Impact of sepsis on neurodevelopmental outcome in a Swiss National Cohort of extremely premature infantsLuregn J Schlapbach
NICU and PICU, Department of Pediatrics, Inselspital, University of Bern, 3010 Bern, Switzerland
Pediatrics 128:e348-57. 2011
..This study aimed to determine the impact of sepsis on neurodevelopment at 2 years' corrected age in extremely preterm infants...
Copeptin concentration in cord blood in infants with early-onset sepsis, chorioamnionitis and perinatal asphyxiaLuregn J Schlapbach
Neonatal and Pediatric Intensive Care Unit, Department of Pediatrics, University of Bern, Switzerland
BMC Pediatr 11:38. 2011
..In contrast, its involvement in neonatal diseases remains unknown. The aim of this study was to establish copeptin concentrations in neonates of different stress states such as sepsis, chorioamnionitis and asphyxia...
Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitisLuregn J Schlapbach
Department of Pediatrics, University of Bern, 3010 Bern, Switzerland
Pediatr Res 64:562-6. 2008
..64). In conclusion, infants later developing NEC had significantly higher MASP-2 cord blood levels compared with controls. Higher MASP-2 may favor complement-mediated inflammation and could thereby predispose to NEC...
M-ficolin in children with cancerLuregn J Schlapbach
Department of Pediatrics, Inselspital, University of Bern, CH 3010 Bern, Switzerland
Immunobiology 216:633-8. 2011
..The aim of this study was to explore association of M-ficolin with clinical and hematological parameters, and to investigate whether the risk of chemotherapy-related infections was related to M-ficolin concentrations in serum...
Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsisLuregn J Schlapbach
Departments of Pediatrics, University of Bern, Bern, Switzerland
Clin Infect Dis 51:153-62. 2010
..The decreased expression of lectin pathway proteins in neonates must be considered to be an additional form of neonatal immunodeficiency...
Serum concentrations of lectin-pathway components in healthy neonates, children and adults: mannan-binding lectin (MBL), M-, L-, and H-ficolin, and MBL-associated serine protease-2 (MASP-2)Seraina Sallenbach
Department of Pediatrics, University of Bern, Bern, Switzerland
Pediatr Allergy Immunol 22:424-30. 2011
..The respective normal ranges for adults should not be used in the pediatric population. The age-specific pediatric ranges established here may be used instead...
Impact of chorioamnionitis and preeclampsia on neurodevelopmental outcome in preterm infants below 32 weeks gestational ageLuregn J Schlapbach
Department of Pediatrics, University of Bern, Switzerland
Acta Paediatr 99:1504-9. 2010
..Intrauterine conditions may interfere with foetal brain development. We compared the neurodevelopmental outcome between infants <32 weeks gestational age after maternal preeclampsia or chorioamnionitis and controls...
Mannan-binding lectin (MBL) and MBL-associated serine protease-2 in children with cancerUrs P Fisch
Department of Pediatrics, University of Bern, Switzerland
Swiss Med Wkly 141:w13191. 2011
..This study aimed to determine if serum concentrations of MBL and MASP-2 differ between children with cancer and healthy age-matched controls...
M-ficolin in the neonatal period: Associations with need for mechanical ventilation and mortality in premature infants with necrotising enterocolitisLuregn J Schlapbach
Department of Pediatrics, Inselspital, University of Bern, Switzerland
Mol Immunol 46:2597-603. 2009
..M-, L- and H-ficolins recognize microorganisms and activate the complement system, but their role in host defense is largely unknown. This study investigated whether ficolin concentrations are associated with NEC...
Prognosis in pediatric hematologic malignancies is associated with serum concentration of mannose-binding lectin-associated serine protease-2 (MASP-2)Aina Zehnder
Department of Pediatrics, University of Bern, Bern, Switzerland
Pediatr Blood Cancer 53:53-7. 2009
..Their serum concentrations show a wide interindividual variability. This study investigated whether the concentration of MBL and MASP-2 is associated with prognosis in pediatric patients with cancer...