Development of hypersynchrony in the cortical network during chemoconvulsant-induced epileptic seizures in vivoAdi Cymerblit-Sabba
Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion, Israel
J Neurophysiol 107:1718-30. 2012
..Hypersynchrony also characterized seizures. However, it initially developed in a small subset of neurons and gradually spread to involve the entire cortical network only in the later more intense ictal phases...
Activation of a calcium-activated cation current during epileptiform discharges and its possible role in sustaining seizure-like events in neocortical slicesYitzhak Schiller
Department of Technology, Rambam Medical Center, 1 Efron St, P O B 9602 Haifa, Israel 31096
J Neurophysiol 92:862-72. 2004
..These results indicated I(can) was activated during epileptiform discharges and probably participated in sustaining seizure-like events...
- Cellular mechanisms underlying antiepileptic effects of low- and high-frequency electrical stimulation in acute epilepsy in neocortical brain slices in vitro
Yitzhak Schiller
Department of Neurology, Rambam Medical Center, 1 Efron St, Haifa 31096, Israel
J Neurophysiol 97:1887-902. 2007
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- Quantifying the response to antiepileptic drugs: effect of past treatment history
Yitzhak Schiller
Department of Neurology, Rambam Medical Center, 1 Efron St, Haifa, Israel
Neurology 70:54-65. 2008
..To quantify the response to treatment with antiepileptic drugs (AEDs) as a function of the past treatment history and identify additional prognostic factors for predicting the response to newly administered AED treatments...
- Seizure relapse and development of drug resistance following long-term seizure remission
Yitzhak Schiller
Epilepsy Service, Department of Neurology, Rambam Medical Center, 1 Efron St, Haifa 31096, Israel
Arch Neurol 66:1233-9. 2009
..To quantify and identify predictive risk factors for seizure relapse and development of drug resistance in patients who achieved long-term (>1 year) antiepileptic drug-induced seizure remission...
- Network dynamics during development of pharmacologically induced epileptic seizures in rats in vivo
Adi Cymerblit-Sabba
Department of Physiology, Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
J Neurosci 30:1619-30. 2010
..These findings advance our understanding of the network dynamics leading to seizure initiation and may in future help in the development of novel seizure prediction algorithms...
- Prolonged ictal aphasia: a diagnosis to consider
Moshe Herskovitz
Department of Neurology, Epilepsy Service, Rambam Medical Center and the Technion Medical School, 1 Efron Street, Haifa 31096, Israel
J Clin Neurosci 19:1605-6. 2012
..In conclusion, prolonged ictal aphasia is a rare but important treatable cause of aphasia. Surface EEG recordings should be obtained in all patients with unexplained prolonged aphasia to diagnose this rare but treatable entity...
- Inter-ictal- and ictal-like epileptic discharges in the dendritic tree of neocortical pyramidal neurons
Yitzhak Schiller
Department of Neurology, Rambam Medical Center, Haifa 31696, Israel
J Neurophysiol 88:2954-62. 2002
..During electrographic seizures the origin of epileptic bursts shifted from the apical dendritic tree to the soma-basal region...
- Atrial fibrillation associated with epileptic seizures
Moshe Herskovitz
Department of Neurology, Rambam Medical Center, 1 Efron St, Haifa 31096, Israel
Arch Neurol 69:1197-9. 2012
..Epileptic seizures are often associated with changes in cardiac autonomic function. Yet atrial fibrillation (AFib) or atrial flutter (AFlu) following epileptic seizures has only rarely been reported in the past...
