David W Scheifele

Summary

Publications

  1. ncbi request reprint Optimizing Canadian public immunization programs: a prescription for action
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation CAIRE
    Can J Public Health 102:193-5. 2011
  2. pmc Safety and immunogenicity of 2010–2011 A/H1N1pdm09-containing trivalent inactivated influenza vaccine in adults previously given AS03-adjuvanted H1N1 2009 pandemic vaccine: results of a randomized trial
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, BC Canada
    Hum Vaccin Immunother 9:136-43. 2013
  3. ncbi request reprint Approved but non-funded vaccines: accessing individual protection
    David W Scheifele
    Vaccine Evaluation Center, University of British Columbia, Vancouver, BC, Canada Electronic address
    Vaccine 32:766-70. 2014
  4. doi request reprint Evaluation of adjuvanted pandemic H1N1(2009) influenza vaccine after one and two doses in young children
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 30:402-7. 2011
  5. doi request reprint Strategies for successful rapid trials of influenza vaccine
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Clin Trials 8:699-704. 2011
  6. doi request reprint The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000-2007
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, BC, Canada
    Vaccine 28:2130-6. 2010
  7. pmc Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: a public health agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study
    Mona Al-Dabbagh
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Vaccine Immunol 20:1108-14. 2013
  8. ncbi request reprint Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007
    David W Scheifele
    Division of Pediatric Infectious and Immunologic Diseases, University of British Columbia, Vancouver, British Columbia
    Pediatr Infect Dis J 27:755-7. 2008
  9. ncbi request reprint A nationwide survey of past hepatitis A infections among Canadian adults
    David W Scheifele
    University of British Columbia, Vancouver, BC, Canada
    Vaccine 28:5174-8. 2010
  10. ncbi request reprint Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB)
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver V5Z4H4, Canada Electronic address
    Vaccine 32:124-30. 2013

Collaborators

Detail Information

Publications41

  1. ncbi request reprint Optimizing Canadian public immunization programs: a prescription for action
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation CAIRE
    Can J Public Health 102:193-5. 2011
    ..Demonstrating that Canadian immunization programs are among the world's best and safest is a sound strategy for maintaining public participation in those programs...
  2. pmc Safety and immunogenicity of 2010–2011 A/H1N1pdm09-containing trivalent inactivated influenza vaccine in adults previously given AS03-adjuvanted H1N1 2009 pandemic vaccine: results of a randomized trial
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, BC Canada
    Hum Vaccin Immunother 9:136-43. 2013
    ..In summary, titers ≥ 40 persisted in only half the participants 9-10 mo after adjuvanted pandemic vaccine but were restored in nearly all after TIV vaccination, with minimal increase in adverse effects...
  3. ncbi request reprint Approved but non-funded vaccines: accessing individual protection
    David W Scheifele
    Vaccine Evaluation Center, University of British Columbia, Vancouver, BC, Canada Electronic address
    Vaccine 32:766-70. 2014
    ..The greatest need is to change the widespread perception that approved vaccines should be publicly funded or ignored. ..
  4. doi request reprint Evaluation of adjuvanted pandemic H1N1(2009) influenza vaccine after one and two doses in young children
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 30:402-7. 2011
    ..When Canada chose an adjuvanted influenza A H1N1(2009) vaccine for pandemic control, dosing requirements and safety in children were unknown. This study compared responses after 1 and 2 doses in young children...
  5. doi request reprint Strategies for successful rapid trials of influenza vaccine
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Clin Trials 8:699-704. 2011
    ..Descriptions of how best to design studies for rapid completion are few...
  6. doi request reprint The effect of routine vaccination on invasive pneumococcal infections in Canadian children, Immunization Monitoring Program, Active 2000-2007
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, BC, Canada
    Vaccine 28:2130-6. 2010
    ..Cefotaxime/ceftriaxone resistance remained unchanged at 2% of isolates annually. Universal pneumococcal conjugate infant immunization programs have dramatically decreased cases of invasive pneumococcal disease...
  7. pmc Elevated inflammatory mediators in adults with oculorespiratory syndrome following influenza immunization: a public health agency of Canada/Canadian Institutes of Health Research Influenza Research Network Study
    Mona Al-Dabbagh
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Vaccine Immunol 20:1108-14. 2013
    ..Further investigations are warranted, as they might identify subjects who are at risk for ORS prior to vaccination. ..
  8. ncbi request reprint Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007
    David W Scheifele
    Division of Pediatric Infectious and Immunologic Diseases, University of British Columbia, Vancouver, British Columbia
    Pediatr Infect Dis J 27:755-7. 2008
    ..Surveillance at 12 pediatric centers in 2004-2007 indicates that vaccine failures remain rare and case totals approach an irreducible minimum, with no age shift...
  9. ncbi request reprint A nationwide survey of past hepatitis A infections among Canadian adults
    David W Scheifele
    University of British Columbia, Vancouver, BC, Canada
    Vaccine 28:5174-8. 2010
    ..A nationwide pediatric serosurvey in 2003 confirmed that HAV infection is uncommon in children. Additional seroepidemiological data for adults would help to guide domestic use of HAV vaccines...
  10. ncbi request reprint Diversity of Canadian meningococcal serogroup B isolates and estimated coverage by an investigational meningococcal serogroup B vaccine (4CMenB)
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver V5Z4H4, Canada Electronic address
    Vaccine 32:124-30. 2013
    ....
  11. ncbi request reprint Invasive pneumococcal infections in Canadian children, 1998-2003: implications for new vaccination programs
    Julie A Bettinger
    Vaccine Evaluation Centre, BC Children s Hospital and the University of British Columbia, Vancouver, BC
    Can J Public Health 98:111-5. 2007
    ..We conducted active surveillance for invasive pneumococcal disease to assess the serotype and antibiotic resistance patterns in Canada prior to universal infant immunization programs, in most provinces...
  12. doi request reprint The disease burden of invasive meningococcal serogroup B disease in Canada
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 32:e20-5. 2013
    ..New serogroup B vaccines may offer the potential for prevention and control. This report examines the disease burden caused by serogroup B invasive meningococcal infections...
  13. ncbi request reprint Cellular immunity as a potential cause of local reactions to booster vaccination with diphtheria and tetanus toxoids and acellular pertussis antigens
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 28:985-9. 2009
    ..Cell-mediated immunity (CMI) develops after primary DTaP vaccination and might contribute to local reactions to booster doses, a possibility explored in this study...
  14. doi request reprint Evaluation of meningococcal serogroup C conjugate vaccine programs in Canadian children: interim analysis
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital, Vancouver, Canada
    Vaccine 30:4023-7. 2012
    ..To assess antibody titers afforded by meningococcal C- (MenC) tetanus toxoid conjugate vaccine at 12 months of age in three different immunization schedules...
  15. ncbi request reprint Effectiveness of pneumococcal conjugate vaccine in Greater Vancouver, Canada: 2004-2005
    Gordean Bjornson
    Vaccine Evaluation Center, BC Children s Hospital, Vancouver, B C, Canada
    Pediatr Infect Dis J 26:540-2. 2007
    ..In the subpopulation with best case ascertainment disease rates for 6-23 month olds decreased 84.6% (92.5% for vaccine serotypes)...
  16. doi request reprint Compatibility of ASO3-adjuvanted H1N1pdm09 and seasonal trivalent influenza vaccines in adults: results of a randomized, controlled trial
    David W Scheifele
    Vaccine Evaluation Center, University of British Columbia, Vancouver, BC, Canada
    Vaccine 30:4728-32. 2012
    ..Adverse event rates were not increased by concurrent vaccinations above those with H1N1pdm09 vaccine alone. This adjuvanted H1N1pdm09 vaccine was immunogenic and compatible with concurrently administered TIV...
  17. ncbi request reprint The impact of childhood meningococcal serogroup C conjugate vaccine programs in Canada
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 28:220-4. 2009
    ..The staggered implementation of universal childhood meningococcal C conjugate (MenC) immunization programs across Canada offers an opportunity to evaluate the influence of these programs...
  18. ncbi request reprint Pandemic influenza in Canadian children: a summary of hospitalized pediatric cases
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, BC, Canada
    Vaccine 28:3180-4. 2010
    ..Close to 50% of children received antiviral medication. Two children died from the infection. The pediatric risk groups affected and course of disease caused by pandemic H1N1 appear similar to seasonal influenza...
  19. doi request reprint Controlling serogroup B invasive meningococcal disease: the Canadian perspective
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, A5 950 West 28th Street, Vancouver, BC V5Z 4H4, Canada
    Expert Rev Vaccines 12:505-17. 2013
    ..In this article, the authors provide an overview of the Canadian epidemiology, serogroup B vaccine characteristics, potential strain coverage, immunization strategies and remaining postmarketing research questions...
  20. ncbi request reprint Immunologic considerations for the timing of the booster dose of 7-valent pneumococcal conjugate vaccine in young children
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, BC, Canada
    Pediatr Infect Dis J 26:387-92. 2007
    ....
  21. doi request reprint Randomized controlled trial of dose response to influenza vaccine in children aged 6 to 23 months
    Danuta M Skowronski
    British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Pediatrics 128:e276-89. 2011
    ..We assessed whether 2 full versus 2 half-doses of trivalent inactivated influenza vaccine (TIV) could improve immunogenicity without increasing reactogenicity in infants (aged 6-11 months) and toddlers (aged 12-23 months)...
  22. pmc Knowledge, attitudes, beliefs and behaviours of older adults about pneumococcal immunization, a Public Health Agency of Canada/Canadian Institutes of Health Research Influenza Research Network (PCIRN) investigation
    Amy Schneeberg
    School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Public Health 14:442. 2014
    ..Fewer Canadian seniors are vaccinated against pneumococcal disease than receive the influenza vaccine annually. Improved understanding of factors influencing pneumococcal vaccination among older adults is needed to improve vaccine uptake...
  23. ncbi request reprint Burden of seasonal influenza in children with neurodevelopmental conditions
    Catherine Burton
    From the Division of Infectious Diseases, Department of Pediatrics, Stollery Children s Hospital, University of Alberta, Edmonton, Alberta Division of Infectious Diseases, Department of Pediatrics, Montreal Children s Hospital, McGill University, Montreal, Québec Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia Division of Infectious Diseases, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario and Canadian Center for Vaccinology, IWK Health Center, Dalhousie University, Halifax, Nova Scotia, Canada
    Pediatr Infect Dis J 33:710-4. 2014
    ..We describe the burden of influenza in hospitalized children with NNC, focusing on those without potential airway compromise...
  24. ncbi request reprint Oculorespiratory syndrome after influenza immunization in children
    Danuta M Skowronski
    Epidemiology Services, UBC Centre for Disease Control, 655 West 12t Avenue, Vancouver, BC, Canada V5Z 4R4
    Pediatr Infect Dis J 24:63-9. 2005
    ..ORS included bilateral red eyes, facial edema or respiratory symptoms beginning within 24 hours of influenza immunization. Few reports involved children. We assessed the rate of ORS in a pediatric cohort...
  25. ncbi request reprint A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trial
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation CAIRE and the Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 24:1059-66. 2005
    ..Large injection site reactions commonly follow booster doses of diphtheria-tetanus-acellular pertussis (DTaP) vaccines at 4-6 years of age. A vaccine with lower diphtheria and pertussis dosage (Tdap) might be better tolerated for this dose...
  26. ncbi request reprint The effect of changing from whole-cell to acellular pertussis vaccine on the epidemiology of hospitalized children with pertussis in Canada
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 26:31-5. 2007
    ..To assess effects on pertussis epidemiology of this nationwide change, we analyzed hospitalizations during 1991-2004 using the Canadian Immunization Monitoring Program, Active (IMPACT) pertussis database...
  27. ncbi request reprint Hepatitis A vaccines: the growing case for universal immunisation of children
    David W Scheifele
    BC Children s Hospital, Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada
    Expert Opin Pharmacother 6:157-64. 2005
    ..Universal programmes are cost-effective, especially when a combined hepatitis A and B vaccine can be used to minimise incremental costs, and deserve wider consideration in developed countries...
  28. doi request reprint Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial
    Simon R M Dobson
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    JAMA 309:1793-802. 2013
    ..Global use of human papillomavirus (HPV) vaccines to prevent cervical cancer is impeded by cost. A 2-dose schedule for girls may be possible...
  29. pmc Heterogeneity of rotavirus testing and admitting practices for gastroenteritis among 12 tertiary care pediatric hospitals: Implications for surveillance
    Julie A Bettinger
    Vaccine Evaluation Centre, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia
    Can J Infect Dis Med Microbiol 22:15-8. 2011
    ..Understanding this variation is important when interpreting surveillance data and estimating the cost-effectiveness of rotavirus vaccination programs...
  30. ncbi request reprint Participant-collected, mail-delivered oral fluid specimens can replace traditional serosurveys: a demonstration-of-feasibility survey of hepatitis A virus-specific antibodies in adults
    Jan J Ochnio
    University of British Columbia, Department of Pediatrics, Vaccine Evaluation Centre, Vancouver
    Can J Public Health 98:37-40. 2007
    ..Use of participant self-collected oral fluid as a diagnostic specimen and mail for specimen delivery has the potential of generating reliable, population-representative data at limited cost...
  31. pmc Canada needs a national immunization program: an open letter to the Honourable Anne McLellan, federal minister of health
    Monika Naus
    Epidemiology Services, BC Centre for Disease Control and University of British Columbia, Vancouver, BC
    CMAJ 168:567-8. 2003
  32. ncbi request reprint Ocular and respiratory symptoms attributable to inactivated split influenza vaccine: evidence from a controlled trial involving adults
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation of Vancouver, British Columbia, Canada
    Clin Infect Dis 36:850-7. 2003
    ..We conclude that certain mild oculorespiratory symptoms were triggered by an influenza vaccine that was otherwise minimally reactogenic and, hence, that such symptoms might be associated with influenza vaccines in general...
  33. doi request reprint The epidemiology of children hospitalized with herpes zoster in Canada: Immunization Monitoring Program, Active (IMPACT), 1991-2005
    Susan H Wootton
    University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 27:112-8. 2008
    ..Varicella vaccine has had a profound impact on the incidence of varicella; however the impact on HZ remains uncertain...
  34. doi request reprint Influenza vaccination in paediatric nurses: cross-sectional study of coverage, refusal, and factors in acceptance
    Seamus P Norton
    Department of Paediatrics, British Columbia s Children s Hospital, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Vaccine 26:2942-8. 2008
    ..We also sought to identify the reasons for which nurses refuse the influenza vaccine and predictors of future vaccination intent...
  35. ncbi request reprint Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
    Vaccine 24:2057-64. 2006
    ..008) and HB responses were reduced (p=0.006) with concurrent dosing, the latter possibly from same thigh injection with DTaP.IPV/Hib. We conclude that PCV7, DTaP.IPV/Hib and HB are compatible with concurrent, separate injections...
  36. ncbi request reprint Population-based epidemiology of invasive pneumococcal infection in children in nine urban centers in Canada, 1994 through 1998
    Gordean L Bjornson
    Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 21:947-50. 2002
    ..To describe the epidemiology of invasive pneumococcal infections in Canadian children 0 to 12 years old...
  37. pmc The challenges facing Canadian trialists in an increasingly competitive global market: What can be done to remain competitive?
    David W Scheifele
    The Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia
    Can J Infect Dis Med Microbiol 18:205-8. 2007
    ..The present article highlights strategies to help researchers remain internationally competitive for industry-sponsored pharmaceutical studies...
  38. pmc Hepatitis A vaccine: is it being used to best advantage?
    David W Scheifele
    Vaccine Evaluation Center, British Columbia s Children s Hospital, Department of Pediatrics, University of British Columbia, Vancouver
    CMAJ 167:44-5. 2002
  39. ncbi request reprint Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection
    Aaron F Hirschfeld
    Department of Paediatrics, BC Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Clin Immunol 122:271-8. 2007
    ....
  40. ncbi request reprint Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus
    Raymond H See
    University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
    J Gen Virol 87:641-50. 2006
    ..Finally, the sera of vaccinated mice contained antibodies to S, further suggesting a role for this protein in conferring protective immunity against SARS-CoV infection...
  41. doi request reprint Adverse neurologic reactions after both doses of pandemic H1N1 influenza vaccine with optic neuritis and demyelination
    Keswadee Lapphra
    Vaccine Evaluation Center, Department of Pediatrics, British Columbia Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 30:84-6. 2011
    ..A causal association is more likely with repeated injury following influenza vaccination...