Dean Scholl

Summary

Publications

  1. ncbi request reprint Genomic analysis of bacteriophages SP6 and K1-5, an estranged subgroup of the T7 supergroup
    D Scholl
    Section of Biochemical Genetics, The National Institute of Mental Health, NIH, 9000 Rockville Pike, Bethesda, MD 20895, USA
    J Mol Biol 335:1151-71. 2004
  2. pmc Escherichia coli K1's capsule is a barrier to bacteriophage T7
    Dean Scholl
    The National Institute of Mental Health, National Institutes of Health, Building 36, Room 3D20, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Appl Environ Microbiol 71:4872-4. 2005
  3. pmc The genome of bacteriophage K1F, a T7-like phage that has acquired the ability to replicate on K1 strains of Escherichia coli
    Dean Scholl
    National Institutes of Mental Health, National Institutes of Health, Building 49, Room B1B20, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Bacteriol 187:8499-503. 2005
  4. pmc Bacteriophage SP6 is closely related to phages K1-5, K5, and K1E but encodes a tail protein very similar to that of the distantly related P22
    Dean Scholl
    Laboratory of Biochemical Genetics, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Bacteriol 184:2833-6. 2002
  5. ncbi request reprint The prospect for bacteriophage therapy in Western medicine
    Carl R Merril
    Section on Biochemical Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Drug Discov 2:489-97. 2003
  6. ncbi request reprint The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities
    Petr G Leiman
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Mol Biol 371:836-49. 2007
  7. pmc Retargeting R-type pyocins to generate novel bactericidal protein complexes
    Steven R Williams
    AvidBiotics Corporation, 385 Oyster Point Blvd, Suite 6A, South San Francisco, CA 94080, USA
    Appl Environ Microbiol 74:3868-76. 2008

Collaborators

Detail Information

Publications7

  1. ncbi request reprint Genomic analysis of bacteriophages SP6 and K1-5, an estranged subgroup of the T7 supergroup
    D Scholl
    Section of Biochemical Genetics, The National Institute of Mental Health, NIH, 9000 Rockville Pike, Bethesda, MD 20895, USA
    J Mol Biol 335:1151-71. 2004
    ....
  2. pmc Escherichia coli K1's capsule is a barrier to bacteriophage T7
    Dean Scholl
    The National Institute of Mental Health, National Institutes of Health, Building 36, Room 3D20, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Appl Environ Microbiol 71:4872-4. 2005
    ..This observation suggests that the capsule plays an important role as a defense against some phages that recognize structures beneath it and that the K1-specific phages evolved to counter this physical barrier...
  3. pmc The genome of bacteriophage K1F, a T7-like phage that has acquired the ability to replicate on K1 strains of Escherichia coli
    Dean Scholl
    National Institutes of Mental Health, National Institutes of Health, Building 49, Room B1B20, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Bacteriol 187:8499-503. 2005
    ..It appears that diverse phages have acquired endosialidase genes by horizontal gene transfer and that these genes or gene products have adapted to different genome and virion architectures...
  4. pmc Bacteriophage SP6 is closely related to phages K1-5, K5, and K1E but encodes a tail protein very similar to that of the distantly related P22
    Dean Scholl
    Laboratory of Biochemical Genetics, National Institute of Mental Health, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    J Bacteriol 184:2833-6. 2002
    ..It now appears that SP6, K1-5, K5, and K1E are very closely related but have different tail fiber proteins, giving them different host specificities...
  5. ncbi request reprint The prospect for bacteriophage therapy in Western medicine
    Carl R Merril
    Section on Biochemical Genetics, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    Nat Rev Drug Discov 2:489-97. 2003
    ..Such efforts will be of importance given the emergence of antibiotic-resistant bacteria...
  6. ncbi request reprint The structures of bacteriophages K1E and K1-5 explain processive degradation of polysaccharide capsules and evolution of new host specificities
    Petr G Leiman
    Department of Biological Sciences, Purdue University, 915 W State Street, West Lafayette, IN 47907 2054, USA
    J Mol Biol 371:836-49. 2007
    ..The enzymes recognize the adapter protein by a conserved N-terminal sequence, providing a mechanism for phages to acquire different enzymes and thus to evolve new host specificities...
  7. pmc Retargeting R-type pyocins to generate novel bactericidal protein complexes
    Steven R Williams
    AvidBiotics Corporation, 385 Oyster Point Blvd, Suite 6A, South San Francisco, CA 94080, USA
    Appl Environ Microbiol 74:3868-76. 2008
    ..Engineered R-type pyocins may offer a novel alternative to traditional antibiotics in some infections...