Gogiraju R, Schroeter M, Bochenek M, Hubert A, Munzel T, Hasenfuss G, et al
. Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice. Cardiovasc Res. 2016;111:204-16 pubmed publisher
..Endothelial PTP1B deletion improves cardiac VEGF signalling and angiogenesis and protects against chronic afterload-induced heart failure. PTP1B may represent a useful target to preserve cardiac function during hypertrophy. ..
Drosos I, Chalikias G, Pavlaki M, Kareli D, Epitropou G, Bougioukas G, et al
. Differences between perivascular adipose tissue surrounding the heart and the internal mammary artery: possible role for the leptin-inflammation-fibrosis-hypoxia axis. Clin Res Cardiol. 2016;105:887-900 pubmed
Bochenek M, Schütz E, Schafer K. Endothelial cell senescence and thrombosis: Ageing clots. Thromb Res. 2016;147:36-45 pubmed publisher
..Finally, we briefly discuss potential targets and therapeutic options to prevent, postpone or treat endothelial senescence and thus the increased burden of thrombosis associated with age. ..
Bochenek M, Rosinus N, Lankeit M, Hobohm L, Bremmer F, SchÃ¼tz E, et al
. From thrombosis to fibrosis in chronic thromboembolic pulmonary hypertension. Thromb Haemost. 2017;117:769-783 pubmed publisher
..This systematic histological characterisation of the material obstructing pulmonary vessels in CTEPH may provide a valuable basis for further studies aimed at determining causal factors underlying this disease. ..
Hubert A, Bochenek M, Schütz E, Gogiraju R, Munzel T, Schafer K. Selective Deletion of Leptin Signaling in Endothelial Cells Enhances Neointima Formation and Phenocopies the Vascular Effects of Diet-Induced Obesity in Mice. Arterioscler Thromb Vasc Biol. 2017;37:1683-1697 pubmed publisher
..These observations and the identification of endothelin-1 as soluble mediator of the cardiovascular risk factor obesity may have relevant therapeutic implications. ..
Schütz E, Bochenek M, Riehl D, Bosmann M, Munzel T, Konstantinides S, et al
. Absence of transforming growth factor beta 1 in murine platelets reduces neointima formation without affecting arterial thrombosis. Thromb Haemost. 2017;117:1782-1797 pubmed publisher
..Our findings support an essential role for platelet-derived TGF?1 for the vascular remodelling response to arterial injury, apparently independent from the role of platelets in thrombosis or haemostasis. ..