The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cellsBrian A Zabel
ChemoCentryx, Inc, 850 Maude Avenue, Mountain View, CA 94043, USA
Mol Cancer 10:73. 2011
..In this study, we set out to assess the potential stimulation by CXCL12 of tumor cell TEM towards other chemokines and whether CXCR7 might be able to regulate such effects...
Overcoming hurdles in developing successful drugs targeting chemokine receptorsThomas J Schall
ChemoCentryx, Inc, 850 Maude Avenue, Mountain View, California 94043, USA
Nat Rev Immunol 11:355-63. 2011
..We highlight evidence suggesting that chemokine receptor inhibition will prove to be an effective therapy in inflammatory diseases...
Proinflammatory proteases liberate a discrete high-affinity functional FPRL1 (CCR12) ligand from CCL23Zhenhua Miao
ChemoCentryx, Mountain View, CA 94043, USA
J Immunol 178:7395-404. 2007
..The sequential activation of a transient FPRL1 ligand and a longer-lived CCR1 ligand within a single chemokine may have important consequences for the development of inflammation or the link between innate and adaptive immunity...
- Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease
Matthew J Walters
ChemoCentryx, Inc, Mountain View, CA 94043, USA
J Pharmacol Exp Ther 335:61-9. 2010
..Analysis of the plasma level of drug associated with this improvement provides an understanding of the pharmacokinetic/pharmacodynamic relationship for CCR9 antagonists in the treatment of intestinal inflammation...
- Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands
Brian A Zabel
ChemoCentryx, Mountain View, CA 94043, USA
J Immunol 183:3204-11. 2009
..CXCR7 ligands, such as the chemokine CXCL11 and the newly described synthetic molecule CCX771, may represent novel therapeutic opportunities for the control of such cells...
- CXCR7 protein is not expressed on human or mouse leukocytes
Robert D Berahovich
ChemoCentryx, Inc, Mountain View, CA 94043, USA
J Immunol 185:5130-9. 2010
..These studies therefore suggest that, whereas CXCR7 protein is expressed by primitive RBCs during murine embryonic development, in adult mammals CXCR7 protein is not expressed by normal peripheral blood cells...
- Evidence for NK cell subsets based on chemokine receptor expression
Robert D Berahovich
ChemoCentryx, 850 Maude Avenue, Mountain View, CA 94043, USA
J Immunol 177:7833-40. 2006
..These results indicate that within both the CD56(bright) and CD56(dim) NK cell populations, subsets with the capacity for differential trafficking programs exist, which likely influence their functions in innate and adaptive immunity...
- Proteolytic activation of alternative CCR1 ligands in inflammation
Robert D Berahovich
ChemoCentryx, Mountain View, CA 94043, USA
J Immunol 174:7341-51. 2005
..These data suggest that alternative CCR1 ligands are converted into potent chemoattractants by proteases released during inflammatory responses in vivo...
- A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development
Jennifer M Burns
ChemoCentryx, Inc, Mountain View, CA 94043, USA
J Exp Med 203:2201-13. 2006
....
- CCR1 blockade reduces tumor burden and osteolysis in vivo in a mouse model of myeloma bone disease
Daniel J Dairaghi
ChemoCentryx Inc, 850 Maude Ave, Mountain View, CA 94043, USA
Blood 120:1449-57. 2012
..These results provide a strong rationale for further development of CCR1 antagonists for the treatment of MM and associated osteolytic bone disease...
- CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature
Zhenhua Miao
ChemoCentryx, Inc, Mountain View, CA 94043, USA
Proc Natl Acad Sci U S A 104:15735-40. 2007
..Taken together, these data suggest that CXCR7 has key functions in promoting tumor development and progression...
- Potent immunosuppressive activities of cytomegalovirus-encoded interleukin-10
Juliet V Spencer
ChemoCentryx, San Carlos, California 94070, USA
J Virol 76:1285-92. 2002
..These results demonstrate for the first time that CMV has a biologically active IL-10 homolog that may contribute to immune evasion during virus infection...
- Comprehensive mapping of poxvirus vCCI chemokine-binding protein. Expanded range of ligand interactions and unusual dissociation kinetics
Jennifer M Burns
Division of Discovery Biology and Molecular Pharmacology, ChemoCentryx, San Carlos, California 94070, USA
J Biol Chem 277:2785-9. 2002
..The determination of the binding fingerprint and unusual binding interactions of vCCI with a large number of chemokines suggest a finely honed evolutionary strategy of chemokine sequestration during viral infection...
