicine and Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 165:3506-18. 2000
    ..Therefore, we propose that early alloresponses, without CD40-CD40L costimulation, induce allospecific tolerance but may trigger allo-independent mechanisms that ultimately result in graft vasculopathy...
  3. ncbi request reprint Reduction of atherosclerosis in mice by inhibition of CD40 signalling
    F Mach
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 394:200-3. 1998
    ..These data support the involvement of inflammatory pathways in atherosclerosis and indicate a role for CD40 signalling during atherogenesis in hyperlipidaemic mice...
  4. pmc Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice
    U Schonbeck
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Avenue, LMRC 309, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 97:7458-63. 2000
    ..This study lends further support to the importance of this specific inflammatory signaling pathway in atherosclerosis and its complications...
  5. ncbi request reprint CD154 (CD40 ligand)
    U Schonbeck
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Int J Biochem Cell Biol 32:687-93. 2000
    ..Accordingly, CD40/CD154 interactions have advanced as a potential therapeutic target for these diseases, whereby two opposing strategies, interruption as well as enhancement of CD40 signaling, are explored for beneficial outcomes...
  6. ncbi request reprint CD40 signaling and plaque instability
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circ Res 89:1092-103. 2001
    ....
  7. pmc The serpin proteinase inhibitor 9 is an endogenous inhibitor of interleukin 1beta-converting enzyme (caspase-1) activity in human vascular smooth muscle cells
    J L Young
    Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 191:1535-44. 2000
    ....
  8. pmc Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis
    F Mach
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 94:1931-6. 1997
    ....
  9. ncbi request reprint Ligation of CD40 onvascular smooth muscle cells mediates loss of interstitial collagen via matrix metalloproteinase activity
    D B Horton
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann N Y Acad Sci 947:329-36. 2001
    ..Thus, CD40/CD40L interactions might play a key role in rendering atheromatous lesions prone to rupture...
  10. ncbi request reprint Soluble CD40L and cardiovascular risk in women
    U Schonbeck
    Leducq Center for Cardiovascular Research, Cardiovascular Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Circulation 104:2266-8. 2001
    ..It is unknown, however, whether elevations of circulating sCD40L precede the onset of acute cardiovascular symptoms...