Herpesvirus DNA (Epstein-Barr virus, herpes simplex virus, cytomegalovirus) in circulating monocytes of patients with coronary artery diseaseAxel Schlitt
Department of Medicine II and Virology, and Institute for Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Germany
Acta Cardiol 60:605-10. 2005
..As a possible trigger, several studies in recent years have suggested that different viruses and bacteria are associated with atherosclerotic diseases...
- Prognostic value of lipoproteins and their relation to inflammatory markers among patients with coronary artery disease
Axel Schlitt
Department of Medicine II, Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, 55101 Mainz, Germany
Int J Cardiol 102:477-85. 2005
..There is growing evidence indicating that those lipoprotein factors are related to the inflammatory process in atherogenesis...
- Anti-inflammatory effects of phospholipid transfer protein (PLTP) deficiency in mice
Axel Schlitt
Department of Anatomy and Cell Biology, State University of New York, Downstate Medical Center, Brooklyn, 11203, USA
Biochim Biophys Acta 1733:187-91. 2005
..The results of our experiments demonstrated an anti-inflammatory effect of PLTP deficiency as a further aspect of its proatherogenic potency...
- Serum sphingomyelin levels are related to the clearance of postprandial remnant-like particles
Axel Schlitt
Department of Anatomy and Cell Biology and Scientific Computing Center, State University of New York, Downstate Medical Center, Brooklyn, NY, USA
J Lipid Res 46:196-200. 2005
..Serum SM was positively correlated with serum TG (P <0.001), RLP SM (P <0.001), RLP TG (P <0.001), and RLP cholesterol (P <0.001) levels. It is our conclusion that serum SM is a marker for the clearance of RLPs...
- CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-alpha levels
Axel Schlitt
Department of Medicine II and Institute of Clinical Chemistry and Laboratory Medicine, Johannes Gutenberg University, Mainz, Germany
Thromb Haemost 92:419-24. 2004
..In accordance, recent animal studies suggest a possibly important role of these monocytes in the development of atherosclerosis...
- Fondaparinux and enoxaparin in comparison to unfractionated heparin in preventing thrombus formation on mechanical heart valves in an ex vivo rabbit model
Axel Schlitt
Department of Medicine II, Johannes Gutenberg University, 55101 Mainz, Germany
Thromb Haemost 90:245-51. 2003
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- Clopidogrel and aspirin in the prevention of thromboembolic complications after mechanical aortic valve replacement (CAPTA)
Axel Schlitt
Department of Medicine II, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, 55131 Mainz, Germany
Thromb Res 109:131-5. 2003
- High plasma phospholipid transfer protein levels as a risk factor for coronary artery disease
Axel Schlitt
Department of Medicine II, Johannes Gutenberg-University, Mainz, Germany
Arterioscler Thromb Vasc Biol 23:1857-62. 2003
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- Comparison of fondaparinux, low molecular-weight heparin and unfractionated heparin in preventing thrombus formation on mechanical heart valves: results of an in-vitro study
Axel Schlitt
Department of Medicine II, Department of Cardiovascular Surgery, and Transfusion Center, Johannes Gutenberg University, Mainz, Germany
J Heart Valve Dis 15:809-14. 2006
..The study aim was to investigate the efficacy of three different anticoagulants in preventing thrombus formation on mechanical heart valves, using an in-vitro system...
- Monocyte-derived dendritic cells of patients with coronary artery disease show an increased expression of costimulatory molecules CD40, CD80 and CD86 in vitro
Jörn F Dopheide
Department of Medicine II, Johannes Gutenberg University, Mainz, Germany
Coron Artery Dis 18:523-31. 2007
..So far, their role in atherosclerosis has not been fully elucidated. We investigated the phenotypic properties of DCs in patients with coronary artery disease (CAD) in comparison to healthy individuals...
- Relation of markers of inflammation (C-reactive protein, fibrinogen, von Willebrand factor, and leukocyte count) and statin therapy to long-term mortality in patients with angiographically proven coronary artery disease
Christoph Bickel
Department of Medicine II, Johannes Gutenberg University Mainz, Germany
Am J Cardiol 89:901-8. 2002
..Statin therapy is associated with elevated hs-CRP, with a risk reduction for fatal coronary events, independent of LDL levels; this, in part, may be explained by the anti-inflammatory effects on atherosclerosis...
- Phospholipid transfer protein in hemodialysis patients
Axel Schlitt
Department of Medicine III, Martin Luther University, Halle Wittenberg, Germany
Am J Nephrol 27:138-43. 2007
..The role of PLTP in atherogenesis is still controversial. We aimed to investigate PLTP activity in hemodialysis (HD) patients, a population which has an increased risk for the development of atherosclerosis...
- In-vitro comparison of fondaparinux, unfractionated heparin, and enoxaparin in preventing cardiac catheter-associated thrombus
Axel Schlitt
Department of Medicine III, Martin Luther University Halle Wittenberg, Halle Wittenberg, Germany
Coron Artery Dis 19:279-84. 2008
..Unexpectedly, there was an increase in catheter-related thrombus formation during percutaneous coronary interventions in fonda-treated patients...
- Myocardial ischemia/reperfusion causes VDAC phosphorylation which is reduced by cardioprotection with a p38 MAP kinase inhibitor
Hansjorg Schwertz
Department of Internal Medicine III, Martin Luther University, Halle Wittenberg, Halle Saale, Germany
Proteomics 7:4579-88. 2007
..Thus, p38 MAP kinase inhibition with PD169316 is cardioprotective, reduces neutrophil activation, and controls protein expression and phosphorylation in MI and reperfusion...
- Apoptosis contributes to septic cardiomyopathy and is improved by simvastatin therapy
Ute Buerke
Department of Medicine III, Martin Luther University, Halle Saale, Germany
Shock 29:497-503. 2008
..We provide novel evidence for the mechanisms by which septicemia causes myocardial depression and hint at a potential role for simvastatin as an inhibitor of apoptosis in sepsis...
- Serine protease inhibitor nafamostat given before reperfusion reduces inflammatory myocardial injury by complement and neutrophil inhibition
Hansjorg Schwertz
Department of Medicine III, Martin Luther University, Halle, Germany
J Cardiovasc Pharmacol 52:151-60. 2008
..Reduced leukocyte accumulation and complement activity seem involved in the mechanism of this cardioprotective effect...
